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Probucol will become a new model for treating cerebral infarction with a high risk of hemorrhage: A narrative review 普罗布考将成为治疗出血风险高的脑梗塞的新模式:叙述性综述
IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_44_23
Liguo Lang, Jianying Zhang, Dongju Zheng, Huanmin Gao
Lipid-lowering agents are relevant in stroke prevention. Probucol (PU) is an antioxidative and lipid-lowering drug that has been used to treat atherosclerotic cardiovascular diseases and xanthomas. The drug penetrates the core of low-density lipoprotein cholesterol (LDL-C) particles, enhancing the activity of plasma cholesterol l ester transfer protein (CETP) and strengthening the liver scavenger receptor type I, resulting in reducing LDL-C; by increasing the activity of paraoxonase 1, upregulating the antioxidant function of high-density lipoprotein (HDL), and it decreases the serum HDL-cholesterol (HDL-C) level. This drug has been retired from the Western markets for lowering HDL-C levels and Q-interval prolongation. The latter side effect has been rarely reported and may be transient. Recent clinical evidence supports the effectiveness of PU in preventing cardiovascular events and in reducing mortality, irrespective of the reduction of HDL-C. Based on basic research and clinical studies, it appears that PU might be a valuable alternative when statins are ineffective or contraindicated, in patients at high risk of recurrence of cerebral ischemia and hemorrhage.
降脂药与中风的预防息息相关。普罗布考(PU)是一种抗氧化和降脂药物,已被用于治疗动脉粥样硬化性心血管疾病和黄疽。该药可穿透低密度脂蛋白胆固醇(LDL-C)颗粒的核心,增强血浆胆固醇酯转移蛋白(CETP)的活性,强化肝脏清道夫受体 I 型,从而降低 LDL-C;通过增加副氧合酶 1 的活性,上调高密度脂蛋白(HDL)的抗氧化功能,降低血清高密度脂蛋白胆固醇(HDL-C)水平。这种药物因降低高密度脂蛋白胆固醇水平和 Q 间期延长而退出西方市场。后一种副作用很少见报道,而且可能是一过性的。最近的临床证据表明,无论高密度脂蛋白胆固醇是否降低,PU 在预防心血管事件和降低死亡率方面都很有效。根据基础研究和临床研究,当他汀类药物无效或禁用时,对于脑缺血和出血复发风险较高的患者来说,PU 似乎是一种有价值的替代药物。
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引用次数: 0
Explore the role of long noncoding RNAs and mRNAs in intracranial atherosclerotic stenosis: From the perspective of neutrophils 探索长非编码 RNA 和 mRNA 在颅内动脉粥样硬化性狭窄中的作用:从中性粒细胞的角度
IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_63_23
Yilin Wang, Tao Wang, Z. Han, Rongliang Wang, Yue Hu, Zhenhong Yang, Tong Shen, Yangmin Zheng, Jichang Luo, Yan Ma, Yumin Luo, Liqun Jiao
CONTEXT: Circulating neutrophils and long noncoding RNAs (lncRNAs) play various roles in intracranial atherosclerotic stenosis (ICAS). OBJECTIVE: Our study aimed to detect differentially expressed (DE) lncRNAs and mRNAs in circulating neutrophils and explore the pathogenesis of atherosclerosis from the perspective of neutrophils. METHODS: Nineteen patients with ICAS and 15 healthy controls were enrolled. The peripheral blood of the participants was collected, and neutrophils were separated. The expression profiles of lncRNAs and mRNAs in neutrophils from five patients and five healthy controls were obtained, and DE lncRNAs and mRNAs were selected. Six lncRNAs were selected and validated using quantitative reverse transcription–polymerase chain reaction (qRT-PCR), and ceRNA and lncRNA-RNA binding protein (RBP)-mRNA networks were constructed. Correlation analysis between lncRNAs and mRNAs was performed. Functional enrichment annotations were also performed. RESULTS: Volcano plots and heat maps displayed the expression profiles and DE lncRNAs and mRNAs, respectively. The qRT-PCR results revealed that the four lncRNAs showed a tendency consistent with the expression profile, with statistical significance. The ceRNA network revealed three pairs of regulatory networks: lncRNA RP3-406A7.3-NAGLU, lncRNA HOTAIRM1-MVK/IL-25/GBF1/CNOT4/ANKK1/PLEKHG6, and lncRNA RP11-701H16.4-ZNF416. The lncRNA-RBP-mRNA network showed five pairs of regulatory networks: lncRNA RP11-701H16.4-TEK, lncRNA RP11-701H16.4-MED17, lncRNA SNHG19-NADH-ubiquinone oxidoreductase core subunit V1, lncRNA RP3-406A7.3-Angel1, and lncRNA HOTAIRM1-CARD16. CONCLUSIONS: Our study identified and verified four lncRNAs in neutrophils derived from peripheral blood, which may explain the transcriptional alteration of neutrophils during the pathophysiological process of ICAS. Our results provide insights for research related to the pathogenic mechanisms and drug design of ICAS.
背景:循环中性粒细胞和长非编码RNA(lncRNA)在颅内动脉粥样硬化性狭窄(ICAS)中发挥着不同的作用。目的:我们的研究旨在检测循环中性粒细胞中差异表达(DE)的lncRNAs和mRNAs,并从中性粒细胞的角度探讨动脉粥样硬化的发病机制。方法:共招募了19名ICAS患者和15名健康对照者。采集患者外周血,分离中性粒细胞。获得5名患者和5名健康对照者中性粒细胞中lncRNAs和mRNAs的表达谱,并筛选出DE lncRNAs和mRNAs。利用反转录聚合酶链反应(qRT-PCR)定量验证了6个lncRNA,并构建了ceRNA和lncRNA-RNA结合蛋白(RBP)-mRNA网络。进行了 lncRNA 与 mRNA 之间的相关性分析。还进行了功能富集注释。结果:火山图和热图分别显示了表达谱以及DE lncRNA和mRNA。qRT-PCR结果显示,四个lncRNA与表达谱呈一致趋势,并具有统计学意义。ceRNA网络显示了三对调控网络:lncRNA RP3-406A7.3-NAGLU、lncRNA HOTAIRM1-MVK/IL-25/GBF1/CNOT4/ANKK1/PLEKHG6和lncRNA RP11-701H16.4-ZNF416。lncRNA-RBP-mRNA网络显示了5对调控网络:lncRNA RP11-701H16.4-TEK、lncRNA RP11-701H16.4-MED17、lncRNA SNHG19-NADH-泛醌氧化还原酶核心亚基V1、lncRNA RP3-406A7.3-Angel1和lncRNA HOTAIRM1-CARD16。结论:我们的研究在来自外周血的中性粒细胞中发现并验证了四个lncRNA,这可能解释了ICAS病理生理过程中中性粒细胞的转录改变。我们的研究结果为ICAS的发病机制和药物设计相关研究提供了启示。
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引用次数: 0
Localization of cerebral vasculopathy following bacterial meningitis: What can we learn about postinfective ischemic sequelae? 细菌性脑膜炎后脑血管病的定位:我们能从感染后缺血性后遗症中学到什么?
IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_97_22
V. Kumar, V. Kumar
Cerebrovascular complications of bacterial meningitis account for a high incidence of mortality and postinfective neurologic sequelae. Cerebrovascular complications occurring during acute bacterial meningitis are evident from angiographic evidence demonstrating arterial occlusion and vessel wall narrowing, histopathological studies demonstrating vessel wall changes, and radiographic studies demonstrating the presence of brain infarcts. Cerebrovascular disease during bacterial meningitis has been demonstrated in of Haemophilus influenzae, Streptococcus pneumonia, Group B Streptococcus, and Mycobacterium tuberculosis models of meningitis. Despite models of bacterial meningitis showing variable patterns of cerebral vasculopathy as a contributor to different aspects of postinfectious neurological decline, very few studies describe the predominant localization of cerebral vasculopathy with different meningitis causing pathogens. Thus, this review attempts to analyze the different locations of cerebral vasculopathic changes occuring in response to different microbial pathogens and provide a pathophysiologic basis for such an observation.
细菌性脑膜炎的脑血管并发症是死亡率和感染后神经系统后遗症的高发因素。急性细菌性脑膜炎期间发生的脑血管并发症可通过血管造影显示动脉闭塞和血管壁狭窄、组织病理学研究显示血管壁变化以及放射学研究显示脑梗塞的存在而得到证实。细菌性脑膜炎期间的脑血管疾病已在流感嗜血杆菌、肺炎链球菌、B 组链球菌和结核分枝杆菌脑膜炎模型中得到证实。尽管细菌性脑膜炎模型显示脑血管病是导致感染后神经功能衰退不同方面的一个因素,但很少有研究描述不同脑膜炎病原体引起的脑血管病的主要定位。因此,本综述试图分析不同微生物病原体引起的脑血管病变的不同部位,并为这种观察提供病理生理学依据。
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引用次数: 0
Optimal rehabilitation strategies for early postacute stroke recovery: An ongoing inquiry 脑卒中急性期后早期恢复的最佳康复策略:持续探索
IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_33_23
Yanna Tong, Yuchuan Ding, Zhenzhen Han, Honglian Duan, Xiaokun Geng
Early rehabilitation is crucial in reducing stroke-related disability, but the optimal training model remains unclear. We conducted a trial comparing different initiation timings and intensities of mobilization strategies after stroke. Results showed that early intensive mobilization had favorable outcomes at 3 months post-stroke, while very early intensive mobilization had poorer chances of favorable outcomes. Our investigation into brain injury mechanisms induced by very early exercise within 24 hours of stroke onset aligned with guidelines advising against high-dose very early mobilization. Additionally, we are studying the effects of various exercise intensities and frequencies on early stroke rehabilitation. Integrated rehabilitation models, such as combining remote ischemic conditioning (RIC) with exercise (RICE), hold promise. Our study found RICE to be safe and feasible for early rehabilitation of acute ischemic stroke patients, and further research is underway to determine its efficacy in a larger sample size. Despite extensive research, identifying the most effective early recovery strategies remains a complex challenge, necessitating ongoing work in the field of early rehabilitation after stroke.
早期康复对减少中风相关残疾至关重要,但最佳训练模式仍不明确。我们进行了一项试验,比较了脑卒中后不同启动时间和强度的动员策略。结果表明,早期强化动员对卒中后 3 个月的预后有利,而极早期强化动员的预后较差。我们对脑卒中发病后 24 小时内过早运动所诱发的脑损伤机制进行了调查,这与反对大剂量过早动员的指导方针是一致的。此外,我们还在研究各种运动强度和频率对中风早期康复的影响。综合康复模式,如将远程缺血调节(RIC)与运动(RICE)相结合,前景广阔。我们的研究发现,RICE 对急性缺血性脑卒中患者的早期康复是安全可行的,目前正在进行进一步的研究,以确定其在更大样本量中的疗效。尽管开展了大量研究,但确定最有效的早期康复策略仍是一项复杂的挑战,因此有必要在中风后早期康复领域持续开展工作。
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引用次数: 0
Recurrent ischemic stroke from reversible extracranial internal carotid artery and middle cerebral artery vasospasm: A case report 可逆性颅外颈内动脉和大脑中动脉血管痉挛导致的复发性缺血性中风:病例报告
IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_47_23
Aini He, K. Dong, Wenbo Zhao, Benke Zhao, Wei Sun, Xiao Wu, Xia Lu, Yanfei Chen, Haiqing Song
Idiopathic internal carotid artery (ICA) vasospasm is a rare cause of ischemic stroke. Its pathophysiology remains unclear and diagnostic and treatment protocols are yet to be defined. A 45-year-old male, presenting with recurrent transient dizziness, blurred vision, and speech disturbances, was diagnosed with recurrent ischemic stroke caused by bilateral ICA and middle cerebral artery (MCA) vasospasm, and the vascular ultrasound and imaging techniques have grabbed the reversible changes in a short time. This case underscores the importance of considering idiopathic ICA vasospasm as a potential cause of recurrent ischemic stroke, even in the absence of common diagnostic markers. The case also indicates the possible, albeit rare, involvement of the MCA in this condition. Therefore, it is crucial to maintain a high index of suspicion for idiopathic ICA vasospasm in similar clinical presentations and to explore more inclusive diagnostic criteria.
特发性颈内动脉(ICA)血管痉挛是缺血性中风的罕见病因。其病理生理学尚不清楚,诊断和治疗方案也尚未确定。一名 45 岁的男性患者反复出现一过性头晕、视力模糊和言语障碍,被诊断为双侧 ICA 和大脑中动脉(MCA)血管痉挛引起的复发性缺血性卒中,血管超声和成像技术在短时间内发现了可逆性改变。本病例强调了将特发性 ICA 血管痉挛视为复发性缺血性卒中潜在病因的重要性,即使缺乏常见的诊断标志物。该病例还表明,尽管罕见,但 MCA 也可能受累于这种情况。因此,对类似临床表现的特发性 ICA 血管痉挛保持高度怀疑并探索更具包容性的诊断标准至关重要。
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引用次数: 0
The microbiome and neurosurgery 微生物组与神经外科
IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_59_23
James Kelbert, Thomas C. Varkey
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引用次数: 0
Rule out alternative causes before attributing polyradiculitis to influenza or severe acute respiratory syndrome coronavirus 2 vaccination 在将多发性神经炎归咎于流感或严重急性呼吸道综合征冠状病毒 2 疫苗接种之前,应排除其他原因
IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_14_23
J. Finsterer
{"title":"Rule out alternative causes before attributing polyradiculitis to influenza or severe acute respiratory syndrome coronavirus 2 vaccination","authors":"J. Finsterer","doi":"10.4103/bc.bc_14_23","DOIUrl":"https://doi.org/10.4103/bc.bc_14_23","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"25 1","pages":"262 - 263"},"PeriodicalIF":1.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139330853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent paraneoplastic cerebral hemorrhage in lung cancer: A case report. 肺癌复发性副肿瘤脑出血1例。
IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-04-01 DOI: 10.4103/bc.bc_78_22
Michele Alessiani, Adriano Bonura, Gianmarco Iaccarino, Marilena Mangiardi, Francesca Romana Pezzella, Maria Cristina Bravi, Domenica Crupi, Michele Galluzzo, Sabrina Anticoli

Cerebral hemorrhage management in a patient requiring anticoagulant therapy is a therapeutic challenge also due to the absence of guidelines that convincingly define the best therapeutic strategy. Although the occurrence of cerebral hemorrhage in a patient with anticoagulant therapy seems to make the bleeding etiology obvious, sometimes, it is better to reflect on other possible causes and set up an adequate diagnostic workup. Herein, we describe a case of a 73-year-old male patient with atrial fibrillation, mechanical heart valve, and pacemaker that experienced an ischemic minor stroke during steady anticoagulation therapy with recurrent intracerebral haemorrhages (ICHs).

需要抗凝治疗的脑出血患者的治疗也是一项治疗挑战,因为缺乏令人信服地确定最佳治疗策略的指南。虽然在接受抗凝治疗的患者中发生脑出血似乎使出血的病因明显,但有时,最好考虑其他可能的原因并建立充分的诊断检查。在此,我们描述了一个73岁的男性心房颤动患者,机械心脏瓣膜和起搏器,经历了一个缺血性轻微中风在稳定抗凝治疗与复发性脑出血(ICHs)。
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引用次数: 0
Basilar artery recanalization by proximal balloon occlusion and aspiration in a single vessel vertebrobasilar system: A case report. 单血管椎基底动脉系统近端球囊闭塞与抽吸再通1例。
IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-04-01 DOI: 10.4103/bc.bc_79_22
Matthew Gusler, Seyed-Mostafa Razavi, Aaron Grossman, Charles Prestigiacomo, Ashkan Mowla, Peyman Shirani

The authors present a case of a patient with a hypoplastic right vertebral artery (VA) ending in the posterior inferior cerebellar artery who sustained an acute onset basilar artery occlusion. A balloon-guided catheter was used to proximally occlude the dominant left VA, and aspiration was applied until reversal of flow was achieved in the basilar artery. Thus, basilar artery reperfusion was achieved without the need for stent-retrieval thrombectomy. We believe this represents the first described case of successful thrombectomy in the vertebrobasilar system using only proximal artery occlusion and aspiration. This novel technique may decrease the time to recanalization and improve outcomes for patients with acute basilar artery occlusion in the setting of a hypoplastic contralateral VA.

作者提出了一个病例与发育不良的右椎动脉(VA)结束于小脑后下动脉谁持续急性发作基底动脉闭塞。使用球囊引导导管近端阻塞左侧主干静脉,并进行抽吸,直至基底动脉血流逆转。因此,无需支架取栓即可实现基底动脉再灌注。我们认为这是第一例椎基底动脉系统中仅使用近端动脉闭塞和抽吸成功取栓的病例。这种新技术可以减少对侧静脉曲张发育不全的急性基底动脉闭塞患者的再通时间并改善预后。
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引用次数: 0
Transradial access for neurointerventional procedures: A practical approach. 神经介入手术的经桡骨通路:一种实用的方法。
IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-04-01 DOI: 10.4103/bc.bc_101_22
Mohammad Hossein Mirbolouk, Feizollah Ebrahimnia, Reza Gorji, Payam Sasannejad, Samira Zabihyan, Mohammad Adeeb Hoveizavi, Yousefali Garivani, Zahra Mirzaasgari, Saeed Abdollahifard, Ashkan Mowla, Humain Baharvahdat

Introduction: Transradial approach (TRA) is a new technique proposed for performing cerebral angiography and neuro-interventional procedures. In this article, we sought to provide a step-by-step guide for carrying out a diagnostic cerebral angiography using this approach and summarize our center's experience.

Material and methods: Records of patients since January 2020 were investigated, and data on demographic indices, reports of the procedures, outcomes, and complications were extracted. Then, these data were used to develop a step-by-step instruction for TRA cerebral angiography.

Results: Two hundred eighty-nine patients matched our eligibility criteria with a mean age of 50 years and a female-to-male ratio of 1.18. Overall, TRA was carried out successfully for 97.2% (281 patients). In case TRA failed, transfemoral approach was considered for the procedure. Three minor complications (two vasospasm and one small hematoma) and two major complications (one pseudoaneurysm of the radial artery and one radial artery avulsion) were observed.

Conclusion: This article covers challenges a neurointerventionalist may face during a diagnostic cerebral angiography using TRA. Furthermore, our findings indicated that cerebral angiography with TRA might be performed safely and with a great success rate.

简介:经桡动脉入路(TRA)是一种用于脑血管造影和神经介入手术的新技术。在这篇文章中,我们试图为使用这种方法进行诊断性脑血管造影提供一个循序渐进的指南,并总结我们中心的经验。材料和方法:调查2020年1月以来的患者记录,提取人口统计学指标、手术报告、结果和并发症的数据。然后,这些数据用于制定TRA脑血管造影的分步指导。结果:289例患者符合我们的资格标准,平均年龄50岁,男女比例为1.18。总体而言,97.2%(281例)的患者成功进行了TRA。如果TRA失败,则考虑经股入路。观察到3例轻微并发症(2例血管痉挛和1例小血肿)和2例主要并发症(1例桡动脉假性动脉瘤和1例桡动脉撕脱)。结论:本文涵盖了神经介入医师在使用TRA诊断脑血管造影时可能面临的挑战。此外,我们的研究结果表明,使用TRA进行脑血管造影是安全的,成功率很高。
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引用次数: 0
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Brain Circulation
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