T. Takayama, A. Fujisaki, S. Ando, S. Kurokawa, T. Morita
Introduction: The efficacy and safety of sunitinib in elderly patients with advanced renal cell carcinoma (RCC) remains poorly documented. Methods: We assessed the efficacy and safety of sunitinib in first-line treatment of advanced RCC in the aged by reviewing the medical records of patients at Jichi Medical University Hospital, Japan. The patients were stratified into age < 75 (n = 38) and ≥ 75 (n = 9) years groups. Results: Median progression-free survival in younger and older patients was comparable, at 7.3 vs. 6.7 months, respectively (HR, 1.101; 95% CI: 0.399-3.039; p = 0.8532). Median overall survival was also comparable, at 19.2 vs. 11.8 months (HR, 0.775; 95% CI: 0.349-1.719; p = 0.5299). Younger and older patients did not significantly differ in the frequency of any grade and grade 3 or more adverse events, or in the incidence of patients with grade 3 or more adverse events. Conclusions: Treatment with sunitinib is effective and safe in elderly patients with advanced RCC although the limited sample size for older group can cause weak statistical power and only patients with no severe comorbidities were selected.
{"title":"Efficacy and Safety of Sunitinib in Elderly Patients with Advanced Renal Cell Carcinoma at a University Hospital in Japan: Before Immuno-Oncology Therapy Era","authors":"T. Takayama, A. Fujisaki, S. Ando, S. Kurokawa, T. Morita","doi":"10.36959/896/599","DOIUrl":"https://doi.org/10.36959/896/599","url":null,"abstract":"Introduction: The efficacy and safety of sunitinib in elderly patients with advanced renal cell carcinoma (RCC) remains poorly documented. Methods: We assessed the efficacy and safety of sunitinib in first-line treatment of advanced RCC in the aged by reviewing the medical records of patients at Jichi Medical University Hospital, Japan. The patients were stratified into age < 75 (n = 38) and ≥ 75 (n = 9) years groups. Results: Median progression-free survival in younger and older patients was comparable, at 7.3 vs. 6.7 months, respectively (HR, 1.101; 95% CI: 0.399-3.039; p = 0.8532). Median overall survival was also comparable, at 19.2 vs. 11.8 months (HR, 0.775; 95% CI: 0.349-1.719; p = 0.5299). Younger and older patients did not significantly differ in the frequency of any grade and grade 3 or more adverse events, or in the incidence of patients with grade 3 or more adverse events. Conclusions: Treatment with sunitinib is effective and safe in elderly patients with advanced RCC although the limited sample size for older group can cause weak statistical power and only patients with no severe comorbidities were selected.","PeriodicalId":92927,"journal":{"name":"Journal of renal cancer","volume":"44 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78062143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rosanne Diaz, F. Antón, M. L. Carreira, I. Martel, A. Moreno
Six months later an intravenous urography showed absence of visualization of the left kidney parenchyma and the ureter. A retrograde pyelography demonstrated a partial obstruction in the proximal third of the left ureter. He underwent ureteroscopy that showed an erythematous lesion not available for biopsy. A sample of urine from selective catheterization of the left ureter showed carcinoma consistent with urothelial carcinoma. A computed tomography (CT) of the thorax and abdomen showed multiple adenopathies in the abdomen and metastasis in the lungs, liver and spine. A bone gammagraphy showed pathological deposits in the left shoulder, ribs, spine and the right pelvis. A biopsy of a liver lesion was positive for urothelial carcinoma.
{"title":"Meningeal Carcinomatosis in a Patient with an Upper Urinary Tract Urothelial Cell Carcinoma","authors":"Rosanne Diaz, F. Antón, M. L. Carreira, I. Martel, A. Moreno","doi":"10.36959/896/600","DOIUrl":"https://doi.org/10.36959/896/600","url":null,"abstract":"Six months later an intravenous urography showed absence of visualization of the left kidney parenchyma and the ureter. A retrograde pyelography demonstrated a partial obstruction in the proximal third of the left ureter. He underwent ureteroscopy that showed an erythematous lesion not available for biopsy. A sample of urine from selective catheterization of the left ureter showed carcinoma consistent with urothelial carcinoma. A computed tomography (CT) of the thorax and abdomen showed multiple adenopathies in the abdomen and metastasis in the lungs, liver and spine. A bone gammagraphy showed pathological deposits in the left shoulder, ribs, spine and the right pelvis. A biopsy of a liver lesion was positive for urothelial carcinoma.","PeriodicalId":92927,"journal":{"name":"Journal of renal cancer","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78065158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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