Pub Date : 2020-01-01Epub Date: 2019-08-20DOI: 10.1007/s00018-019-03278-z
Jinshou Yang, Bo Ren, Gang Yang, Huanyu Wang, Guangyu Chen, Lei You, Taiping Zhang, Yupei Zhao
Pancreatic ductal adenocarcinoma is prone to distant metastasis and is expected to become the second leading cause of cancer-related death. In an extremely nutrient-deficient and hypoxic environment resulting from uncontrolled growth, vascular disturbances and desmoplastic reactions, pancreatic cancer cells utilize "metabolic reprogramming" to satisfy their energy demand and support malignant behaviors such as metastasis. Notably, pancreatic cancer cells show extensive enhancement of glycolysis, including glycolytic enzyme overexpression and increased lactate production, and this is caused by mitochondrial dysfunction, cancer driver genes, specific transcription factors, a hypoxic tumor microenvironment and stromal cells, such as cancer-associated fibroblasts and tumor-associated macrophages. The metabolic switch from oxidative phosphorylation to glycolysis in pancreatic cancer cells regulates the invasion-metastasis cascade by promoting epithelial-mesenchymal transition, tumor angiogenesis and the metastatic colonization of distant organs. In addition to aerobic glycolysis, oxidative phosphorylation also plays a critical role in pancreatic cancer metastasis in ways that remain unclear. In this review, we expound on the intracellular and extracellular causes of the enhancement of glycolysis in pancreatic cancer and the strong association between glycolysis and cancer metastasis, which we expect will yield new therapeutic approaches targeting cancer metabolism.
{"title":"The enhancement of glycolysis regulates pancreatic cancer metastasis.","authors":"Jinshou Yang, Bo Ren, Gang Yang, Huanyu Wang, Guangyu Chen, Lei You, Taiping Zhang, Yupei Zhao","doi":"10.1007/s00018-019-03278-z","DOIUrl":"10.1007/s00018-019-03278-z","url":null,"abstract":"<p><p>Pancreatic ductal adenocarcinoma is prone to distant metastasis and is expected to become the second leading cause of cancer-related death. In an extremely nutrient-deficient and hypoxic environment resulting from uncontrolled growth, vascular disturbances and desmoplastic reactions, pancreatic cancer cells utilize \"metabolic reprogramming\" to satisfy their energy demand and support malignant behaviors such as metastasis. Notably, pancreatic cancer cells show extensive enhancement of glycolysis, including glycolytic enzyme overexpression and increased lactate production, and this is caused by mitochondrial dysfunction, cancer driver genes, specific transcription factors, a hypoxic tumor microenvironment and stromal cells, such as cancer-associated fibroblasts and tumor-associated macrophages. The metabolic switch from oxidative phosphorylation to glycolysis in pancreatic cancer cells regulates the invasion-metastasis cascade by promoting epithelial-mesenchymal transition, tumor angiogenesis and the metastatic colonization of distant organs. In addition to aerobic glycolysis, oxidative phosphorylation also plays a critical role in pancreatic cancer metastasis in ways that remain unclear. In this review, we expound on the intracellular and extracellular causes of the enhancement of glycolysis in pancreatic cancer and the strong association between glycolysis and cancer metastasis, which we expect will yield new therapeutic approaches targeting cancer metabolism.</p>","PeriodicalId":92933,"journal":{"name":"Letters in peptide science : LIPS","volume":"9 1","pages":"305-321"},"PeriodicalIF":8.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73918959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Ruczyński, Z. Konstański, R. Korolkiewicz, J. Petrusewicz, P. Rekowski
{"title":"Galanin and its analogues: A structure-activity relationship studies in rat isolated gastric smooth muscles","authors":"J. Ruczyński, Z. Konstański, R. Korolkiewicz, J. Petrusewicz, P. Rekowski","doi":"10.1007/BF02576870","DOIUrl":"https://doi.org/10.1007/BF02576870","url":null,"abstract":"","PeriodicalId":92933,"journal":{"name":"Letters in peptide science : LIPS","volume":"1 1","pages":"91-99"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02576870","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52291469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Solvent assistance in regiospecific disulfide formation in dimethylsulfoxide","authors":"J. Tam, X. Dong, Cui-Rong Wu","doi":"10.1007/BF02443421","DOIUrl":"https://doi.org/10.1007/BF02443421","url":null,"abstract":"","PeriodicalId":92933,"journal":{"name":"Letters in peptide science : LIPS","volume":"6 1","pages":"265-273"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02443421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51858470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mathieu, C. Lehmann, A. Razaname, G. Tuchscherer
{"title":"Engineering of zinc finger and MHC motifs to locked-in tertiary folds","authors":"M. Mathieu, C. Lehmann, A. Razaname, G. Tuchscherer","doi":"10.1007/BF02443520","DOIUrl":"https://doi.org/10.1007/BF02443520","url":null,"abstract":"","PeriodicalId":92933,"journal":{"name":"Letters in peptide science : LIPS","volume":"4 1","pages":"95-100"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02443520","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51861942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of peptide-modified pyoverdins by a fluorescentPseudomonas strain grown in isoleucine-supplemented medium","authors":"M. Ongena, P. Jacques, E. Pauw, P. Thonart","doi":"10.1007/BF02443574","DOIUrl":"https://doi.org/10.1007/BF02443574","url":null,"abstract":"","PeriodicalId":92933,"journal":{"name":"Letters in peptide science : LIPS","volume":"8 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02443574","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51863710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Maji, D. Velmurugan, A. Razak, H. Fun, A. Banerjee
{"title":"5-Membered NH…N hydrogen bonded molecular scaffold in a model dipeptide containing 3-aminophenylacetic acid: Crystal and solution conformations","authors":"S. Maji, D. Velmurugan, A. Razak, H. Fun, A. Banerjee","doi":"10.1007/BF02443599","DOIUrl":"https://doi.org/10.1007/BF02443599","url":null,"abstract":"","PeriodicalId":92933,"journal":{"name":"Letters in peptide science : LIPS","volume":"7 1","pages":"353-358"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02443599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51864005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Luo, Yan‐Mei Li, Zhongzhou Chen, Hiroshi Abe, Li-Ping Cui, H. Nakanishi, X. Qin, Yu-Fen Zhao
{"title":"Synthesis and matrix assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry study of phosphopeptide","authors":"S. Luo, Yan‐Mei Li, Zhongzhou Chen, Hiroshi Abe, Li-Ping Cui, H. Nakanishi, X. Qin, Yu-Fen Zhao","doi":"10.1007/BF02443643","DOIUrl":"https://doi.org/10.1007/BF02443643","url":null,"abstract":"","PeriodicalId":92933,"journal":{"name":"Letters in peptide science : LIPS","volume":"10 1","pages":"57-62"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02443643","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51864805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nucleo amino acids as arginine mimetics in cyclic peptides","authors":"K. Lorenz, U. Diederichsen","doi":"10.1007/BF02443650","DOIUrl":"https://doi.org/10.1007/BF02443650","url":null,"abstract":"","PeriodicalId":92933,"journal":{"name":"Letters in peptide science : LIPS","volume":"10 1","pages":"111-117"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02443650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51865159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Blanchfield, J. Dutton, R. Hogg, D. Craik, David John Adams, Richard G. Lewis, P. Alewood, I. Toth
{"title":"The synthesis and structure of an n-terminal dodecanoic acid conjugate of α-conotoxin MII","authors":"J. Blanchfield, J. Dutton, R. Hogg, D. Craik, David John Adams, Richard G. Lewis, P. Alewood, I. Toth","doi":"10.1007/BF02446522","DOIUrl":"https://doi.org/10.1007/BF02446522","url":null,"abstract":"","PeriodicalId":92933,"journal":{"name":"Letters in peptide science : LIPS","volume":"46 1","pages":"235-239"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02446522","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51952067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of stable cysteine-heterodisulphides","authors":"E. Cros, M. Planas, E. Bardaji","doi":"10.1007/BF02538300","DOIUrl":"https://doi.org/10.1007/BF02538300","url":null,"abstract":"","PeriodicalId":92933,"journal":{"name":"Letters in peptide science : LIPS","volume":"69 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02538300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51808024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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