首页 > 最新文献

Archives of depression and anxiety最新文献

英文 中文
Prevalence of anxiety and depression in ecuadorian adolescents 厄瓜多尔青少年焦虑和抑郁的患病率
Pub Date : 2023-08-02 DOI: 10.17352/2455-5460.000080
Ramírez Zhindón Marina del Rocío, Ramón Herrera Angel Ricardo, Ortega Jimenez David Mauricio
Objective: To determine the prevalence and incidence of anxiety disorders and depression with loneliness in a sample of adolescents. Material and methodology: Quantitative, correlational, cross-sectional study including 330 Ecuadorian adolescents selected by non-probabilistic purposive sampling. The Ad Hoc Questionnaire, the Depression, Anxiety, and Stress Scale (DASS-21), and the UCLA Loneliness Scale were used for data collection. Results: Of the 330 adolescents, 65.5% were male, and the mean age was 16.8 years. Sixty, 60% are in their third year of high school and 39.4% are in their second year. Most of them live in the province of Pichincha 36.1%. In anxiety they present an average of 6.4 and in depression of 5.7; they have an average of 42 in loneliness. There is a positive correlation between anxiety, depression and loneliness. Finally, females have higher levels of depression. Conclusion: Adolescents do not present anxiety or depression disorders, however, they present high levels of loneliness. There is a positive correlation between anxiety, depression, and loneliness, that is, the higher the levels of loneliness, the higher the probability that adolescents present anxiety or depression. Likewise, there is evidence of higher levels of depression in females.
目的:了解青少年焦虑障碍和抑郁伴孤独的患病率和发病率。材料和方法:定量的、相关的、横断面研究,包括330名厄瓜多尔青少年,通过非概率目的抽样选择。采用特设问卷、抑郁、焦虑和压力量表(DASS-21)和加州大学洛杉矶分校孤独量表进行数据收集。结果:330例青少年中,男性占65.5%,平均年龄16.8岁。60%在高中三年级39.4%在高中二年级。他们大多数住在皮钦查省36.1%。焦虑的平均得分为6.4分,抑郁的平均得分为5.7分;他们的孤独感平均为42。焦虑、抑郁和孤独之间存在正相关关系。最后,女性的抑郁程度更高。结论:青少年没有出现焦虑或抑郁障碍,但他们表现出高度的孤独感。焦虑、抑郁和孤独之间存在正相关关系,即孤独水平越高,青少年出现焦虑或抑郁的可能性越高。同样,有证据表明女性的抑郁程度更高。
{"title":"Prevalence of anxiety and depression in ecuadorian adolescents","authors":"Ramírez Zhindón Marina del Rocío, Ramón Herrera Angel Ricardo, Ortega Jimenez David Mauricio","doi":"10.17352/2455-5460.000080","DOIUrl":"https://doi.org/10.17352/2455-5460.000080","url":null,"abstract":"Objective: To determine the prevalence and incidence of anxiety disorders and depression with loneliness in a sample of adolescents. Material and methodology: Quantitative, correlational, cross-sectional study including 330 Ecuadorian adolescents selected by non-probabilistic purposive sampling. The Ad Hoc Questionnaire, the Depression, Anxiety, and Stress Scale (DASS-21), and the UCLA Loneliness Scale were used for data collection. Results: Of the 330 adolescents, 65.5% were male, and the mean age was 16.8 years. Sixty, 60% are in their third year of high school and 39.4% are in their second year. Most of them live in the province of Pichincha 36.1%. In anxiety they present an average of 6.4 and in depression of 5.7; they have an average of 42 in loneliness. There is a positive correlation between anxiety, depression and loneliness. Finally, females have higher levels of depression. Conclusion: Adolescents do not present anxiety or depression disorders, however, they present high levels of loneliness. There is a positive correlation between anxiety, depression, and loneliness, that is, the higher the levels of loneliness, the higher the probability that adolescents present anxiety or depression. Likewise, there is evidence of higher levels of depression in females.","PeriodicalId":92986,"journal":{"name":"Archives of depression and anxiety","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43990819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to help managing emotions felt by bipolar patients? 如何帮助管理双相情感障碍患者的情绪?
Pub Date : 2023-07-01 DOI: 10.17352/2455-5460.000079
B. Michel
The regulation of the control of the emotional experience is one of the determining parameters of the adaptation of an individual to his environment. Bipolar disorder is a psychiatric pathology in which disturbances in the processing of emotions are particularly marked during acute episodes and persist during the interictal period. Treatment with mood stabilizers generally improves the perception of emotions, while antidepressants are brakes on this perception. Finally, simple psychological measures can be useful in controlling emotions.
情绪体验控制的调节是个体适应环境的决定性参数之一。双相情感障碍是一种精神病理学,其中情绪处理障碍在急性发作期间特别明显,并在发作间期持续存在。情绪稳定剂的治疗通常能改善情绪感知,而抗抑郁药则能抑制这种感知。最后,简单的心理措施在控制情绪方面是有用的。
{"title":"How to help managing emotions felt by bipolar patients?","authors":"B. Michel","doi":"10.17352/2455-5460.000079","DOIUrl":"https://doi.org/10.17352/2455-5460.000079","url":null,"abstract":"The regulation of the control of the emotional experience is one of the determining parameters of the adaptation of an individual to his environment. Bipolar disorder is a psychiatric pathology in which disturbances in the processing of emotions are particularly marked during acute episodes and persist during the interictal period. Treatment with mood stabilizers generally improves the perception of emotions, while antidepressants are brakes on this perception. Finally, simple psychological measures can be useful in controlling emotions.","PeriodicalId":92986,"journal":{"name":"Archives of depression and anxiety","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44675551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing anxiety disorders in bipolar patients 双相情感障碍患者的焦虑障碍管理
Pub Date : 2023-06-20 DOI: 10.17352/2455-5460.000078
B. Michel
Anxiety disorders are among the main comorbidities encountered in patients with bipolar disease. Numerous clinical and epidemiological studies show an increased prevalence of anxiety pathologies (generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder, panic disorder, and post-traumatic stress disorder) in bipolar subjects compared to the frequencies in the general population. Anxiety disorders are not without consequences on the evolutionary course of the mood disorder, including a significant reduction in euthymia time and less sensitivity to conventional medicinal therapies.
焦虑障碍是双相情感障碍患者遇到的主要合并症之一。大量临床和流行病学研究表明,与普通人群相比,双相情感障碍受试者的焦虑症(广泛性焦虑症、社交焦虑症、强迫症、恐慌症和创伤后应激障碍)患病率增加。焦虑症对情绪障碍的进化过程并非没有影响,包括处女膜时间显著缩短和对传统药物治疗的敏感性降低。
{"title":"Managing anxiety disorders in bipolar patients","authors":"B. Michel","doi":"10.17352/2455-5460.000078","DOIUrl":"https://doi.org/10.17352/2455-5460.000078","url":null,"abstract":"Anxiety disorders are among the main comorbidities encountered in patients with bipolar disease. Numerous clinical and epidemiological studies show an increased prevalence of anxiety pathologies (generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder, panic disorder, and post-traumatic stress disorder) in bipolar subjects compared to the frequencies in the general population. Anxiety disorders are not without consequences on the evolutionary course of the mood disorder, including a significant reduction in euthymia time and less sensitivity to conventional medicinal therapies.","PeriodicalId":92986,"journal":{"name":"Archives of depression and anxiety","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43259890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep and bipolar disorder 睡眠与双相情感障碍
Pub Date : 2023-06-01 DOI: 10.17352/2455-5460.000077
B. Michel
A growing international scientific literature demonstrates the existence of sleep abnormalities and sleep/wake (or circadian) rhythms in bipolar disorder. These abnormalities exist during the acute phases of the disease, with the classic presentation of insomnia or hypersomnia during depressive episodes and a reduced need for sleep without feeling tired during manic episodes. But these disturbances can also appear or persist during phases of mood stability. However, it has now been clearly demonstrated that these disturbances can precipitate a new depressive or manic episode.
越来越多的国际科学文献表明,双相情感障碍中存在睡眠异常和睡眠/觉醒(或昼夜节律)节律。这些异常存在于疾病的急性期,在抑郁发作期间典型表现为失眠或嗜睡,在躁狂发作期间需要睡眠减少而不感到疲倦。但这些干扰也可能在情绪稳定阶段出现或持续。然而,现在已经清楚地表明,这些干扰可能引发新的抑郁或躁狂发作。
{"title":"Sleep and bipolar disorder","authors":"B. Michel","doi":"10.17352/2455-5460.000077","DOIUrl":"https://doi.org/10.17352/2455-5460.000077","url":null,"abstract":"A growing international scientific literature demonstrates the existence of sleep abnormalities and sleep/wake (or circadian) rhythms in bipolar disorder. These abnormalities exist during the acute phases of the disease, with the classic presentation of insomnia or hypersomnia during depressive episodes and a reduced need for sleep without feeling tired during manic episodes. But these disturbances can also appear or persist during phases of mood stability. However, it has now been clearly demonstrated that these disturbances can precipitate a new depressive or manic episode.","PeriodicalId":92986,"journal":{"name":"Archives of depression and anxiety","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46561635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bullying, spirituality, anxiety and depression 欺凌、精神、焦虑和抑郁
Pub Date : 2023-05-17 DOI: 10.17352/2455-5460.000076
Chatlos John Calvin
A recently developed Cognitive Behavioral Theory (CBT)-based process has been used to understand and explore the nature of spirituality and spiritual experience and its healing characteristics. Experiences of self-worth and dignity (both are operationalized) as the core of spirituality are directly injured by bullying with resultant depression and anxiety. Bullying experiences with progression to actively bullying are devastating to our spiritual core and undermine fundamental faith in self, others and life. This level of injury is often not recognized by many bullying programs. This preliminary communication is presented for researchers in these areas to consider how this process may be used for further research and prevention and intervention efforts.
最近发展的一种基于认知行为理论(CBT)的过程被用来理解和探索灵性和精神体验的本质及其治疗特征。作为精神核心的自我价值和尊严的体验(两者都是可操作的)直接受到欺凌的伤害,导致抑郁和焦虑。欺凌经历发展到主动欺凌对我们的精神核心是毁灭性的,破坏了对自我、他人和生活的基本信念。这种程度的伤害通常没有被许多欺凌项目所认识到。这一初步交流是为这些领域的研究人员提供的,以考虑如何将这一过程用于进一步的研究、预防和干预工作。
{"title":"Bullying, spirituality, anxiety and depression","authors":"Chatlos John Calvin","doi":"10.17352/2455-5460.000076","DOIUrl":"https://doi.org/10.17352/2455-5460.000076","url":null,"abstract":"A recently developed Cognitive Behavioral Theory (CBT)-based process has been used to understand and explore the nature of spirituality and spiritual experience and its healing characteristics. Experiences of self-worth and dignity (both are operationalized) as the core of spirituality are directly injured by bullying with resultant depression and anxiety. Bullying experiences with progression to actively bullying are devastating to our spiritual core and undermine fundamental faith in self, others and life. This level of injury is often not recognized by many bullying programs. This preliminary communication is presented for researchers in these areas to consider how this process may be used for further research and prevention and intervention efforts.","PeriodicalId":92986,"journal":{"name":"Archives of depression and anxiety","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47310550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of the "Golden Circle" exercise on personal goal achievements of stroke survivors: Preliminary findings “黄金圈”运动对中风幸存者个人目标实现的影响:初步发现
Pub Date : 2023-05-09 DOI: 10.17352/2455-5460.000075
Carmeli Eli, Grencel Irit, Fogelman Yacov
The success of a patient's rehabilitation depends greatly on many variables. Stroke survivors are often not sufficiently or fully aware of their mental health condition, and as a result are unresponsive, frustrated, and have difficulty with executive functions. The aim was to investigate the effect of the "Golden Circle" cognitive exercise on the quality of life of post-stroke patients. The subjects were 30 volunteers at a subacute stage after an ischemic stroke. They were randomly allocated to either an experimental group (n = 15) or a control group (n = 15). Quality of life questionnaire and Visual Analogue Scale administered. They were asked to draw a circle on a blank A4 page and at the top to write a title, and within the circle to write their problems, their suggested solutions and to intuitively write associations to a color, a taste, an animal, and a general physical sensation, and below these the date. Following the intervention experimental group showed improvement in walking, standing up, daily activities and general quality of life. Using the "Golden Circle" exercise to improve self-awareness and motivation in stroke survivors contributes to coping and taking responsibility for their rehabilitation.
患者康复的成功在很大程度上取决于许多变量。中风幸存者往往没有充分或完全意识到自己的心理健康状况,因此反应迟钝、沮丧,执行功能困难。目的是研究“黄金圈”认知锻炼对脑卒中后患者生活质量的影响。受试者是30名处于缺血性中风亚急性期的志愿者。他们被随机分配到一个实验组(n=15)或一个对照组(n=5)。生活质量调查表和视觉模拟量表。他们被要求在一张空白的A4纸上画一个圆圈,在顶部写一个标题,在圆圈内写下他们的问题、建议的解决方案,并直观地写下与颜色、味道、动物和一般身体感觉的关联,在这些关联下面写下日期。干预后,实验组在行走、站立、日常活动和总体生活质量方面均有改善。使用“黄金圈”练习来提高中风幸存者的自我意识和动机,有助于应对和承担康复责任。
{"title":"The effect of the \"Golden Circle\" exercise on personal goal achievements of stroke survivors: Preliminary findings","authors":"Carmeli Eli, Grencel Irit, Fogelman Yacov","doi":"10.17352/2455-5460.000075","DOIUrl":"https://doi.org/10.17352/2455-5460.000075","url":null,"abstract":"The success of a patient's rehabilitation depends greatly on many variables. Stroke survivors are often not sufficiently or fully aware of their mental health condition, and as a result are unresponsive, frustrated, and have difficulty with executive functions. The aim was to investigate the effect of the \"Golden Circle\" cognitive exercise on the quality of life of post-stroke patients. The subjects were 30 volunteers at a subacute stage after an ischemic stroke. They were randomly allocated to either an experimental group (n = 15) or a control group (n = 15). Quality of life questionnaire and Visual Analogue Scale administered. They were asked to draw a circle on a blank A4 page and at the top to write a title, and within the circle to write their problems, their suggested solutions and to intuitively write associations to a color, a taste, an animal, and a general physical sensation, and below these the date. Following the intervention experimental group showed improvement in walking, standing up, daily activities and general quality of life. Using the \"Golden Circle\" exercise to improve self-awareness and motivation in stroke survivors contributes to coping and taking responsibility for their rehabilitation.","PeriodicalId":92986,"journal":{"name":"Archives of depression and anxiety","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48462085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and predictive factors of depression among medical health care workers and medical residents 医护人员和住院医师抑郁症患病率及预测因素
Pub Date : 2023-04-13 DOI: 10.17352/2455-5460.000074
Alqahtani Mohammed Qasem
Mental health is one of the 3 essential health columns which is defined according to WHO as "a state of complete physical, mental and social well-being and not merely the absence of disease and infirmity".
心理健康是三个基本健康栏目之一,根据世界卫生组织的定义,这三个栏目是“身体、精神和社会完全健康的状态,而不仅仅是没有疾病和虚弱”。
{"title":"Prevalence and predictive factors of depression among medical health care workers and medical residents","authors":"Alqahtani Mohammed Qasem","doi":"10.17352/2455-5460.000074","DOIUrl":"https://doi.org/10.17352/2455-5460.000074","url":null,"abstract":"Mental health is one of the 3 essential health columns which is defined according to WHO as \"a state of complete physical, mental and social well-being and not merely the absence of disease and infirmity\".","PeriodicalId":92986,"journal":{"name":"Archives of depression and anxiety","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41845549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidepressants and memory effects of ketamine under the neuromolecular view: A literature review 神经分子视野下氯胺酮的抗抑郁和记忆作用:文献综述
Pub Date : 2023-03-28 DOI: 10.17352/2455-5460.000073
GP Felipe Da Silva, Gabriel Rezende M, Scapatici Lohana Pompelli, de Araujo Luísa Zanelatto, Lombardi Bruna Carrara, Vidal Caroline, Wiedmer David Batista, Schoeler Lucas, Gisele Minhoto R, R. Andreatini
Objective: Major Depressive Disorder (MDD) has as diagnostics characteristics chronic deep sadness, anhedonia, sleeping disorder, lower energy, and cognition impairment like memory deficits. Among the pharmacological treatments that have been used until the moment, most of them act by monoaminergic pathways. Overall, the antidepressant effects promoted by this kind of medication usually delay starting, resulting in treatment resistance by the patients; moreover, in some cases, this kind of treatment has shown to be inefficient in depression remission. With this, new treatments have been studied for resistant cases and an immediate antidepressant effect, for example, ketamine – whose action occurs in glutamatergic pathways. This study aimed to analyze, from a literature review, the molecular mechanisms involved in the action of ketamine - focusing on the neuroplastic hypothesis of depression. Methods: A literature search was conducted in PubMed, MEDLINE, and SciELO databases using the following terms as descriptors: "ketamine AND depression AND neuroplasticity," with criterion PICO, resulting in 60 bibliographic texts. Results/discussion: The studies analyzed demonstrated that ketamine could exert its antidepressant effects through the inhibition of GABAergic interneurons, activation of TRK-B/AKT/mTORC pathways involved with cell survival/growth through the neurotrophine BDNF and increased activation of AMPAr by glutamate. Furthermore, it is evident that the pharmacodynamics of ketamine involves different molecular cascades present in the impaired neural plasticity pathways in individuals with MDD. Conclusion: Thus, more research on the effectiveness of ketamine is needed to consolidate its use in MDD and to evolve with glutamatergic pharmacological therapy for other mental disorders, such as bipolar and neurodegenerative affective disorders, an example of Alzheimer's disease.
目的:重度抑郁症(MDD)具有慢性深度悲伤、快感缺乏、睡眠障碍、低能量和记忆缺陷等认知障碍的诊断特征。在迄今为止使用的药物治疗中,大多数通过单胺能途径发挥作用。总的来说,这类药物促进的抗抑郁作用通常会延迟开始,导致患者对治疗产生耐药性;此外,在某些情况下,这种治疗已被证明在抑郁症缓解方面效率低下。有了这一点,新的治疗方法已经被研究用于耐药性病例和即时抗抑郁效果,例如氯胺酮——其作用发生在谷氨酸能通路中。本研究旨在从文献综述中分析氯胺酮作用的分子机制,重点是抑郁症的神经可塑性假说。方法:在PubMed、MEDLINE和SciELO数据库中进行文献检索,使用以下术语作为描述符:“氯胺酮与抑郁和神经可塑性”,标准为PICO,共有60篇文献。结果/讨论:所分析的研究表明,氯胺酮可以通过抑制GABA能中间神经元、通过神经营养因子BDNF激活与细胞存活/生长有关的TRK-B/AKT/mTORC通路以及谷氨酸增加AMPAr的激活来发挥其抗抑郁作用。此外,很明显,氯胺酮的药效学涉及MDD患者受损神经可塑性通路中存在的不同分子级联。结论:因此,需要对氯胺酮的有效性进行更多的研究,以巩固其在MDD中的应用,并发展谷氨酸能药物治疗其他精神障碍,如双相情感障碍和神经退行性情感障碍,阿尔茨海默病的一个例子。
{"title":"Antidepressants and memory effects of ketamine under the neuromolecular view: A literature review","authors":"GP Felipe Da Silva, Gabriel Rezende M, Scapatici Lohana Pompelli, de Araujo Luísa Zanelatto, Lombardi Bruna Carrara, Vidal Caroline, Wiedmer David Batista, Schoeler Lucas, Gisele Minhoto R, R. Andreatini","doi":"10.17352/2455-5460.000073","DOIUrl":"https://doi.org/10.17352/2455-5460.000073","url":null,"abstract":"Objective: Major Depressive Disorder (MDD) has as diagnostics characteristics chronic deep sadness, anhedonia, sleeping disorder, lower energy, and cognition impairment like memory deficits. Among the pharmacological treatments that have been used until the moment, most of them act by monoaminergic pathways. Overall, the antidepressant effects promoted by this kind of medication usually delay starting, resulting in treatment resistance by the patients; moreover, in some cases, this kind of treatment has shown to be inefficient in depression remission. With this, new treatments have been studied for resistant cases and an immediate antidepressant effect, for example, ketamine – whose action occurs in glutamatergic pathways. This study aimed to analyze, from a literature review, the molecular mechanisms involved in the action of ketamine - focusing on the neuroplastic hypothesis of depression. Methods: A literature search was conducted in PubMed, MEDLINE, and SciELO databases using the following terms as descriptors: \"ketamine AND depression AND neuroplasticity,\" with criterion PICO, resulting in 60 bibliographic texts. Results/discussion: The studies analyzed demonstrated that ketamine could exert its antidepressant effects through the inhibition of GABAergic interneurons, activation of TRK-B/AKT/mTORC pathways involved with cell survival/growth through the neurotrophine BDNF and increased activation of AMPAr by glutamate. Furthermore, it is evident that the pharmacodynamics of ketamine involves different molecular cascades present in the impaired neural plasticity pathways in individuals with MDD. Conclusion: Thus, more research on the effectiveness of ketamine is needed to consolidate its use in MDD and to evolve with glutamatergic pharmacological therapy for other mental disorders, such as bipolar and neurodegenerative affective disorders, an example of Alzheimer's disease.","PeriodicalId":92986,"journal":{"name":"Archives of depression and anxiety","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41841789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bipolar disorder and aging 双相情感障碍与衰老
Pub Date : 2023-03-17 DOI: 10.17352/2455-5460.000072
B. Michel
Bipolar disorder is a chronic illness, defined by a succession of depressive and/or manic periods separated by free intervals. Its evolution with aging is marked by a high suicide mortality rate. Bipolar disorders raise the question of their evolution when the age of the subject, in particular with regard to their frequency, their clinical characteristics, their prognosis and their management. The evolution of bipolar disorder with aging poses several difficulties in clinical practice due to its underestimated frequency and its misleading presentation and in particular by the presence of sometimes significant cognitive alterations leading sometimes to dementia.
双相情感障碍是一种慢性疾病,由一系列由自由间隔分隔的抑郁和/或躁狂期定义。它随着年龄的增长而进化,其特点是自杀死亡率很高。双相情感障碍在受试者的年龄时提出了其进化的问题,特别是在其频率、临床特征、预后和管理方面。双相情感障碍随着年龄的增长而演变,这在临床实践中带来了一些困难,因为它的频率被低估,其表现具有误导性,尤其是有时会出现显著的认知改变,有时会导致痴呆。
{"title":"Bipolar disorder and aging","authors":"B. Michel","doi":"10.17352/2455-5460.000072","DOIUrl":"https://doi.org/10.17352/2455-5460.000072","url":null,"abstract":"Bipolar disorder is a chronic illness, defined by a succession of depressive and/or manic periods separated by free intervals. Its evolution with aging is marked by a high suicide mortality rate. Bipolar disorders raise the question of their evolution when the age of the subject, in particular with regard to their frequency, their clinical characteristics, their prognosis and their management. The evolution of bipolar disorder with aging poses several difficulties in clinical practice due to its underestimated frequency and its misleading presentation and in particular by the presence of sometimes significant cognitive alterations leading sometimes to dementia.","PeriodicalId":92986,"journal":{"name":"Archives of depression and anxiety","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48300930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcultural aspects in the treatment of posttraumatic and situational distress among middle eastern refugees 中东难民创伤后和情境痛苦治疗中的跨文化因素
Pub Date : 2022-10-03 DOI: 10.17352/2455-5460.000071
Kizilhan Jan
The increasing size of displaced populations seeking protection in third countries, should be considered in public health and especially in Psychotherapy in that countries. Refugees from the Middle East, usually from collective cultures, require special skills and modifications in the treatment setting. The cultural formulation (CF) of illness and suffering, as described in the recent version of medical standard manuals, is part of this challenge. Besides bridging cultures, the specific nature of trauma, especially highly complex issues such as a genocidal environment, - in our case example - the both transgenerational and the immediate persecution experienced by the Yazidi ethnic and religious minority - the therapist must also consider aspects of distress caused by displacement and exile. The article discusses the needed adaptations in the therapeutic setting, using the case of a Yezidi woman surviving ISIS violence abduction. Within the framework of our treatment, she received cognitive behavioral therapy with individual and group therapies (multimodal interventions) over a period of 10 weeks. Besides establishing stability, safety and orientation and strengthening her self-consciousness, her traumatic experiences were considered from an individual, collective, socio - cultural and political point of view. Both the causes and maintaining conditions of the symptoms as well as the symptoms themselves are being worked on. The sensitive confrontation with the trauma was particularly helpful for the patient. In addition, she learned to participate actively in everyday life and in new social contacts again during therapy. She was able to overcome the passive - avoidant lifestyle since the traumatic event in a somewhat stable manner, although she will still need time to develop a stable perspective in the long term. She was offered the prospect of renewed follow-up treatment if necessary.
在第三国寻求保护的流离失所者人数不断增加,应在公共卫生中加以考虑,特别是在这些国家的心理治疗中。来自中东的难民,通常来自集体文化,在治疗环境中需要特殊技能和改变。正如最新版本的医疗标准手册中所描述的,疾病和痛苦的文化表述是这一挑战的一部分。除了弥合文化、创伤的具体性质,特别是高度复杂的问题,如种族灭绝环境,在我们的例子中,雅兹迪少数民族和宗教少数群体经历的跨性别和直接迫害,治疗师还必须考虑流离失所和流亡造成的痛苦。这篇文章以一名在ISIS暴力绑架中幸存的耶兹迪妇女为例,讨论了在治疗环境中需要的适应措施。在我们的治疗框架内,她接受了为期10周的认知行为治疗,包括个人和团体治疗(多模式干预)。除了建立稳定、安全、定向和增强自我意识外,她的创伤经历还从个人、集体、社会文化和政治的角度进行了考虑。症状的原因、维持条件以及症状本身都在研究中。与创伤的敏感对抗对患者特别有帮助。此外,在治疗期间,她学会了积极参与日常生活和新的社会交往。她能够以某种稳定的方式克服创伤事件后被动回避的生活方式,尽管从长远来看,她仍需要时间来发展稳定的观点。如有必要,她有可能再次接受后续治疗。
{"title":"Transcultural aspects in the treatment of posttraumatic and situational distress among middle eastern refugees","authors":"Kizilhan Jan","doi":"10.17352/2455-5460.000071","DOIUrl":"https://doi.org/10.17352/2455-5460.000071","url":null,"abstract":"The increasing size of displaced populations seeking protection in third countries, should be considered in public health and especially in Psychotherapy in that countries. Refugees from the Middle East, usually from collective cultures, require special skills and modifications in the treatment setting. The cultural formulation (CF) of illness and suffering, as described in the recent version of medical standard manuals, is part of this challenge. Besides bridging cultures, the specific nature of trauma, especially highly complex issues such as a genocidal environment, - in our case example - the both transgenerational and the immediate persecution experienced by the Yazidi ethnic and religious minority - the therapist must also consider aspects of distress caused by displacement and exile. The article discusses the needed adaptations in the therapeutic setting, using the case of a Yezidi woman surviving ISIS violence abduction. Within the framework of our treatment, she received cognitive behavioral therapy with individual and group therapies (multimodal interventions) over a period of 10 weeks. Besides establishing stability, safety and orientation and strengthening her self-consciousness, her traumatic experiences were considered from an individual, collective, socio - cultural and political point of view. Both the causes and maintaining conditions of the symptoms as well as the symptoms themselves are being worked on. The sensitive confrontation with the trauma was particularly helpful for the patient. In addition, she learned to participate actively in everyday life and in new social contacts again during therapy. She was able to overcome the passive - avoidant lifestyle since the traumatic event in a somewhat stable manner, although she will still need time to develop a stable perspective in the long term. She was offered the prospect of renewed follow-up treatment if necessary.","PeriodicalId":92986,"journal":{"name":"Archives of depression and anxiety","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49077148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Archives of depression and anxiety
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1