Brain Research Bulletin最新文献

{"title":"The impact of task difficulty on neural modulation throughout a visuomotor multi-day practice training.","authors":"Shuai Feng, Siyu Hong, Xin Zhang, Xing Wang, Lin Chen","doi":"10.1016/j.brainresbull.2024.111124","DOIUrl":"10.1016/j.brainresbull.2024.111124","url":null,"abstract":"<p><p>The effectiveness of rehabilitation is contingent upon the motor recovery process which typically involves long-term motor skill re-acquisition. Given that the learning process can be modulated by task difficulty, elucidating the underlying neural mechanism is essential for optimizing rehabilitation prescription to suit different patient conditions. This study aimed to investigate the impact of task difficulty on cortical response during force-control training via electroencephalography (EEG). An 8-day visuomotor force-tracking training experiment was conducted. Healthy right-handed participants (N=33) were recruited and randomly assigned to 3 groups, and each group was tasked with a different level of difficulty. The task difficulty was manipulated by variation in force-production complexity and execution sequence assignments, with real-time visual feedback provided to participants for self-output adjustment. Behavioral performance was quantitatively assessed using a pre-defined score metric related to performance accuracy. The EEG signals were collected, and corresponding event-related desynchronization (ERD) and relative functional connectivity (FC) during the task execution were analyzed within the alpha- (8-13 Hz) and beta- (15-30 Hz) bands. A post-training experiment was also performed to evaluate the near-transfer capability of learning. Results showed all the behavioral performances improved during practice, while higher task difficulty level was affiliated with better post-training near-transfer ability. The dynamic neural response to training could be mediated by changes in difficulty level, where increased task complexity corresponded with the heightened activities in the beta-band priorly within the right dorsolateral prefrontal area. Additionally, stronger alpha-band functional connectivity was observed to be predominantly associated with the left motor area (LMA) during challenging tasks, and the intensification in connectivity persisted selectively post-training which appeared to be acritical factor for skill transfer performance improvement. These findings illustrated the dynamic neural mechanism through which task difficulty affects behavioral performance during long-term motor training with accurate force-control purpose. The selectively strengthened functional connectivity may contribute to facilitating new task execution after training interventions. Therefore, beneficial neural modulation can be expected to be feasible by well-designed task difficulty strategies for effective motor rehabilitation.</p>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":" ","pages":"111124"},"PeriodicalIF":3.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated fiber quantification analysis identifies tract-specific microstructural alterations in brain in intermittent exotropia","authors":"Jianlin Guo ,&nbsp;Leqing Zhou ,&nbsp;Ying Wang ,&nbsp;Di Hu ,&nbsp;Yanqiu Lv ,&nbsp;Huiying Kang ,&nbsp;Li Li ,&nbsp;Yun Peng","doi":"10.1016/j.brainresbull.2024.111113","DOIUrl":"10.1016/j.brainresbull.2024.111113","url":null,"abstract":"<div><h3>Background</h3><div>Growing evidence of neuroimaging has indicated brain microstructural abnormalities in comitant strabismus. Nonetheless, few studies have investigated neuropathological alterations in patients with intermittent exotropia (IXT). This study aimed at examining the characteristics of brain microstructure along major fiber tracts in IXT patients using an automated fiber quantification analysis.</div></div><div><h3>Methods</h3><div>A total of 25 patients with IXT as well as 25 healthy participants matched for age and gender finished the diffusion tensor imaging scanning and the ophthalmic examination. Automated fiber quantification analysis of 20 major fiber tracts was carried out for IXT patients and healthy subjects, respectively. Diffusion metrics of 100 equidistant nodes resampled along each tract were measured for every subject and compared between two groups. Effect size analysis was performed to identify the most affected fiber tracts in IXT.</div></div><div><h3>Results</h3><div>Widely declined mean diffusivity was noted in IXT along major tracts containing bilateral thalamic radiations, bilateral corticospinal fasciculi, bilateral cingulum cingulate, left inferior fronto-occipital fasciculus, right arcuate fasciculus and superior longitudinal fasciculus. Local reduction in fractional anisotropy was observed in IXT along left cingulum hippocampus, right inferior longitudinal fasciculus and right uncinate fasciculus, in contrast to the regionally increased fractional anisotropy along bilateral thalamic radiation, left corticospinal tract and left arcuate fasciculus. Among the tracts with significantly changed diffusion metrics in IXT, right inferior longitudinal fasciculus was the most affected one in fractional anisotropy while left thalamic radiation was the most influenced one in mean diffusivity.</div></div><div><h3>Conclusions</h3><div>Abnormalities in microstructural properties along visual-related fiber tracts are likely to contribute to difficulties in visual information processing in IXT patients, which could serve as the neural basis of underlying pathological mechanism of IXT.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"219 ","pages":"Article 111113"},"PeriodicalIF":3.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dopamine D4 receptors in the lateral habenula regulate anxiety-related behaviors in a rat model of Parkinson's disease","authors":"Chengxue Du ,&nbsp;Jiachen Wang ,&nbsp;Huihui Tan ,&nbsp;Nannan Han ,&nbsp;Xiaobo Li ,&nbsp;Baihua Sun ,&nbsp;Gejuan Zhang ,&nbsp;Mingze Chang","doi":"10.1016/j.brainresbull.2024.111122","DOIUrl":"10.1016/j.brainresbull.2024.111122","url":null,"abstract":"<div><div>Although the output of the lateral habenula (LHb) controls the activity of midbrain dopamine (DA) and 5-hydroxytryptamine (5-HT) containing systems, which are implicated in the pathophysiology of anxiety, it is not clear how activation and blockade of LHb D₄ receptors affects anxiety-like behaviors, particularly in Parkinson’s disease related anxiety. In this study, unilateral 6-hydroxydopamine lesions of the substantia nigra pars compacta (SNc) in rats induced anxiety-like behaviors, which attribute to hyperactivity of LHb neurons and decrease in the level of DA in the medial prefrontal cortex (mPFC), amygdala and ventral hippocampus (vHip) compared to sham-operated rats. Intra-LHb injection of D₄ receptor agonist A412997 induced or increased the expression of anxiety-like behaviors, while injection of D₄ receptor antagonist L741742 showed anxiolytic effects in sham-operated and the SNc-lesioned rats. However, the doses producing behavioral effects in the lesioned rats were higher than those of sham-operated rats. Intra-LHb injection of A412997 increased firing rate of LHb neurons, and decreased levels of DA and 5-HT in the mPFC, amygdala and vHip; conversely, L741742 decreased firing rate of LHb neurons, and increased levels of DA and 5-HT in two groups of rats. Compared to sham-operated rats, the duration of A412997 and L741742 action on the firing rate of neurons was markedly shortened in the lesioned rats. Collectively, these findings suggest that D₄ receptors in the LHb are involved in the regulation of anxiety-like behaviors, and degeneration of the nigrostriatal pathway down-regulates function and/or expression of these receptors.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"219 ","pages":"Article 111122"},"PeriodicalIF":3.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suppression of PINK1 autophosphorylation attenuates pilocarpine-induced seizures and neuronal injury in rats","authors":"Yujie Zhai ,&nbsp;Yi Yuan ,&nbsp;Yaru Cui ,&nbsp;Xiaoqian Wang ,&nbsp;Hua Zhou ,&nbsp;Qian Teng ,&nbsp;Hongjin Wang ,&nbsp;Bohan Sun ,&nbsp;Hongliu Sun ,&nbsp;Jianhua Tang","doi":"10.1016/j.brainresbull.2024.111117","DOIUrl":"10.1016/j.brainresbull.2024.111117","url":null,"abstract":"<div><div>PTEN-induced kinase 1 (PINK1) autophosphorylation triggers the PINK1/Parkin pathway, which is the main mitophagic pathway in the mammalian nervous system. In the present study, we aimed to mechanistically explore the role of PINK1 in pilocarpine-induced status epilepticus (SE) in Sprague-Dawley rats. Evidence from immunohistochemistry, western blotting, biochemical assays, and behavioral testing showed that pilocarpine-induced SE led to increased levels of PINK1 phosphorylation, mitophagy, mitochondrial oxidative stress, neuronal damage and learning and memory deficits. Using shRNA interference to suppress the expression of translocase outer mitochondrial membrane 7, a positive regulator of PINK1 autophosphorylation, lowered the increased levels of phosphorylated PINK1 following pilocarpine administration. It also reduced the levels of mitophagy, mitochondrial oxidative stress and neuronal damage, and attenuated seizure severity and cognitive deficits. In contrast, suppressing the expression of overlapping with the m-AAA protease 1 homolog, a negative regulator of PINK1 autophosphorylation, led to higher levels of phosphorylated PINK1 following pilocarpine administration. It also led to more serious mitophagy, neuronal damage, as well as worsened seizure severity and cognitive deficits. Our results indicate that PINK1 autophosphorylation plays a vital role in epileptic seizures and neuronal injury by mediating mitophagy. Regulating PINK1 autophosphorylation may change the adverse consequences of epilepsy, and may be an effective neuroprotective strategy.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"219 ","pages":"Article 111117"},"PeriodicalIF":3.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"scRNA-Seq reveals age-dependent microglial evolution as a determinant of immune response following spinal cord injury","authors":"Lufei Shao ,&nbsp;Yueliang Chang ,&nbsp;Jinfang Liu ,&nbsp;Leilei Lin ,&nbsp;Long Chang ,&nbsp;Jialin Zhang ,&nbsp;Zhibin Lan ,&nbsp;Honglai Zhang ,&nbsp;Xiaolei Chen","doi":"10.1016/j.brainresbull.2024.111116","DOIUrl":"10.1016/j.brainresbull.2024.111116","url":null,"abstract":"<div><div>Spinal cord injury (SCI) is a debilitating condition of the central nervous system (CNS) that leads to severe impairments in sensory and motor functions. Previous studies have pointed out that patient age is a critical factor influencing SCI prognosis. However, the role of microglia in age-related differences in SCI outcomes remains unclear. The current study aims to identify specific microglial subtypes and investigate their responses and functional differences in SCI recovery across different age groups. Single-cell RNA sequencing (scRNA-seq) data were obtained from the Gene Expression Omnibus (GEO) database, integrating multiple datasets to identify microglial subtypes. We performed pseudotime trajectory analysis and cell-cell communication analysis to understand microglial differentiation and interactions. Finally, immunofluorescence staining of mouse model samples was conducted to validate our bioinformatics findings. Microglia were classified into four subtypes: Homeostatic, Proliferating, Inflammatory A, and Inflammatory B. The Young SCI group exhibited a higher proportion of Homeostatic microglia and Inflammatory microglia A, whereas the old SCI group had more Inflammatory Microglia B but lacked Homeostatic Microglia. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses revealed that markers for homeostasis microglia were enriched in immune modulation pathways. While makers for Inflammatory Microglia were enriched in immune response pathways. Specifically, markers for Inflammatory microglia B were enriched in pathways associated with overactive immune response. Pseudotime analysis indicated that microglia in young mice predominantly differentiated into Inflammatory Microglia A and Homeostatic Microglia, whereas in old mice, they tended to only differentiate into Inflammatory Microglia B. CellChat analysis showed increased pro-inflammatory signaling generated by Inflammatory Microglia B, exclusively in the old group. Our study demonstrates significant differences in microglial subtypes and functions between different age groups following SCI. These findings provide novel insights into the development of age-related therapeutic strategies and microglia-targeted biological treatments for SCI.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"219 ","pages":"Article 111116"},"PeriodicalIF":3.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of expected and perceived treatment efficacy concerning open-label placebos for reducing emotional distress","authors":"Anne Schienle ,&nbsp;Albert Wabnegger","doi":"10.1016/j.brainresbull.2024.111121","DOIUrl":"10.1016/j.brainresbull.2024.111121","url":null,"abstract":"<div><h3>Background</h3><div>Treatment expectations for open-label placebos (OLPs) - placebos prescribed transparently - refer to what a person anticipates will happen as a result of taking the placebo. The actual outcome of OLP treatment may deviate from the initial expectation.</div></div><div><h3>Method</h3><div>A total of 108 participants received OLP treatment for reducing visually induced emotional distress during functional magnetic resonance imaging. They rated the expected effect of the OLP before the experiment, and evaluated the perceived effect after the experiment. Ratings reflecting the degree of outcome deviation from expectation were correlated with brain activity in regions of interest (dorsolateral/ventrolateral prefrontal cortex, anterior cingulate cortex (ACC), insula, inferior parietal cortex).</div></div><div><h3>Results</h3><div>Activity in the ACC, the insula, and parietal regions (region-of-interest findings), as well as the parahippocampus (whole-brain finding) was lower when the perceived treatment outcome met or even exceeded expectations.</div></div><div><h3>Conclusions</h3><div>A positive expectation-outcome evaluation for the OLP was associated with reduced activity in brain regions decoding the salience (insula, ACC) and context of stimuli (parahippocampus). These findings shed light on the mechanisms through which OLPs influence emotion regulation.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"219 ","pages":"Article 111121"},"PeriodicalIF":3.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of alterations in the composition of intestinal microbiota on neurovascular coupling and cognitive dysfunction in individuals afflicted with CSVD","authors":"Wei Zhang ,&nbsp;Xianfeng Yu ,&nbsp;Min Wei ,&nbsp;Jie Zhou ,&nbsp;Yajun Zhou ,&nbsp;Xia Zhou ,&nbsp;Kai Zhao ,&nbsp;Xiaoqun Zhu","doi":"10.1016/j.brainresbull.2024.111115","DOIUrl":"10.1016/j.brainresbull.2024.111115","url":null,"abstract":"<div><h3>Introduction</h3><div>An expanding body of research has explored the crucial role of gut microbiota in cerebral small vessel disease (CSVD). The objective of this study is to investigate alterations in the gut microbiota structure among CSVD patients, to explore the correlation between differential taxonomic levels and the neurovascular coupling index as well as cognitive function and to elucidate the imaging and biomarkers of mild cognitive impairment (MCI) in CSVD.</div></div><div><h3>Methods</h3><div>We enrolled 104 patients with CSVD and 40 healthy controls (HC). Based on cognitive test scores, CSVD patients were categorized into a cognitively normal group (CSVD-NCI, n=61) and a mild cognitive impairment group (CSVD-MCI, n=43). Performing magnetic resonance imaging (MRI) scans, gut microbiota analysis, as well as clinical and neuropsychological assessments for all participants. Based on arterial spin labeling (ASL) and blood oxygen level-dependent (BOLD) imaging data, cerebral blood flow (CBF) and neural activity indices are computed. The coupling indices of CBF/mReHo, CBF/mfALFF, CBF/mALFF, and CBF/mDC are calculated to assess the whole-brain neurovascular coupling changes in patients with CSVD.</div></div><div><h3>Results</h3><div>Species annotation revealed differences in the composition at the phylum and genus levels among the HC, CSVD-NCI, and CSVD-MCI groups. Additionally, differential analysis using the Kruskal-Wallis test demonstrated specific dominant microbial communities in all three groups. The relative abundance of certain dominant microbial communities in CSVD patients exhibited correlations with neurovascular coupling and cognitive function. The combined assessment of Bacteroides genus and CBF/mDC proved effective in distinguishing between CSVD-NCI and CSVD-MCI, providing a novel non-invasive approach for the diagnosis of MCI in CSVD.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"219 ","pages":"Article 111115"},"PeriodicalIF":3.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations of regional homogeneity and functional connectivity in different hoehn and yahr stages of Parkinson's disease","authors":"Xinhui Wang ,&nbsp;Yu Shen ,&nbsp;Wei Wei ,&nbsp;Yan Bai ,&nbsp;Panlong Li ,&nbsp;Kaiyue Ding ,&nbsp;Yihang Zhou ,&nbsp;Jiapei Xie ,&nbsp;Xianchang Zhang ,&nbsp;Zhiping Guo ,&nbsp;Meiyun Wang","doi":"10.1016/j.brainresbull.2024.111110","DOIUrl":"10.1016/j.brainresbull.2024.111110","url":null,"abstract":"<div><h3>Purpose</h3><div>Using regional homogeneity (ReHo) and functional connectivity (FC) to assess alterations in brain function and their potential relation to different Hoehn and Yahr (H&amp;Y) stages in Parkinson's disease (PD).</div></div><div><h3>Materials and methods</h3><div>66 patients with PD and 57 age- and sex-matched healthy control (HC) participants were recruited. All subjects underwent clinical assessments and resting-state functional magnetic resonance imaging (rs-fMRI) scanning. We analyzed alterations in regional brain activity using ReHo analyses in all subjects and further explored their relationship to disease severity. Finally, the brain region significantly associated with disease severity was used as a seed point to analyze the FC changes between it and other brain regions in the whole brain.</div></div><div><h3>Results</h3><div>Compared with HC participants, PD patients showed a significant decrease ReHo in the sensorimotor network (bilateral precentral and postcentral gyrus). The ReHo value of the left precentral gyrus in PD patients decreased with increasing H&amp;Y stage and correlated negatively with Unified Parkinson’s Disease Rating Scale (UPDRS) III scores. Further, FC analysis of the left precentral gyrus as a region of interest showed that functional activity between the left precentral gyrus and sensorimotor network, default network, and visual network was decreased.</div></div><div><h3>Conclusion</h3><div>The left precentral gyrus plays an important role in the pathophysiological mechanisms of PD patients, and this finding further highlights the potential of the primary motor cortex (M1) as a non-invasive therapeutic target for neuromodulation in PD patients.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"218 ","pages":"Article 111110"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of clozapine on immune-related biomarkers in schizophrenia patients","authors":"Lu Shao,&nbsp;Yu Li,&nbsp;ZhiYao Yuan,&nbsp;XiYu Guo,&nbsp;GuoJi Zeng,&nbsp;JunPeng Liu","doi":"10.1016/j.brainresbull.2024.111104","DOIUrl":"10.1016/j.brainresbull.2024.111104","url":null,"abstract":"<div><div>Globally, schizophrenia is one of the main causes of disability. Approximately 1 % of the general population suffers from schizophrenia, and 30 % of cases are unresponsive to therapy. Clozapine is the gold standard for therapy-resistant schizophrenia (TRS), yet it has limited effectiveness and serious adverse events in some patients. Because of the possibility of severe neutropenia, clozapine administration requires monthly hematological monitoring in the first four months. Previous investigations have demonstrated the immune system alteration after clozapine treatment in schizophrenia patients. Besides, it has been proposed that clozapine changes the cytokines profile in schizophrenia patients. These findings highlighted the need to learn more about the disease's etiology and investigate the relationship between peripheral immune system markers and clozapine response to support strategies for better treatment outcomes. The time decision-making to start clozapine could be significantly decreased if some biomarkers were developed to assist physicians in anticipating whether a particular patient will respond to the medication. Therefore, this study aimed to comprehensively review the effect of clozapine on immune-related biomarkers in schizophrenia patients.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"218 ","pages":"Article 111104"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of asymmetrical abnormalities in functional connectivity and brain network topology for migraine sufferers: A preliminary study based on resting-state fMRI data","authors":"Weifang Nie ,&nbsp;Weiming Zeng ,&nbsp;Jiajun Yang ,&nbsp;Lei Wang ,&nbsp;Yuhu Shi","doi":"10.1016/j.brainresbull.2024.111109","DOIUrl":"10.1016/j.brainresbull.2024.111109","url":null,"abstract":"<div><div>Research on the neural mechanisms underlying brain asymmetry in patients with migraine patients using fMRI is insufficient. This study proposed using lateralized algorithms for functional connectivity and brain network topology and investigated changes in their lateralization in patients with migraine. In study 1, laterality indices of functional connectivity (LFunctionCorr) and brain network topological properties (LBetweennessCentrality, LDegree, and LStrength) were defined. Differences between migraineurs and normal subjects were compared at whole-brain, half-brain, and region levels. In study 2, laterality indices were used to classify migraine and were validated using independent samples and the segment method for repeatability. In study 3, abnormal brain regions related to migraine were extracted based on the classification results and differences analysis. Study 1 found no significant differences related to in for migraine at the whole-brain level; however, significant differences were identified at the half-brain level for the hemispheric lateralization of the LFunctionCorr, while 11 significantly different brain regions were also identified at the brain region level. Furthermore, the classification accuracy in study 2 was 0.9366. With repeated validation, the accuracy reached 0.8561. Furthermore, after extending the samples according to the segmentation strategy, the classification accuracies were improved to 0.9408 and 0.8585. Study 3 identified 10 crucial brain regions with asymmetrical specificity based on laterality indices distributed across the visual network, the frontoparietal control network, the default mode network, the salience/ventral attention network and the limbic system. The results revealed novel insights and avenues for research into the mechanisms of migraine asymmetry and showed that the laterality indices could be used as a potential diagnostic imaging marker for migraine.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"218 ","pages":"Article 111109"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}