A couple of weeks ago, Minerva mentioned a large trial of low dose aspirin in asymptomatic older people. It turned out that aspirin had no benefit where the primary outcome—disability-free survival—was concerned. Worse, it carried a small increase in the risk of intracranial bleeding. During the five years of the trial, more than a third of participants in the aspirin group stopped taking their allocated treatment. A re-analysis of trial data, adjusting for compliance, still finds no benefit from aspirin on survival but discovers that for haemorrhage, cancer mortality, and all-cause mortality, the risks are greater than estimated by the intention-to-treat analysis (Am J Epidemiol doi:10.1093/aje/kwad168).
{"title":"Aspirin . . . and other stories","authors":"","doi":"10.1136/bmj.p2042","DOIUrl":"https://doi.org/10.1136/bmj.p2042","url":null,"abstract":"A couple of weeks ago, Minerva mentioned a large trial of low dose aspirin in asymptomatic older people. It turned out that aspirin had no benefit where the primary outcome—disability-free survival—was concerned. Worse, it carried a small increase in the risk of intracranial bleeding. During the five years of the trial, more than a third of participants in the aspirin group stopped taking their allocated treatment. A re-analysis of trial data, adjusting for compliance, still finds no benefit from aspirin on survival but discovers that for haemorrhage, cancer mortality, and all-cause mortality, the risks are greater than estimated by the intention-to-treat analysis (Am J Epidemiol doi:10.1093/aje/kwad168).","PeriodicalId":9314,"journal":{"name":"BMJ","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134912173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A child presented with this firm, immobile, and painless lump over the right eyebrow (fig 1). The lump was not warm to touch. It had developed gradually following an injury to the area three months previously and had persisted despite topical antibiotics. Excisional biopsy and immunohistochemical staining revealed B-lymphoblastic lymphoma. Lymphoblastic lymphoma is a highly aggressive non-Hodgkin’s lymphoma which most commonly affects children.1 Skin involvement in lymphoblastic lymphoma is seen in fewer than 2% of cases, and usually presents as a large solitary tumour in the head and neck region.1 Cutaneous manifestations may grow rapidly and have accompanying systemic symptoms such as fever, weight loss, and night sweats,2 although this child did not experience any of these.
{"title":"A pink swelling on the eyebrow","authors":"Wenqing Zhang, Dan Deng","doi":"10.1136/bmj-2022-073394","DOIUrl":"https://doi.org/10.1136/bmj-2022-073394","url":null,"abstract":"A child presented with this firm, immobile, and painless lump over the right eyebrow (fig 1). The lump was not warm to touch. It had developed gradually following an injury to the area three months previously and had persisted despite topical antibiotics. Excisional biopsy and immunohistochemical staining revealed B-lymphoblastic lymphoma. Lymphoblastic lymphoma is a highly aggressive non-Hodgkin’s lymphoma which most commonly affects children.1 Skin involvement in lymphoblastic lymphoma is seen in fewer than 2% of cases, and usually presents as a large solitary tumour in the head and neck region.1 Cutaneous manifestations may grow rapidly and have accompanying systemic symptoms such as fever, weight loss, and night sweats,2 although this child did not experience any of these.","PeriodicalId":9314,"journal":{"name":"BMJ","volume":"358 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134911854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Richard Evans","authors":"R R Hall, Helen H Lucraft","doi":"10.1136/bmj.p880","DOIUrl":"https://doi.org/10.1136/bmj.p880","url":null,"abstract":"","PeriodicalId":9314,"journal":{"name":"BMJ","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135463579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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