Pub Date : 2023-11-10DOI: 10.46439/autoimmune.4.015
R. Akoum, Rita Chidiac, Joseph Yammine, M. Saade, E. Brihi
Objective: Myeloproliferative neoplasms (MPN) are occasionally associated with autoimmune manifestations. The prevalence of positive direct antiglobulin test (DAT) in patients with JAK2V617F mutation is not yet known. Methods: We conducted a cohort study of all consecutive patients with JAK2V617F mutation who underwent DAT at presentation from 2010 to 2022. We also looked for the prevalence of autoimmune diseases (AIDs) and relation to thrombosis. Results: Fifty nine patients formed the cohort, 22 females and 37 males, with a mean age of 65 years. The median follow-up time was 90 months. A positive-DAT was found in 6 to 7% of essential thrombocythemia (ET) and polycythemia vera (PV) patients, 60% of primary myelofibrosis (PMF) patients and 50% of myelodysplasia/myeloproliferation (MDS/MPN) patients with or without anemia. Autoimmune manifestations were present in 13% of patients with PV and 50% of those with MDS/MPN features. Overall, 25% of patients had autoimmune phenomena including the 15% with positive-DAT. Conclusion: In patients with JAK2V617F mutation, those with PMF and MDS/MPN subtypes are most likely to display a positive-DAT results and autoimmune manifestations (≥ 50%). Patients with PV and ET are less likely to exhibit autoimmune manifestations (≤ 10%). No correlation with the occurrence of thrombosis was seen.
{"title":"Positive-DAT and autoimmune manifestations in patients with JAK2V617F mutation","authors":"R. Akoum, Rita Chidiac, Joseph Yammine, M. Saade, E. Brihi","doi":"10.46439/autoimmune.4.015","DOIUrl":"https://doi.org/10.46439/autoimmune.4.015","url":null,"abstract":"Objective: Myeloproliferative neoplasms (MPN) are occasionally associated with autoimmune manifestations. The prevalence of positive direct antiglobulin test (DAT) in patients with JAK2V617F mutation is not yet known. Methods: We conducted a cohort study of all consecutive patients with JAK2V617F mutation who underwent DAT at presentation from 2010 to 2022. We also looked for the prevalence of autoimmune diseases (AIDs) and relation to thrombosis. Results: Fifty nine patients formed the cohort, 22 females and 37 males, with a mean age of 65 years. The median follow-up time was 90 months. A positive-DAT was found in 6 to 7% of essential thrombocythemia (ET) and polycythemia vera (PV) patients, 60% of primary myelofibrosis (PMF) patients and 50% of myelodysplasia/myeloproliferation (MDS/MPN) patients with or without anemia. Autoimmune manifestations were present in 13% of patients with PV and 50% of those with MDS/MPN features. Overall, 25% of patients had autoimmune phenomena including the 15% with positive-DAT. Conclusion: In patients with JAK2V617F mutation, those with PMF and MDS/MPN subtypes are most likely to display a positive-DAT results and autoimmune manifestations (≥ 50%). Patients with PV and ET are less likely to exhibit autoimmune manifestations (≤ 10%). No correlation with the occurrence of thrombosis was seen.","PeriodicalId":93164,"journal":{"name":"Archives of autoimmune diseases","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139280754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-23DOI: 10.46439/autoimmune.4.014
Zeppieri Marco, Grando Martina
{"title":"COVID-19 and the liver: Uncovering the hidden culprit behind liver injury","authors":"Zeppieri Marco, Grando Martina","doi":"10.46439/autoimmune.4.014","DOIUrl":"https://doi.org/10.46439/autoimmune.4.014","url":null,"abstract":"","PeriodicalId":93164,"journal":{"name":"Archives of autoimmune diseases","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82032061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.46439/autoimmune.3.013
{"title":"Stromal cells set the myeloma bone marrow on fire","authors":"","doi":"10.46439/autoimmune.3.013","DOIUrl":"https://doi.org/10.46439/autoimmune.3.013","url":null,"abstract":"","PeriodicalId":93164,"journal":{"name":"Archives of autoimmune diseases","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89136112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.46439/autoimmune.2.011
{"title":"A unified viral theory of autoimmunity","authors":"","doi":"10.46439/autoimmune.2.011","DOIUrl":"https://doi.org/10.46439/autoimmune.2.011","url":null,"abstract":"","PeriodicalId":93164,"journal":{"name":"Archives of autoimmune diseases","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83063873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.46439/autoimmune.2.012
{"title":"Rheumatic fever: A classical model of a postinfection autoimmune disease and vaccine perspectives","authors":"","doi":"10.46439/autoimmune.2.012","DOIUrl":"https://doi.org/10.46439/autoimmune.2.012","url":null,"abstract":"","PeriodicalId":93164,"journal":{"name":"Archives of autoimmune diseases","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87307982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-27DOI: 10.46439/autoimmune.1.009
{"title":"Occurrence of cervical spine arthritis highly responsive to adalimumab in a patient with psoriatic peripheral arthritis and longstanding remission while on etanercept therapy","authors":"","doi":"10.46439/autoimmune.1.009","DOIUrl":"https://doi.org/10.46439/autoimmune.1.009","url":null,"abstract":"","PeriodicalId":93164,"journal":{"name":"Archives of autoimmune diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85737736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-27DOI: 10.46439/autoimmune.1.007
{"title":"Role of estrogen in neuroimmunomodulation in the periphery and onset of autoimmune dysfunction","authors":"","doi":"10.46439/autoimmune.1.007","DOIUrl":"https://doi.org/10.46439/autoimmune.1.007","url":null,"abstract":"","PeriodicalId":93164,"journal":{"name":"Archives of autoimmune diseases","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87888749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-27DOI: 10.46439/autoimmune.1.010
{"title":"Opsoclonus myoclonus syndrome and hyper IgM syndrome in the pediatric patient: A nonimmunosuppressive approach","authors":"","doi":"10.46439/autoimmune.1.010","DOIUrl":"https://doi.org/10.46439/autoimmune.1.010","url":null,"abstract":"","PeriodicalId":93164,"journal":{"name":"Archives of autoimmune diseases","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82137470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-27DOI: 10.46439/autoimmune.1.006
{"title":"iBALT and nodular lymphoid hyperplasia in TNF-overexpressing mice","authors":"","doi":"10.46439/autoimmune.1.006","DOIUrl":"https://doi.org/10.46439/autoimmune.1.006","url":null,"abstract":"","PeriodicalId":93164,"journal":{"name":"Archives of autoimmune diseases","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86352884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-27DOI: 10.46439/autoimmune.1.008
{"title":"The Role Of IL-16 as a lymphocyte attractant appears to be conserved through phylogeny: preliminary evidence that recombinant human IL-16 preferentially attracts regulatory lymphocytes in the amphibian, Xenopus laevis","authors":"","doi":"10.46439/autoimmune.1.008","DOIUrl":"https://doi.org/10.46439/autoimmune.1.008","url":null,"abstract":"","PeriodicalId":93164,"journal":{"name":"Archives of autoimmune diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84512438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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