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Recurrent Idiopathic Methicillin-sensitive Staphylococcus aureus Pericarditis in a Patient with SARS-CoV-2 Infection and Septic Bacteremia: Case Report. SARS-CoV-2感染合并脓毒性菌血症患者复发特发性甲氧西林敏感金黄色葡萄球菌心包炎1例
Pub Date : 2025-02-10 eCollection Date: 2025-01-01 DOI: 10.15420/usc.2024.43
Deitrich Gerlt, Sharon Mathai, Kristopher Aten, Colin Ly, Matthew Cali, Ursa Petric, A Nasser Khan

Purulent pericarditis (PPc) is a rare but clinically significant form of pericarditis that is typically associated with severe infection. Diagnosis is made by aspirating purulent fluid from the pericardial space, although cultures or gram stains of this fluid often yield negative results. Early detection and treatment are important in preventing severe complications such as cardiac tamponade, persistent infection, and the need for advanced therapies. This report describes the case of a 56-year-old man with multiple comorbidities, including diabetic ketoacidosis, COVID-19, and methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia, who was diagnosed with PPc after developing early cardiac tamponade and undergoing successful pericardiocentesis.

化脓性心包炎(PPc)是一种罕见但临床上重要的心包炎形式,通常与严重感染有关。通过从心包间隙抽吸化脓性液体来诊断,尽管这种液体的培养或革兰氏染色常呈阴性结果。早期发现和治疗对于预防严重并发症(如心脏填塞、持续感染)和先进治疗的需要非常重要。本报告描述了一例56岁男性患者,患有多种合并症,包括糖尿病酮症酸中毒、COVID-19和甲氧西林敏感金黄色葡萄球菌(MSSA)菌血症,他在早期发现心脏填塞并成功进行心包穿刺后被诊断为PPc。
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引用次数: 0
Pharmacotherapy, Lifestyle Modification, and Cardiac Rehabilitation after Myocardial Infarction or Percutaneous Intervention. 心肌梗塞或经皮介入治疗后的药物疗法、生活方式调整和心脏康复。
Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.15420/usc.2024.34
Nicholas Nguyen, Katherine C Michelis

Coronary artery disease is the leading cause of death in the US, and approximately 25% of MIs occurring each year are reinfarctions. Due to advances in percutaneous coronary intervention (PCI) and medical therapy, patients with prior MIs live longer but may be susceptible to additional cardiac events. Thus, secondary prevention after MI or PCI is key to improving mortality and quality of life. This review discusses pharmacotherapies and lifestyle interventions with a special focus on cardiac rehabilitation in the post-MI or PCI period to improve cardiovascular outcomes.

冠状动脉疾病是美国死亡的主要原因,每年发生的MIs中约有25%是再梗死。由于经皮冠状动脉介入治疗(PCI)和药物治疗的进步,既往有MIs的患者寿命更长,但可能容易发生额外的心脏事件。因此,心肌梗死或PCI后的二级预防是提高死亡率和生活质量的关键。这篇综述讨论了药物治疗和生活方式干预,特别关注心肌梗死后或PCI期的心脏康复,以改善心血管预后。
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引用次数: 0
Aortic Endograft Infection: Timely Recognition Is Key. 主动脉移植感染:及时识别是关键。
Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.15420/usc.2024.56
Salwan Al-Hani, Luai Madanat, Aiden Van Loo, Simon R Dixon, Richard Bloomingdale
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引用次数: 0
Remote Monitoring in Heart Failure: Revolutionizing Patient Management and Outcomes. 心力衰竭的远程监测:革命性的患者管理和结果。
Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.15420/usc.2024.23
Hanad Bashir, Pooja Prasad, Cali Clark, Ankit Bhatia, William T Abraham

Heart failure (HF) is a global health issue, contributing significantly to morbidity and mortality, particularly in North America. The management of HF is complex, requiring diligent monitoring to prevent decompensation and clinical progression. While there have been improvements in treating HF, it still leads to significant negative health outcomes and heavily contributes to the use of healthcare services. Outpatient management for HF lacks consistent application of proven therapies and the early identification and management of worsening conditions. Remote monitoring (RM) offers a solution to these challenges and there has been growing attention from HF healthcare providers and medical systems. This review explores the evolution and role of RM in the ambulatory care of HF patients, particularly emphasizing the impact of RM on clinical outcomes amid the COVID-19 pandemic.

心力衰竭(HF)是一个全球性的健康问题,对发病率和死亡率有重大影响,特别是在北美。心衰的管理是复杂的,需要认真监测以防止失代偿和临床进展。虽然心衰的治疗已经有所改善,但它仍然会导致严重的负面健康结果,并严重影响医疗保健服务的使用。心衰的门诊管理缺乏已证实的治疗方法的一致性应用以及病情恶化的早期识别和管理。远程监测(RM)为这些挑战提供了解决方案,心衰医疗保健提供者和医疗系统对其的关注日益增加。本综述探讨了RM在HF患者门诊护理中的演变和作用,特别强调了RM在COVID-19大流行期间对临床结果的影响。
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引用次数: 0
Cardiopulmonary Exercise Testing: Methodology, Interpretation, and Role in Exercise Prescription for Cardiac Rehabilitation. 心肺运动试验:方法、解释和在心脏康复运动处方中的作用。
Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.15420/usc.2024.37
Kaoutar Kabbadj, Nora Taiek, Wiame El Hjouji, Oumaima El Karrouti, Abdelkader Jalil El Hangouche

Cardiopulmonary exercise testing (CPET) is a crucial tool for assessing cardiorespiratory function, providing invaluable insights into individual physiological capacities. This review explores the clinical indications of CPET, its contraindications, as well as a comprehensive protocol for its execution. Additionally, it highlights key parameters measured during CPET and their interpretation, as well as the role of CPET in the prescription of aerobic training in cardiac rehabilitation. This review aims to provide a comprehensive, up-to-date synthesis of advances in the field of CPET and their clinical implications.

心肺运动测试(CPET)是评估心肺功能的重要工具,为个体生理能力提供了宝贵的见解。本文综述了CPET的临床适应症、禁忌症以及实施CPET的综合方案。此外,它强调了CPET期间测量的关键参数及其解释,以及CPET在心脏康复有氧训练处方中的作用。这篇综述的目的是提供一个全面的,最新的合成在CPET领域的进展及其临床意义。
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引用次数: 0
Giant Left Atrial Myxoma Presenting with Severe Pulmonary Hypertension. 巨型左心房肌瘤伴严重肺动脉高压
Pub Date : 2024-11-13 eCollection Date: 2024-01-01 DOI: 10.15420/usc.2024.02
Preet Shaikh, Mario Rodriguez Rivera, Michael A Beal, Matthew R Schill, Amit Pawale, Jonathan D Moreno

The etiology of cardiac tumors has a broad differential diagnosis. The use of a multidisciplinary team along with appropriate workup with multimodality imaging is critical for patient management. A 41-year-old man with a history of heavy tobacco use presented with abdominal distension, edema, and dyspnea for the past month. Prior to this presentation, he had experienced two episodes of right upper extremity and left lower extremity paresthesias that resolved spontaneously. A chest computed tomography (CT scan revealed an 8.5 cm mass that obliterated the left atrium and protruded across the mitral valve. Multimodal imaging (transthoracic echocardiography and cardiac MRI) confirmed a diagnosis of myxoma. Highlighting the severity of the presentation, hemodynamics revealed severe pulmonary hypertension. The patient underwent surgical resection with complete resolution of symptoms. Atrial myxomas are rare, but are among the most common type of benign cardiac tumors. Prompt optimization and definitive surgical management are critical.

心脏肿瘤的病因有广泛的鉴别诊断。多学科团队的合作以及适当的多模态成像检查对患者的治疗至关重要。一名有大量吸烟史的 41 岁男子在过去一个月里出现腹胀、水肿和呼吸困难。在此之前,他曾出现过两次右上肢和左下肢麻痹,但都自行缓解。胸部计算机断层扫描(CT 扫描)显示,一个 8.5 厘米的肿块堵塞左心房并突出于二尖瓣。多模态成像(经胸超声心动图和心脏核磁共振成像)确诊为肌瘤。由于病情严重,血液动力学检查显示患者患有严重的肺动脉高压。患者接受了手术切除,症状完全缓解。心房肌瘤虽然罕见,但却是最常见的心脏良性肿瘤之一。及时优化和明确的手术治疗至关重要。
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引用次数: 0
Successful Percutaneous Transcatheter Aortic Valve Replacement for Severe Aortic Regurgitation in a High-risk Patient with Cardiorenal Syndrome. 经皮经导管主动脉瓣置换术成功治疗心肾综合征高危患者的严重主动脉瓣反流。
Pub Date : 2024-11-13 eCollection Date: 2024-01-01 DOI: 10.15420/usc.2024.19
Deniz Mutlu, Ibrahim Halil Inanc, Ozgecan Piril Zanbak Mutlu, Konstantinos Marmagkiolis, Cezar A Iliescu, Mehmet Cilingiroglu

The absence of a Food and Drug Administration-approved percutaneous valve technology for the treatment of severe aortic regurgitation (AR) presents a challenge for high-risk patients. In this report, we describe the successful treatment of an 84-year-old male patient suffering from severe symptomatic AR and concomitant cardiorenal syndrome with renal failure using a 34 mm Evolut R (Medtronic) self-expanding transcatheter aortic valve replacement. This intervention resulted in the resolution of AR, cardiorenal syndrome, and congestive heart failure symptoms.

目前还没有一种经皮瓣膜技术获得美国食品和药物管理局批准用于治疗严重的主动脉瓣反流(AR),这给高危患者带来了挑战。在本报告中,我们介绍了使用 34 毫米 Evolut R(美敦力公司)自扩张经导管主动脉瓣置换术成功治疗一名患有严重症状性 AR 并伴有心肾综合征和肾衰竭的 84 岁男性患者的情况。这次介入治疗缓解了 AR、心肾综合征和充血性心力衰竭症状。
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引用次数: 0
Reporting Sex and Gender Differences in Cardiovascular Research. 报告心血管研究中的性别差异。
Pub Date : 2024-11-08 eCollection Date: 2024-01-01 DOI: 10.15420/usc.2024.18
Kadijah F Porter, Brototo Deb, Andriy Katyukha, Natdanai Punnanithinont, Michael G Fradley, Stephen C Cook

Incorporating sexual orientation, gender identity, and expression (SOGIE) data into cardiovascular research design is necessary to reduce cardiovascular healthcare disparities among sexual and gender minority (SGM) people. To achieve this, researchers should not only understand appropriate terminology, but also implement inclusive survey tools that respect privacy and cultural nuances, as the benefit of obtaining SOGIE information is critical to tailoring cardiovascular interventions and ensuring equitable healthcare outcomes. In order to address potential concerns related to disclosing SOGIE information, we must prioritize sensitivity training for healthcare professionals to foster an inclusive environment for data collection, ethical considerations, and confidentiality safeguards. This review aims to develop and inform critical thinking about sex and gender and to identify strategic mechanisms to include SOGIE data in cardiovascular research, thus improving cardiovascular health outcomes for SGM individuals. By embracing a more comprehensive and inclusive approach to data collection, cardiovascular research can contribute significantly to advancing personalized and inclusive healthcare practices and medical education, and ultimately promote better health outcomes for all SGM individuals.

将性取向、性别认同和表达(SOGIE)数据纳入心血管研究设计是减少性少数群体和性别少数群体(SGM)心血管医疗差距的必要条件。为此,研究人员不仅应了解适当的术语,还应采用尊重隐私和文化差异的包容性调查工具,因为获取 SOGIE 信息的益处对于定制心血管干预措施和确保公平的医疗结果至关重要。为了解决与披露 SOGIE 信息相关的潜在问题,我们必须优先对医疗保健专业人员进行敏感性培训,为数据收集、伦理考虑和保密保障营造一个包容性的环境。本综述旨在发展和充实有关性和性别的批判性思维,并确定战略机制,将性别与平等数据纳入心血管研究,从而改善 SGM 患者的心血管健康状况。通过采用更全面、更具包容性的数据收集方法,心血管研究可为推进个性化、包容性的医疗保健实践和医学教育做出重大贡献,并最终改善所有 SGM 患者的健康状况。
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引用次数: 0
Hypertrophic Cardiomyopathy as a Form of Heart Failure with Preserved Ejection Fraction: Diagnosis, Drugs, and Procedures. 肥厚型心肌病是一种射血分数保留型心力衰竭:诊断、药物和手术。
Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI: 10.15420/usc.2023.21
Sukriti Banthiya, Larissa Check, Jessica Atkins

Hypertrophic cardiomyopathy (HCM) is a complex and heterogeneous cardiac disorder characterized by cardiac hypertrophy disproportionate to loading stimuli (e.g. hypertension or aortic stenosis). Diagnosing HCM requires a thorough examination of clinical symptoms, with echocardiography as the key initial imaging tool. Multimodality imaging further supports diagnosis, helps assess left ventricular outflow obstruction, and aids in risk stratification for sudden cardiac death. The cornerstone of HCM management remains pharmacological therapy with β-blockers and calcium channel blockers serving as first-line agents to alleviate symptoms and reduce left ventricular outflow tract obstruction. More recently, cardiac myosin inhibitors have revolutionized the treatment paradigm for obstructive HCM. Procedural interventions such as septal reduction therapy are reserved for refractory cases. Genetic testing and risk stratification for sudden cardiac death play a critical role in treatment decisions, guiding further testing in first-degree relatives and ICD implantation in high-risk individuals. Exercise recommendations have evolved based on recent data, challenging traditional restrictions and emphasizing individualized plans.

肥厚性心肌病(HCM)是一种复杂的异质性心脏疾病,其特征是心脏肥大与负荷刺激(如高血压或主动脉瓣狭窄)不成比例。诊断 HCM 需要对临床症状进行全面检查,而超声心动图则是关键的初始成像工具。多模态成像可进一步支持诊断,帮助评估左心室流出道梗阻,并有助于对心脏性猝死进行风险分层。HCM 治疗的基石仍然是药物治疗,β 受体阻滞剂和钙通道阻滞剂是缓解症状和减少左心室流出道梗阻的一线药物。最近,心肌酶抑制剂彻底改变了阻塞性 HCM 的治疗模式。房间隔缩窄疗法等程序性干预措施仅用于难治性病例。心脏性猝死的基因检测和风险分层在治疗决策中起着至关重要的作用,可指导一级亲属进行进一步检测,并为高危患者植入 ICD。根据最新数据,运动建议也发生了变化,对传统限制提出了挑战,并强调了个性化计划。
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引用次数: 0
Functional Tricuspid Regurgitation in the Transcatheter Aortic Valve Replacement Population and Emerging Transcatheter Tricuspid Valve Interventions. 经导管主动脉瓣置换术人群中的功能性三尖瓣反流和新兴的经导管三尖瓣介入治疗。
Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.15420/usc.2023.24
Molly Silkowski, Payton Kendsersky, Nicholas Amoroso

Transcatheter aortic valve replacement (TAVR) has revolutionized the management of aortic valve disease. However, its success has brought attention to concurrent tricuspid valve disease and the inadequacy of treatments. This review explores the emerging field of transcatheter tricuspid valve interventions (TTVI) after TAVR. We address the pathophysiology and prevalence of post-TAVR tricuspid valve disease and TTVI strategies, including repair, replacement, annuloplasty, and edge-to-edge repair. We also discuss clinical studies assessing TTVI safety and efficacy, including for patients with previous TAVR. Collaboration among clinical disciplines remains crucial for advancing this emerging field to establish best practices regarding patient selection and procedural complexities.

经导管主动脉瓣置换术(TAVR)彻底改变了主动脉瓣疾病的治疗方法。然而,它的成功使人们开始关注并发的三尖瓣疾病和治疗方法的不足。本综述探讨了 TAVR 术后经导管三尖瓣介入治疗(TTVI)这一新兴领域。我们探讨了 TAVR 术后三尖瓣疾病的病理生理学和患病率以及 TTVI 策略,包括修复、置换、瓣环成形术和边缘到边缘修复。我们还讨论了评估 TTVI 安全性和有效性的临床研究,包括针对既往接受过 TAVR 患者的研究。临床学科之间的合作对于推动这一新兴领域的发展至关重要,以建立有关患者选择和程序复杂性的最佳实践。
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引用次数: 0
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US cardiology
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