Pub Date : 2023-03-02DOI: 10.1089/forensic.2023.0004
Nicole M. M. Novroski
{"title":"The Idaho Student Homicides and the Future of Forensic Genetic Genealogy","authors":"Nicole M. M. Novroski","doi":"10.1089/forensic.2023.0004","DOIUrl":"https://doi.org/10.1089/forensic.2023.0004","url":null,"abstract":"","PeriodicalId":93434,"journal":{"name":"Forensic genomics","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77434123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.1089/forensic.2022.0013
David A. Russell, Erin M. Gorden, Michelle A. Peck, Christina M. Neal, Mary C. Heaton, Jessica L. Bouchet, Alexander F. Koeppel, Elayna Ciuzio, Stephen D. Turner, Carmen R. Reedy
Microarray processing, which interrogates hundreds of thousands of single nucleotide polymorphisms (SNPs) across the human genome, has recently gained traction in forensics due to its use in forensic genetic genealogy, which is based on analysis using SNPs to compare distant relatives in publicly curated databases for the purposes of developing investigative leads or identifying human remains. To date, there has been no published developmental validation of microarray processing using the Scientific Working Group on DNA Analysis Methods (SWGDAM) Validation Guidelines for DNA Analysis Methods and Federal Bureau of Investigation Quality Assurance Standards. Validation of these methods are warranted to identify samples suitable for microarray analysis and to assess the quality of the data obtained before upload to genealogical databases. In this study, we validated the Global Screening Array for use in forensic investigations according to SWGDAM guidelines, including the following studies: precision and accuracy, sensitivity, contamination, degradation, species specificity, mock case-type samples, mixtures, repeatability and reproducibility, and stability. Results indicated accurate genotype calls with SNP call rates >95% at DNA input as low as 0.20 ng. In addition to SNP call rate, we developed interpretation thresholds for signal intensity and heterozygosity to allow for sample quality assessment and identification of highly degraded and/or non-human DNA. This study demonstrates that high-quality data can be generated from multiple sample types, including mock forensic evidence that simulated the challenges that are often encountered in forensic cold cases.
{"title":"Developmental Validation of the Illumina Infinium Assay Using the Global Screening Array on the iScan System for Use in Forensic Laboratories","authors":"David A. Russell, Erin M. Gorden, Michelle A. Peck, Christina M. Neal, Mary C. Heaton, Jessica L. Bouchet, Alexander F. Koeppel, Elayna Ciuzio, Stephen D. Turner, Carmen R. Reedy","doi":"10.1089/forensic.2022.0013","DOIUrl":"https://doi.org/10.1089/forensic.2022.0013","url":null,"abstract":"Microarray processing, which interrogates hundreds of thousands of single nucleotide polymorphisms (SNPs) across the human genome, has recently gained traction in forensics due to its use in forensic genetic genealogy, which is based on analysis using SNPs to compare distant relatives in publicly curated databases for the purposes of developing investigative leads or identifying human remains. To date, there has been no published developmental validation of microarray processing using the Scientific Working Group on DNA Analysis Methods (SWGDAM) Validation Guidelines for DNA Analysis Methods and Federal Bureau of Investigation Quality Assurance Standards. Validation of these methods are warranted to identify samples suitable for microarray analysis and to assess the quality of the data obtained before upload to genealogical databases. In this study, we validated the Global Screening Array for use in forensic investigations according to SWGDAM guidelines, including the following studies: precision and accuracy, sensitivity, contamination, degradation, species specificity, mock case-type samples, mixtures, repeatability and reproducibility, and stability. Results indicated accurate genotype calls with SNP call rates >95% at DNA input as low as 0.20 ng. In addition to SNP call rate, we developed interpretation thresholds for signal intensity and heterozygosity to allow for sample quality assessment and identification of highly degraded and/or non-human DNA. This study demonstrates that high-quality data can be generated from multiple sample types, including mock forensic evidence that simulated the challenges that are often encountered in forensic cold cases.","PeriodicalId":93434,"journal":{"name":"Forensic genomics","volume":"174 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136095449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.1089/forensic.2023.0001
Sarah Abbas, Ijaz Anwar, I. Mansour
{"title":"Impact of Religious Inbreeding on the Genetic Structure of the Subpopulations Versus Villages from Lebanon","authors":"Sarah Abbas, Ijaz Anwar, I. Mansour","doi":"10.1089/forensic.2023.0001","DOIUrl":"https://doi.org/10.1089/forensic.2023.0001","url":null,"abstract":"","PeriodicalId":93434,"journal":{"name":"Forensic genomics","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76911148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.1089/forensic.2022.29014.ack
Forensic GenomicsVol. 3, No. 1 AcknowledgmentFree AccessAcknowledgment of Reviewers 2022Published Online:15 Mar 2023https://doi.org/10.1089/forensic.2022.29014.ackAboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail Critical evaluations of articles by expert reviewers make a vital contribution to ensuring the high quality of a journal's content. The editorial leadership of Forensic Genomics is very grateful for the support of the highly qualified peer reviewers who have dedicated their time and effort to reviewing our articles. We would like to show our appreciation by thanking the following individuals for their assistance with the review of articles for the journal in 2022.**Data through November 30, 2022.Lisa BrightBruce BudowleBrendan ChapmanDaniela CuencaKatherine GettingsJodi IrwinHarmeet KaurAna NeckovicNicole NovroskiMuhammad SajjadNathan ScudderChristopher StaleyAndreas TillmarIrina VelskoJodie WardFrank WendtFiguresReferencesRelatedDetails Volume 3Issue 1Mar 2023 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Acknowledgment of Reviewers 2022.Forensic Genomics.Mar 2023.30-30.http://doi.org/10.1089/forensic.2022.29014.ackPublished in Volume: 3 Issue 1: March 15, 2023Online Ahead of Print:January 27, 2023PDF download
{"title":"Acknowledgment of Reviewers 2022","authors":"","doi":"10.1089/forensic.2022.29014.ack","DOIUrl":"https://doi.org/10.1089/forensic.2022.29014.ack","url":null,"abstract":"Forensic GenomicsVol. 3, No. 1 AcknowledgmentFree AccessAcknowledgment of Reviewers 2022Published Online:15 Mar 2023https://doi.org/10.1089/forensic.2022.29014.ackAboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail Critical evaluations of articles by expert reviewers make a vital contribution to ensuring the high quality of a journal's content. The editorial leadership of Forensic Genomics is very grateful for the support of the highly qualified peer reviewers who have dedicated their time and effort to reviewing our articles. We would like to show our appreciation by thanking the following individuals for their assistance with the review of articles for the journal in 2022.**Data through November 30, 2022.Lisa BrightBruce BudowleBrendan ChapmanDaniela CuencaKatherine GettingsJodi IrwinHarmeet KaurAna NeckovicNicole NovroskiMuhammad SajjadNathan ScudderChristopher StaleyAndreas TillmarIrina VelskoJodie WardFrank WendtFiguresReferencesRelatedDetails Volume 3Issue 1Mar 2023 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Acknowledgment of Reviewers 2022.Forensic Genomics.Mar 2023.30-30.http://doi.org/10.1089/forensic.2022.29014.ackPublished in Volume: 3 Issue 1: March 15, 2023Online Ahead of Print:January 27, 2023PDF download","PeriodicalId":93434,"journal":{"name":"Forensic genomics","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136173679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.1089/forensic.2023.0003
Nicole M. M. Novroski
{"title":"The Role of Biomedical Communication in Forensic Genetics Education: An Interview with Michie Wu","authors":"Nicole M. M. Novroski","doi":"10.1089/forensic.2023.0003","DOIUrl":"https://doi.org/10.1089/forensic.2023.0003","url":null,"abstract":"","PeriodicalId":93434,"journal":{"name":"Forensic genomics","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83663314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-16DOI: 10.1089/forensic.2022.29015.editorial
Nicole M. M. Novroski
{"title":"Highlighting the Forensic Impact of ISHI33","authors":"Nicole M. M. Novroski","doi":"10.1089/forensic.2022.29015.editorial","DOIUrl":"https://doi.org/10.1089/forensic.2022.29015.editorial","url":null,"abstract":"","PeriodicalId":93434,"journal":{"name":"Forensic genomics","volume":"157 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73046014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-11DOI: 10.1089/forensic.2022.0008.correx
{"title":"Correction to: Developmental Validation of the forensicGEM Universal Kit for the Extraction of Genomic DNA, by Conte et al. Forensic Genom 2022;2(3):71–79; doi: 10.1089/forensic.2022.0008","authors":"","doi":"10.1089/forensic.2022.0008.correx","DOIUrl":"https://doi.org/10.1089/forensic.2022.0008.correx","url":null,"abstract":"","PeriodicalId":93434,"journal":{"name":"Forensic genomics","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81281201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.1089/forensic.2022.0008
J. Conte, Janine Kishbaugh, Dylan J. Baxter, Robert Thompson, Shrivastava Pankaj, R. Chilukuri, Pamela Marshall
{"title":"Developmental Validation of the forensicGEM Universal Kit for the Extraction of Genomic DNA","authors":"J. Conte, Janine Kishbaugh, Dylan J. Baxter, Robert Thompson, Shrivastava Pankaj, R. Chilukuri, Pamela Marshall","doi":"10.1089/forensic.2022.0008","DOIUrl":"https://doi.org/10.1089/forensic.2022.0008","url":null,"abstract":"","PeriodicalId":93434,"journal":{"name":"Forensic genomics","volume":"283 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72567749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.1089/forensic.2022.29013.editorial
Nicole M. M. Novroski
{"title":"Forensic Genomics: A New Era","authors":"Nicole M. M. Novroski","doi":"10.1089/forensic.2022.29013.editorial","DOIUrl":"https://doi.org/10.1089/forensic.2022.29013.editorial","url":null,"abstract":"","PeriodicalId":93434,"journal":{"name":"Forensic genomics","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80007946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1089/forensic.2022.0009
V. Nagraj, M. Scholz, Shakeel Jessa, Jianye Ge, Meng Huang, August E. Woerner, Dixie Peters, B. Budowle, M. Coble, Stephen D. Turner
{"title":"Relationship Inference with Low-Coverage Whole Genome Sequencing on Forensic Samples","authors":"V. Nagraj, M. Scholz, Shakeel Jessa, Jianye Ge, Meng Huang, August E. Woerner, Dixie Peters, B. Budowle, M. Coble, Stephen D. Turner","doi":"10.1089/forensic.2022.0009","DOIUrl":"https://doi.org/10.1089/forensic.2022.0009","url":null,"abstract":"","PeriodicalId":93434,"journal":{"name":"Forensic genomics","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74178345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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