{"title":"A matter for concern","authors":"L. Besaw","doi":"10.1007/BF03021337","DOIUrl":"https://doi.org/10.1007/BF03021337","url":null,"abstract":"","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"126 1","pages":"89-90"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85276434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1987-06-01DOI: 10.1097/00132586-198706000-00006
R. Mirakhur
Plasma cholinesterase activity was estimated following administration of edrophonium 0.5 or 1.0 mg X kg-1 given for antagonism of atracurium-induced neuromuscular block. There was no inhibition of enzyme activity for up to three hours following edrophonium administration. This is in contrast to profound and prolonged inhibition of enzyme activity seen following neostigmine and pyridostigmine.
血浆胆碱酯酶活性在给药0.5或1.0 mg X kg-1艾络芬用于对抗阿曲库利引起的神经肌肉阻滞后进行估计。给药后3小时内酶活性无抑制作用。这与新斯的明和吡哆斯的明对酶活性的深刻和长期抑制形成对比。
{"title":"Edrophonium and plasma cholinesterase activity.","authors":"R. Mirakhur","doi":"10.1097/00132586-198706000-00006","DOIUrl":"https://doi.org/10.1097/00132586-198706000-00006","url":null,"abstract":"Plasma cholinesterase activity was estimated following administration of edrophonium 0.5 or 1.0 mg X kg-1 given for antagonism of atracurium-induced neuromuscular block. There was no inhibition of enzyme activity for up to three hours following edrophonium administration. This is in contrast to profound and prolonged inhibition of enzyme activity seen following neostigmine and pyridostigmine.","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"97 1","pages":"588-90"},"PeriodicalIF":0.0,"publicationDate":"1987-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85273992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The anaesthetic management of children with glycogen-storage disease type IIa (Pompe's disease) presents a variety of challenges. A modification of a femoral nerve block, the inguinal paravascular block, as described by Winnie, was used in conjunction with intravenous ketamine to provide anaesthesia for a diagnostic muscle biopsy in a 5.5-month-old infant with Pompe's disease. A peripheral nerve stimulator was used to locate the femoral nerve in lieu of eliciting a paraesthesia.
{"title":"Anaesthesia for diagnostic muscle biopsy in an infant with Pompe's disease.","authors":"K R Rosen, L M Broadman","doi":"10.1007/BF03027132","DOIUrl":"https://doi.org/10.1007/BF03027132","url":null,"abstract":"<p><p>The anaesthetic management of children with glycogen-storage disease type IIa (Pompe's disease) presents a variety of challenges. A modification of a femoral nerve block, the inguinal paravascular block, as described by Winnie, was used in conjunction with intravenous ketamine to provide anaesthesia for a diagnostic muscle biopsy in a 5.5-month-old infant with Pompe's disease. A peripheral nerve stimulator was used to locate the femoral nerve in lieu of eliciting a paraesthesia.</p>","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"33 6","pages":"790-4"},"PeriodicalIF":0.0,"publicationDate":"1986-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03027132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14589991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The efficacy of preanaesthetic intravenous cimetidine versus ranitidine with and without metoclopramide for acid aspiration prophylaxis was assessed in 60 morbidly obese patients in a double-blind manner. Group 1 patients received cimetidine 300 mg + saline. Group 2 patients received cimetidine 300 mg + metoclopramide 10 mg. Group 3 patients received ranitidine 100 mg + saline. Group 4 patients received ranitidine 100 mg + metoclopramide 10 mg. Gastric fluid was aspirated for analysis of volume and pH following induction of anaesthesia. All four premedication regimens were equally effective in reducing the gastric volume and acidity and the inclusion of metoclopramide had no additive effect. Although statistically not significant, two patients in the cimetidine groups remained at risk (volume greater than 25 ml and pH less than 2.5) while no patients in the ranitidine groups remained so.
{"title":"The effects of cimetidine and ranitidine with and without metoclopramide on gastric volume and pH in morbidly obese patients.","authors":"A M Lam, D M Grace, P H Manninen, C Diamond","doi":"10.1007/BF03027129","DOIUrl":"https://doi.org/10.1007/BF03027129","url":null,"abstract":"<p><p>The efficacy of preanaesthetic intravenous cimetidine versus ranitidine with and without metoclopramide for acid aspiration prophylaxis was assessed in 60 morbidly obese patients in a double-blind manner. Group 1 patients received cimetidine 300 mg + saline. Group 2 patients received cimetidine 300 mg + metoclopramide 10 mg. Group 3 patients received ranitidine 100 mg + saline. Group 4 patients received ranitidine 100 mg + metoclopramide 10 mg. Gastric fluid was aspirated for analysis of volume and pH following induction of anaesthesia. All four premedication regimens were equally effective in reducing the gastric volume and acidity and the inclusion of metoclopramide had no additive effect. Although statistically not significant, two patients in the cimetidine groups remained at risk (volume greater than 25 ml and pH less than 2.5) while no patients in the ranitidine groups remained so.</p>","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"33 6","pages":"773-9"},"PeriodicalIF":0.0,"publicationDate":"1986-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03027129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14897078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Flexion deformity of metacarpo-phalangeal joint following extravasation of thiopentone.","authors":"V Venkateswaran","doi":"10.1007/BF03027144","DOIUrl":"https://doi.org/10.1007/BF03027144","url":null,"abstract":"","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"33 6","pages":"827-8"},"PeriodicalIF":0.0,"publicationDate":"1986-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03027144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14897084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Cunliffe, V M Lucero, M E McLeod, F A Burrows, J Lerman
To compare the effectiveness of succinylcholine and pancuronium for rapid intubation in children, 49 healthy children ages two to eight years were studied. After induction of anaesthesia with thiopentone and atropine, and administration of droperidol, fentanyl, nitrous oxide, and oxygen, each child received one of the following muscle relaxants: succinylcholine 1.5 mg X kg-1 (n = 12), succinylcholine 1.0 mg X kg-1 (n = 13), pancuronium 0.15 mg X kg-1 (n = 11), or pancuronium 0.10 mg X kg-1 (n = 13). The force of thumb adduction was measured by stimulating the ulnar nerve with repetitive supramaximal single twitches (0.15 Hz). The time to 95 per cent twitch depression (mean +/- S.D.) was most rapid with succinylcholine 1.5 mg X kg-1 (40.8 +/- 3.0 seconds) and succinylcholine 1.0 mg X kg-1 (51.8 +/- 14.0 seconds), slowest with pancuronium 0.10 mg X kg-1 (150.9 +/- 38.0 seconds), and intermediate with pancuronium 0.15 mg X kg-1 (80.3 +/- 21.8 seconds) (p less than 0.005). The intubating conditions were excellent in 100% of the children who received succinylcholine 1.5 and 1.0 mg X kg-1, and pancuronium 0.15 mg X kg-1, but were excellent in only 69 per cent of those who received pancuronium 0.10 mg X kg-1. We conclude that succinylcholine 1.5 mg X kg-1 produces the most rapid onset of excellent intubating conditions in children. In children in whom succinylcholine is contra-indicated, pancuronium 0.15 mg X kg-1 provides excellent intubating conditions within 80 seconds.
为了比较琥珀胆碱和泮库溴铵在儿童快速插管中的有效性，对49名2至8岁的健康儿童进行了研究。在用硫贲妥和阿托品诱导麻醉，并给药哌啶醇、芬太尼、氧化亚氮和氧气后，每个儿童接受以下一种肌肉松弛剂:琥珀胆碱1.5 mg X kg-1 (n = 12)、琥珀胆碱1.0 mg X kg-1 (n = 13)、潘库溴铵0.15 mg X kg-1 (n = 11)或潘库溴铵0.10 mg X kg-1 (n = 13)。通过重复最大上单次抽搐(0.15 Hz)刺激尺神经测量拇指内收力。琥珀酰胆碱1.5 mg X kg-1组(40.8 +/- 3.0 s)和琥珀酰胆碱1.0 mg X kg-1组(51.8 +/- 14.0 s)达到95%抽搐抑制时间最快，泮库溴铵0.10 mg X kg-1组(150.9 +/- 38.0 s)最慢，泮库溴铵0.15 mg X kg-1组(80.3 +/- 21.8 s)居中(p < 0.005)。接受琥珀胆碱1.5和1.0 mg X kg-1和泮库溴铵0.15 mg X kg-1的患儿插管情况100%良好，但接受泮库溴铵0.10 mg X kg-1的患儿插管情况良好。我们得出结论，琥珀酰胆碱1.5 mg X kg-1在儿童中产生最快速的良好插管条件。在琥珀胆碱禁忌的儿童中，泮库溴铵0.15 mg X kg-1可在80秒内提供良好的插管条件。
{"title":"Neuromuscular blockade for rapid tracheal intubation in children: comparison of succinylcholine and pancuronium.","authors":"M Cunliffe, V M Lucero, M E McLeod, F A Burrows, J Lerman","doi":"10.1007/BF03027127","DOIUrl":"https://doi.org/10.1007/BF03027127","url":null,"abstract":"<p><p>To compare the effectiveness of succinylcholine and pancuronium for rapid intubation in children, 49 healthy children ages two to eight years were studied. After induction of anaesthesia with thiopentone and atropine, and administration of droperidol, fentanyl, nitrous oxide, and oxygen, each child received one of the following muscle relaxants: succinylcholine 1.5 mg X kg-1 (n = 12), succinylcholine 1.0 mg X kg-1 (n = 13), pancuronium 0.15 mg X kg-1 (n = 11), or pancuronium 0.10 mg X kg-1 (n = 13). The force of thumb adduction was measured by stimulating the ulnar nerve with repetitive supramaximal single twitches (0.15 Hz). The time to 95 per cent twitch depression (mean +/- S.D.) was most rapid with succinylcholine 1.5 mg X kg-1 (40.8 +/- 3.0 seconds) and succinylcholine 1.0 mg X kg-1 (51.8 +/- 14.0 seconds), slowest with pancuronium 0.10 mg X kg-1 (150.9 +/- 38.0 seconds), and intermediate with pancuronium 0.15 mg X kg-1 (80.3 +/- 21.8 seconds) (p less than 0.005). The intubating conditions were excellent in 100% of the children who received succinylcholine 1.5 and 1.0 mg X kg-1, and pancuronium 0.15 mg X kg-1, but were excellent in only 69 per cent of those who received pancuronium 0.10 mg X kg-1. We conclude that succinylcholine 1.5 mg X kg-1 produces the most rapid onset of excellent intubating conditions in children. In children in whom succinylcholine is contra-indicated, pancuronium 0.15 mg X kg-1 provides excellent intubating conditions within 80 seconds.</p>","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"33 6","pages":"760-4"},"PeriodicalIF":0.0,"publicationDate":"1986-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03027127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14897077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contralateral spread of local anaesthetic solutions.","authors":"M Schnapp, K S Mays","doi":"10.1007/BF03027145","DOIUrl":"https://doi.org/10.1007/BF03027145","url":null,"abstract":"","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"33 6","pages":"828-9"},"PeriodicalIF":0.0,"publicationDate":"1986-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03027145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14897085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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