Cancer Prevention Research最新文献

{"title":"Editors' Selections from Relevant Scientific Publications","authors":"","doi":"10.1158/1940-6207.capr-16-10-hfl","DOIUrl":"https://doi.org/10.1158/1940-6207.capr-16-10-hfl","url":null,"abstract":"Highlights from the Literature| October 02 2023 Editors' Selections from Relevant Scientific Publications Author & Article Information Online ISSN: 1940-6215 Print ISSN: 1940-6207 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Prev Res (Phila) (2023) 16 (10): 539. https://doi.org/10.1158/1940-6207.CAPR-16-10-HFL Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record October 2 2023 Citation Editors' Selections from Relevant Scientific Publications. Cancer Prev Res (Phila) 1 October 2023; 16 (10): 539. https://doi.org/10.1158/1940-6207.CAPR-16-10-HFL Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Breast cancer cells (by Annie Cavanagh via Flickr) Using phylogenetic of microdissected samples of cancer and non-cancer proliferative lesions, Nishimura et al. explored the genetic evolution of breast cancer, revealing a unique evolutionary pattern harboring der(1;16), a common driver alteration in 20% of all breast cancers and one-third of Luminal A breast cancers. In der(1;16)(+) cancers, the derivative chromosome was acquired from early puberty to late adolescence, followed by the emergence of a common ancestor by the patient's early 30s, leading to both cancerous and non-cancerous clones. These clones expanded significantly within the premenopausal breast before cancer diagnosis. Interestingly, multiple cancer clones originated from noncancer ancestors and there was no correlation between histology and the number of driver events, suggesting the involvement of epigenetic or microenvironmental factors in cancer development. These findings contribute to a better understanding of breast carcinogenesis and may improve early detection and prevention strategies. Nishimura... You do not currently have access to this content.","PeriodicalId":9373,"journal":{"name":"Cancer Prevention Research","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135833465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editors' Selections from Relevant Scientific Publications","authors":"","doi":"10.1158/1940-6207.capr-16-8-hfl","DOIUrl":"https://doi.org/10.1158/1940-6207.capr-16-8-hfl","url":null,"abstract":"Highlights from the Literature| August 01 2023 Editors' Selections from Relevant Scientific Publications Author & Article Information Online ISSN: 1940-6215 Print ISSN: 1940-6207 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Prev Res (Phila) (2023) 16 (8): 419. https://doi.org/10.1158/1940-6207.CAPR-16-8-HFL Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record August 1 2023 Citation Editors' Selections from Relevant Scientific Publications. Cancer Prev Res (Phila) 1 August 2023; 16 (8): 419. https://doi.org/10.1158/1940-6207.CAPR-16-8-HFL Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Polygenic risk scores for screening (from Centers for Disease Control and Prevention) Using UK metrics, Huntley et al. conducted a modeling analysis on the performance of polygenic risk score (PRS) tools and PRS-stratified cancer screening. They estimated the potential annual numbers of cancer cases detected and deaths averted for eight different cancers. The results suggested that, under favorable assumptions, hypothetical PRS-stratified screening programs could modestly improve efficiency for three cancer types. Specifically, they could reduce maximum number of annual deaths from 102 to 80 for breast cancer, 188 to 155 for prostate cancer, and 158 to 95 for colorectal cancer. However, UK-specific cluster-randomized trials are required to evaluate the real-world clinical impact, costs, and potential harm of PRS stratification. Huntley C, … Turnbull C. Lancet Oncol. 2023 Jun;24(6): 658-668. Illustration of deep learning (by OpenClipart via FreeSVG) Pancreatic cancer is often diagnosed too late to achieve good clinical outcomes,... You do not currently have access to this content.","PeriodicalId":9373,"journal":{"name":"Cancer Prevention Research","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135970943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editors' Selections from Relevant Scientific Publications","authors":"","doi":"10.1158/1940-6207.capr-16-6-hfl","DOIUrl":"https://doi.org/10.1158/1940-6207.capr-16-6-hfl","url":null,"abstract":"Highlights from the Literature| June 01 2023 Editors' Selections from Relevant Scientific Publications Author & Article Information Online ISSN: 1940-6215 Print ISSN: 1940-6207 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Prev Res (Phila) (2023) 16 (6): 303. https://doi.org/10.1158/1940-6207.CAPR-16-6-HFL Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record June 1 2023 Citation Editors' Selections from Relevant Scientific Publications. Cancer Prev Res (Phila) 1 June 2023; 16 (6): 303. https://doi.org/10.1158/1940-6207.CAPR-16-6-HFL Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Obese adipose tissue in the mammary gland (by Arendt et al. via Cancer Research Bhardwaj et al. investigated whether high body mass index (BMI) increases breast cancer risks for women carrying BRCA 1 or BRCA2 mutations. They examined noncancerous breast tissue from 69 such women and found that BMI and biomarkers of metabolic dysfunction were positively correlated with DNA damage in epithelia. RNA sequencing data revealed that obesity altered breast adipose microenvironment and activated estrogen biosynthesis. Blocking signaling pathways mediated by either estrogen or obesity-associated factors leptin or insulin, reduced DNA damage. Additionally, a high-fat diet increased DNA damage and mammary tumors in Brca1+/−mice. These results provide mechanistic insight linking obesity and breast cancer in BRCA mutation carriers, and suggest that reducing risk may involve maintaining a lower body weight, addressing metabolic problems and targeting estrogen. Bhardwaj P, … Brown KA. Sci Transl Med. 2023 Feb 22;15(684):eade1857.... You do not currently have access to this content.","PeriodicalId":9373,"journal":{"name":"Cancer Prevention Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135727769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgment to Reviewers","authors":"","doi":"10.1158/1940-6207.capr-16-1-ar","DOIUrl":"https://doi.org/10.1158/1940-6207.capr-16-1-ar","url":null,"abstract":"The Cancer Prevention Research editors wish to acknowledge with sincere appreciation the assistance of the following reviewers who have generously contributed their time and effort during the past year1 in the appraisal of manuscripts. These reviewers have been enormously helpful in assessing the merit of original articles: their careful analysis and critique and their constructive recommendations have greatly enhanced the value of manuscripts they have handled. The quality of the journal can be attributed in large measure to the quality of their effort. We are sincerely grateful.Abdelwadoud, M.Agarwal, R.Alexeeff, S.Allanson, E.Alshalalfa, M.Amos, C.Anderson, K.Arayici, M.Arendt, L.Arthur, R.Aslam, M.Ballester, V.Bansal, A.Barry, K.Beane, J.Behrens, G.Benedetti, I.Benjaminsen Borch, K.Beretta, L.Bergan, R.Boland, R.Bosland, M.Bossuyt, P.Bouras, E.Bowers, L.Bresalier, R.Brooks, J.Brown, K.Brown, R.Burris, J.Butsch Kovacic, M.Butt, J.Carchman, E.Carlo, M.Chan, A.Chan, C.Chang, G.Charvat, H.Chen, H.Chen, J.Chen, M.Chen, W.Cho, H.Choi, J.Clapper, M.Colditz, G.Coronado, G.Cronin-Fenton, D.Croy, R.Cummings, K.D'Angelo, H.Daly, M.DeCensi, A.DeStephano, C.Djuric, Z.Dmitrovsky, E.Dooley, W.Dossus, L.Dubinett, S.Dwivedi, C.El-Bayoumy, K.Ellaithi, M.Eltoum, I.Eshak, E.Esserman, L.Evans, D.Falk, D.Fang, C.Figueroa, J.Ford, M.Fournier, A.Fowke, J.Franco, E.Freedland, S.Freisling, H.Friedenreich, C.Gail, M.Genkinger, J.George, S.Gershenwald, J.Giorgi-Rossi, P.Giovannucci, E.Gleber-Netto, F.Goetz, L.Goodwin, P.Gowans, E.Grant, E.Groopman, J.Grossman, D.Gu, J.Guerrero-Preston, R.Gümüş, Z.Han, Y.Hanash, S.Harper, D.Hecht, S.Heckman-Stoddard, B.Henry, K.Hilakivi-Clarke, L.Hodge, A.Hong, C.Hong, Y.Huang, Y.Hung, M.Huo, D.Hur, J.Imperiale, T.Inadomi, J.Iwasaki, M.Janakiram, N.Kadara, H.Kassie, F.Kensler, K.Khairan, P.Khan, S.Kim, J.Kim, R.Kingham, T.Kinney, A.Kong, A.Kratz, C.Kühn, T.Kypriotakis, G.La Vecchia, C.Lam, S.Land, S.Lazcano-Ponce, E.Lebwohl, B.Lee, H.Lee, J.Liby, K.Lipkin, S.Longatto-Filho, A.Lopez, D.Lu, J.Lu, Q.Lundberg, A.Luu, H.Lynch, P.MacInnis, R.Mandle, H.Manne, S.Mao, J.Mariosa, D.Marshall, J.Matthews, C.Mayrand, M.Mehta, A.Melkonian, S.Michail, G.Miller, M.Milne, R.Mitzner, W.Mix, J.Mohammed, A.Molokwu, J.Montuenga, L.Mousavi Seresht, L.Muller, D.Müller, M.Mulshine, J.Murphy, G.Murphy, N.Narayanapillai, S.Nash, S.Nasrollahzadeh, D.Neale, R.Nelson, K.Noh, H.Nounu, A.O'Dwyer, P.O'Mara, T.Ogunsina, K.Oh, H.Ondrey, F.Ortiz, A.Ose, J.Park, H.Parker, B.Paskett, E.Pass, H.Passarelli, M.Pepper, J.Perkins, R.Permuth, J.Petrick, J.Phillips, K.Piazza, G.Playdon, M.Porter, W.Qiao, Y.Quaife, S.Rachocki, C.Ramsey, A.Rao, C.Rauh-Hain, J.Robbins, H.Robson, M.Rosenberg, D.Sawada, N.Sboner, A.Scalbert, A.Schmeler, K.Schnoll, R.Seno, H.Sethi, S.Shahid, A.Shaukat, A.Shen, Q.Shen, Z.Sherman, M.Shibata, D.Shu, X.Shureiqi, I.Singh, S.Smith, S.Sporn, M.Srivastava, S.Stanton, S.Stevens, V.Stewart, S.Stoffel, E.Stoner, G.Sturgeon, S.Sukumar, S.Sun, C.Sun, Y.Surh, Y.Tabun","PeriodicalId":9373,"journal":{"name":"Cancer Prevention Research","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135500361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}