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New Onset, Refractory Hyperglycemia with Diabetic Ketoacidosis After Enfortumab Vedotin Treatment: A Case Report 恩福妥单抗韦多汀治疗后新发难治性高血糖合并糖尿病酮症酸中毒一例报告
Pub Date : 2023-08-11 DOI: 10.46804/2641-2225.1159
Ross Heinrich, M. Caldwell
Introduction: A patient with no prior diagnosis of diabetes presented with diabetic ketoacidosis (DKA) and severe insulin resistance after being treated with enfortumab vedotin (EV). EV-associated DKA is uncommon— described in only a few case reports—and has unknown pathophysiology. This case characterizes the unique features of DKA in this patient and an unusual amount of insulin resistance not typically seen in patients with diabetes. Clinical Findings: A 71-year-old male presented with fatigue, xerostomia, and increased thirst. He had a history of obesity, hypertension, and invasive, high-grade papillary urothelial carcinoma. His laboratory results were consistent with DKA. Clinical Course: The patient was admitted to the hospital and treated using a standardized protocol to correct the hyperosmolality, hypovolemia, metabolic acidosis, and hyperglycemia associated with DKA. After the DKA resolved, the patient needed substantial daily doses of insulin, up to 1000 units per day, for multiple days before being transitioned to an oral antihyperglycemic regimen. His workup included negative results for autoantibodies associated with type 1 diabetes and an elevated C-peptide level, suggesting preserved endogenous production of insulin with severe insulin resistance. Conclusions: EV has a clear role in treating urothelial carcinoma, showing improved survival in certain clinical contexts. Hyperglycemia is a common (14% of patients) side effect, with DKA being a rare and potentially fatal consequence. Patients with known risk factors, such as obesity or elevated hemoglobin A1c, should be closely monitored for hyperglycemia and DKA during EV treatment.
引言:一名既往未诊断为糖尿病的患者在接受恩福单抗韦多汀(EV)治疗后,出现糖尿病酮症酸中毒(DKA)和严重的胰岛素抵抗。EV相关的DKA并不常见——仅在少数病例报告中有描述——并且具有未知的病理生理学。该病例的特点是该患者DKA的独特特征,以及糖尿病患者中常见的不寻常的胰岛素抵抗量。临床发现:一名71岁男性,表现为疲劳、口干和口渴加剧。他有肥胖、高血压和侵袭性高级别乳头状尿路上皮癌病史。他的实验室结果与DKA一致。临床过程:患者入院并使用标准化方案进行治疗,以纠正与DKA相关的高渗、低血容量、代谢性酸中毒和高血糖。DKA消退后,患者需要大量的每日胰岛素剂量,每天高达1000单位,持续多日,然后转入口服抗高血糖方案。他的研究包括与1型糖尿病相关的自身抗体的阴性结果和C肽水平的升高,这表明在严重胰岛素抵抗的情况下,胰岛素的内源性产生得以保留。结论:EV在治疗尿路上皮癌方面具有明显的作用,在某些临床情况下显示出生存率的提高。高血糖是一种常见的副作用(14%的患者),DKA是一种罕见且可能致命的后果。有已知危险因素的患者,如肥胖或血红蛋白A1c升高,应在EV治疗期间密切监测高血糖和DKA。
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引用次数: 0
Referral Patterns for Pediatric Sports-Related Concussion in One New England Health Care System 新英格兰医疗系统中儿童运动相关脑震荡的转诊模式
Pub Date : 2023-08-10 DOI: 10.46804/2641-2225.1154
Joseph Benert, Amy E. Haskins, C. Holt, Krystian Bigosinski
Introduction: Patients with concussion may benefit from care provided by professionals from multiple disciplines based on the constellation of symptoms being reported. This study analyzed referral patterns from primary care and sports medicine clinicians for pediatric patients with sports-related concussion in one health care system. Methods: A retrospective chart review identified referrals placed to physical therapy, occupational therapy, speech pathology, optometry, psychology, neuropsychology, audiology, neurology, ophthalmology, otolaryngology, psychiatry, and sports medicine for pediatric patients with sports-related concussion. These patients were evaluated at MaineHealth family medicine, internal medicine/pediatrics, pediatrics, and sports medicine clinics in southern Maine between February 2019 and June 2022. Results: We identified 375 patients with concussions. These patients were most often evaluated by pediatrics (199; 53.1%) and sports medicine (160; 42.7%), with fewer evaluated by family medicine (28; 7.5%), internal medicine/pediatrics (8 patients; 2.1%), or internal medicine (6; 1.6%). The most common referrals were to physical therapy (40; 10.7%), sports medicine (21; 5.6%), psychology (11; 2.9%), and neurology (9; 2.4%). Sports medicine placed a significantly higher number of referrals ( P < .0001) than non-sports medicine disciplines. Discussion: Compared to prior research, fewer referrals were placed in this cohort of patients with concussion. Possible explanations include a larger population of uncomplicated concussions, the more rural setting in which this study occurred, or a lack of awareness of resources for further concussion care. Conclusions:
引言:脑震荡患者可能会根据报告的症状群,从多个学科的专业人员提供的护理中受益。本研究分析了初级保健和运动医学临床医生在一个医疗保健系统中对运动相关脑震荡儿童患者的转诊模式。方法:一项回顾性图表审查确定了接受物理治疗、职业治疗、言语病理学、验光、心理学、神经心理学、听力学、神经病学、眼科、耳鼻喉科、精神病学和运动医学的转诊儿童运动相关脑震荡患者。2019年2月至2022年6月,这些患者在缅因州南部的MaineHealth家庭医学、内科/儿科、儿科和运动医学诊所接受了评估。结果:我们确定了375名脑震荡患者。这些患者最常通过儿科(199;53.1%)和运动医学(160;42.7%)进行评估,较少通过家庭医学(28;7.5%)、内科/儿科(8名患者;2.1%)或内科(6;1.6%)进行评估。最常见的转诊是物理治疗(40;10.7%)、运动医学(21;5.6%)、心理学(11;2.9%),和神经病学(9;2.4%)。运动医学的转诊人数明显高于非运动医学学科(P<.0001)。讨论:与先前的研究相比,这一脑震荡患者队列中的转诊人数较少。可能的解释包括更多的无并发症脑震荡人群,这项研究发生在更偏远的农村地区,或者缺乏对进一步脑震荡护理资源的认识。结论:
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引用次数: 0
Optimizing Psychological Safety: Using a Focus Group to Acquire Perspectives from Standardized Patients Who Identify as LGBTQ+ 优化心理安全:使用焦点小组获取来自LGBTQ+标准化患者的观点
Pub Date : 2023-08-09 DOI: 10.46804/2641-2225.1158
B. Brown, Rachel Kupferman, Bethany Rocheleau, Christine Mallar, Karissa Hannifan, Bette Gray, V. Hayes, Leah A. Mallory
Introduction: Gender and sexual minority (lesbian, gay, bisexual, transgender, questioning; LGBTQ+) patients report poor health care experiences, partly because health care providers are not trained to meet their needs. Simulation can help learners practice competencies related to diversity, equity, and inclusion, but there are psychological safety considerations when recruiting standardized patients (SPs). Our objective was to incorporate the expertise of members of the LGBTQ+ community in our SP pool as we developed related curriculum. Methods: All SPs were invited to participate in a focus group if they identified as LGBTQ+ and wanted to contribute. Content experts developed a focus group guide and facilitated the meeting. Additional members of the research team took de-identified notes. After notes were reviewed for agreement, a thematic analysis was performed. An anonymous survey was sent to SP participants after the focus group meeting. Results: Six SPs verbally participated in a 90-minute focus group, and 4 completed an anonymous follow-up survey. SPs acknowledged psychological safety risks but universally supported the developing curriculum. Most were willing to assume personal risk for the greater good. They emphasized the importance of lived experience to authentic portrayal, but they were open to eventual broader casting with coaching and proposed SP peer support and learner preparation as possible protective measures. Discussion: SPs appreciated the recognition of content expertise and opportunity to influence curricular design. They shared concerns about LGBTQ+ SP self-portrayal in simulation and offered creative suggestions to promote psychological safety. Conclusion: SPs with lived experience can share nuanced feedback and be a resource to co-create curriculum related to diversity, equity, and inclusion.
性别和性少数群体(女同性恋,男同性恋,双性恋,变性人,质疑者;LGBTQ+)患者报告说,他们的卫生保健经历很差,部分原因是卫生保健提供者没有接受过满足他们需求的培训。模拟可以帮助学习者练习与多样性、公平性和包容性相关的能力,但在招募标准化患者(SPs)时需要考虑心理安全问题。我们的目标是在开发相关课程时,将LGBTQ+社区成员的专业知识纳入我们的SP池。方法:邀请所有被认定为LGBTQ+并希望做出贡献的SPs参加焦点小组。内容专家制定了焦点小组指南,并为会议提供了便利。研究小组的其他成员也记下了不具名的笔记。在审查了说明以取得一致意见后,进行了专题分析。焦点小组会议后,向SP参与者发送了一份匿名调查。结果:6名SPs口头参与了90分钟的焦点小组,4名完成了匿名随访调查。SPs承认心理安全风险,但普遍支持开发课程。大多数人愿意为了更大的利益承担个人风险。他们强调了生活经验对真实描绘的重要性,但他们对最终更广泛的选择持开放态度,并建议SP同伴支持和学习者准备作为可能的保护措施。讨论:SPs对内容专业知识的认可和影响课程设计的机会表示赞赏。他们分享了对LGBTQ+ SP在模拟中的自我塑造的担忧,并提出了创造性的建议,以促进心理安全。结论:具有生活经验的sp可以分享细微的反馈,并成为共同创建与多样性,公平和包容性相关的课程的资源。
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引用次数: 1
Improving Inclusive Communication: Pilot Results from a Simulation-Based Learning Opportunity to Practice Taking a Sexual Health History 改善包容性沟通:基于模拟的性健康史实践学习机会的试点结果
Pub Date : 2023-08-09 DOI: 10.46804/2641-2225.1157
Rachel Kupferman, Bette Gray, Bethany Rocheleau, Christine Mallar, Karissa Hannifan, V. Hayes, Leah B. Mallory, B. Brown
Sexual and gender minority (lesbian, gay, bisexual, transgender, questioning; LGBTQ+) patients experience health care inequities. Simulation using standardized patients (SPs) is an effective tool for communication-based training. To promote equitable practice, we created an experiential learning opportunity for residents to practice inclusive communication and improve their comfort in caring for LGBTQ+ patients while maintaining the psychological safety of SPs. Methods: Our interdisciplinary team explored relevant simulation curricula, conducted a focus group with LGBTQ+ SPs, created a didactic presentation, and designed and implemented a simulated case. Family medicine residents participated in the training and completed pre-and post-training surveys rating their confidence in sexual health communication and working with sexual and gender minority patients. We compared Likert scale ratings in pre-and post-training surveys using a Wilcoxon signed-rank test. SPs completed post-simulation surveys rating their psychological safety. Results: Residents completed pre-training (n = 13) and post-training (n = 12) surveys. Confidence improved in every category, reaching significance for confidence in obtaining a sexual health history from LGBTQ+ patients. Four SPs completed post-simulation surveys. All SPs reported that the event had educational value and was a positive experience.
性少数和性别少数(女同性恋、男同性恋、双性恋、跨性别者、质疑;LGBTQ+)患者经历了医疗保健的不公平。使用标准化患者(SP)进行模拟是基于沟通的培训的有效工具。为了促进公平的实践,我们为居民创造了一个体验式学习机会,让他们在保持SP的心理安全的同时,进行包容性沟通,提高他们照顾LGBTQ+患者的舒适度。方法:我们的跨学科团队探索了相关的模拟课程,与LGBTQ+SP进行了焦点小组讨论,创建了一个教学演示,并设计和实施了一个模拟案例。家庭医学住院医师参加了培训,并完成了培训前和培训后的调查,评估了他们对性健康沟通以及与性少数群体和性别少数群体患者合作的信心。我们使用Wilcoxon符号秩检验比较了训练前和训练后调查中的Likert量表评分。SP完成了模拟后的调查,对其心理安全性进行了评级。结果:居民完成了培训前(n=13)和培训后(n=12)的调查。每个类别的信心都有所提高,对获得LGBTQ+患者性健康史的信心具有重要意义。四个SP完成了模拟后调查。所有SP都报告说,这次活动具有教育价值,是一次积极的经历。
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引用次数: 1
Under One Roof – An Integrated Clinic for Substance Use Disorder and Viral Hepatitis/HIV Treatment 在一个屋檐下-药物使用障碍和病毒性肝炎/艾滋病毒治疗的综合诊所
Pub Date : 2023-08-09 DOI: 10.46804/2641-2225.1140
Sarah Hipkens, E. Caron, W. Craig, K. Thakarar
Introduction: Integration of viral hepatitis/HIV care and substance use disorder (SUD) treatment has been shown to improve patient outcomes, but data are lacking in rural states like Maine. Our study objective was to assess the baseline characteristics and outcomes of patients with SUD who receive combined substance use and viral hepatitis/HIV treatment at a recently established “Bridge Program” in our rural state. Methods: We conducted a retrospective chart review of patients enrolled in the Bridge Program between January 2020 and November 2021. We then performed a descriptive analysis of demographics, health characteristics, preventive services, and treatment outcomes. Results: A total of 14 patients were enrolled in the Bridge Program, of which 13/14 (93%) had hepatitis C, and 3/14 (21%) had HIV. When indicated, 100% of participants received appropriate medication for addiction treatment (buprenorphine/naloxone or naltrexone), naloxone kits, and hepatitis A and B vaccinations. Among patients with hepatitis C, 12/13 (92%) started antiviral treatment, of which 10/12 (83%) either achieved treatment cure or are receiving ongoing treatment. Discussion: Integrated care models can successfully treat SUD and HIV/viral hepatitis as co-occurring medical conditions. These models must consider approaches to reduce the number of visits and travel time required for optimal treatment, and enhance recovery by consistently prescribing evidence-based medication for SUD. Conclusions: Our study shows how an integrated clinic model in a rural state can provide comprehensive care, including SUD treatment, naloxone prescribing, vaccinations, and, importantly, high rates of successful hepatitis C/HIV treatment.
病毒性肝炎/艾滋病毒护理和物质使用障碍(SUD)治疗的整合已被证明可以改善患者的预后,但在缅因州等农村州缺乏相关数据。我们的研究目的是评估在我们农村州最近建立的“桥梁计划”中接受药物使用和病毒性肝炎/艾滋病联合治疗的SUD患者的基线特征和结果。方法:我们对2020年1月至2021年11月期间参加桥梁计划的患者进行了回顾性图表回顾。然后,我们对人口统计学、健康特征、预防服务和治疗结果进行了描述性分析。结果:桥梁项目共纳入14例患者,其中13/14(93%)患有丙型肝炎,3/14(21%)患有艾滋病毒。当有指示时,100%的参与者接受适当的药物成瘾治疗(丁丙诺啡/纳洛酮或纳曲酮),纳洛酮试剂盒和甲型肝炎和乙型肝炎疫苗接种。在丙型肝炎患者中,12/13(92%)开始抗病毒治疗,其中10/12(83%)获得治疗治愈或正在接受持续治疗。讨论:综合护理模式可以成功地将SUD和HIV/病毒性肝炎作为共同发生的疾病进行治疗。这些模型必须考虑减少最佳治疗所需的就诊次数和旅行时间的方法,并通过持续开具循证治疗SUD的药物来提高康复。结论:我们的研究表明,农村地区的综合诊所模式可以提供全面的护理,包括SUD治疗、纳洛酮处方、疫苗接种,以及更重要的是,丙型肝炎/艾滋病毒治疗成功率高。
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引用次数: 0
How Are Our Athletes Doing? A Cross-Sectional Analysis of Student-Athlete Mental Health in Fall 2022 at a Maine Division III University 我们的运动员怎么样?缅因州第三赛区大学2022年秋季学生运动员心理健康的横断面分析
Pub Date : 2023-07-12 DOI: 10.46804/2641-2225.1155
Emma Cronk, Adriana Isacke, Amy E. Haskins, C. Holt, Krystian Bigosinski
Recommended Citation Cronk, Emma; Isacke, Adriana; Haskins, Amy; Holt, Christina; and Bigosinski, Krystian (2023) "How Are Our Athletes Doing? A Cross-Sectional Analysis of Student-Athlete Mental Health in Fall 2022 at a Maine Division III University," Journal of Maine Medical Center: Vol. 5 : Iss. 2 , Article 7. Available at: https://knowledgeconnection.mainehealth.org/jmmc/vol5/iss2/7 https://doi.org/10.46804/ 2641-2225.1155
推荐引文Cronk,Emma;伊萨克,阿德里安娜;哈斯金斯,艾米;克里斯蒂娜·霍尔特;和Bigosinski,Krystian(2023)“我们的运动员过得怎么样?缅因州第三赛区大学2022年秋季学生运动员心理健康的横断面分析”,《缅因州医学中心杂志》:第5卷:Iss。2,第7条。网址:https://knowledgeconnection.mainehealth.org/jmmc/vol5/iss2/7https://doi.org/10.46804/2641-2225.1155
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引用次数: 0
Artificial Intelligence (AI): Promise or peril for the publishing world? 人工智能:出版界的希望还是危险?
Pub Date : 2023-06-12 DOI: 10.46804/2641-2225.1166
R. Bing-You
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引用次数: 0
Improving PubMed for the Novice at the Expense of the Expert: Surveying Librarians 3 Years Post-New PubMed 以专家为代价为新手改进PubMed:新PubMed后3年的测量馆员
Pub Date : 2023-05-24 DOI: 10.46804/2641-2225.1163
Tim Kenny, Heather Kemp
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引用次数: 0
A Cascade of Care of Patients with Hepatitis C Infection in a Rural State 农村地区丙型肝炎感染患者的级联护理
Pub Date : 2023-04-20 DOI: 10.46804/2641-2225.1137
W. Agmas, W. Craig, Kathleen M. Fairfield, B. F. King, Elizabeth Eisenhardt, K. Thakarar
The
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引用次数: 0
A Case of Congenital Coronary Sinus Ostial Atresia with Persistent Left Superior Vena Cava 先天性冠状窦口闭锁伴持续性左上腔静脉1例
Pub Date : 2023-03-06 DOI: 10.46804/2641-2225.1136
Laura L. Onderko, T. Miller, Sean H Novak, J. Rosenblatt
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引用次数: 0
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Journal of Maine Medical Center
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