Ageing research reviews最新文献

Recent developments in healthcare and scientific research have shifted the perception of ageing from a period of decline to recognising its potential for sustained functional ability, well-being, and societal contributions. In light of this perspective, a multidisciplinary panel of experts from five European countries conducted a narrative review of the literature. It convened for a one-day consensus meeting to identify key barriers, facilitators, and research priorities related to healthy ageing. Thus, this paper aims to (1) define the concept of positive ageing, (2) discuss barriers and facilitators to healthy ageing, (3) examine the role of healthcare professionals in maintaining and improving intrinsic capacity, and (4) propose a research agenda to address gaps in healthy ageing. The panel identified 70 barriers and 64 facilitators, structured within the WHO's ICOPE framework, related to intrinsic capacity. Twenty-six interventions across five domains-locomotor, sensory, psychological, cognitive capacities, and vitality- were proposed, aimed at both frail and robust individuals, focusing on social integration, psychological well-being, physiological resilience, deficit management, and disorder prevention. The panel also outlined a research agenda emphasising AI-driven ageing support, improved communication strategies, early frailty detection, and the development of locally adapted guidelines and infrastructure for healthy and positive ageing. This framework emphasizes the importance of early-life interventions and advocates for a preventive, holistic, and multidisciplinary approach to aging. In conclusion, the MIPAG's fosters a proactive mindset and early interventions throughout life to prevent the decline and optimise intrinsic capacity.

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Alzheimer's disease (AD) is the most common type of cognitive impairment. AD is closely related to orthopedic diseases, such as osteoporosis and osteoarthritis, in terms of epidemiology and pathogenesis. Brain and bone tissues can regulate each other in different manners through bone-brain axis. This article reviews the research progress of the relationship between AD and orthopedic diseases, bone-brain axis mechanisms of AD, and AD therapy by targeting bone-brain axis, in order to deepen the understanding of bone-brain communication, promote early diagnosis and explore new therapy for AD patients.

Alzheimer's disease (AD) is the most common neurodegenerative disorder that affects the cerebral cortex and hippocampus, and is characterised by progressive cognitive decline and memory loss. A recent report of a patient carrying a novel gain-of-function variant of RELN (H3447R, termed RELN-COLBOS) who developed resilience against presenilin-linked autosomal-dominant AD (ADAD) has generated enormous interest. The RELN-COLBOS variant enhances interactions with the apolipoprotein E receptor 2 (ApoER2) and very-low-density lipoprotein receptor (VLDLR), which are associated with delayed AD onset and progression. These findings were validated in a transgenic mouse model. Reelin is involved in neurodevelopment, neurogenesis, and neuronal plasticity. The evidence accumulated thus far has demonstrated that the Reelin pathway links apolipoprotein E4 (ApoE4), amyloid-β (Aβ), and tubulin-associated unit (Tau), which are key proteins that have been implicated in AD pathogenesis. Reelin and key components of the Reelin pathway have been highlighted as potential therapeutic targets and biomarkers for AD.