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Zidovudine, a brief history before the first antirretroviral in Mexico. 齐多夫定,墨西哥第一种抗逆转录病毒药物问世前的简史。
Pub Date : 2024-01-01 DOI: 10.24875/CIRU.22000250
Hans Malagón-Tejeida

In the 1980s in Mexico, that of the «moral renewal», there was the opening to the market and the manifestation of human immunodeficiency virus (HIV) and AIDS. In this writing, the historical and therapeutic conditions are related to alleviate the syndrome until the arrival of the first antiretroviral. It is a reconstruction of the events, of which the medical-social, main clinical manifestations and of course the pharmacological therapy, until de the development zidovudina or azidotimidina of AZT, the first antiretroviral to be approved. Nevertheless, in the Mexican context, this event wasn't decisive to significantly change the morbility and the mortality.

20 世纪 80 年代的墨西哥,正值 "道德复兴 "时期,市场开放,人体免疫缺陷病毒 (HIV)和艾滋病也随之出现。在这篇文章中,介绍了在第一种抗逆转录病毒药物问世之前,缓解艾滋病综合症的历史和治疗条件。它是事件的重建,其中医疗社会、 主要临床表现和当然的药物治疗,直到 de 开发 zidovudina 或 AZT,第一个抗逆转录病毒药物批准的 zidotimidina。然而,在墨西哥,这一事件并没有决定性地显著改变发病率和死亡率。
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引用次数: 0
Endoscopic submucosal dissection for the treatment of gastrointestinal neoplasia in a tertiary-care center in Mexico. 墨西哥一家三级医疗中心采用内镜粘膜下剥离术治疗胃肠道肿瘤。
Pub Date : 2024-01-01 DOI: 10.24875/CIRU.23000052
Óscar V Hernández-Mondragón, Luis F García-Contreras

Objective: The aim of this study was to evaluate the experience of using endoscopic submucosal dissection (ESD), a technique considered as first-line of treatment, for the management of early neoplastic lesions (ENL), and subepithelial lesions (SEL) < 4 cms in size, in a tertiary-care, high-volume medical center in Mexico.

Method: Patients > 18 years-old, candidates to ESD with ENL and SMT, between January 2008 and October 2022 were included.

Results: ESD was performed in 246 patients (137 ENL and 109 SMT), 52.2% gastric, 23.1% colonic, 19.5% esophageal and 5.2% in duodenum. Benign/premalignant were 74.4%, and 25.6% malignant, being the SMT the most frequent (44.3%) and gastrointestinal stromal tumor. En-bloc resection, R0, and curative resection rates were 97.2%, 94.5%, and 85.8%, respectively. The most common adverse event was transprocedural bleeding (18.3%) followed by perforation (6.9%), both endoscopically treated without mortality. Recurrence was presented in 9.44% at 177 months of follow-up.

Conclusions: ESD is a safe and effective endoscopic surgical option of treatment for ENL and SMT in Mexican population when performed in experienced centers.

研究目的本研究旨在评估墨西哥一家三级高容量医疗中心使用内镜黏膜下剥离术(ESD)治疗早期肿瘤病变(ENL)和上皮下病变(SEL)(小于4厘米)的经验,ESD是一种被视为一线治疗的技术:方法:纳入2008年1月至2022年10月期间年龄大于18岁、患有ENL和SMT的ESD候选患者:246名患者(137名ENL患者和109名SMT患者)接受了ESD治疗,其中52.2%为胃癌,23.1%为结肠癌,19.5%为食管癌,5.2%为十二指肠癌。良性/前恶性占74.4%,恶性占25.6%,其中以SMT和胃肠道间质瘤最为常见(44.3%)。原位切除率、R0率和治愈率分别为97.2%、94.5%和85.8%。最常见的不良反应是经手术出血(18.3%),其次是穿孔(6.9%),这两种情况均在内镜下处理,无死亡病例。在177个月的随访中,9.44%的患者出现复发:在经验丰富的医疗中心进行ESD手术,是治疗墨西哥ENL和SMT的一种安全有效的内镜手术选择。
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引用次数: 0
Comparing costs and timing of ankle sprain care in two first-tier care systems. 比较两个一级护理系统中踝关节扭伤护理的成本和时间。
Pub Date : 2024-01-01 DOI: 10.24875/CIRU.23000024
Arlette R Ordóñez-Flores, José J Rivera-Sánchez, M Valeria Jiménez-Baez, David Rojano-Mejía, Macedonia G Moreno-Tovar, Alma I Guerrero-Martínez

Objective: To compare the costs of care and the opportunity of care for the management of grade I-II ankle sprain in two Family Medicine Units, one with rehabilitation service (FMU 13) and one without rehabilitation service (FMU 41).

Method: Observational analytical study, records with diagnosis of grade I-II ankle sprain attended at the FMU were included January-November 2021. Consultations were recorded in the emergency department, family medicine, rehabilitation, cabinet studies and time to grant the appointment in the rehabilitation service (opportunity of care), the Mann-Whitney U test was used to compare costs of care and timeliness of care.

Results: In FMU 41, care costs were higher compared to FMU 13 ($13,990 vs $8,063); however, this difference was not significant, as was the cost of care in family medicine, rehabilitation, and opportunity of care.

Conclusions: The costs of care and the opportunity of care were similar in both models of care (FMU 13-FMU 41) of grade I-II ankle sprain.

目的比较两家全科医疗单位(一家有康复服务(FMU 13),一家没有康复服务(FMU 41))治疗 I-II 级踝关节扭伤的护理成本和护理机会:方法:观察分析研究,纳入 2021 年 1 月至 11 月在全科医疗单位就诊的 I-II 级踝关节扭伤诊断记录。记录了急诊科、家庭医学科、康复科、内阁研究室的就诊情况以及康复服务预约时间(护理机会),采用曼-惠特尼U检验比较护理成本和护理及时性:结果:41号家庭医疗单元的护理成本高于13号家庭医疗单元(13 990美元对8 063美元),但这一差异并不显著,家庭医疗、康复和护理机会的护理成本也是如此:结论:I-II级踝关节扭伤的两种护理模式(FMU 13-FMU 41)的护理成本和护理机会相似。
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引用次数: 0
Comparison of clinical efficacy of different colon anastomosis methods in laparoscopic radical resection of colorectal cancer. 腹腔镜大肠癌根治术中不同结肠吻合方法的临床疗效比较
Pub Date : 2024-01-01 DOI: 10.24875/CIRU.23000602
Weimin Sun, Jie Zhang

Objective: The objective of this study was to investigate the clinical effect of overlap anastomosis and functional end-to-end anastomosis (FEEA) in laparoscopic radical resection of colorectal cancer (CRC).

Methods: The clinical data of 180 patients who underwent laparoscopic radical resection of CRC and side-to-side anastomosis were retrospectively collected; the patients were divided into the Overlap group and FEEA group, according to the anastomosis method that was used to treat them.

Results: The Overlap group had a shorter operation time, anastomosis time, post-operative hospital stay, post-operative feeding time, and post-operative exhaust time than the FEEA group (p < 0.05). The total incidence of post-operative complications was 14.4% (13/90) in the FEEA group and 0.7% (6/90) in the Overlap group, and there was no significant difference between the two groups (p > 0.05).

Conclusions: Overlapping anastomosis can shorten the operation time and accelerate the recovery of intestinal function without increasing the incidence of post-operative complications, and it will not affect the quality of life and survival of patients in the short term after surgery.

研究目的本研究旨在探讨腹腔镜大肠癌(CRC)根治性切除术中重叠吻合和功能性端端吻合(FEEA)的临床效果:回顾性收集了180例接受腹腔镜结直肠癌根治性切除术并行侧对侧吻合术的患者的临床资料,根据吻合方式的不同将患者分为重叠吻合组和功能性端对端吻合组:Overlap组的手术时间、吻合时间、术后住院时间、术后进食时间和术后排气时间均短于FEEA组(P<0.05)。FEEA组术后并发症总发生率为14.4%(13/90),重叠组为0.7%(6/90),两组间无显著差异(P > 0.05):结论:重叠吻合术可缩短手术时间,加快肠道功能的恢复,且不会增加术后并发症的发生率,术后短期内也不会影响患者的生活质量和生存期。
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引用次数: 0
Nationwide reduction in COVID-19 mortality among patients with asthma and other chronic diseases in Mexican adults according to epidemic wave. 根据流行病浪潮,在全国范围内降低墨西哥成人哮喘和其他慢性病患者的 COVID-19 死亡率。
Pub Date : 2024-01-01 DOI: 10.24875/CIRU.22000576
Martín Bedolla-Barajas, Jaime Morales-Romero
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引用次数: 0
Pneumopericardium caused by gastric ulcer perforation into the pericardium. An inusual complication. 胃溃疡穿孔进入心包引起的气胸。一种罕见的并发症。
Pub Date : 2024-01-01 DOI: 10.24875/CIRU.22000269
Luis J García-Vega, Guillermo I Rivas-Santana, Raymundo García-González

Pneumopericardium is an unusual condition defined by the presence of gas into the pericardial sac. Gastric perforation into pericardium is a complication of gastric ulcer with high mortality. In this clinical case, we describe the condition of a male with a silent gastric ulcer, which penetrated into the pericardium, developing pneumopericardium and purulent pericarditis as a complication.

心包积气是一种不常见的病症,是指气体进入心包囊。胃穿孔进入心包是胃溃疡的一种并发症,死亡率很高。在本临床病例中,我们描述了一名男性患者的情况,他患有无声胃溃疡,溃疡穿入心包后并发气胸和化脓性心包炎。
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引用次数: 0
Littoral cell angioma of the spleen in a 70-year-old male patient with myelodysplastic syndrome: a case report. 一名患有骨髓增生异常综合征的 70 岁男性患者的脾脏沿岸细胞血管瘤:病例报告。
Pub Date : 2024-01-01 DOI: 10.24875/CIRU.22000284
Ioannidis Orestis, Symeonidis Savvas, Aggeliki Koltsida, Papadopoulou Stauroula, Malliora Anastasia, Christidis Panagiotis, Ouzounidis Nikolaos, Kotidis Efstathios, Pramateftakis Manousos George, Mantzoros Ioannis, Angelopoulos Stamatios

Introduction: Littoral cell angioma (LCA) is a new subtype of vascular tumor, which has been reported infrequently worldwide. It is associated with visceral malignancies and other immunologic conditions.

Clinical case: We present a case of a 70-year-old Caucasian male with a 6-year history of myelodysplastic syndrome, which was investigated for splenomegaly and pancytopenia. Radiological and histopathological examinations revealed an LCA and an open splenectomy were performed. The patient had an uneventful post-operative recovery.

Conclusion: LCA is a rare tumor, with atypical presentation often associated with other malignancies or immunologic conditions. Diagnosis is challenging, and so far, splenectomy is the gold standard treatment.

导言滨海细胞血管瘤(LCA)是血管肿瘤的一种新亚型,在世界范围内鲜有报道。它与内脏恶性肿瘤和其他免疫性疾病有关:我们报告了一例 70 岁的白种男性病例,其骨髓增生异常综合征病史长达 6 年。放射学和组织病理学检查显示患者患有 LCA,于是对其进行了开腹脾切除术。患者术后恢复顺利:结论:LCA 是一种罕见的肿瘤,表现不典型,通常与其他恶性肿瘤或免疫性疾病相关。诊断具有挑战性,迄今为止,脾切除术是治疗的金标准。
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引用次数: 0
Hemorrhagic shock secondary to ruptured hypogastric artery pseudoaneurysm. A rare complication of colorectal anastomotic leakage. 胃下动脉假性动脉瘤破裂继发失血性休克。结肠直肠吻合口漏的罕见并发症。
Pub Date : 2024-01-01 DOI: 10.24875/CIRU.22000395
Cristina de la Cruz-Cuadrado, Dácil Montesdeoca-Cabrera, Daniel Cubillo-Prieto, Esteban Pérez-Alonso, Juan R Hernández-Hernández

Massive bleeding due to rupture of hypogastric artery pseudoaneurysm is an exceptional complication of colorectal anastomotic leakage. A 41-year-old woman with history of rectal cancer surgery, who debuted with massive rectorrhagia and hypovolemic shock due to rupture of a hypogastric artery pseudoaneurysm as a late complication of a colorectal anastomosis leak. The ruptured hypogastric artery pseudoaneurysm should be taken into account in the differential diagnosis of patients with massive rectorrhagia and history of colorectal anastomosis leak. Endovascular embolization is considered the first-line treatment.

胃下动脉假性动脉瘤破裂导致的大出血是结肠直肠吻合口漏的一种特殊并发症。一名 41 岁的女性患者曾接受过直肠癌手术,由于结肠直肠吻合口漏的晚期并发症--胃下动脉假性动脉瘤破裂,导致大量再出血和低血容量性休克。在对有大量再出血和结肠直肠吻合口漏病史的患者进行鉴别诊断时,应将胃下动脉假性动脉瘤破裂考虑在内。血管内栓塞被认为是一线治疗方法。
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引用次数: 0
Clinical and urodynamics outcomes in pediatric primary bladder diverticula: a comparative study. 小儿原发性膀胱憩室的临床和尿动力学结果:一项比较研究。
Pub Date : 2024-01-01 DOI: 10.24875/CIRU.23000294
Birgül Karaaslan, Mehmet O Kuzdan

Objective: This study aimed to compare the effects of bladder diverticula smaller than 30 (SD) mm and larger than 30 mm (LD) on bladder functions and urodynamics.

Materials and methods: Our retrospective analysis involved a cohort of 40 pediatric patients diagnosed with primary bladder diverticula.

Results: The predicted mean bladder capacity (MBC) was 197.7 ± 95.8 mL, whereas the observed MBC was lower at an average of 170.1 ± 79.6 mL. This indicates that the observed MBC was 88.2 ± 12.9% of the predicted value (percentage). The mean diverticula diameter recorded was 33 ± 19.5 mm, and the diverticula to MBC ratio were calculated to be 0.25 ± 0.18. The distribution of urinary tract infections (UTIs) differed significantly between the groups (p < 0.001). Upper UT dilatation was significantly more common in the LD group (60%, n = 12) than in the SD group (15%, n = 3) (p = 0.003). The mean detrusor pressure (P[detrusor]) was significantly higher in the LD group (137.2 ± 24.1 cm H2O) than in the SD group (63.9 ± 5.8 cm H2O) (p = 0.001). In addition, the mean peak flow rate (Qmax) was significantly higher in the SD group (20.7 ± 7.9 mL/s) compared to the LD group (12.7 ± 3.8 mL/s) (p < 0.001).

Conclusion: Bladder diverticula size is a significant factor in the clinical presentation and management of primary bladder diverticula in pediatric patients.

摘要本研究旨在比较小于30(SD)毫米和大于30毫米(LD)的膀胱憩室对膀胱功能和尿动力学的影响:我们的回顾性分析涉及40名被诊断为原发性膀胱憩室的儿科患者:结果:预测的平均膀胱容量(MBC)为197.7 ± 95.8 mL,而观察到的平均膀胱容量较低,为170.1 ± 79.6 mL。这表明观察到的 MBC 是预测值(百分比)的 88.2 ± 12.9%。憩室的平均直径为 33 ± 19.5 毫米,憩室与 MBC 的比值为 0.25 ± 0.18。两组患者的尿路感染(UTI)分布差异显著(P < 0.001)。LD 组(60%,n = 12)上尿路扩张的发生率明显高于 SD 组(15%,n = 3)(p = 0.003)。LD 组的平均逼尿肌压力(P[detrusor])(137.2 ± 24.1 cm H2O)明显高于 SD 组(63.9 ± 5.8 cm H2O)(P = 0.001)。此外,SD 组的平均峰值流速(Qmax)(20.7 ± 7.9 mL/s)明显高于 LD 组(12.7 ± 3.8 mL/s)(P < 0.001):膀胱憩室的大小是影响儿科原发性膀胱憩室临床表现和治疗的重要因素。
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引用次数: 0
Impact of COVID-19 on pre-existing liver disease. COVID-19 对原有肝病的影响。
Pub Date : 2024-01-01 DOI: 10.24875/CIRU.23000409
Juan M Abdo-Francis, Rosalba Moreno-Alcantar, José L Pérez-Hernández, José M Remes-Troche, Antonio Velarde-Ruiz Velasco, Eira Cerda-Reyes, Fátima Higuera-de la Tijera, Graciela Castro-Narro

Patients with chronic liver disease of any etiology who become infected with SARS-CoV-2 have been found to have a higher risk of mortality compared to those patients who do not have chronic liver disease. A literature review was conducted in the relationship between COVID 19 and preexistence of liver disease. The proportion of COVID-19 patients with abnormal liver function on admission ranged from 40 % to 75 % and the proportion with liver injury was close to 30%. Current studies show an important association between preexisting liver disease and COVID-19. The presence of cirrhosis is now an independent predictor of severity for COVID-19 and prolonged hospitalization in this group of patients. Patients with cirrhosis have a higher mortality rate, and this rate rises with increasing severity.

研究发现,与没有慢性肝病的患者相比,感染 SARS-CoV-2 的任何病因的慢性肝病患者的死亡风险更高。我们对 COVID-19 与先期肝病之间的关系进行了文献综述。COVID-19 患者入院时肝功能异常的比例从 40% 到 75% 不等,肝损伤的比例接近 30%。目前的研究表明,原有肝病与 COVID-19 之间存在重要关联。肝硬化是预测 COVID-19 严重程度和这类患者住院时间延长的一个独立因素。肝硬化患者的死亡率较高,而且随着病情的加重,死亡率也会上升。
{"title":"Impact of COVID-19 on pre-existing liver disease.","authors":"Juan M Abdo-Francis, Rosalba Moreno-Alcantar, José L Pérez-Hernández, José M Remes-Troche, Antonio Velarde-Ruiz Velasco, Eira Cerda-Reyes, Fátima Higuera-de la Tijera, Graciela Castro-Narro","doi":"10.24875/CIRU.23000409","DOIUrl":"10.24875/CIRU.23000409","url":null,"abstract":"<p><p>Patients with chronic liver disease of any etiology who become infected with SARS-CoV-2 have been found to have a higher risk of mortality compared to those patients who do not have chronic liver disease. A literature review was conducted in the relationship between COVID 19 and preexistence of liver disease. The proportion of COVID-19 patients with abnormal liver function on admission ranged from 40 % to 75 % and the proportion with liver injury was close to 30%. Current studies show an important association between preexisting liver disease and COVID-19. The presence of cirrhosis is now an independent predictor of severity for COVID-19 and prolonged hospitalization in this group of patients. Patients with cirrhosis have a higher mortality rate, and this rate rises with increasing severity.</p>","PeriodicalId":93936,"journal":{"name":"Cirugia y cirujanos","volume":"92 1","pages":"131-136"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Cirugia y cirujanos
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