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Safety of intermittent versus continuous enteral nutrition in critically ill patients. Randomized clinical trial 危重患者间歇与持续肠内营养的安全性。随机临床试验
Pub Date : 2025-08-18 DOI: 10.1016/j.enfie.2025.500561
María Dolores Saiz-Vinuesa RN, MSc, PhD candidate , Eloina Rodriguez-Moreno RN , Francisca Calero-Yánez RN, MSc, PhD candidate , Ana María Piqueras-Carrión TCAE , Carmen Carrilero-López RN , Isabel Murcia-Sáez MD, PhD , María Pilar Córcoles-Jimenez RN, MSc, PhD , Milagros Molina-Alarcón Psy, PhD

Introduction

Enteral nutrition (EN) is a common nutritional support in intensive care units (ICU). The administration method can be continuous (CEN)or intermittent (IEN), but there are controversies and a lack of evidence on which method is more effective in achieving good nutritional status while minimizing complications.

Objectives

To evaluate the safety (no increase in complications) NEI versus NEC during administration of EN with a gastric feeding tube (GFT) in ICU patients.

Methods

Randomized,open clinical trial.Registered in Clinical Trials. Population: Adults >18 years admitted to ICU,with GFT, indication of EN, signed consent. Exclusion: insulin-dependent diabetic. Intervention: Control (CEN): continuous administration via infusion pump; Experimental (IEN): the total amount divided into 4 doses, administered q6 h via infusion pump,for 1 h each dose. Outcome variables: complications (gastrointestinal,respiratory,metabolic), achievement of caloric goal (CG) Others: demographic data, nutritional status, severity (APACHE), EN type, mechanical ventilation (MV), duration of EN, causes of interruption. Statistical analysis: SPSS. Intention-to-treat analysis. Measures of central tendency and dispersión (standard deviation or interquartile range: IQR), absolute and relative frequencies. Bivariate analysis: Chi2, t-Student, and U-Mann–Whitney. Ethical aspects: CEIm approval.

Results

40 patients (18CEN/22IEN), 70% (28) men, age 62.65 DE:13.27 years (95% CI 58.40−66.90), BMI: 27.93 (IQR:4.6), APACHE II: 18.85 DE: 5.83 (95% CI 16.98−20.72), MV:11.5days (IQR:13).17.5% (7) diabetic. The CEN and IEN groups were homogeneous for all variables except APACHE (CEN 21.22 vs IEN 16.91; p = 0.018). CG was achieved by 82.5% (33) (88.9% CEN vs77.3% IEN, p = 0.33), time to achieve it (36 h CEN vs 34 h IEN; p = 0.28). Complications: vomiting:20% (8) patients (4 per group, p = 0.75). Diarrhea: (16.7%CEN vs 22.7% IEN, p = 0.63). Bronchial aspiration and GRV >500cc 1 case in IEN. Median interruptions (2.5 (IQR: 2) CEN vs 1 (IQR: 2) IEN; p = 0.005).

Discussion

The results are similar to other studies. CG was achieved in a high percentage, with no differences between groups. The use of INE shows feweer interruptions, which may lead to better compliance with caloric guidelines without increasing complications, maintaining physiological guidelines.

Conclusion

IEN in ICU patients shows no differences in terms of complications, compared to CEN, nor less effectiveness in achieving the CG. A larger sample is needed to identify the advantages and complications of each method.
肠内营养(EN)是重症监护病房(ICU)常见的营养支持。给药方法可以是连续给药(CEN)或间歇给药(IEN),但关于哪种给药方法更有效地达到良好的营养状态,同时最大限度地减少并发症,存在争议和缺乏证据。目的评价NEI与NEC在ICU患者胃饲管(GFT)给药期间的安全性(未增加并发症)。方法随机、开放临床试验。临床试验注册。人群:18岁成人,ICU, GFT, EN指征,已签署同意。排除:胰岛素依赖型糖尿病。干预:控制(CEN):通过输液泵持续给药;实验(IEN):总剂量分为4个剂量,每6 h通过泵给药,每1 h给药。结局变量:并发症(胃肠道、呼吸、代谢)、热量目标(CG)的实现其他:人口统计数据、营养状况、严重程度(APACHE)、EN类型、机械通气(MV)、EN持续时间、中断原因。统计分析:SPSS。意向处理分析。集中趋势和dispersión(标准差或四分位数间距:IQR)、绝对频率和相对频率的度量。双变量分析:Chi2, t-Student和U-Mann-Whitney。伦理方面:CEIm批准。结果40例患者(18CEN/22IEN),男性占70%(28例),年龄62.65岁DE:13.27岁(95% CI 58.40 ~ 66.90), BMI: 27.93 (IQR:4.6), APACHE II: 18.85 DE: 5.83 (95% CI 16.98 ~ 20.72), MV:11.5天(IQR:13), 17.5%(7)为糖尿病患者。除APACHE外,CEN组和IEN组在所有变量上均均匀(CEN 21.22 vs IEN 16.91;p = 0.018)。CG达到82.5% (33)(CEN为88.9%,IEN为77.3%,p = 0.33),时间(CEN为36 h, IEN为34 h;p = 0.28)。并发症:呕吐:20%(8例)(每组4例,p = 0.75)。腹泻:(16.7%CEN vs 22.7% IEN, p = 0.63)。IEN支气管吸入及GRV 500cc 1例。中位中断(2.5 (IQR: 2) CEN vs 1 (IQR: 2) IEN;p = 0.005)。讨论结果与其他研究相似。CG达到了很高的百分比,组间无差异。INE的使用显示更少的中断,这可能导致更好地遵守热量指南,而不会增加并发症,维持生理指南。结论与CEN相比,ien在ICU患者的并发症方面没有差异,在实现CG方面的效果也不差。需要更大的样本来确定每种方法的优点和复杂性。
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引用次数: 0
Perception of needs of relatives of patients at pediatric intensive care units 儿童重症监护病房患者亲属需求的感知
Pub Date : 2025-08-16 DOI: 10.1016/j.enfie.2025.500557
Mónica Padilla-Lamadrid RN, MSN , Ana Pardo-Fernández RN, MSN , Raquel Torres-Luna RN, MSc , Alberto García-Gómez RN, MSN , Julia de Villarreal-Arracò RN, MSN , Elena García-González RN, MSN , Laura Frade-Pardo RN, MSN , Pedro Piqueras-Rodríguez RN, MSN , Eva del Ara Muñoz-Granda RN

Background

Pediatric Critical Care has undergone important changes in the last decades. In order to adapt pediatric care to the patient-family binomial and guarantee its quality, the evaluation of the needs perceived by family members during hospital stay is becoming increasingly relevant.

Objective

To determine the perception of the needs of the relatives of patients admitted to the Pediatric Critical Care Units (PCCU) in a tertiary level hospital.

Methods

Cross-sectional descriptive observational quantitative study was run through the distribution of the modified version of the Critical Care Family Needs Inventory (CCFNI). Population: Parents or legal caregivers of patients admitted to two CCUs with >48 h stay between September 2023 and January 2024. Descriptive analysis, Mann–Whitney U and Kruskal–Wallis tests were performed.

Results

Eighty-four questionnaires were completed. The median total score on the questionnaire was 15.00, corresponding to a high perception of fulfillment of needs. The subscale with the highest degree of compliance of the needs was “Patient care” (3.00), followed by “Information and communication” (3.00) and “Family care” (4.50); the subscale “Possible perceived improvements” (4.50) was the one with the worst results.
Statistically significant differences were found when comparing the total score between units (p = 0.046) and according to the type of room (p = 0.016) and the educational level of the relatives (p = 0.049). No significant differences were found during the analysis of the remaining variables.

Conclusions

The findings suggest that the hospital environment, specifically type of room, have a significant impact on the perception of family members’ needs fulfillment. It is considered essential to adapt pediatric critical care units in order to suit today’s family-centered care approach.
在过去的几十年里,儿科重症监护经历了重要的变化。为了使儿科护理适应患者-家庭二项关系并保证其质量,对住院期间家庭成员感知到的需求进行评估变得越来越重要。目的了解某三级医院儿科重症监护病房(pcccu)住院患者家属的需求认知。方法采用横断面描述性观察性定量研究,采用修订后的重症监护家庭需求量表(CCFNI)进行调查。人群:在2023年9月至2024年1月期间入住两个CCUs并住院48小时的患者的父母或法定照顾者。进行描述性分析、Mann-Whitney U检验和Kruskal-Wallis检验。结果共完成问卷84份。问卷总得分中位数为15.00,对应于需求满足的高感知。满足需求程度最高的子量表是“病人护理”(3.00),其次是“信息与沟通”(3.00)和“家庭护理”(4.50);“可能感知到的改善”子量表(4.50)的结果最差。在单位间比较总分(p = 0.046)、房间类型比较总分(p = 0.016)、亲属教育程度比较总分(p = 0.049)差异有统计学意义。在分析其余变量时未发现显著差异。结论医院环境,特别是病房类型,对家庭成员需求满足的感知有显著影响。它被认为是必要的调整儿科重症监护病房,以适应今天的家庭为中心的护理方法。
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引用次数: 0
The impact of COVID-19 vaccination on hospital costs in critically ill patients in an intensive care unit during the pandemic COVID-19疫苗接种对大流行期间重症监护病房重症患者住院费用的影响
Pub Date : 2025-07-01 DOI: 10.1016/j.enfie.2025.500551
Alejandro González-Castro MD, pHD , David Iglesias MD , Yhivian Peñasco MD, pHD , Carmen Huertas Marín MD , Elena Cuenca-Fito MD , Trinidad Dierssen-Soto MD, pHD , Reinhard Wallmann MD , Raquel Ferrero-Franco RN , Camilo González MD , Juan Carlos Rodríguez-Borregán MD

Background and objective

COVID-19 vaccination may alter the course of severe disease and influence hospital discharge costs. This study compares hospital discharge costs among ICU-admitted COVID-19 patients based on vaccination status, adjusted for All Patient Refined Diagnosis Related Groups (APR-DRG) and severity.

Patients and methods

A retrospective study (March 2020–March 2022) was conducted in an ICU, categorizing patients into three groups: unvaccinated, fully vaccinated, and partially vaccinated. Full vaccination included all required doses and boosters per the vaccination schedule. Disease severity was classified as mild, moderate, severe, and critical. Direct hospital costs, including ICU stay, medical procedures, medications, and life support, were analysed using data from Order SAN/35/2017, adjusted for inflation. Chi-square and Kruskal-Wallis tests with Bonferroni correction were used for comparisons.

Results

A total of 456 patients were included: 262 (57%) unvaccinated, 32 (7%) partially vaccinated, and 162 (35%) fully vaccinated. Median costs were:
Unvaccinated: €10,653 (IQR: €6160–€18,274)
Partially vaccinated: €17,360 (IQR: €5061–€26,085)
Fully vaccinated: €10,653 (IQR: €6160–€26,085)
Cost differences were not statistically significant (p = 0.28). Critical severity patients had the highest costs, while mild cases had the lowest (p < 0.05). No significant cost differences were found within each severity level or in APR-DRG relative weight (p = 0.38).

Conclusions

No significant differences in hospital discharge costs by APR-DRG were found based on vaccination status. However, vaccination may reduce disease severity and the need for intensive resources, with potential economic and clinical implications for future research.
背景与目的covid -19疫苗接种可能改变重症病程,影响出院费用。本研究比较了icu收治的COVID-19患者基于疫苗接种状况的出院费用,并根据所有患者精细诊断相关组(APR-DRG)和严重程度进行了调整。患者和方法回顾性研究(2020年3月- 2022年3月)在ICU进行,将患者分为三组:未接种疫苗、完全接种疫苗和部分接种疫苗。全面疫苗接种包括按疫苗接种计划接种所需的所有剂量和加强剂。疾病严重程度分为轻度、中度、重度和危重。直接住院费用,包括ICU住院、医疗程序、药物和生命支持,使用SAN/35/2017号命令的数据进行分析,并根据通货膨胀进行调整。比较采用卡方检验和Kruskal-Wallis检验,并采用Bonferroni校正。结果共纳入456例患者:未接种疫苗262例(57%),部分接种疫苗32例(7%),完全接种疫苗162例(35%)。中位数成本为:未接种疫苗:10,653欧元(IQR:€6160 -€18,274)部分接种疫苗:17,360欧元(IQR:€5061 -€26,085)完全接种疫苗:10,653欧元(IQR:€6160 -€26,085)成本差异无统计学意义(p = 0.28)。重症患者的费用最高,而轻度患者的费用最低(p <;0.05)。在每个严重程度级别或APR-DRG相对权重中没有发现显著的成本差异(p = 0.38)。结论不同疫苗接种情况下APR-DRG的出院费用无显著差异。然而,疫苗接种可能降低疾病严重程度和对密集资源的需求,对未来的研究具有潜在的经济和临床意义。
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引用次数: 0
Effect of a music therapy intervention on the mood of the critically ill patient 音乐治疗干预对危重病人情绪的影响
Pub Date : 2025-07-01 DOI: 10.1016/j.enfie.2025.500549
M. del Mar Vega Castosa MSN, M. del Carmen Jover Sancho MSN, PhD, Joan Trujols Albet PhD

Introduction

The critically ill patient is in a state of fragility, helplessness, and vulnerability that hinders the communication of their emotions and feelings. Music therapy could be a valid tool to improve mood. The main objective was to evaluate the effect on mood of an individualised music therapy intervention compared to standard care and analyze the impact on pain and hemodynamic variables.

Methodology

randomised, parallel, and open clinical trial. Patients were randomised into the experimental group, receiving combined music therapy and standard care, or the control group, receiving standard care only. The study population consisted of patients admitted to the Intensive Care Unit with a Glasgow 15−11 T score, excluding those with confusion, agitation, and significant cognitive deficits. The primary variable was mood, assessed using the Profile of Mood States questionnaire. Secondary variables included pain, heart rate, blood pressure, respiratory rate, and oxygen saturation.

Results

A total of 151 patients were included, randomly distributed into the EG (n = 75) and CG (n = 76). Mood improvement was significant in all 6 subscales of the POMS, in the time effect between pre- and post-intervention assessment, and in the time effect by group interaction for Anger (p = 0.020), Fatigue (p = 0.002), Vigor (p = 0.029), and Tension (p = 0.042), indicating that the improvement was related to the music therapy intervention in the EG. Following the music therapy intervention, a decrease in pain (p = 0.024) and heart rate (p = 0.017) was observed in the time effect, and an increase in systolic blood pressure (p = 0.004) was related to the music therapy intervention.

Discussion

This clinical trial demonstrates that music therapy, with a personalised music intervention, has a positive effect on the mood of critically ill patients. Further lines of research are needed to continue advancing scientific knowledge and develop news forms of assistance to improve mood.
危重病人处于脆弱、无助和脆弱的状态,这阻碍了他们的情绪和感受的交流。音乐疗法可能是改善情绪的有效工具。主要目的是评估与标准治疗相比,个性化音乐治疗干预对情绪的影响,并分析对疼痛和血流动力学变量的影响。方法:随机、平行、开放临床试验。患者被随机分为实验组和对照组,实验组接受音乐治疗和标准治疗,对照组只接受标准治疗。研究人群包括格拉斯哥15−11 T评分入重症监护病房的患者,排除那些有精神错乱、躁动和显著认知缺陷的患者。主要变量是情绪,使用情绪状态问卷进行评估。次要变量包括疼痛、心率、血压、呼吸频率和血氧饱和度。结果共纳入151例患者,随机分为EG组(n = 75)和CG组(n = 76)。在POMS的所有6个分量表、干预前和干预后评估的时间效应以及小组互动对愤怒(p = 0.020)、疲劳(p = 0.002)、活力(p = 0.029)和紧张(p = 0.042)的时间效应上均有显著改善,表明音乐治疗干预与EG的改善有关。音乐治疗干预后,疼痛减轻(p = 0.024),心率降低(p = 0.017),收缩压升高(p = 0.004)与音乐治疗干预有关。这个临床试验表明,音乐疗法,与个性化的音乐干预,对危重病人的情绪有积极的影响。需要进一步的研究来继续推进科学知识,并开发新的帮助改善情绪的方式。
{"title":"Effect of a music therapy intervention on the mood of the critically ill patient","authors":"M. del Mar Vega Castosa MSN,&nbsp;M. del Carmen Jover Sancho MSN, PhD,&nbsp;Joan Trujols Albet PhD","doi":"10.1016/j.enfie.2025.500549","DOIUrl":"10.1016/j.enfie.2025.500549","url":null,"abstract":"<div><h3>Introduction</h3><div>The critically ill patient is in a state of fragility, helplessness, and vulnerability that hinders the communication of their emotions and feelings. Music therapy could be a valid tool to improve mood. The main objective was to evaluate the effect on mood of an individualised music therapy intervention compared to standard care and analyze the impact on pain and hemodynamic variables.</div></div><div><h3>Methodology</h3><div>randomised, parallel, and open clinical trial. Patients were randomised into the experimental group, receiving combined music therapy and standard care, or the control group, receiving standard care only. The study population consisted of patients admitted to the Intensive Care Unit with a Glasgow 15−11 T score, excluding those with confusion, agitation, and significant cognitive deficits. The primary variable was mood, assessed using the Profile of Mood States questionnaire. Secondary variables included pain, heart rate, blood pressure, respiratory rate, and oxygen saturation.</div></div><div><h3>Results</h3><div>A total of 151 patients were included, randomly distributed into the EG (n = 75) and CG (n = 76). Mood improvement was significant in all 6 subscales of the POMS, in the time effect between pre- and post-intervention assessment, and in the time effect by group interaction for Anger (p = 0.020), Fatigue (p = 0.002), Vigor (p = 0.029), and Tension (p = 0.042), indicating that the improvement was related to the music therapy intervention in the EG. Following the music therapy intervention, a decrease in pain (p = 0.024) and heart rate (p = 0.017) was observed in the time effect, and an increase in systolic blood pressure (p = 0.004) was related to the music therapy intervention.</div></div><div><h3>Discussion</h3><div>This clinical trial demonstrates that music therapy, with a personalised music intervention, has a positive effect on the mood of critically ill patients. Further lines of research are needed to continue advancing scientific knowledge and develop news forms of assistance to improve mood.</div></div>","PeriodicalId":93991,"journal":{"name":"Enfermeria intensiva","volume":"36 3","pages":"Article 500549"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recovery and severity of acute kidney injury in critically ill clinical and surgical patients 临床及外科危重病人急性肾损伤的恢复及严重程度
Pub Date : 2025-07-01 DOI: 10.1016/j.enfie.2025.500545
Raquel Teles-Mesquita Graduated , Natália Vieira-Araújo-Cunha MSN , Marcia Cristina-da-Silva-Magro PhD , Kamilla Grasielle-Nunes-da-Silva MSN

Introduction

The identification of patients at risk has implications on the management of clinical and surgical patients. The severity of acute kidney injury (AKI) has a negative impact on the patient's prognosis and effects on kidney function recovery.

Objective

To determine the cases of renal recovery and level of severity of AKI in clinical and surgical patients admitted to the intensive care unit. (ICU).

Method

Prospective, observational, longitudinal, and quantitative analytical study. It was carried out in an ICU of a teaching hospital. The sample was non-probabilistic, consisting of 59 surgical and clinical patients. A structured questionnaire consisting of 38 questions subdivided into sections was used for data collection such as hospitalization data; surgery data; history of current hospitalization; hemodynamic and laboratory parameters; AKI severity. Variable analysis was based on non-parametric tests. Two-sided p values < 0.05 were considered statistically significant.

Results

The most severe AKI according to the classification KDIGO (Kidney Disease: Improving Global Outcomes) was 3 and mainly affected clinical patients (34.5%). Surgical patients predominantly developed AKI – KDIGO 2 and 3 (23.3%). The length of hospital stay (p = 0.04), and ICU stay (p = 0.001) was significant in patients who developed AKI. Renal recovery occurred predominantly in surgical patients (20.3%).

Conclusions

Clinical patients admitted to the ICU are more affected by more severe AKI (KDIGO 3). Renal recovery was observed in approximately two out of every five patients, being more significant in surgical patients.
高危患者的识别对临床和外科患者的管理具有重要意义。急性肾损伤(acute kidney injury, AKI)的严重程度对患者的预后和肾功能恢复有负面影响。目的了解重症监护病房临床及外科患者肾恢复情况及严重程度。(ICU)。方法前瞻性、观察性、纵向、定量分析研究。手术是在一所教学医院的重症监护室进行的。样本是非概率的,包括59例外科和临床患者。数据收集采用了包含38个细分问题的结构化问卷,如住院数据;手术数据;当前住院史;血流动力学和实验室参数;阿基严重性。变量分析基于非参数检验。双侧p值<; 0.05认为具有统计学意义。结果KDIGO (Kidney Disease: improved Global Outcomes)分类中最严重的AKI为3,主要影响临床患者(34.5%)。手术患者主要发展为AKI - KDIGO 2和3(23.3%)。在发生AKI的患者中,住院时间(p = 0.04)和ICU住院时间(p = 0.001)具有显著性。肾脏恢复主要发生在手术患者中(20.3%)。结论临床入ICU患者AKI发生率越高(KDIGO 3)。大约每5名患者中有2名患者肾脏恢复,手术患者的肾功能恢复更为显著。
{"title":"Recovery and severity of acute kidney injury in critically ill clinical and surgical patients","authors":"Raquel Teles-Mesquita Graduated ,&nbsp;Natália Vieira-Araújo-Cunha MSN ,&nbsp;Marcia Cristina-da-Silva-Magro PhD ,&nbsp;Kamilla Grasielle-Nunes-da-Silva MSN","doi":"10.1016/j.enfie.2025.500545","DOIUrl":"10.1016/j.enfie.2025.500545","url":null,"abstract":"<div><h3>Introduction</h3><div>The identification of patients at risk has implications on the management of clinical and surgical patients. The severity of acute kidney injury (AKI) has a negative impact on the patient's prognosis and effects on kidney function recovery.</div></div><div><h3>Objective</h3><div>To determine the cases of renal recovery and level of severity of AKI in clinical and surgical patients admitted to the intensive care unit. (ICU).</div></div><div><h3>Method</h3><div>Prospective, observational, longitudinal, and quantitative analytical study. It was carried out in an ICU of a teaching hospital. The sample was non-probabilistic, consisting of 59 surgical and clinical patients. A structured questionnaire consisting of 38 questions subdivided into sections was used for data collection such as hospitalization data; surgery data; history of current hospitalization; hemodynamic and laboratory parameters; AKI severity. Variable analysis was based on non-parametric tests. Two-sided <em>p</em> values<!--> <!-->&lt;<!--> <!-->0.05 were considered statistically significant.</div></div><div><h3>Results</h3><div>The most severe AKI according to the classification KDIGO (Kidney Disease: Improving Global Outcomes) was 3 and mainly affected clinical patients (34.5%). Surgical patients predominantly developed AKI – KDIGO 2 and 3 (23.3%). The length of hospital stay (<em>p</em> <!-->=<!--> <!-->0.04), and ICU stay (<em>p</em> <!-->=<!--> <!-->0.001) was significant in patients who developed AKI. Renal recovery occurred predominantly in surgical patients (20.3%).</div></div><div><h3>Conclusions</h3><div>Clinical patients admitted to the ICU are more affected by more severe AKI (KDIGO 3). Renal recovery was observed in approximately two out of every five patients, being more significant in surgical patients.</div></div>","PeriodicalId":93991,"journal":{"name":"Enfermeria intensiva","volume":"36 3","pages":"Article 500545"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central venous catheter-related bacteremia in critically ill patients: Epidemiology and risk factor’s 危重病人中心静脉导管相关性菌血症:流行病学及危险因素
Pub Date : 2025-07-01 DOI: 10.1016/j.enfie.2025.500538
Esther Mancheño-Maciá PhD , Beatriz Muñoz-Sánchez RN , Inés González-Sánchez PhD , Marina Leal-Clavel RN, MsN , Vanesa Escudero-Ortiz PhD

Introduction

Central venous catheter-related bacteremia is a common nosocomial infection in intensive care units (ICU), the prevalence is worrying. In recent years, due to Covid-19, the number of central venous catether’s patients, treated with immunosuppressive drugs, has been increased. Our objective was to determine the prevalence of central catheter bacteremia in ICU, during 2022, as well as to determine associated risk factors.

Methods

Descriptive cross-sectional study in ICU of hospita (HGU Dr. Balmis Hospital Alicante, Spain). Were included 466 patients admitted to ICU in 2022. Sociodemographic, clinical, catheter-related data and APACHE-II and q-SOFA scale scores were collected.

Results

The prevalence of bacteriemia was 3,65%. Significant factors associated with bacteriemia were the number of catheters inserted in each patient (p-value < 0,001) and the use of immunosuppressive drugs (p-value = 0,002). Patients who had a peripherally inserted catheter (PICC) had a lower probability of develop bacteriemia and patients with conventional catheter and PICC had a higher probability. The rest of the variables, including Covid-19, without significant differences

Discussion and conclusions

In line with other authors, we can affirm that the administration of immunosuppressive drugs is a risk factor of central venous catheter-related bacteremia; A correct risk-benefit assessment is recommended when prescribing this drugs, in Covid’s patients the biological drug tocilizumab could be the recommended one. An increase by one unit in the number of catheters inserted causes a 5-fold increase in probability of developing bacteremia (Odds ratio: 4,984, 95% confidence interval 2,984−9,136). Covid-19, sex, age, comorbidities and q-SOFA and APACHE-II scores do not seem to show a relationship whith bacteremia and PICCs devices do seem to be safer versus conventional CVCs.
中心静脉导管相关性菌血症是重症监护病房(ICU)常见的院内感染,其发病率令人担忧。近年来,由于Covid-19,中心静脉导管患者使用免疫抑制药物治疗的人数有所增加。我们的目的是确定2022年ICU中心导管菌血症的患病率,并确定相关的危险因素。方法在西班牙阿利坎特市Balmis医院ICU进行描述性横断面研究。纳入2022年ICU住院患者466例。收集社会人口学、临床、导管相关数据以及APACHE-II和q-SOFA量表评分。结果细菌血症发生率为3.65%。与菌血症相关的重要因素是每位患者插入导管的数量(p值<;0,001)和使用免疫抑制药物(p值 = 0,002)。采用外周导管(PICC)的患者发生菌血症的概率较低,而采用常规导管和PICC的患者发生菌血症的概率较高。讨论与结论与其他作者一致,我们可以肯定免疫抑制药物的使用是中心静脉置管相关菌血症的危险因素;在处方这种药物时,建议进行正确的风险-效益评估,在Covid患者中,生物药物tocilizumab可能是推荐的药物。插入导管数量每增加一个单位,导致发生菌血症的概率增加5倍(优势比:4,984,95%置信区间2,984−9,136)。Covid-19、性别、年龄、合并症以及q-SOFA和APACHE-II评分似乎没有显示出与菌血症的关系,PICCs设备似乎比传统cvc更安全。
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引用次数: 0
Teamwork training methodology: Five editions of the TeamSTEPPS® course 团队合作培训方法:五个版本的TeamSTEPPS®课程
Pub Date : 2025-07-01 DOI: 10.1016/j.enfie.2025.500563
Marta Raurell-Torredà (MA) , Ignacio Zaragoza-García , Francisco Javier Sánchez Chillón , Anna Maria Aliberch Raurell , Ana Carolina Amaya Arias , Andrés Rojo Rojo , Oscar Arrogante
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引用次数: 0
Clinical skills in therapeutic plasmapheresis in intensive care: A scoping review 重症监护中血浆置换治疗的临床技能:范围综述
Pub Date : 2025-07-01 DOI: 10.1016/j.enfie.2025.500556
Pedro Ramos-Figueiras MSc , Maria Pinto-Marques PhD , Margarida Palma-Goes PhD , Henrique Oliveira PhD

Background

Therapeutic plasmapheresis is a procedure primarily focused on modulating the immune system by removing specific antibodies and albumin-bound toxins implicated in the development of serious pathologies, and it is being used more frequently in intensive care units. In this therapeutic intervention, nursing teams mostly use the knowledge and skills acquired through experience with continuous dialysis techniques. However, the procedure is complex and advanced, requiring the development of specific skills.

Aim

To map the nursing interventions that facilitate the development of specific clinical skills for therapeutic plasmapheresis.

Methodology

The methodology adopted was based on a scoping review. The Population, Concept, Context methodology was used to formulate the review question and to select the articles. The search was carried out in the scientific databases CINAHL, MEDLINE, COCHRANE, Virtual Health Library and international journals specializing in apheresis techniques knowledge, with the inclusion criteria “nursing care”, “peer-reviewed articles” and the exclusion criteria “no full text” and “date less than 2017” applied. In addition, the most recent international guidelines on therapeutic plasmapheresis were included.

Results

A total of 11 articles were identified, of which 7 are textual evidence articles, based on expert opinions and database searches, and 4 are quantitative studies; in addition to 5 guidelines related to the subject under analysis. These reflect the importance of developing skills in therapeutic plasmapheresis, categorized into general, technical, management and communication domains. Nursing interventions are based on the principle of clinical reasoning, promoting evidence-based practice. The relevance of certifying these skills through training is also highlighted, emphasizing the need for structured programs for an adequate approach to highly complex therapeutic interventions.

Conclusion

Therapeutic plasmapheresis plays an essential role in intensive care settings, covering various clinical scenarios, which requires an individualized approach and careful consideration of the person's specific clinical condition.
治疗性血浆置换是一种主要侧重于通过去除与严重病理发展相关的特异性抗体和白蛋白结合毒素来调节免疫系统的手术,它在重症监护病房中使用得更频繁。在这种治疗干预中,护理团队主要使用通过持续透析技术获得的知识和技能。然而,这个过程是复杂和先进的,需要发展特定的技能。目的制定护理干预措施,促进治疗性血浆置换的特定临床技能的发展。方法采用的方法是基于范围审查。使用人口、概念、背景方法来制定审查问题和选择文章。检索科学数据库CINAHL、MEDLINE、COCHRANE、Virtual Health Library及国际采血技术知识专业期刊,纳入标准为“nursing care”、“同行评议文章”,排除标准为“无全文”和“日期小于2017”。此外,还包括最新的治疗性血浆置换国际指南。结果共鉴定出11篇论文,其中基于专家意见和数据库检索的文本证据文章7篇,定量研究4篇;除了与所分析的主题有关的5项准则之外。这反映了发展治疗性血浆分离技术的重要性,分为一般、技术、管理和交流领域。护理干预以临床推理原则为基础,促进循证实践。通过培训证明这些技能的相关性也得到了强调,强调了对高度复杂的治疗干预采取适当方法的结构化方案的必要性。结论治疗性血浆置换在重症监护环境中发挥着至关重要的作用,它涵盖了各种临床情况,需要个性化的方法并仔细考虑患者的具体临床情况。
{"title":"Clinical skills in therapeutic plasmapheresis in intensive care: A scoping review","authors":"Pedro Ramos-Figueiras MSc ,&nbsp;Maria Pinto-Marques PhD ,&nbsp;Margarida Palma-Goes PhD ,&nbsp;Henrique Oliveira PhD","doi":"10.1016/j.enfie.2025.500556","DOIUrl":"10.1016/j.enfie.2025.500556","url":null,"abstract":"<div><h3>Background</h3><div>Therapeutic plasmapheresis is a procedure primarily focused on modulating the immune system by removing specific antibodies and albumin-bound toxins implicated in the development of serious pathologies, and it is being used more frequently in intensive care units. In this therapeutic intervention, nursing teams mostly use the knowledge and skills acquired through experience with continuous dialysis techniques. However, the procedure is complex and advanced, requiring the development of specific skills.</div></div><div><h3>Aim</h3><div>To map the nursing interventions that facilitate the development of specific clinical skills for therapeutic plasmapheresis.</div></div><div><h3>Methodology</h3><div>The methodology adopted was based on a scoping review. The Population, Concept, Context methodology was used to formulate the review question and to select the articles. The search was carried out in the scientific databases CINAHL, MEDLINE, COCHRANE, Virtual Health Library and international journals specializing in apheresis techniques knowledge, with the inclusion criteria “nursing care”, “peer-reviewed articles” and the exclusion criteria “no full text” and “date less than 2017” applied. In addition, the most recent international guidelines on therapeutic plasmapheresis were included.</div></div><div><h3>Results</h3><div>A total of 11 articles were identified, of which 7 are textual evidence articles, based on expert opinions and database searches, and 4 are quantitative studies; in addition to 5 guidelines related to the subject under analysis. These reflect the importance of developing skills in therapeutic plasmapheresis, categorized into general, technical, management and communication domains. Nursing interventions are based on the principle of clinical reasoning, promoting evidence-based practice. The relevance of certifying these skills through training is also highlighted, emphasizing the need for structured programs for an adequate approach to highly complex therapeutic interventions.</div></div><div><h3>Conclusion</h3><div>Therapeutic plasmapheresis plays an essential role in intensive care settings, covering various clinical scenarios, which requires an individualized approach and careful consideration of the person's specific clinical condition.</div></div>","PeriodicalId":93991,"journal":{"name":"Enfermeria intensiva","volume":"36 3","pages":"Article 500556"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validity and sensitivity to change of the Clinical Frailty Scale-Spain in patients admitted to intensive care 临床虚弱量表-西班牙在重症监护患者中的有效性和敏感性
Pub Date : 2025-07-01 DOI: 10.1016/j.enfie.2025.500558
Susana Arias-Rivera RN, MSN, PhDc , Marta Raurell-Torredà RN, PhD , María Nieves Moro-Tejedor RN, PhD , Israel John Thuissard-Vasallo PhD , Cristina Andreu-Vázquez MVD, MsC, PhD , Fernando Frutos-Vivar MD , CFS-Es-ICU Group

Introduction

Frailty scales, developed to assess elderly patients, are being implemented in critically ill patients. One of the most widely used is Clinical Frailty Scale, wrecently adapted to Spanish(CFS-España).

Objective

To evaluate the validity and sensitivity to change of the CFS-España in a cohort of critically ill patients aged ≥18 years.

Methodology

A prospective, multicenter, observational, metric-based study was conducted between January-2020 and July-2024. Adult patients with ICU stays >48 h were included. Follow-up was performed during the stay and up to one year after discharge. Variables: frailty, sociodemographic characteristics, quality of life, comorbidities, severity(SAPS3), ICU outcome variables, length of stay, and discharge destination. Statistical analysis: exploratory, bivariate regression to assess the relationship between frailty and the recorded variables; multivariate regression of significant variables in bivariate. Spearman correlation of CFS-España with quantitative variables. Comparison of means with Student's t-test for sensitivity to change.

Results

A total of 493 patients were included, 17.4% of whom were frail(CFS-Spain = 5−9). Age, being female, and being dependent increased the risk of frailty, as did previous hospitalizations, comorbidities, poorer physical quality of life, low academic level, and low annual income. Frailty predicts muscle weakness, hypoglycemia, the need for extrarenal blood pressure, invasive mechanical ventilation, vasoactive drugs, cardiopulmonary resuscitation, or limitation of life-sustaining treatment, and is associated with mortality. Frailty was not associated with mental quality of life, SAPS3, SOFA or ICU/hospital stay. The greatest change observed was between admission and 3 months after discharge. The effect size for changes in CFS-Es between admission, midpoints, and discharge was high (d = 0.832).

Conclusions

The CFS-España shows good convergent validity with age, women, dependency, poorer physical quality of life, days of previous hospitalization, academic level and low annual income. Good predictive validity for the level of vital support in ICU, mortality and destination at hospital discharge.
为评估老年患者而开发的虚弱量表正在对危重患者实施。其中最广泛使用的是临床虚弱量表,最近被西班牙语改编(CFS-España)。目的评价≥18岁危重患者CFS-España变化的有效性和敏感性。在2020年1月至2024年7月期间进行了一项前瞻性、多中心、观察性、基于指标的研究。纳入ICU住院的成年患者>;48 h。在住院期间和出院后一年进行随访。变量:虚弱、社会人口学特征、生活质量、合并症、严重程度(SAPS3)、ICU结局变量、住院时间和出院目的地。统计分析:探索性、双变量回归评估脆弱性与记录变量之间的关系;双变量中显著变量的多元回归。CFS-España与定量变量的Spearman相关性。对变化敏感性的均值与学生t检验的比较。结果共纳入493例患者,体弱患者占17.4% (CFS-Spain = 5−9)。年龄、女性和依赖他人增加了衰弱的风险,既往住院、合并症、较差的身体生活质量、较低的学术水平和较低的年收入也是如此。虚弱预示着肌肉无力、低血糖、需要体外血压、有创机械通气、血管活性药物、心肺复苏或生命维持治疗的限制,并与死亡率相关。虚弱与精神生活质量、SAPS3、SOFA或ICU/住院时间无关。观察到的最大变化发生在入院和出院后3个月。入院、中点和出院间CFS-Es变化的效应量很高(d = 0.832)。结论CFS-España与年龄、女性、受抚养程度、身体生活质量差、住院天数、学历水平、低收入者均有较好的收敛效度。对ICU生命支持水平、死亡率和出院目的地有较好的预测效度。
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引用次数: 0
Monitoring of night-time nursing interventions in Spanish paediatric critical care units 监测夜间护理干预在西班牙儿科重症监护病房
Pub Date : 2025-07-01 DOI: 10.1016/j.enfie.2025.500555
Alicia Gomez-Merino RN, MSc , Patricia Luna-Castaño PhD, RN, MSc , Marta Martín-Velasco RN , Natalia González-Martínez RN, MSc , Pedro Piqueras-Rodríguez RN, MSc , Irina Marcos-Blázquez RN, MSc , Sara Álvarez-Blanco RN , Lucía Gutiérrez-Horrillo RN, MSc , Elia Mas-Company RN , Enara Otero-Arbella RN , Elena Martín-Camacho RN, MSc , María Teresa Arias-Latorre RN, MSc , Sara Rodríguez-Flórez RN, MSc , María de los Ángeles Morán-Barrio RN , María Teresa Moreno-Casbas RN, PhD, FEAN, FAAN

Introduction

The hostile environment in Paediatric Intensive Care Units (PICU) favours sleep-wake biorhythm dysregulation. Sleep disorders have detrimental impact on the immune, neurological and cardiovascular systems, in addition to increasing morbidity and mortality rates. Sleep plays a crucial role in brain development, rendering paediatric patients particularly vulnerable to the adverse effects of sleep disorders due to their ongoing neurological growth. The factors that affect rest include, among others, noise, lighting, treatment, and nocturnal nursing interventions, although the evidence for the latter is still scarce.

Objective

To identify the nocturnal nursing interventions, following the NIC Taxonomy, carried out in PICUs.

Method

A Multicentre, cross-sectional, descriptive study was performed using an ad hoc survey to identify nocturnal nursing interventions in the PICU. The collected variables were characteristics of the participating PICU and those derived from the nursing interventions. During the analysis, mean and standard deviation of quantitative variables, and frequency tables and percentages were generated for qualitative variables. The variables were operationalized and Student's t-test and ANOVA were calculated for comparison between variables.

Results

100 records were obtained, encompassing 5017 interventions, with the most repeated intervention being “Vital signs monitoring”. The mean number of different interventions identified was 23 ± 7.66 and the mean frequency of these was 50.17 ± 19.28. There were significant differences between the hospital variable and the number and frequency of interventions performed (P < .001).

Discussion

We agreed with other studies in identifying “Vital signs monitoring” as the most frequent intervention. “Improving sleep” was one of the most frequently reported, in contrast to other studies where interventions related to rest were not documented.

Conclusions

The most frequently performed interventions in the PICU were identified. In most of the registers some intervention on improving rest was identified, which could indicate the latent concern of the health care professionals for the sleep of the critical child.
儿科重症监护病房(PICU)的恶劣环境有利于睡眠-觉醒生物节律失调。睡眠障碍除了增加发病率和死亡率外,还对免疫、神经和心血管系统产生有害影响。睡眠在大脑发育中起着至关重要的作用,由于儿科患者的神经系统正在发育,因此他们特别容易受到睡眠障碍的不利影响。影响休息的因素包括噪音、照明、治疗和夜间护理干预,尽管后者的证据仍然很少。目的探讨重症监护病房夜间护理干预方法。方法采用一项多中心、横断面、描述性研究,通过特别调查确定PICU的夜间护理干预措施。收集的变量是参与PICU的特征和护理干预的特征。在分析过程中,生成定量变量的均值和标准差,以及定性变量的频率表和百分比。对变量进行操作化处理,并计算学生t检验和方差分析进行变量间比较。结果共获得100条记录,干预措施5017项,其中重复次数最多的是“生命体征监测”。不同干预的平均次数为23±7.66次,平均频率为50.17±19.28次。医院变量与进行干预的次数和频率之间存在显著差异(P <;措施)。讨论我们同意其他研究将“生命体征监测”确定为最常见的干预措施。“改善睡眠”是最常被报道的研究之一,而在其他研究中,与休息相关的干预措施没有记录在案。结论确定了PICU中最常用的干预措施。在大多数的记录中都发现了一些改善休息的干预措施,这可能表明卫生保健专业人员对危重儿童的睡眠存在潜在的关注。
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引用次数: 0
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Enfermeria intensiva
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