Hematology, transfusion and cell therapy最新文献

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HLA-DR-DQ associations, combined with PLASMIC score, are reliable predictors of acquired thrombotic thrombocytopenic purpura (aTTP) and aid in differentiating aTTP from other thrombotic microangiopathies HLA-DR-DQ 关联与 PLASMIC 评分相结合，是获得性血栓性血小板减少性紫癜（aTTP）的可靠预测指标，有助于区分 aTTP 和其他血栓性微血管病

Hematology, transfusion and cell therapy

Pub Date : 2024-02-01 DOI: 10.1016/j.htct.2023.11.016

Soumya Pandey, Akul Shrivastava, Y. Harville, Michele Cottler-Fox, T. Harville

引用次数: 0

Anti-PF4 antibodies and their relationship with COVID infection 抗 PF4 抗体及其与 COVID 感染的关系

Hematology, transfusion and cell therapy

Pub Date : 2024-02-01 DOI: 10.1016/j.htct.2023.11.012

Chieh Yang, Irene Wang, Akshit Chitkara, Jibin Swankutty, Rushin Patel, Samir V Kubba

引用次数: 0

Hemorrhagic code protocol, a successful case in the patient blood management model for patients with severe hemorrhages 出血代码协议--严重出血患者血液管理模式的成功案例

Hematology, transfusion and cell therapy

Pub Date : 2024-02-01 DOI: 10.1016/j.htct.2024.01.002

João Carlos de Campos Guerra, Michele Jaures, Roseny dos Reis Rodrigues, A. Cypriano, D. Malheiro, Anna Carolina Batista Dantas, Fernanda Paulino Fernandes, Neila Maria Marques Negrini, V. Teich

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Epidemiology, patient journey and unmet needs related to hemophilia in Brazil: a scoping review with evidence map 巴西与血友病有关的流行病学、患者历程和未满足的需求：附有证据地图的范围界定审查

Hematology, transfusion and cell therapy

Pub Date : 2024-02-01 DOI: 10.1016/j.htct.2023.12.004

N. B. Schneider, C. L. P. de Araujo, Harryson Wings Godoy dos Santos, Simone Lima, Maicon Falavigna, D. Pachito

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Evaluation of C-reactive protein and its prognostic relationship in patients with Hodgkin's Lymphoma. 评估霍奇金淋巴瘤患者的 C 反应蛋白及其与预后的关系。

Hematology, transfusion and cell therapy

Pub Date : 2024-01-20 DOI: 10.1016/j.htct.2023.11.011

Elizete Aparecida da Silva Negreiros, Talita Máira Bueno da Silveira, Sérgio Costa Fortier, Carlos Sérgio Chiattone

Objectives: To assess the prognostic value of C-Reactive Protein (CRP), at diagnosis and during follow-up, of patients with Hodgkin´s Lymphoma treated at the Hematology Service of the Santa Casa de São Paulo Hospital, and to correlate serum CRP levels with disease stage and treatment response.

Methods: A retrospective study involving review of 71 medical records of patients diagnosed with Hodgkin´s Lymphoma between February 2012 and January 2016 was performed. Three patients were subsequently excluded, giving a total of 68 patients for analysis. A level of CRP > 1mg/dl was considered elevated.

Results: Patients were predominantly male (61.8%) and mean age was 34 years. Fifty-three (78%) patients had advanced stage and (76.5%) had B symptoms. Elevated baseline CRP was associated with greater likelihood of B symptoms (p= 0.02) and of advanced stage (p= 0.015). Patients with Low CRP level after 5th and 6th cycles of chemotherapy was associated with complete response (p=0.04 and p=0.03, respectively). Treatment-refractory patients had greater risk of death (p=0.002).

Conclusion: CRP is clinically important for follow-up of patients with Hodgkin´s Lymphoma, where high levels were associated with advanced disease and/or presence of B symptoms. CRP level was considered a predictor of treatment response. Persistence of high CRP values during treatment was associated with refractoriness.

目的评估在圣保罗圣卡萨医院血液科接受治疗的霍奇金淋巴瘤患者在诊断时和随访期间C反应蛋白（CRP）的预后价值，并将血清CRP水平与疾病分期和治疗反应相关联：该研究回顾了2012年2月至2016年1月期间诊断为霍奇金淋巴瘤患者的71份病历。随后排除了3名患者，共有68名患者接受了分析。CRP水平大于1毫克/分升即为升高：患者主要为男性（61.8%），平均年龄为 34 岁。53名患者（78%）为晚期，76.5%的患者有B型症状。基线 CRP 升高与出现 B 型症状（p= 0.02）和晚期（p= 0.015）的可能性增加有关。第 5 和第 6 个化疗周期后 CRP 水平较低的患者与完全缓解相关（分别为 p=0.04 和 p=0.03）。治疗难治患者的死亡风险更高（P=0.002）：CRP对霍奇金淋巴瘤患者的随访具有重要的临床意义，CRP水平高与疾病晚期和/或出现B症状有关。CRP水平被认为是治疗反应的预测因子。治疗期间 CRP 值持续偏高与难治性有关。

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