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Risk Factors for Cardiovascular Disease among Pregnant Women in San Juan, Puerto Rico. 波多黎各圣胡安孕妇心血管疾病的危险因素
Pub Date : 2025-06-01
Andrea A López-Cepero, Stephanie Cameron, Mariana González, Deborah Santos-Sierra, Yaritza Inostroza-Nieves

Objective: Cardiovascular disease (CVD) is the leading cause of death among women in Puerto Rico (PR). Cardiovascular disease risk factors (CVDRF) during pregnancy, such as obesity, type 2 diabetes (T2D), hypertension, and hypertensive disorders of pregnancy, increase risks for maternal and neonatal health. Limited data exist on CVDRF prevalence among pregnant women in PR.

Methods: This cross-sectional study analyzed medical records of 264 pregnant women aged 21-35 years with no prior pregnancies from an outpatient clinic in San Juan, PR, during 2018-2019. Key CVDRFs included pre-pregnancy obesity, T2D, gestational diabetes, hypertension, and hypertensive disorders of pregnancy. Age groups (21-25, 26-30, 31-35 years) were assessed for CVDRF prevalence. Logistic and multinomial regressions adjusted for sociodemographic variables were used to evaluate associations.

Results: Pre-pregnancy obesity was the most prevalent CVDRF (23.5%). Women aged 31-35 years had significantly higher odds of T2D/ gestational diabetes (OR=4.66; 95% CI=1.18, 18.4) and were more likely to experience two or more CVDRFs (RRR=2.73; 95% CI=1.10, 6.80).

Discussion: Findings align with global data showing increased CVDRF prevalence with age among pregnant women. Comparisons with Latino and non-Latino populations reveal shared risks, such as higher rates of gestational diabetes and obesity in older age groups, emphasizing the universal relevance of addressing maternal CVDRFs. Significance: This study highlights the importance of identifying and managing CVDRF among pregnant women in PR, particularly those aged 31-35 years. The findings provide critical data to inform targeted interventions, optimize prenatal care, and reduce long-term maternal and neonatal complications, contributing to improved health outcomes for Puerto Rican women.

目的:心血管疾病(CVD)是波多黎各妇女死亡的主要原因。妊娠期心血管疾病风险因素(CVDRF),如肥胖、2型糖尿病(T2D)、高血压和妊娠期高血压疾病,增加了孕产妇和新生儿健康的风险。关于PR孕妇CVDRF患病率的数据有限。方法:本横断面研究分析了2018-2019年PR圣胡安一家门诊诊所264名年龄21-35岁未怀孕的孕妇的病历。关键cvdrf包括孕前肥胖、T2D、妊娠期糖尿病、高血压和妊娠期高血压疾病。评估各年龄组(21-25岁、26-30岁、31-35岁)CVDRF患病率。采用社会人口变量调整后的Logistic回归和多项回归来评估相关性。结果:妊娠前肥胖是最常见的CVDRF(23.5%)。31-35岁的女性患T2D/妊娠期糖尿病的几率明显更高(OR=4.66;95% CI=1.18, 18.4),更有可能经历两次或两次以上的cvdrf (RRR=2.73;95% ci =1.10, 6.80)。讨论:研究结果与全球数据一致,显示孕妇CVDRF患病率随年龄增加。与拉丁裔和非拉丁裔人群的比较揭示了共同的风险,例如老年群体的妊娠糖尿病和肥胖症发生率较高,强调了解决孕产妇CVDRFs的普遍相关性。意义:本研究强调了在PR孕妇中识别和管理CVDRF的重要性,特别是31-35岁的孕妇。研究结果提供了关键数据,为有针对性的干预措施提供信息,优化产前护理,减少孕产妇和新生儿的长期并发症,有助于改善波多黎各妇女的健康状况。
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引用次数: 0
Smoking, Sociodemographic Characteristics, and Health History among Adults with Mental Illness in Puerto Rico. 波多黎各成年精神疾病患者的吸烟、社会人口学特征和健康史
IF 0.3 Pub Date : 2025-06-01
Ruthmarie Hernández-Torres, Paola Carminelli-Corretjer, Francisco Cartujano-Barrera, Juliette Rivera-Collazo, Ana Paula Cupertino, Leopoldo J Cabassa, Eliut Rivera-Segarra

Objective: In Puerto Rico, two in ten adults aged 18 to 64 (18.7%) are diagnosed with a mental illness (MI), such as schizophrenia, bipolar disorder, and major depressive disorder. People with MI diagnosis report higher frequencies of chronic diseases (e.g., diabetes, cancer, heart diseases) and cigarette smoking than the general population. This study explores associations between smoking, sociodemographic characteristics and health history (i.e. chronic diseases and MI diagnosis) among adults with a MI diagnosis in Puerto Rico.

Methods: This cross-sectional study includes data from 285 Puerto Rican adults (> 21 years) with a MI diagnosis receiving psychiatric or psychological treatment in a community healthcare facility between May 2017 to May 2020. Chi-square tests evaluated the associations between smoking and sociodemographic characteristics, chronic diseases and MI diagnosis. Multiple logistic regression explained the relationship between smoking, sociodemographic characteristics, and MI diagnosis.

Results: A total of 25.3% (n=72) of participants reported current smoking. Significant associations were found between smoking with sociodemographic characteristics and MI diagnosis among Puerto Ricans diagnosed with MI. The logistic regression model explained 18.9% of the variance in smoking and classified 76.1% of cases.

Conclusion: Results confirm high prevalence rates of current smoking and the potential impact on health among Puerto Ricans with MI diagnosis. Tailored treatments for smoking cessation for Puerto Ricans living with MI are needed.

目的:在波多黎各,每10名18至64岁的成年人中就有2人(18.7%)被诊断患有精神疾病(MI),如精神分裂症、双相情感障碍和重度抑郁症。诊断为心肌梗死的人报告患慢性疾病(如糖尿病、癌症、心脏病)和吸烟的频率高于一般人群。本研究探讨了波多黎各被诊断为心肌梗死的成年人中吸烟、社会人口学特征和健康史(即慢性病和心肌梗死诊断)之间的关系。方法:本横断面研究包括2017年5月至2020年5月期间在社区医疗机构接受精神或心理治疗的285名确诊为心肌梗死的波多黎各成年人(bb0 - 21岁)的数据。卡方检验评估吸烟与社会人口学特征、慢性疾病和心肌梗死诊断之间的关系。多元逻辑回归解释了吸烟、社会人口学特征和心肌梗死诊断之间的关系。结果:共有25.3% (n=72)的参与者报告目前吸烟。在诊断为心肌梗死的波多黎各人中,吸烟与社会人口学特征和心肌梗死诊断之间存在显著关联。logistic回归模型解释了18.9%的吸烟方差,并分类了76.1%的病例。结论:研究结果证实,在诊断为心肌梗死的波多黎各人中,目前吸烟的流行率很高,并可能对健康产生影响。需要为患有心肌梗死的波多黎各人提供量身定制的戒烟治疗。
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引用次数: 0
Association of 6-Minute Walk Test (6MWT) Data with Cardiopulmonary Factors in Hispanic Systemic Sclerosis Patients. 西班牙系统性硬化症患者6分钟步行试验(6MWT)数据与心肺因素的关联
Pub Date : 2025-06-01
Grissel Rios, Naydi Pérez-Ríos

Objective: Systemic Sclerosis (SSc) is an autoimmune disease with significant morbidity and mortality secondary to pulmonary manifestations. The six-minute walk test (6MWT) has been used in SSc studies to measure respiratory complications, particularly pulmonary hypertension. In this study, we evaluated whether the six-minute walk distance (6MWD), measured during the 6MWT, is associated with clinical SSc symptoms in Puerto Rican patients in a rheumatology clinic.

Methods: We prospectively collected 6MWT data for 37 consecutive SSc patients at the University of Puerto Rico every three months for one year between 2013 and 2015. A linear mixed regression model was used to investigate the effects of the SSc clinical features and subtypes on average 6MWD over time.

Results: The average baseline distance walked by SSc patients was 365.2 (± 8.1) meters, with no significant differences over time. No statistically significant differences (p>0.05) were found in the sixminute walk distance (6MWD) at different time intervals for SSc subtypes. Two clinical features, palpitations and lung crackles, were associated with a significantly shorter 6MWD(p<0.05).

Conclusion: Our study showed that the 6MWT can be used to evaluate SSc patients. No association was found between 6MWD and most clinical SSc symptoms in our population. Two clinical symptoms, lung crackles and palpitations, were associated with decreased 6MWD.

目的:系统性硬化症(SSc)是一种继发于肺部的自身免疫性疾病,发病率和死亡率很高。6分钟步行试验(6MWT)已在SSc研究中用于测量呼吸系统并发症,特别是肺动脉高压。在这项研究中,我们评估了在6分钟步行距离(6MWD)期间测量的6分钟步行距离(6MWD)是否与风湿病诊所波多黎各患者的临床SSc症状相关。方法:2013年至2015年,我们前瞻性地收集波多黎各大学37例连续SSc患者的6MWT数据,每三个月一次,持续一年。采用线性混合回归模型研究SSc临床特征和亚型对平均6MWD随时间的影响。结果:SSc患者的平均基线步行距离为365.2(±8.1)米,随时间变化无显著差异。SSc亚型不同时间间隔的6分钟步行距离(6MWD)差异无统计学意义(p < 0.05)。心悸和肺裂两个临床特征与6MWT明显缩短相关(结论:我们的研究表明6MWT可以用于评估SSc患者。在我们的人群中,没有发现6MWD与大多数SSc临床症状之间的关联。两种临床症状,肺噼啪声和心悸,与6MWD下降有关。
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引用次数: 0
Predicting Pneumoconiosis Risk in Coal Workers using Artificial Neural Networks. 应用人工神经网络预测煤矿工人尘肺发病风险。
Pub Date : 2025-06-01
Isil Zorlu, Mehmet Ali Kurcer

Objective: This study aimed to create a model to predict pneumoconiosis risk in coal workers using artificial neural networks (ANNs).

Methods: An ANN-based model was developed using the health records of a population of coal workers (all men). Input neurons comprised current age, year the worker began his employment, occupational category, the number of days spent working underground, the total days spent working, the duration of employment in working underground (i.e., in a so-called group 1 job), and smoking status. Output neurons comprised the states of having pneumoconiosis and being free of pneumoconiosis.

Results: The study found that an ANN model incorporating the variables age, the duration of employment in a group 1 job, the number of days spent working underground, year the worker began his employment, the total days spent working, smoking status, and occupational category can be used to estimate pneumoconiosis risk. The model's success rate was 95.3%; sensitivity was 90.3%, and specificity was 96.5%. The most influential input variable for pneumoconiosis was age, followed by the duration of employment in a group 1 job.

Conclusion: Predicting pneumoconiosis risk in coal workers provides great advantages for strategically monitoring miners and developing preventive health programs. Artificial neural network models should be developed, integrated into occupational medicine practice, and used to evaluate workers' health status.

目的:建立基于人工神经网络的煤矿工人尘肺发病风险预测模型。方法:利用煤矿工人(全部为男性)的健康记录建立基于人工神经网络的模型。输入神经元包括当前年龄、工人开始工作的年份、职业类别、在地下工作的日数、工作的总日数、在地下工作的受雇时间(即所谓的第一类工作)和吸烟状况。输出神经元包括有尘肺和无尘肺状态。结果:研究发现,结合年龄、第一类工作的工作年限、地下工作日数、工人开始工作的年份、总工作日数、吸烟状况和职业类别等变量的人工神经网络模型可以用来估计尘肺病的风险。模型的成功率为95.3%;敏感性为90.3%,特异性为96.5%。对尘肺病影响最大的输入变量是年龄,其次是在第一组工作的工作时间。结论:预测煤矿工人尘肺发病风险对有策略地监测和制定预防健康规划具有重要意义。应发展人工神经网络模型,并将其融入职业医学实践,用于评价劳动者的健康状况。
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引用次数: 0
Ischemia in the Splenium of the Corpus Callosum: A Rare Manifestation of Malaria. 胼胝体脾脏缺血:疟疾的一种罕见表现。
IF 0.3 Pub Date : 2025-03-01
Esra Soyer-Guldogan, Mustafa Cagan-Akay, Mutlucan Kurt, Murat Albas

Malaria is a parasitic disease common in many regions of the world. Cerebral malaria can cause cortical, cerebellar, and pontine infarctions. Although callosal ischemia (CI) due to diabetes mellitus, hypertension, hyperlipidemia and postoperative factors have been described in the literature, isolated CI due to malaria is very rare. We present a patient with isolated corpus callosum ischemia-an unusual complication of cerebral malaria-a case that we believe will contribute to the literature since the woman is 23 years old and has no comorbidities.

疟疾是世界许多地区常见的一种寄生虫病。脑疟疾可引起皮质、小脑和脑桥梗死。虽然文献中有关于由糖尿病、高血压、高脂血症和术后因素引起的胼胝体缺血(calloal ischemia, CI)的报道,但由疟疾引起的孤立的胼胝体缺血非常罕见。我们报告一位患有孤立性胼胝体缺血的患者,这是脑疟疾的一种不寻常的并发症,我们认为这一病例将有助于文献研究,因为该患者年龄23岁,没有合并症。
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引用次数: 0
The Effect of Foot Self-Massage on Peripheral Neuropathic Pain, Peripheral Skin Temperature and Patient Comfort in Individuals with Diabetes: A Randomized Controlled Trial. 足部自我按摩对糖尿病患者周围神经性疼痛、周围皮肤温度和患者舒适度的影响:一项随机对照试验。
Pub Date : 2025-03-01
Kadriye Sayin-Kasar, Guler Duru-Asiret

Objective: The aim of this study was to evaluate the effect of foot self massage on peripheral neuropathic pain, peripheral skin temperature and patient comfort in individuals with diabetes.

Methods: The sample of the study consisted of 52 individuals with type 2 diabetes (26 self foot massage group and 26 control group) between August 2021 and July 2022. Individuals in the foot self-massage group performed a foot massage for 30 minutes (15 minutes for each foot) three times a week for four weeks after training. Data were collected using an Individual Description Form, a Visual Analog Scale (VAS), the DN4 Pain Questionnaire and the General Comfort Scale-Short Form and peripheral skin temperature was measured. The data were evaluated using the Independent Sample-t test, Paired Sample-t test, Mann-Whitney U test, and Wilcoxon test. Continuity correction and Pearson-χ2 (chi-square) tests were used to compare categorical variables.

Results: In this study, it was found that foot self-massage did not affect the peripheral neuropathic pain level of the patients, but the mean pain (VAS) scores of the patients in the foot massage group significantly decreased compared to the patients in the control groups. In addition, it was found that foot self-massage did not affect patients' peripheral skin temperature and patient comfort.

Conclusion: It is recommended that foot massage, which can be applied by itself without time and place restrictions, be learned by patients and supported by health professionals because it is easy to apply, practical and economical.

研究目的本研究旨在评估足部自我按摩对糖尿病患者外周神经性疼痛、外周皮肤温度和患者舒适度的影响:研究样本由 2021 年 8 月至 2022 年 7 月期间的 52 名 2 型糖尿病患者组成(足部自我按摩组 26 人,对照组 26 人)。足部自我按摩组的患者在接受培训后的四周内,每周进行三次足部按摩,每次 30 分钟(每只脚 15 分钟)。使用个人描述表、视觉模拟量表(VAS)、DN4 疼痛问卷和一般舒适度量表-简表收集数据,并测量外周皮肤温度。采用独立样本 t 检验、配对样本 t 检验、曼-惠特尼 U 检验和威尔科克森检验对数据进行评估。连续性校正和 Pearson-χ2 (卡方)检验用于比较分类变量:研究发现,足部自我按摩并不影响患者的周围神经痛程度,但足部按摩组患者的平均疼痛(VAS)评分与对照组相比明显下降。此外,研究还发现足部自我按摩不会影响患者的外周皮肤温度和患者的舒适度:足部按摩不受时间和地点的限制,可自行进行,因其操作简便、实用、经济,建议患者学习并得到医护人员的支持。
{"title":"The Effect of Foot Self-Massage on Peripheral Neuropathic Pain, Peripheral Skin Temperature and Patient Comfort in Individuals with Diabetes: A Randomized Controlled Trial.","authors":"Kadriye Sayin-Kasar, Guler Duru-Asiret","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the effect of foot self massage on peripheral neuropathic pain, peripheral skin temperature and patient comfort in individuals with diabetes.</p><p><strong>Methods: </strong>The sample of the study consisted of 52 individuals with type 2 diabetes (26 self foot massage group and 26 control group) between August 2021 and July 2022. Individuals in the foot self-massage group performed a foot massage for 30 minutes (15 minutes for each foot) three times a week for four weeks after training. Data were collected using an Individual Description Form, a Visual Analog Scale (VAS), the DN4 Pain Questionnaire and the General Comfort Scale-Short Form and peripheral skin temperature was measured. The data were evaluated using the Independent Sample-t test, Paired Sample-t test, Mann-Whitney U test, and Wilcoxon test. Continuity correction and Pearson-χ2 (chi-square) tests were used to compare categorical variables.</p><p><strong>Results: </strong>In this study, it was found that foot self-massage did not affect the peripheral neuropathic pain level of the patients, but the mean pain (VAS) scores of the patients in the foot massage group significantly decreased compared to the patients in the control groups. In addition, it was found that foot self-massage did not affect patients' peripheral skin temperature and patient comfort.</p><p><strong>Conclusion: </strong>It is recommended that foot massage, which can be applied by itself without time and place restrictions, be learned by patients and supported by health professionals because it is easy to apply, practical and economical.</p>","PeriodicalId":94183,"journal":{"name":"Puerto Rico health sciences journal","volume":"44 1","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143757004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical Activity in Puerto Rico: Recommendations for Research, Surveillance, and Policy Development. 波多黎各的体育活动:研究、监测和政策制定的建议。
Pub Date : 2025-03-01
Raúl D Gierbolini-Rivera, Alexandre A De Paula da Silva, Milena F Silva, Ana L Favarão Leão, Farah A Ramirez-Marrero

Objective: The objectives of this report were to 1) describe the 2015 and 2020 physical activity (PA) Country Cards of Puerto Rico (PR), including data beyond the 2020 Country Card, and 2) propose recommendations for promoting PA research, surveillance, and policy development.

Methods: A comparison of the 2015 and 2020 data from the PR Country Cards provided by the Global Observatory for Physical Activity (GoPA!) was conducted. Country Card data were collected from the World Bank, the United Nations, PubMed, and the Behavioral Risk Factor Surveillance Survey (BRFSS). This ensured that data indicators were standardized for global comparability. Local representatives facilitated data collection through a collaborative review process with GoPA! Country Card data included demographic characteristics, mortality rates, PA prevalence, surveillance data, policy, and research indicators.

Results: In 2015, the BRFSS data indicated a PA prevalence of 34% in PR, decreasing to 20% in 2020. No data on inactivity-related mortality or a national standalone plan focused on PA was available. From 2015 to 2020, research output in PR increased slightly, improving its global ranking from the 61st to the 58th position.

Conclusion: The PR Country Card is a tool to raise awareness and identify surveillance, research, and policy gaps. Recommendations include establishing a dedicated PR health monitoring system, integrating PA into PR national public health plans, and establishing an interinstitutional coalition for PA research (in PR). Multi-sector efforts from policymakers, researchers, and stakeholders are essential for meaningful progress in improving PA levels and public health in PR.

目的:本报告的目的是:1)描述波多黎各(PR) 2015年和2020年体育活动(PA)国家卡,包括2020年国家卡以外的数据;2)提出促进体育活动研究、监测和政策制定的建议。方法:对全球体育活动观测站(GoPA!)提供的2015年和2020年PR国家卡数据进行比较。国家卡数据收集自世界银行、联合国、PubMed和行为风险因素监测调查(BRFSS)。这确保了数据指标的标准化,以供全球比较。当地代表通过与GoPA的合作审查过程促进了数据收集!国家卡数据包括人口特征、死亡率、PA患病率、监测数据、政策和研究指标。结果:2015年,BRFSS数据显示PR中PA患病率为34%,2020年降至20%。没有关于不活动相关死亡率的数据,也没有专门针对PA的国家独立计划。从2015年到2020年,公关研究产出略有增长,全球排名从第61位上升到第58位。结论:公共关系国别卡是提高认识和确定监测、研究和政策差距的工具。建议包括建立一个专门的公关健康监测系统,将公关纳入公关国家公共卫生计划,以及建立一个机构间的公关研究联盟(在公关领域)。决策者、研究人员和利益攸关方的多部门努力对于在提高公共卫生水平和公共卫生方面取得有意义的进展至关重要。
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引用次数: 0
Impact of the Pandemic on Food Security on Households with Children with Special Health Care Needs in Puerto Rico: A Survey Study. 大流行病对波多黎各有特殊保健需要的儿童家庭粮食安全的影响:一项调查研究。
Pub Date : 2025-03-01
Ana L Mulero-Portela, Carmen L Colón-Santaella, Winna Rivera

Objective: This study examined how the COVID-19 pandemic contributed to food insecurity in households in Puerto Rico with children with disabilities, compared to households with children without disabilities.

Methods: The present study used a 2-group, cross-sectional design. Participants were interviewed once to describe experiences of food insecurity during the 12 months before the COVID-19 pandemic and again during the pandemic lockdown. In addition, demographic characteristics and mental and physical health were assessed.

Results: Before the COVID-19 pandemic, food insecurity in Puerto Rico was significantly higher in households with children with disabilities (n = 48) than in households with children without disabilities (n = 49) (P < .001). During the COVID-19 pandemic, this difference remained (P = .029). Food insecurity was higher before the pandemic among children in households with children with disabilities (odds ratio [OR]: 3.62; 95% CI:1.19-11.05), and in households overall (OR: 4.72; 95% CI: 1.83 12.14), when assessing adults and children in the same household. This was also true during the pandemic for households overall (OR: 2.54; 95% CI: 1.09-5.96), but to a lesser degree. Food insecurity was not statistically significant in children during the pandemic (OR: 2.56; 95% CI: 0.97-6.74). In both types of households, physical and mental health scores were more than 1 standard deviation below the United States mean.

Conclusion: Both types of households experienced food insecurity during the pandemic. No relationship between food insecurity, disability, and health status was observed in the study sample. All the participants reported low physical and mental health.

目的:本研究考察了与无残疾儿童家庭相比,2019冠状病毒病大流行如何导致波多黎各有残疾儿童家庭的粮食不安全。方法:本研究采用两组横断面设计。参与者接受了一次采访,描述了在2019冠状病毒病大流行之前的12个月和在大流行封锁期间的粮食不安全经历。此外,还对人口特征和身心健康进行了评估。结果:在2019冠状病毒病大流行之前,波多黎各有残疾儿童的家庭(n = 48)的粮食不安全状况显著高于有无残疾儿童的家庭(n = 49) (P < .001)。在COVID-19大流行期间,这一差异仍然存在(P = 0.029)。大流行前,有残疾儿童的家庭中儿童的粮食不安全状况更高(优势比[OR]: 3.62;95% CI:1.19-11.05),以及家庭整体(OR: 4.72;95% CI: 1.83 12.14),当评估同一家庭中的成人和儿童时。在大流行期间,总体家庭也是如此(OR: 2.54;95% CI: 1.09-5.96),但程度较轻。大流行期间儿童的粮食不安全没有统计学意义(OR: 2.56;95% ci: 0.97-6.74)。在这两种类型的家庭中,身体和心理健康得分比美国平均水平低1个标准差以上。结论:这两类家庭在疫情期间都经历了粮食不安全。在研究样本中没有观察到食品不安全、残疾和健康状况之间的关系。所有的参与者都报告身体和心理健康状况不佳。
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引用次数: 0
Long-Term Outcomes of Short versus Long Dental Implants with Sinus Lift in Atrophied Posterior Maxillae: A Systematic Review and Meta-Analysis. 后上颌萎缩的短牙种植体与长牙种植体鼻窦提升的远期疗效:一项系统综述和荟萃分析。
IF 0.3 Pub Date : 2025-03-01
Brayann O Alemán, Irelsy Rivera-Velazquez, Zareth Jana-Hernández, Sona Rivas-Tumanyan, Lidia M Guerrero-Rodríguez, Augusto R Elias-Boneta

This study aimed to evaluate implant outcomes, including success or survival, complications, and marginal bone loss (MBL), in randomized controlled trials (RCTs), comparing short versus long implants with sinus augmentation (SA) after 5 or more years of loading. The objective was to update the qualitative and quantitative evidence on this topic and provide a comprehensive analysis of the previously identified implant outcomes. Electronic searches were conducted in 4 scientific databases from 2016 through 2024. Only RCTs with a minimum follow-up period of 5 years were included (7 studies); these were rated using the revised Cochrane risk-of-bias (RoB 2) tool for main outcomes. The overall risk of bias was "High" in 5 studies, whereas 2 studies were rated as "Some concerns." The risk ratio (RR) and 95% confidence interval (CI) were calculated with Stata software, version 18, for implant success and survival (2.37; 95% CI: 0.83-6.78, P = .11) and for implant complications (0.88; 95% CI: 0.64-1.21, P = .43). The Cohen's d for MBL was -0.41 mm (95% CI: -0.72 to -0.09, P = .01). There was no statistically significant difference in implant success and survival between short and long implants with SA (P = .60). Due to the overall high risk of bias, no definitive conclusions can be drawn regarding the success or survival of short versus long implants. Further RCTs with clear descriptions of implant outcomes, rigorous standardization and calibration protocols, meticulous sample-size calculation, and extended follow-up periods are needed.

本研究旨在评估种植体的结果,包括成功或存活、并发症和边缘骨质流失(MBL),在随机对照试验(rct)中,比较短种植体和长种植体与窦性增强(SA)在5年或更长时间的负荷。目的是更新这一主题的定性和定量证据,并对先前确定的种植结果进行全面分析。从2016年到2024年,在4个科学数据库中进行了电子检索。仅纳入最低随访期为5年的rct(7项研究);使用修订后的Cochrane风险偏倚(RoB 2)工具对主要结果进行评分。5项研究的总体偏倚风险为“高”,而2项研究被评为“一些关注”。使用Stata软件,版本18计算植入成功和生存的风险比(RR)和95%置信区间(CI) (2.37;95% CI: 0.83-6.78, P = 0.11)和种植体并发症(0.88;95% ci: 0.64-1.21, p = 0.43)。MBL的Cohen’s d为-0.41 mm (95% CI: -0.72 ~ -0.09, P = 0.01)。SA短种植体和长种植体的种植成功率和生存期差异无统计学意义(P = 0.60)。由于整体偏倚风险较高,对于短植入物与长植入物的成功或存活,没有明确的结论。进一步的随机对照试验需要明确描述种植体结果、严格的标准化和校准方案、细致的样本量计算和延长的随访期。
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引用次数: 0
Associations between Tumor Ploidy and Overall Survival in Pediatric Neuroblastoma. 儿童神经母细胞瘤肿瘤倍性与总生存率的关系。
IF 0.3 Pub Date : 2025-03-01
Tyrel R Porter, Emir Rinaldi-Pérez, Marcel Grau-Rodríguez, Lilia Y Kucheryavykh

Objective: To investigate the relationships between pediatric neuroblastoma outcomes, tumor ploidy, and ethnicity, focusing on disparities in overall survival (OS) while also accounting for race and ethnicity.

Methods: Clinical and tumor ploidy data for 63 Hispanic White, 561 non-Hispanic White, and 86 non-Hispanic Black patients were obtained from cBioPortal for Cancer Genomics (TARGET [Therapeutically Applicable Research to Generate Effective Treatments], 2018). Kaplan Meier survival curves were analyzed using log-rank and Gehan-Breslow Wilcoxon tests. Hazard ratios (HR) with 95% CIs were calculated using the Mantel-Haenszel method. Associations between ethnicity and tumor ploidy were assessed using the chi-square test.

Results: Significant differences in overall survival (OS) were observed between White patients who self-identified as Hispanic and those who identified as non Hispanic, with Hispanic patients exhibiting worse outcomes. (P = .0076, HR = 1.907, 95% CI: 1.187-3.062). Median survival for Hispanic patients was 94 months but was undefined for non-Hispanic patients. Diploid tumors were associated with worse outcomes than hyperdiploid tumors were (P < .0001, HR = 2.291, 95% CI: 1.689-3.109). The chi square test revealed a significant association between ethnicity and tumor ploidy (χ2 = 4.220, P = .0400), with non-Hispanic patients having a higher proportion of hyperdiploid tumors (66.99%) than Hispanic patients (53.97%).

Conclusion: Hispanic White patients with neuroblastoma had lower OS than did non-Hispanic White patients, partly due to the former having a higher proportion of diploid tumors. These findings highlight the importance of considering ethnicity and tumor ploidy in risk stratification and treatment strategies.

目的:探讨小儿神经母细胞瘤预后、肿瘤倍性和种族之间的关系,重点关注总生存期(OS)的差异,同时考虑种族和民族因素。方法:从cBioPortal for Cancer Genomics (TARGET [Therapeutically applied Research to Generate Effective therapies], 2018)获取63名西班牙裔白人、561名非西班牙裔白人和86名非西班牙裔黑人患者的临床和肿瘤倍体数据。Kaplan Meier生存曲线分析采用log-rank检验和Gehan-Breslow Wilcoxon检验。采用Mantel-Haenszel方法计算95% ci的风险比(HR)。使用卡方检验评估种族与肿瘤倍性之间的关系。结果:在自认为是西班牙裔的白人患者和自认为是非西班牙裔的白人患者之间观察到总生存期(OS)的显著差异,其中西班牙裔患者表现出更差的预后。(p = 0.0076, hr = 1.907, 95% ci: 1.187-3.062)。西班牙裔患者的中位生存期为94个月,但非西班牙裔患者的中位生存期不确定。二倍体肿瘤的预后比超二倍体肿瘤差(P < 0.0001, HR = 2.291, 95% CI: 1.689-3.109)。卡方检验显示,种族与肿瘤倍性之间存在显著相关性(χ2 = 4.220, P = 0.0400),非西班牙裔患者患超二倍体肿瘤的比例(66.99%)高于西班牙裔患者(53.97%)。结论:西班牙裔白人神经母细胞瘤患者的OS低于非西班牙裔白人患者,部分原因是前者具有更高比例的二倍体肿瘤。这些发现强调了在风险分层和治疗策略中考虑种族和肿瘤倍性的重要性。
{"title":"Associations between Tumor Ploidy and Overall Survival in Pediatric Neuroblastoma.","authors":"Tyrel R Porter, Emir Rinaldi-Pérez, Marcel Grau-Rodríguez, Lilia Y Kucheryavykh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationships between pediatric neuroblastoma outcomes, tumor ploidy, and ethnicity, focusing on disparities in overall survival (OS) while also accounting for race and ethnicity.</p><p><strong>Methods: </strong>Clinical and tumor ploidy data for 63 Hispanic White, 561 non-Hispanic White, and 86 non-Hispanic Black patients were obtained from cBioPortal for Cancer Genomics (TARGET [Therapeutically Applicable Research to Generate Effective Treatments], 2018). Kaplan Meier survival curves were analyzed using log-rank and Gehan-Breslow Wilcoxon tests. Hazard ratios (HR) with 95% CIs were calculated using the Mantel-Haenszel method. Associations between ethnicity and tumor ploidy were assessed using the chi-square test.</p><p><strong>Results: </strong>Significant differences in overall survival (OS) were observed between White patients who self-identified as Hispanic and those who identified as non Hispanic, with Hispanic patients exhibiting worse outcomes. (P = .0076, HR = 1.907, 95% CI: 1.187-3.062). Median survival for Hispanic patients was 94 months but was undefined for non-Hispanic patients. Diploid tumors were associated with worse outcomes than hyperdiploid tumors were (P < .0001, HR = 2.291, 95% CI: 1.689-3.109). The chi square test revealed a significant association between ethnicity and tumor ploidy (χ2 = 4.220, P = .0400), with non-Hispanic patients having a higher proportion of hyperdiploid tumors (66.99%) than Hispanic patients (53.97%).</p><p><strong>Conclusion: </strong>Hispanic White patients with neuroblastoma had lower OS than did non-Hispanic White patients, partly due to the former having a higher proportion of diploid tumors. These findings highlight the importance of considering ethnicity and tumor ploidy in risk stratification and treatment strategies.</p>","PeriodicalId":94183,"journal":{"name":"Puerto Rico health sciences journal","volume":"44 1","pages":"69-73"},"PeriodicalIF":0.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12558111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Puerto Rico health sciences journal
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