Reumatologia clinica最新文献_第10页

Situational analysis of interventional rheumatology in Spain: Multicenter observational study 西班牙介入风湿病的情境分析：多中心观察性研究

Reumatologia clinica

Pub Date : 2025-03-01 Epub Date: 2025-04-21 DOI: 10.1016/j.reumae.2025.501850

Marco Aurelio Ramírez Huaranga , Juan Carlos Quevedo Abeledo , Julio Sánchez Martin , Álvaro García Martos , Angel Estuardo Plasencia Ezaine , David Castro Corredor , Vanesa Hernández Hernández , Yanira Pérez Vera , Enrique Ornilla Laraundogoitia , Rocío Arenal Lopez , Félix Manuel Francisco Hernández , Cristina Zamora Ramos , Paz Collado Ramos , Fernando Felipe Poma Vera , Javier Seoane Romero , Tamara Libertad Rodríguez Araya , on behalf of the INTERVSER Working Group

Introduction

Interventional procedures are highly useful and applicable in Rheumatology for degenerative and inflammatory diseases such a therapeutic alternative available for our patients.

Objective

To describe the current clinical characteristics of interventional procedures in Rheumatology departments in our country and to identify the training needs in this area.

Materials and methods

This is a multicenter, observational, descriptive, and cross-sectional study conducted through a survey sent to all heads of Rheumatology departments/sections across the national territory, registered with the Spanish Society of Rheumatology.

Results

A total of 38 appropriately completed and valid surveys were received for analysis (56% of those sent). 94.7% of the departments have one or more ultrasound machines, and 60.53% have a designated physical space specifically for performing procedures. 97.73% perform joint injections, 31.58% perform sacroiliac joint injections, 21.05% perform lumbar facet injections, 15.79% perform myofascial injections, 13.16% perform epidural injections, and only 5.26% have access to radiofrequency therapy. Other procedures described were synovial biopsy (15.79%), salivary gland biopsy (10.53%), and isotopic synoviorthesis (7.89%). In 89.47% of the departments, the procedures are part of the rheumatology activities services, and 73.68% have nursing/auxiliary nursing support. Finally, 81.6% agree that there is insufficient specific training in performing more complex procedures.

Conclusion

The 21st-century rheumatologist must also be trained in performing interventional procedures for the treatment of mechanical and/or inflammatory pain, with the aim of incorporating them into their daily clinical practice and continuing to expand the range of care we can offer our patients.

介入性手术在风湿病退行性和炎症性疾病中非常有用和适用，是我们患者的治疗选择。目的描述目前我国风湿病科介入手术的临床特点，确定该领域的培训需求。材料和方法这是一项多中心、观察性、描述性和横断面研究，通过向西班牙风湿病学会注册的全国所有风湿病部门/部门负责人发送调查进行。结果共收到38份正确填写并有效的问卷用于分析，占发送问卷的56%。94.7%的科室拥有一台或多台超声机，60.53%的科室拥有专门用于执行手术的物理空间。97.73%接受关节注射，31.58%接受骶髂关节注射，21.05%接受腰椎关节突注射，15.79%接受肌筋膜注射，13.16%接受硬膜外注射，仅有5.26%接受射频治疗。其他手术包括滑膜活检（15.79%）、唾液腺活检（10.53%）和同位素滑膜穿刺（7.89%）。在89.47%的科室中，该程序是风湿病活动服务的一部分，73.68%的科室有护理/辅助护理支持。最后，81.6%的人认为在执行更复杂的程序方面缺乏专门的培训。21世纪的风湿病学家还必须接受介入治疗机械性和/或炎症性疼痛的培训，目的是将其纳入日常临床实践，并继续扩大我们可以为患者提供的护理范围。

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引用次数: 0

Right ventriculoarterial coupling as a marker of subclinical myocardial damage in rheumatoid arthritis 右心室-动脉偶联是类风湿关节炎亚临床心肌损害的标志

Reumatologia clinica

Pub Date : 2025-03-01 Epub Date: 2025-04-21 DOI: 10.1016/j.reumae.2025.501841

Tomás Miranda-Aquino , Diego Alejandro Ramos-Aguas , Silvia Esmeralda Pérez-Topete , María del Socorro Cepeda-Rocha , Xochitl Citlalli Gómez-Gómez , Daniel Ochoa-Castillo , Sergio Cerpa-Cruz , Verónica González-Díaz , Christian González-Padilla , Jorge Eduardo Hernández-del Río

Background

Right ventriculoarterial coupling (RVAC) is altered early before presenting right ventricular dysfunction and pulmonary hypertension, its measurement in patients with RA has been barely studied.

Objectives

To determine if there is a difference in right ventricular arterial coupling (RVAC) in patients with RA. Analyze if there are differences in patients with normal vs abnormal right RVAC. To investigate if there is an association in patients with RA to present abnormal RVAC.

Methods

A single-center, analytical, cross-sectional, observational study was performed. Patients with a diagnosis of RA were included according to the ACR/EULAR 2010 classification criteria, without any other comorbidity, the echocardiograms were made at the Hospital Civil de Guadalajara “Fray Antonio Alcalde”. An ACUSON SC 2000 echocardiogram was used. Patients were compared with healthy controls matched by age and gender. The clinical, laboratory and echocardiographic variables were contrasted. The RVAC was determined with the right ventricular free wall longitudinal strain (RVFWLS) / pulmonary artery systolic pressure (PSAP) ratio.

Results

Fifty one patients were included in each group. Among the echocardiographic variables, it was found that patients with RA had a greater right ventricular diastolic area and the PASP; while the RV FAC, the RVFWLS and the RVAC were lower. RA was independently associated to an abnormal RVAC.

Conclusion

The right ventricular subclinical myocardial damage, determined by the RVAC, is present in patients with rheumatoid arthritis, and it was associated with an abnormal ventriculoarterial coupling.

背景右心室动脉偶联（RVAC）在出现右心室功能障碍和肺动脉高压之前就已经改变，但在RA患者中RVAC的测量研究很少。目的探讨RA患者右心室动脉偶联（RVAC）是否存在差异。分析右RVAC正常与异常患者是否有差异。目的：探讨RA患者是否与RVAC异常有关。方法采用单中心、分析、横断面、观察性研究。根据ACR/EULAR 2010分类标准纳入诊断为RA的患者，无任何其他合并症，超声心动图在瓜达拉哈拉民间医院“Fray Antonio Alcalde”进行。使用ACUSON SC 2000超声心动图。将患者与按年龄和性别匹配的健康对照组进行比较。对比临床、实验室和超声心动图指标。采用右心室自由壁纵向应变(RVFWLS) /肺动脉收缩压（PSAP）比值测定RVAC。结果每组共纳入51例患者。超声心动图变量中，RA患者右心室舒张面积和PASP较大；rvfac、RVFWLS和RVAC均较低。RA与RVAC异常独立相关。结论类风湿关节炎患者存在由RVAC确定的右心室亚临床心肌损害，并与心室-动脉偶联异常有关。

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引用次数: 0

Giant cell tumor of the tendon sheaths 腱鞘巨细胞瘤

Reumatologia clinica

Pub Date : 2025-03-01 Epub Date: 2025-04-21 DOI: 10.1016/j.reumae.2025.501844

Carmen Raya-Santos , José Antonio Bernal , José Rosas , María Cabezas Macían

引用次数: 0

Effect of Plasminogen Activator Inhibitor-1 on extracellular matrix homeostasis in scaffold-free spheroids from human chondrocytes 纤溶酶原激活物抑制剂-1对人软骨细胞无支架球体细胞外基质稳态的影响

Reumatologia clinica

Pub Date : 2025-03-01 Epub Date: 2025-04-30 DOI: 10.1016/j.reumae.2025.501815

Carlos Suarez-Ahedo , Carlos Martinez-Armenta , Laura E. Martínez-Gómez , Oswaldo González-Mendoza , María de Jesús Hernández Rocha , Gabriela A. Martínez-Nava , Carlos Pineda , Alberto López-Reyes

Introduction

New trends in osteoarthritis research focus on the use of biological therapy; in this context, the use of Plasminogen Activator Inhibitor-1 (PAI-1) is considered a potential therapeutic strategy to prevent extracellular matrix (ECM) degradation in osteoarthritis (OA) management. However, in vitro studies have not demonstrated its effect on the expression of ECM homeostasis-related genes.

Methods

Human OA cartilage-derived chondrocytes were used to generate scaffold-free spheroids under hypoxia conditions. The spheroids were exposed to PAI-1 for 24 h, and cell viability was measured. Then qRT-PCR was used to analyze the expression of ECM components and degradative enzymes, including COL2A1, SOX9, ACAN, COL1A1, MMP3, MMP9, MMP13, ADAMTS4, ADAMTS5, TIMP1, TIMP2, TIMP3, uPA and tPA.

Results

PAI-1 treatment consistently maintained cell viability and chondrocyte spheroid integrity. At the 50 ng/mL concentration, PAI-1 increased the gene expression of COL2A1 and reduced SOX9, ACAN, MMP3, MMP9, TIMP2, and tPA. Moreover, the functional COL2A1/COL1A1 ratio was significantly increased in PAI-1-treated spheroids.

Conclusion

Our results suggest that PAI-1 treatment exerts a complex and multifaceted influence on spheroids’ ECM. While it supports matrix integrity by reducing the gene expression of ECM remodeling enzymes, such as MMPs and ADAMTS5, it also induces unfavorable changes in chondrogenesis-related marker genes, such as SOX9 and ACAN. These findings indicate that the cellular response to PAI-1 is not unidirectional, warranting further investigation to understand its precise biological implications.

骨关节炎研究的新趋势是生物疗法的应用；在这种情况下，使用纤溶酶原激活物抑制剂-1 （PAI-1）被认为是防止骨关节炎（OA）治疗中细胞外基质（ECM）降解的潜在治疗策略。然而，体外研究尚未证实其对ECM稳态相关基因表达的影响。方法利用人OA软骨源性软骨细胞在缺氧条件下生成无支架球体。将球体暴露于PAI-1 24 h，测定细胞活力。然后用qRT-PCR分析ECM组分和降解酶COL2A1、SOX9、ACAN、COL1A1、MMP3、MMP9、MMP13、ADAMTS4、ADAMTS5、TIMP1、TIMP2、TIMP3、uPA和tPA的表达情况。结果spai -1治疗可持续维持细胞活力和软骨细胞球体完整性。在50 ng/mL浓度下，PAI-1增加COL2A1基因的表达，降低SOX9、ACAN、MMP3、MMP9、TIMP2和tPA的表达。此外，在pai -1处理的球体中，COL2A1/COL1A1的功能比值显著增加。结论PAI-1治疗对球体的ECM具有复杂和多方面的影响。虽然它通过降低ECM重塑酶（如MMPs和ADAMTS5）的基因表达来支持基质完整性，但它也会诱导软骨形成相关标记基因（如SOX9和ACAN）的不利变化。这些发现表明，细胞对PAI-1的反应不是单向的，需要进一步研究以了解其确切的生物学意义。

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引用次数: 0

Rare C1q deficiency presenting as pediatric SLE: A case study of two consanguineous siblings 罕见的C1q缺乏表现为小儿SLE：两个近亲兄弟姐妹的病例研究

Reumatologia clinica

Pub Date : 2025-03-01 Epub Date: 2025-04-30 DOI: 10.1016/j.reumae.2025.501843

Kerem Parlar , Berkay Aktaş , Sena Ladin Sicakyüz , Sezgin Şahin , Özgür Kasapçopur , Serdal Uğurlu

C1q deficiency is a rare autosomal recessive genetic condition characterized by mutations in genes C1qA, C1qB, or C1qC which can cause a SLE-like disease. Here, we report the cases of two siblings with C1q deficiency, both of whom had homozygous mutations in the C1QA gene. Both of our patients had NP involvement, and the brother had chilblain lesions. Diagnosis of C1q deficiency was delayed, highlighting the importance of clinical suspicion and genetic testing. This is especially crucial in cases with atypical presentations of SLE and a family history of consanguinity.

C1q缺乏症是一种罕见的常染色体隐性遗传病，其特征是基因C1qA、C1qB或C1qC突变，可导致sle样疾病。在这里，我们报告了两个患有C1q缺乏症的兄弟姐妹，他们都有C1QA基因的纯合突变。我们的两个病人都有NP受累，兄弟有冻疮病变。C1q缺乏症的诊断被推迟，凸显了临床怀疑和基因检测的重要性。这在SLE的非典型表现和有家族血缘史的病例中尤为重要。

引用次数: 0

Safety of biologic and synthetic targeted therapies in patients with immune-mediated diseases: data from the BIOBADAGUAY registry 免疫介导性疾病患者生物和合成靶向治疗的安全性：来自BIOBADAGUAY注册的数据

Reumatologia clinica

Pub Date : 2025-02-01 Epub Date: 2025-02-24 DOI: 10.1016/j.reumae.2025.101798

Paloma de Abreu , Sonia Cabrera , Darwin Cordovilla , Lourdes Román , Cristina Brunengo , Patricia Melgarejo , Macarena Soto , Vannia Valinotti , Angelica Amarilla , Belem Acevedo , Alexis Pineda , Evelyn Leiva , Paola Pusineri , Sandra Consani , Mariela Zarza , Clyde Parodi , Zoilo Morel , Roger Rolón , Paola Jara , Raquel Aranda , Rosario Jurado

Objective

To analyze the safety of biologic (DMARDs-b) and synthetic targeted therapies (DMARDs-sd) in the BIOBADAGUAY registry (Paraguayan-Uruguayan registry of adverse events (AEs) in patients with inflammatory rheumatic diseases).

Methods

BIOBADAGUAY is a registry to prospectively evaluate the efficacy and safety of FAME-b and FAME-sd. The full methodology is available at https://biobadaguay.ser.es. Variables associated with the safety of the therapies were used for the present study. The incidence of AA was calculated as incidence rate (IR) per 1000 patient-years, with 95% confidence intervals (CI) and Poisson regression for the incidence rate ratio (IRR).

Results

1104 patients (73.3% female) with 1366 AA, predominantly mild (87.2%), were analyzed. The overall incidence of AEs was 251.75 per 1000 patient-years. Infections were the most frequent (55.0%), with an incidence of 138.4 per 1000 patient-years. Rheumatoid arthritis and corticosteroid use were associated with more global AEs, while anti-TNF was associated with less AEs.

Conclusions

This study from the BIOBADAGUAY registry has provided valuable data on the safety of DMARD-b, sd in a cohort of patients with inflammatory rheumatic diseases. The incidence of predominantly mild AEs, with infections as the most frequent adverse event, underscores the need for rigorous and constant monitoring in this population.

目的：分析生物（DMARDs-b）和合成靶向治疗（DMARDs-sd）在BIOBADAGUAY登记（巴拉圭-乌拉圭不良事件登记（ae）在炎症性风湿病患者中的安全性）。方法：BIOBADAGUAY是一个前瞻性评价FAME-b和FAME-sd的疗效和安全性的注册表。完整的方法可在https://biobadaguay.ser.es上找到。本研究使用了与治疗安全性相关的变量。AA的发病率以每1000患者年的发病率（IR）计算，发病率比（IRR）采用95%置信区间（CI）和泊松回归。结果：共分析1104例AA患者（女性73.3%），1366例，以轻度为主（87.2%）。ae的总发生率为251.75 / 1000患者年。感染是最常见的（55.0%），发病率为138.4 / 1000患者年。类风湿关节炎和皮质类固醇的使用与更多的整体不良事件相关，而抗tnf与更少的不良事件相关。结论：这项来自BIOBADAGUAY注册的研究为炎症性风湿病患者队列中的DMARD-b， sd的安全性提供了有价值的数据。以感染为最常见不良事件的轻微不良事件发生率占主导地位，强调了对这一人群进行严格和持续监测的必要性。

{"title":"Safety of biologic and synthetic targeted therapies in patients with immune-mediated diseases: data from the BIOBADAGUAY registry","authors":"Paloma de Abreu , Sonia Cabrera , Darwin Cordovilla , Lourdes Román , Cristina Brunengo , Patricia Melgarejo , Macarena Soto , Vannia Valinotti , Angelica Amarilla , Belem Acevedo , Alexis Pineda , Evelyn Leiva , Paola Pusineri , Sandra Consani , Mariela Zarza , Clyde Parodi , Zoilo Morel , Roger Rolón , Paola Jara , Raquel Aranda , Rosario Jurado","doi":"10.1016/j.reumae.2025.101798","DOIUrl":"10.1016/j.reumae.2025.101798","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the safety of biologic (DMARDs-b) and synthetic targeted therapies (DMARDs-sd) in the BIOBADAGUAY registry (Paraguayan-Uruguayan registry of adverse events (AEs) in patients with inflammatory rheumatic diseases).</div></div><div><h3>Methods</h3><div>BIOBADAGUAY is a registry to prospectively evaluate the efficacy and safety of FAME-b and FAME-sd. The full methodology is available at <span><span>https://biobadaguay.ser.es</span><svg><path></path></svg></span>. Variables associated with the safety of the therapies were used for the present study. The incidence of AA was calculated as incidence rate (IR) per 1000 patient-years, with 95% confidence intervals (CI) and Poisson regression for the incidence rate ratio (IRR).</div></div><div><h3>Results</h3><div>1104 patients (73.3% female) with 1366 AA, predominantly mild (87.2%), were analyzed. The overall incidence of AEs was 251.75 per 1000 patient-years. Infections were the most frequent (55.0%), with an incidence of 138.4 per 1000 patient-years. Rheumatoid arthritis and corticosteroid use were associated with more global AEs, while anti-TNF was associated with less AEs.</div></div><div><h3>Conclusions</h3><div>This study from the BIOBADAGUAY registry has provided valuable data on the safety of DMARD-b, sd in a cohort of patients with inflammatory rheumatic diseases. The incidence of predominantly mild AEs, with infections as the most frequent adverse event, underscores the need for rigorous and constant monitoring in this population.</div></div>","PeriodicalId":94193,"journal":{"name":"Reumatologia clinica","volume":"21 2","pages":"Article 101798"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the psychometric properties of the Functional Ability Scale in children with juvenile idiopathic arthritis 青少年特发性关节炎患儿功能能力量表心理测量特征的评价

Reumatologia clinica

Pub Date : 2025-02-01 Epub Date: 2025-03-08 DOI: 10.1016/j.reumae.2025.101802

Juan Pablo Ford , Enrique Roberto Soriano , Mauro Andreu

Background and objective

Juvenile idiopathic arthritis (JIA) has a generalized impact on physical function, thus functional capacity (FC) is one of the main outcome measures in this population. FC can be evaluated using self-referential questionnaires and with observational tests such as the Functional Ability Scale (CAPFUN). The psychometric properties of this scale have not been tested yet.

The objective of this study to evaluate the psychometric properties of the CAPFUN in children with JIA according to Consensus-based Standards for the selection of health Measurements Instruments (COSMIN).

Material and methods

Psychometric properties measurement study. Children were admitted between January 2018 and November 2019. Inclusion criteria: age between 6 and 16 years, diagnosis of JIA, complete physical therapy evaluation, including: CAPFUN scale, Childhood Health Assessment Questionnaire (C-HAQ), Visual Numerical Scale of patient's self-perceived Functional Capacity (VNSFC), Global Rating of Change (GROC) scale and Steinbrocker Scale. Subjects who discontinued follow-up were excluded. The psychometric properties evaluated were: reliability, construct validity, responsiveness, and interpretability.

Results

A total of 114 children were analyzed. The internal consistency was acceptable, as indicated by a Cronbach alpha of 0.93. Test–retest reliability showed a high level of consistency with an intraclass correlation coefficient of 0.999 (95% CI: 0.998–0.999). Regarding structural validity, the exploratory factor analysis yielded acceptable results, demonstrating the reliability of the instrument. All correlation coefficients were strong and all predetermined hypotheses were verified. The minimal clinically important difference was 0.04. [AUC 0.90 (95% CI: 0.83–0.91)].

Conclusions

The evaluations of the psychometric properties of the CAPFUN were satisfactory, demonstrating acceptable values for reliability, construct validity, responsiveness, and interpretability. Based on these results, this tool can effectively assess FC in children with JIA, both in clinical practice and research contexts.

背景与目的青少年特发性关节炎（JIA）对身体功能有广泛的影响，因此功能容量（FC）是该人群的主要预后指标之一。FC可以通过自我参照问卷和功能能力量表（CAPFUN）等观察性测试来评估。这个量表的心理测量特性还没有经过测试。本研究的目的是根据基于共识的健康测量工具选择标准（COSMIN）评估JIA儿童CAPFUN的心理测量特性。材料与方法：对称性能测量研究。这些儿童在2018年1月至2019年11月期间被录取。纳入标准：年龄6 - 16岁，JIA诊断，完整的物理治疗评估，包括：CAPFUN量表、儿童健康评估问卷（C-HAQ）、患者自我感知功能能力视觉数值量表（VNSFC）、全球变化评定量表（GROC）和Steinbrocker量表。停止随访的受试者被排除在外。评估的心理测量特性包括：信度、构念效度、反应性和可解释性。结果共对114例患儿进行分析。内部一致性是可以接受的，Cronbach alpha为0.93。重测信度一致性高，类内相关系数为0.999 （95% CI: 0.998-0.999）。在结构效度方面，探索性因子分析产生了可接受的结果，证明了该工具的可靠性。所有的相关系数都很强，所有预定的假设都得到了验证。最小临床重要差异为0.04。[auc 0.90 (95% ci: 0.83-0.91)]。结论对CAPFUN的心理测量特性的评价是令人满意的，在信度、构念效度、反应性和可解释性方面表现出可接受的值。基于这些结果，无论在临床实践还是研究背景下，该工具都可以有效评估JIA患儿的FC。

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引用次数: 0

Rheumatological diseases in patients with autoimmune hepatitis in a fourth level hospital in Bogotá between 2013 and 2023 2013年至2023年波哥大一家四级医院<e:1>自身免疫性肝炎患者的风湿病

Reumatologia clinica

Pub Date : 2025-02-01 Epub Date: 2025-02-24 DOI: 10.1016/j.reumae.2025.501812

Juan Sebastián Almánzar Cortés , Cathalina Vergara Cabra , María Paula Uchima-Vera , Gerardo Quintana , Fernando Sierra

Introduction

Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease with low prevalence worldwide. The coexistence of this entity with rheumatic diseases has been evaluated in multiple studies and is highly variable. The objective of this study is to identify the frequency of coexistence of rheumatic diseases and autoimmune hepatitis in adults who have been treated for 10 years in a fourth-level hospital in Bogota, Colombia.

Materials and methods

Analytical, observational, cross-sectional study in a single center that included patients over 18 years of age of both sexes with a diagnosis of AIH by simplified score ≥7 points, with a medical history registered at the Fundacion Santa Fe de Bogota in Bogota, Colombia between January 2013 and December 2023.

Results

A total of 66 patients met inclusion criteria. 36.4% of patients had a concomitant autoimmune disease, with Sjögren's syndrome, systemic lupus erythematosus and autoimmune thyroid disease being the most prevalent.

Conclusion

The frequency of coexistence of autoimmune hepatitis with rheumatic diseases in adult patients is 36.4% for the cohort studied, which is within the range of what has already been reported globally, where a prevalence of 14 to 44% has been described.

自身免疫性肝炎（AIH）是一种全球低患病率的慢性炎症性肝病。该实体与风湿病的共存已在多项研究中进行了评估，并且是高度可变的。本研究的目的是确定在哥伦比亚波哥大一家四级医院治疗10年的成人中风湿性疾病和自身免疫性肝炎共存的频率。材料和方法：在单中心进行分析性、观察性、横断面研究，纳入年龄在18岁以上、简化评分≥7分诊断为AIH的患者，病史于2013年1月至2023年12月在哥伦比亚波哥大的Fundacion Santa Fe de Bogota登记。结果：66例患者符合纳入标准。36.4%的患者伴有自身免疫性疾病，其中Sjögren综合征、系统性红斑狼疮和自身免疫性甲状腺疾病最为常见。结论：在研究的队列中，自身免疫性肝炎与风湿性疾病在成人患者中共存的频率为36.4%，这与全球已报道的14%至44%的患病率范围一致。

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引用次数: 0

Evaluation of performance of the Still Activity Score for assessment of Adult-onset Still's Disease: Comparative study with Systemic Feature Score and Modified Pouchot-Activity Score Still活动评分在成人发病Still病评估中的应用：与系统特征评分和改良袋活动评分的比较研究

Reumatologia clinica

Pub Date : 2025-02-01 Epub Date: 2025-03-08 DOI: 10.1016/j.reumae.2025.501814

Emine Uslu , Müçteba Enes Yayla , Didem Şahin-Eroğlu , Büşra Atmaca-Haktaniyan , Nilgün Göveç-Giynaş , Recep Yilmaz , Ahmet İlbay , Abdulbaki Gaydan , Yeter Mahmutoğlu , Ahmet Usta , Tahsin Murat Turgaya , Gülay Kinikli , Aşkın Ateş

Backgrounds

Adult-onset Still's Disease (AOSD) is a systemic inflammatory disorder. There is no definitive AOSD activity indicator. Two of the currently used disease activity scores are the Modified Pouchot Activity Score (mPoS), and Systemic Feature Score (SFS). Another scoring system has been recently introduced, named the Still Activity Score (SAS).

Aims

In this single-center cross-sectional study, we aimed to compare the performance of the SAS with the mPoS and SFS, both of which have been used for a long time for measuring disease activity in patients with AOSD.

Method

69 patients aged 18 or older were screened in the study who attended the Ankara University Faculty of Medicine between 2010 and 2020 with a diagnosis of AOSD. We compared SAS, SFS and mPoS with physician global assessment (PhGA) in patients with AOSD.

Results

Of 69 patients screened, 45 patients with AOSD who fulfilled the Yamaguchi criteria were analyzed. The results showed no significant difference in SAS between patients with PhGA < 6 and PhGA ≥ 6, but mPoS and SFS scores were higher in the PhGA ≥ 6 group (p = 0.053, p = 0.001, p = 0.007, respectively). There was a significant correlation between mPoS and PhGA (p = 0.018).

Conclusion

This is the first study to evaluate the SAS score, which is used for patients with AOSD. SAS is user-friendly but may not be as sensitive as mPoS and SFS for assessing disease activity in AOSD.

成人发病的斯蒂尔氏病（AOSD）是一种全身性炎症性疾病。没有明确的AOSD活动指标。目前使用的两种疾病活动度评分是改良袋chot活动评分（mPoS）和系统特征评分（SFS）。最近引入了另一个评分系统，称为静止活动评分（SAS）。在这项单中心横断面研究中，我们的目的是比较SAS与mPoS和SFS的性能，这两种方法长期以来一直用于测量AOSD患者的疾病活动性。方法筛选2010年至2020年期间在安卡拉大学医学院就诊的69例18岁及以上的AOSD患者。我们比较了SAS、SFS和mPoS与AOSD患者的医师整体评估（PhGA）。结果69例AOSD患者中，45例符合Yamaguchi标准。结果显示，PhGA和lt患者的SAS无显著差异；PhGA≥6组和PhGA≥6组的mPoS和SFS评分较高（p = 0.053, p = 0.001, p = 0.007）。mPoS与PhGA有显著相关性（p = 0.018）。结论本研究首次评价了用于AOSD患者的SAS评分。SAS是用户友好的，但在评估AOSD的疾病活动性方面可能不如mPoS和SFS敏感。

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引用次数: 0

Nontraumatic terminal ileal perforation in a patient with resistant palindromic rheumatism treated with sarilumab: A case report 非外伤性回肠终末穿孔在病人的顽固性复发性风湿病治疗沙伐单抗：一个病例报告。

Reumatologia clinica

Pub Date : 2025-02-01 Epub Date: 2025-03-01 DOI: 10.1016/j.reumae.2025.501811

Anastasia Mocritcaia , Rocío García-Pérez , Beatriz Frade , Raimon Sanmartí

Intestinal perforation, a rare complication of interleukin (IL)-6 therapy for immune-mediated diseases (mainly rheumatoid arthritis), typically manifests in the lower gastrointestinal tract, often in association with prior history of diverticulitis. Patients may present with acute abdominal pain and suspicion for this complication should remain high even in the absence of elevated C-reactive protein. We describe a 69-year-old female patient with a history of resistant seropositive palindromic rheumatism treated with sarilumab who developed a nontraumatic terminal ileal perforation.

肠穿孔是白细胞介素(IL)-6治疗免疫介导性疾病（主要是类风湿性关节炎）的一种罕见并发症，通常表现在下胃肠道，通常与憩室炎病史相关。患者可能出现急性腹痛，即使没有c反应蛋白升高，对这种并发症的怀疑也应该很高。我们描述了一位69岁的女性患者，她有耐药血清阳性的回复性风湿病史，接受了沙伐单抗治疗，并发了非创伤性回肠末端穿孔。

引用次数: 0