The Lancet. Child & adolescent health最新文献

{"title":"Tuberculosis research principles and priorities in children and adolescents: an international consensus statement","authors":"Moorine P Sekadde, Silvia S Chiang, Annemieke Brands, Martina Casenghi, Chishala Chabala, Stephen M Graham, Tiziana Masini, James A Seddon, Sabine E Verkuijl, Kerri Viney, Ben J Marais, Shakil Ahmed, Pauline M. Amuge, Robindra Basu Roy, Maryline Bonnet, Grania Brigden, Charlotte Colvin, Claudia M. Denkinger, Peter J. Dodd, Leslie A. Enane, Molly F. Franke, Jennifer J. Furin, Betina Mendez Alcântra Gabardo, Anthony J. Garcia-Prats, Norma E. González, Graeme Hoddinott, Cleotilde H. How, Helena Huerga, Julie Huynh, Devan Jaganath, Alexander W. Kay, Kobto G. Koura, Katharina Kranzer, Marian Loveday, Elizabeth Maleche-Obimbo, Mariama Mahmoud, Olivier Marcy, Mansa Mbenga, Lindsay R. McKenna, Brittany K. Moore, Sharon Nachman, Nicole Salazar-Austin, Clemax C. Sant'Anna, Adong Shen, H. Simon Schaaf, Sangeeta Sharma, Alena Skrahina, Jeffrey R. Starke, Marc Tebruegge, Rina Triasih, Marieke M. van der Zalm, Courtney M. Yuen, Heather J. Zar","doi":"10.1016/s2352-4642(26)00046-5","DOIUrl":"https://doi.org/10.1016/s2352-4642(26)00046-5","url":null,"abstract":"","PeriodicalId":94246,"journal":{"name":"The Lancet. Child & adolescent health","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric TB: celebrating the people behind the progress","authors":"","doi":"10.1016/s2352-4642(26)00071-4","DOIUrl":"https://doi.org/10.1016/s2352-4642(26)00071-4","url":null,"abstract":"","PeriodicalId":94246,"journal":{"name":"The Lancet. Child & adolescent health","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycophenolate mofetil versus prednisone for the initial treatment of idiopathic steroid-sensitive nephrotic syndrome in children in Germany (INTENT): a multicentre, open-label, randomised, controlled, parallel-group, non-inferiority, phase 3 trial","authors":"Marcus R Benz MD, Anja Sander PhD, Rasmus Ehren MD, Prof Britta Höcker MD, Alexander Fichtner MD, Jutta Gellermann MD, Julia Thumfart MD, Brigitte Mayer MD, Katja Sauerstein MD, Anne Mühlig PhD, Raphael Schild MD, Nele Kanzelmeyer MD, Prof Dieter Haffner MD, Henry Fehrenbach MD, Prof Martin Pohl MD, Prof Günter Klaus MD, Silke C Schmidt MD, Prof Martin Konrad MD, Prof Uwe Querfeld MD, Prof Peter F Hoyer MD, Prof Jörg Dötsch MD, Prof Markus J Kemper MD, Alexandra Balzer MSc, Jan Meis PhD, Prof Burkhard Tönshoff MD, Prof Lutz T Weber MD, INTENT investigators, Marcus R. Benz, Anja Sander, Rasmus Ehren, Britta Höcker, Alexander Fichtner, Jutta Gellermann, Julia Thumfart, Norbert Jorch, Brigitte Mayer, Maria Heyde, Matthias Galiano, Katja Sauerstein, Ludwig Patzer, Jun Oh, Anne Mühlig, Raphael Schild, Nele Kanzelmeyer, Dieter Haffner, Henry Fehrenbach, Felix Lechner, Bärbel Lange-Sperandio, Michael van Husen, Martin Pohl, Karsten Häffner, Katalin Dittrich, Stefanie Weber, Günter Klaus, Martin Konrad, Jens König, Ulrike Walden, Silke C. Schmidt, Christina J. Huppertz-Kessler, Marcus Weitz, Uwe Querfeld, Peter F. Hoyer, Jörg Dötsch, Markus J. Kemper, Alexandra Balzer, Jan Meis, Burkhard Tönshoff, Lutz T. Weber","doi":"10.1016/s2352-4642(25)00373-6","DOIUrl":"https://doi.org/10.1016/s2352-4642(25)00373-6","url":null,"abstract":"Prolonged glucocorticoid therapy is the standard initial treatment for idiopathic nephrotic syndrome in children, but is associated with marked toxic effects. We aimed to assess whether a novel treatment protocol with mycophenolate mofetil is as effective as standard therapy with prednisone, while reducing the burden of glucocorticoid-related side-effects.","PeriodicalId":94246,"journal":{"name":"The Lancet. Child & adolescent health","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Listening to the room","authors":"Apurva Parikh","doi":"10.1016/s2352-4642(26)00068-4","DOIUrl":"https://doi.org/10.1016/s2352-4642(26)00068-4","url":null,"abstract":"","PeriodicalId":94246,"journal":{"name":"The Lancet. Child & adolescent health","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autistic SPACE: clinician advocacy for improving school environments for autistic young people","authors":"Chun-Hao Liu, Mary Doherty, Meng-Chuan Lai","doi":"10.1016/s2352-4642(26)00043-x","DOIUrl":"https://doi.org/10.1016/s2352-4642(26)00043-x","url":null,"abstract":"","PeriodicalId":94246,"journal":{"name":"The Lancet. Child & adolescent health","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Support without identification: a regressive shift in neurodevelopmental care?","authors":"Jason Lang, Marion Rutherford, Ruchika Gajwani, Sebastian C K Shaw, Mary Doherty, Helen Minnis","doi":"10.1016/s2352-4642(26)00037-4","DOIUrl":"https://doi.org/10.1016/s2352-4642(26)00037-4","url":null,"abstract":"","PeriodicalId":94246,"journal":{"name":"The Lancet. Child & adolescent health","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival, kidney function, and complications in the first year of life following intrauterine shunting for first-trimester fetal megacystis (IUS1st): analysis of a prospective observational cohort","authors":"Eva C Weber, Stefan Kohl, Ingo Gottschalk, Florian Recker, Nikolas Neumann, Ina Memetaj-Lang, Thomas M Boemers, Jules Kohaut, Angela Kribs, Lutz Thorsten Weber, Andreas Müller, Brigitte Strizek, Sandra Habbig, Christoph Berg","doi":"10.1016/s2352-4642(26)00011-8","DOIUrl":"https://doi.org/10.1016/s2352-4642(26)00011-8","url":null,"abstract":"","PeriodicalId":94246,"journal":{"name":"The Lancet. Child & adolescent health","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early fetal intervention: balancing technological breakthroughs and long-term morbidity","authors":"Eva Pajkrt","doi":"10.1016/s2352-4642(26)00064-7","DOIUrl":"https://doi.org/10.1016/s2352-4642(26)00064-7","url":null,"abstract":"","PeriodicalId":94246,"journal":{"name":"The Lancet. Child & adolescent health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral rehydration for severe malnutrition in children with moderate and severe dehydration (GASTROSAM): a phase 2, open-label, superiority randomised controlled trial.","authors":"Kathryn Maitland,Hadiza Sainna,Roisin Connon,San Maurice Ouattara,Temmy Sunyoto,Abdullahi Chara,Oluwakemi F Ogundipe,Amadou Saidou Maguina,Mainga Hamaluba,Peter Olupot-Olupot,Florence Alaroker,William Okiror,Denis Aromut,Eric Mwajombo,Emmanuel Oguda,Christabel Mogaka,Céline Langendorf,Juan Emmanuel Dewez,Iza Ciglenecki,Diana M Gibb,Roberta Petrucci,Matthew E Coldiron,Elizabeth C George, ","doi":"10.1016/s2352-4642(25)00371-2","DOIUrl":"https://doi.org/10.1016/s2352-4642(25)00371-2","url":null,"abstract":"BACKGROUNDInternational guidelines for treatment of children with severe acute malnutrition advise against giving standard oral rehydration solutions (ORS) for dehydration secondary to diarrhoea. Instead, they recommend exclusive use of low-sodium rehydration solution for malnutrition (ReSoMal), due to concerns about both sodium and fluid overload. Supportive evidence is lacking, warranting reappraisal of this guidance. We aimed to assess the safety and superiority of standard WHO-ORS versus ReSoMal.METHODSGASTROSAM was a phase 2, factorial, open-label, superiority randomised controlled trial conducted at six hospitals in four African countries (Kenya, Niger, Nigeria, and Uganda). Children aged 6 months to 12 years with severe acute malnutrition who were admitted to hospital with severe (stratum A) or moderate (stratum B) dehydration and diarrhoea were randomly assigned in a 1:1 ratio to receive ReSoMal or low-osmolarity WHO-ORS. A simultaneous randomisation in stratum A compared two intravenous strategies versus an oral control rehydration strategy (results reported elsewhere). Children with severe dehydration (stratum A) received their allocated ORS as soon as possible. The primary endpoint was change in sodium concentration at 24 h from baseline in all randomised participants and analysed on an intention-to-treat basis. Children with lived experience were not involved in the study design. The trial is registered on the ISRCTN registry (ISRCTN76149273) and the Pan-African Clinical Trials Registry (PACTR202103852542919).FINDINGSBetween Sept 2, 2019, and Oct 27, 2024, 415 eligible children were enrolled (218 [53%] male; 197 [47%] female); 272 were enrolled into stratum A (137 to ReSoMal and 135 to WHO-ORS) and 143 were enrolled into stratum B (69 to ReSoMal and 74 to WHO-ORS). Children were followed up for 28 days; 11 (3%) were lost to follow-up or withdrew. The primary endpoint was assessed in 387 (93%) of 415 participants. The increase in sodium concentration was similar in both groups (5·3 mmol/L [SD 8·1] with ReSoMal vs 5·0 mmol/L [7·6] with WHO-ORS; mean difference for WHO-ORS vs ReSoMal -0·6 [95% CI -1·9 to 0·7], p=0·37). There was no difference in day 28 mortality between the WHO-ORS and ReSoMal groups (19 [9%] vs 24 [12%]; adjusted hazard ratio 0·76 [95% CI 0·41 to 1·41], p=0·39). Fluid overload events (pulmonary oedema and cardiac overload) were actively monitored: none was observed.INTERPRETATIONWHO-ORS resulted in similar outcomes to ReSoMal, and neither strategy led to fluid overload. This finding informs the simplification of guidelines supporting the use of WHO-ORS for the management of dehydration in children regardless of nutritional status.FUNDINGJoint Global Health Trials Scheme of the UK Medical Research Council, UK Department for International Development, Wellcome, and Médecins Sans Frontières.","PeriodicalId":94246,"journal":{"name":"The Lancet. Child & adolescent health","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Little kidneys on the global agenda: leveraging the WHO Kidney Health Resolution and World Kidney Day for children.","authors":"Randall Lou-Meda,Valerie A Luyckx,Rukshana Shroff","doi":"10.1016/s2352-4642(26)00006-4","DOIUrl":"https://doi.org/10.1016/s2352-4642(26)00006-4","url":null,"abstract":"","PeriodicalId":94246,"journal":{"name":"The Lancet. Child & adolescent health","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}