Background: During the COVID-19 pandemic, cardiovascular hospitalizations decreased and in-hospital mortality for ST-elevation myocardial infarction and heart failure increased. However, limited research has been conducted on hospitalization and mortality rates for cardiovascular disease (CVD) other than ischemic heart disease and heart failure. Methods and Results: We analyzed the records of 530 certified hospitals affiliated with the Japanese Circulation Society obtained from the nationwide JROAD-DPC database between April 2014 and March 2021. A quasi-Poisson regression model was used to predict the counterfactual number of hospitalizations for CVD treatment, assuming there was no pandemic. The observed number of inpatients compared with the predicted number in 2020 was 88.1% for acute CVD, 78% for surgeries or procedures, 77.2% for catheter ablation, and 68.5% for left ventricular assist devices. Furthermore, there was no significant change in in-hospital mortality, and the decrease in hospitalizations for catheter ablation and valvular heart disease constituted 47.6% of the total decrease in annual hospitalization costs during the COVID-19 pandemic. Conclusions: Cardiovascular hospitalizations decreased by more than 10% in 2020, and the number of patients scheduled for left ventricular assist device implantation decreased by over 30%. In addition, in response to the COVID-19 pandemic, annual cardiovascular hospitalization costs were reduced, largely attributed to decreased catheter ablation and valvular heart disease.
{"title":"Cardiovascular Hospitalizations and Hospitalization Costs in Japan During the COVID-19 Pandemic.","authors":"Tadafumi Sugimoto, Atsushi Mizuno, Daisuke Yoneoka, Shingo Matsumoto, Chisa Matsumoto, Yuya Matsue, Mari Ishida, Michikazu Nakai, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Koichi Node","doi":"10.1253/circrep.CR-23-0072","DOIUrl":"10.1253/circrep.CR-23-0072","url":null,"abstract":"<p><p><b><i>Background:</i></b> During the COVID-19 pandemic, cardiovascular hospitalizations decreased and in-hospital mortality for ST-elevation myocardial infarction and heart failure increased. However, limited research has been conducted on hospitalization and mortality rates for cardiovascular disease (CVD) other than ischemic heart disease and heart failure. <b><i>Methods and Results:</i></b> We analyzed the records of 530 certified hospitals affiliated with the Japanese Circulation Society obtained from the nationwide JROAD-DPC database between April 2014 and March 2021. A quasi-Poisson regression model was used to predict the counterfactual number of hospitalizations for CVD treatment, assuming there was no pandemic. The observed number of inpatients compared with the predicted number in 2020 was 88.1% for acute CVD, 78% for surgeries or procedures, 77.2% for catheter ablation, and 68.5% for left ventricular assist devices. Furthermore, there was no significant change in in-hospital mortality, and the decrease in hospitalizations for catheter ablation and valvular heart disease constituted 47.6% of the total decrease in annual hospitalization costs during the COVID-19 pandemic. <b><i>Conclusions:</i></b> Cardiovascular hospitalizations decreased by more than 10% in 2020, and the number of patients scheduled for left ventricular assist device implantation decreased by over 30%. In addition, in response to the COVID-19 pandemic, annual cardiovascular hospitalization costs were reduced, largely attributed to decreased catheter ablation and valvular heart disease.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"5 10","pages":"381-391"},"PeriodicalIF":0.0,"publicationDate":"2023-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/a1/circrep-5-381.PMC10561996.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-16eCollection Date: 2023-10-10DOI: 10.1253/circrep.CR-23-0073
Shiro Nakahara, Yuichi Hori, Reiko Fukuda, Hirotsugu Sato, Hideyuki Aoki, Tetsuya Ishikawa, Yuji Itabashi, Sayuki Kobayashi, Isao Taguchi, Yasuo Okumura
Background: Adverse atrial remodeling, including epicardial adipose tissue (EAT) deposition in the left atrium (LA), is implicated in atrial fibrillation (AF). Radiofrequency hotballoon (RHB) ablation can produce wide planar lesions because the balloon is highly compliant; however, chronic effects of RHB ablation on structural remodeling remain unknown. This clinical-experimental investigation characterized chronic effects of RHB ablation on EAT in persistent AF (PsAF). Methods and Results: The clinical study involved 91 patients (obese, n=30; non-obese, n=61) undergoing RHB ablation for PsAF. LA-EAT was assessed from computed tomography images obtained before ablation and 6 months later. Tissue effects of RHB ablation were explored in a chronic swine model. RHB ablation significantly reduced LA volume (mean [±SD] 177.7±29.7 vs. 138.4±29.6 mL; P<0.001) and LA-EAT volume (median [interquartile range] 22.0 [12.4-33.3] vs. 16.5 [7.9-25.8] mL; P<0.001). The reduction in EAT was significantly greater in the pulmonary vein (PV) antrum than in other LA regions (37.9% vs. 15.8%; P<0.001). The percentage reduction in PV antrum EAT was equivalent between obese and non-obese patients, as was the postablation success rate (73% vs. 70%; P=0.77). RHB ablation produced transmural lesions reaching the pigs' epicardial fat region. Conclusions: RHB-based planar-transmural lesions altered the structurally remodeled LA, including EAT. Further studies are needed to determine whether factors other than PV isolation contribute to the clinical success of RHB ablation.
{"title":"Chronic Effect of HotBalloon-Based Wide Planar Ablation on Epicardial Adipose Tissue in Persistent Atrial Fibrillation.","authors":"Shiro Nakahara, Yuichi Hori, Reiko Fukuda, Hirotsugu Sato, Hideyuki Aoki, Tetsuya Ishikawa, Yuji Itabashi, Sayuki Kobayashi, Isao Taguchi, Yasuo Okumura","doi":"10.1253/circrep.CR-23-0073","DOIUrl":"10.1253/circrep.CR-23-0073","url":null,"abstract":"<p><p><b><i>Background:</i></b> Adverse atrial remodeling, including epicardial adipose tissue (EAT) deposition in the left atrium (LA), is implicated in atrial fibrillation (AF). Radiofrequency hotballoon (RHB) ablation can produce wide planar lesions because the balloon is highly compliant; however, chronic effects of RHB ablation on structural remodeling remain unknown. This clinical-experimental investigation characterized chronic effects of RHB ablation on EAT in persistent AF (PsAF). <b><i>Methods and Results:</i></b> The clinical study involved 91 patients (obese, n=30; non-obese, n=61) undergoing RHB ablation for PsAF. LA-EAT was assessed from computed tomography images obtained before ablation and 6 months later. Tissue effects of RHB ablation were explored in a chronic swine model. RHB ablation significantly reduced LA volume (mean [±SD] 177.7±29.7 vs. 138.4±29.6 mL; P<0.001) and LA-EAT volume (median [interquartile range] 22.0 [12.4-33.3] vs. 16.5 [7.9-25.8] mL; P<0.001). The reduction in EAT was significantly greater in the pulmonary vein (PV) antrum than in other LA regions (37.9% vs. 15.8%; P<0.001). The percentage reduction in PV antrum EAT was equivalent between obese and non-obese patients, as was the postablation success rate (73% vs. 70%; P=0.77). RHB ablation produced transmural lesions reaching the pigs' epicardial fat region. <b><i>Conclusions:</i></b> RHB-based planar-transmural lesions altered the structurally remodeled LA, including EAT. Further studies are needed to determine whether factors other than PV isolation contribute to the clinical success of RHB ablation.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"5 10","pages":"371-380"},"PeriodicalIF":0.0,"publicationDate":"2023-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/4d/circrep-5-371.PMC10561997.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-10DOI: 10.1253/circrep.cr-66-0010
M. Sata
{"title":"Message From the Editor-in-Chief ― Circulation Reports: 4 Years of Progress After Launch ―","authors":"M. Sata","doi":"10.1253/circrep.cr-66-0010","DOIUrl":"https://doi.org/10.1253/circrep.cr-66-0010","url":null,"abstract":"","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"20 1","pages":"1 - 3"},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90167188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-16DOI: 10.1253/circrep.CR-22-0023
Takeshi Shimizu, Yuya Sakuma, Yuta Kurosawa, Yuuki Muto, Akihiko Sato, S. Abe, T. Misaka, M. Oikawa, A. Yoshihisa, T. Yamaki, K. Nakazato, T. Ishida, Y. Takeishi
Background: The utility of the Japanese version of high bleeding risk (J-HBR) criteria compared with contemporary bleeding risk criteria, including Academic Research Consortium for High Bleeding Risk criteria, has not been fully investigated. Methods and Results: This study included patients who underwent percutaneous coronary intervention between 2010 and 2019. The J-HBR score was calculated by assigning 1 point for each major criterion and 0.5 points for each minor criterion in the J-HBR criteria. Among 1,643 patients, 1,143 (69.6%) met the J-HBR criteria. Accumulated major bleeding event rates at 1 year were higher among those who met the J-HBR criteria (4.8% vs. 0.6%; P<0.001). J-HBR criteria had higher sensitivity (94.8%) and lower specificity (31.4%) than contemporary bleeding risk criteria in predicting major bleeding. Bleeding events increased with increasing J-HBR score. The C statistic for the J-HBR score for predicting major bleeding at 1 year was 0.75 (95% confidence interval 0.69–0.81), and is comparable to that of other risk scores. In multivariate analysis, of the factors included in J-HBR criteria, chronic kidney disease, heart failure, and active malignancy were associated with major bleeding. Conclusions: J-HBR criteria identified patients at high bleeding risk with high sensitivity and low specificity. Bleeding risk was closely related to J-HBR score and its individual components. The discriminative ability of the J-HBR score was comparable to that of contemporary bleeding risk scores.
背景:日本版高出血风险(J-HBR)标准与当代出血风险标准(包括高出血风险学术研究联盟标准)的效用尚未得到充分调查。方法和结果:本研究纳入了2010年至2019年间接受经皮冠状动脉介入治疗的患者。J-HBR评分的计算方法是，J-HBR标准中每个主要标准1分，每个次要标准0.5分。1643例患者中，1143例(69.6%)符合J-HBR标准。1年累积大出血事件发生率在符合J-HBR标准的患者中较高(4.8% vs 0.6%;P < 0.001)。J-HBR在预测大出血方面的敏感性(94.8%)高于当代出血风险标准，特异性(31.4%)低于当代出血风险标准。出血事件随着J-HBR评分的增加而增加。J-HBR评分预测1年大出血的C统计量为0.75(95%可信区间0.69-0.81)，与其他风险评分相当。在多变量分析中，J-HBR标准中包括的因素中，慢性肾脏疾病、心力衰竭和活动性恶性肿瘤与大出血相关。结论:J-HBR标准识别高出血风险患者具有高敏感性和低特异性。出血风险与J-HBR评分及其各组成部分密切相关。J-HBR评分的判别能力与当代出血风险评分相当。
{"title":"Validation of Japanese Bleeding Risk Criteria in Patients After Percutaneous Coronary Intervention and Comparison With Contemporary Bleeding Risk Criteria","authors":"Takeshi Shimizu, Yuya Sakuma, Yuta Kurosawa, Yuuki Muto, Akihiko Sato, S. Abe, T. Misaka, M. Oikawa, A. Yoshihisa, T. Yamaki, K. Nakazato, T. Ishida, Y. Takeishi","doi":"10.1253/circrep.CR-22-0023","DOIUrl":"https://doi.org/10.1253/circrep.CR-22-0023","url":null,"abstract":"Background: The utility of the Japanese version of high bleeding risk (J-HBR) criteria compared with contemporary bleeding risk criteria, including Academic Research Consortium for High Bleeding Risk criteria, has not been fully investigated. Methods and Results: This study included patients who underwent percutaneous coronary intervention between 2010 and 2019. The J-HBR score was calculated by assigning 1 point for each major criterion and 0.5 points for each minor criterion in the J-HBR criteria. Among 1,643 patients, 1,143 (69.6%) met the J-HBR criteria. Accumulated major bleeding event rates at 1 year were higher among those who met the J-HBR criteria (4.8% vs. 0.6%; P<0.001). J-HBR criteria had higher sensitivity (94.8%) and lower specificity (31.4%) than contemporary bleeding risk criteria in predicting major bleeding. Bleeding events increased with increasing J-HBR score. The C statistic for the J-HBR score for predicting major bleeding at 1 year was 0.75 (95% confidence interval 0.69–0.81), and is comparable to that of other risk scores. In multivariate analysis, of the factors included in J-HBR criteria, chronic kidney disease, heart failure, and active malignancy were associated with major bleeding. Conclusions: J-HBR criteria identified patients at high bleeding risk with high sensitivity and low specificity. Bleeding risk was closely related to J-HBR score and its individual components. The discriminative ability of the J-HBR score was comparable to that of contemporary bleeding risk scores.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"18 1","pages":"230 - 238"},"PeriodicalIF":0.0,"publicationDate":"2022-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74690624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-15DOI: 10.1253/circrep.cr-22-0003
T. Nakashima, Katsutaka Hashiba, M. Kikuchi, J. Yamaguchi, S. Kojima, H. Hanada, T. Mano, Takeshi Yamamoto, A. Tanaka, K. Matsuo, Naoki Nakayama, Osamu Nomura, T. Matoba, Y. Tahara, H. Nonogi
Background: To achieve early reperfusion therapy for ST-elevation myocardial infarction (STEMI), proper and prompt patient transportation and activation of the catheterization laboratory are required. We investigated the efficacy of prehospital 12-lead electrocardiogram (ECG) acquisition and destination hospital notification in patients with STEMI. Methods and Results: This is a systematic review of observational studies. We searched the PubMed database from inception to March 2020. Two reviewers independently performed literature selection. The critical outcome was short-term mortality. The important outcome was door-to-balloon (D2B) time. We used the GRADE approach to assess the certainty of the evidence. For the critical outcome, 14 studies with 29,365 patients were included in the meta-analysis. Short-term mortality was significantly lower in the group with prehospital 12-lead ECG acquisition and destination hospital notification than in the control group (odds ratio 0.72; 95% confidence interval [CI] 0.61–0.85; P<0.0001). For the important outcome, 10 studies with 2,947 patients were included in the meta-analysis. D2B time was significantly shorter in the group with prehospital 12-lead ECG acquisition and destination hospital notification than in the control group (mean difference −26.24; 95% CI −33.46, −19.02; P<0.0001). Conclusions: Prehospital 12-lead ECG acquisition and destination hospital notification is associated with lower short-term mortality and shorter D2B time than no ECG acquisition or no notification among patients with suspected STEMI outside of a hospital.
{"title":"Impact of Prehospital 12-Lead Electrocardiography and Destination Hospital Notification on Mortality in Patients With Chest Pain ― A Systematic Review ―","authors":"T. Nakashima, Katsutaka Hashiba, M. Kikuchi, J. Yamaguchi, S. Kojima, H. Hanada, T. Mano, Takeshi Yamamoto, A. Tanaka, K. Matsuo, Naoki Nakayama, Osamu Nomura, T. Matoba, Y. Tahara, H. Nonogi","doi":"10.1253/circrep.cr-22-0003","DOIUrl":"https://doi.org/10.1253/circrep.cr-22-0003","url":null,"abstract":"Background: To achieve early reperfusion therapy for ST-elevation myocardial infarction (STEMI), proper and prompt patient transportation and activation of the catheterization laboratory are required. We investigated the efficacy of prehospital 12-lead electrocardiogram (ECG) acquisition and destination hospital notification in patients with STEMI. Methods and Results: This is a systematic review of observational studies. We searched the PubMed database from inception to March 2020. Two reviewers independently performed literature selection. The critical outcome was short-term mortality. The important outcome was door-to-balloon (D2B) time. We used the GRADE approach to assess the certainty of the evidence. For the critical outcome, 14 studies with 29,365 patients were included in the meta-analysis. Short-term mortality was significantly lower in the group with prehospital 12-lead ECG acquisition and destination hospital notification than in the control group (odds ratio 0.72; 95% confidence interval [CI] 0.61–0.85; P<0.0001). For the important outcome, 10 studies with 2,947 patients were included in the meta-analysis. D2B time was significantly shorter in the group with prehospital 12-lead ECG acquisition and destination hospital notification than in the control group (mean difference −26.24; 95% CI −33.46, −19.02; P<0.0001). Conclusions: Prehospital 12-lead ECG acquisition and destination hospital notification is associated with lower short-term mortality and shorter D2B time than no ECG acquisition or no notification among patients with suspected STEMI outside of a hospital.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"103 1","pages":"187 - 193"},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82550836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-09DOI: 10.1253/circrep.CR-22-0026
N. Kobayashi, Shunsuke Uetake, Nobuaki Itoh, Y. Miyauchi
the LA into 2 parts, a main chamber (MC) and an accessory chamber (AC). In addition, a fenestration was observed in the posteroinferior side of the membrane (Figure A–D). The right and left pulmonary veins (PVs) were connected to the AC and the MC, respectively. The fossa ovalis was A 50-year-old man underwent catheter ablation for symptomatic paroxysmal atrial fibrillation. Preprocedural cardiac computed tomography showed an abnormal septum extending from the interatrial septum to the posterior wall of the left atrium (LA) that divided
{"title":"Successful Catheter Ablation of Atrial Fibrillation in a Patient With an Abnormal Septum in the Left Atrium","authors":"N. Kobayashi, Shunsuke Uetake, Nobuaki Itoh, Y. Miyauchi","doi":"10.1253/circrep.CR-22-0026","DOIUrl":"https://doi.org/10.1253/circrep.CR-22-0026","url":null,"abstract":"the LA into 2 parts, a main chamber (MC) and an accessory chamber (AC). In addition, a fenestration was observed in the posteroinferior side of the membrane (Figure A–D). The right and left pulmonary veins (PVs) were connected to the AC and the MC, respectively. The fossa ovalis was A 50-year-old man underwent catheter ablation for symptomatic paroxysmal atrial fibrillation. Preprocedural cardiac computed tomography showed an abnormal septum extending from the interatrial septum to the posterior wall of the left atrium (LA) that divided","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"77 1","pages":"239 - 240"},"PeriodicalIF":0.0,"publicationDate":"2022-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83311094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-06DOI: 10.1253/circrep.cr-21-0159
Y. Saito, Y. Otaki, Tetsu Watanabe, M. Wanezaki, D. Kutsuzawa, S. Kato, H. Tamura, S. Nishiyama, T. Arimoto, Hiroki Takahashi, Y. Ueno, T. Konta, Masafumi Watanabe
Background: Single nucleotide polymorphisms (SNPs) in nitric oxide synthase 3 (NOS3) are associated with cardiovascular risk factors. However, it is not clear whether the NOS3 SNP is a genetic risk factor for cardiovascular diseases. Methods and Results: This prospective cohort study included 2,726 subjects aged ≥40 years who participated in a community-based health checkup. We genotyped 639 SNPs, including 2 NOS3 SNPs (rs1799983 and rs1808593). All subjects were monitored prospectively over a median follow-up period of 16.0 years, with the endpoint being cardiovascular events, including cardiovascular death and/or non-fatal myocardial infarction. Kaplan-Meier analysis demonstrated that both rs1799983 GT/TT and rs1808593 GG carriers had a higher risk of the endpoint than non-carriers. Univariate and multivariate Cox proportional hazard regression analyses revealed that both rs1799983 GT/TT and rs1808593 GG were independently associated with cardiovascular events after adjusting for confounding risk factors. The net reclassification index and integrated discrimination index were significantly improved by the addition of NOS3 SNPs as cardiovascular risk factors. Conclusions:NOS3 gene polymorphisms could be genetic risk factors for cardiovascular events in the general Japanese population, and could be used to facilitate the early identification of individuals at high risk of cardiovascular events.
背景:一氧化氮合酶3 (NOS3)的单核苷酸多态性(snp)与心血管危险因素相关。然而，目前尚不清楚NOS3 SNP是否为心血管疾病的遗传危险因素。方法和结果:这项前瞻性队列研究包括2726名年龄≥40岁的受试者，他们参加了社区健康检查。我们对639个snp进行了基因分型，包括2个NOS3 snp (rs1799983和rs1808593)。所有受试者的中位随访期为16.0年，随访终点为心血管事件，包括心血管死亡和/或非致死性心肌梗死。Kaplan-Meier分析显示，rs1799983 GT/TT和rs1808593 GG携带者的终点风险均高于非携带者。单因素和多因素Cox比例风险回归分析显示，在校正混杂危险因素后，rs1799983 GT/TT和rs1808593 GG与心血管事件独立相关。添加NOS3 snp作为心血管危险因素后，净重分类指数和综合判别指数均有显著提高。结论:NOS3基因多态性可能是日本普通人群心血管事件的遗传危险因素，可用于促进心血管事件高危个体的早期识别。
{"title":"Effects of Nitric Oxide Synthase 3 Gene Polymorphisms on Cardiovascular Events in a General Japanese Population ― The Yamagata (Takahata) Study ―","authors":"Y. Saito, Y. Otaki, Tetsu Watanabe, M. Wanezaki, D. Kutsuzawa, S. Kato, H. Tamura, S. Nishiyama, T. Arimoto, Hiroki Takahashi, Y. Ueno, T. Konta, Masafumi Watanabe","doi":"10.1253/circrep.cr-21-0159","DOIUrl":"https://doi.org/10.1253/circrep.cr-21-0159","url":null,"abstract":"Background: Single nucleotide polymorphisms (SNPs) in nitric oxide synthase 3 (NOS3) are associated with cardiovascular risk factors. However, it is not clear whether the NOS3 SNP is a genetic risk factor for cardiovascular diseases. Methods and Results: This prospective cohort study included 2,726 subjects aged ≥40 years who participated in a community-based health checkup. We genotyped 639 SNPs, including 2 NOS3 SNPs (rs1799983 and rs1808593). All subjects were monitored prospectively over a median follow-up period of 16.0 years, with the endpoint being cardiovascular events, including cardiovascular death and/or non-fatal myocardial infarction. Kaplan-Meier analysis demonstrated that both rs1799983 GT/TT and rs1808593 GG carriers had a higher risk of the endpoint than non-carriers. Univariate and multivariate Cox proportional hazard regression analyses revealed that both rs1799983 GT/TT and rs1808593 GG were independently associated with cardiovascular events after adjusting for confounding risk factors. The net reclassification index and integrated discrimination index were significantly improved by the addition of NOS3 SNPs as cardiovascular risk factors. Conclusions:NOS3 gene polymorphisms could be genetic risk factors for cardiovascular events in the general Japanese population, and could be used to facilitate the early identification of individuals at high risk of cardiovascular events.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"17 1","pages":"222 - 229"},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75035077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.1253/circrep.CR-22-0022
N. Ikeda, S. Yachi, M. Takeyama, Y. Nishimoto, I. Tsujino, J. Nakamura, N. Yamamoto, Hiroko Nakata, S. Ikeda, Michihisa Umetsu, S. Aikawa, H. Hayashi, H. Satokawa, Yoshinori Okuno, Eriko Iwata, Yoshito Ogihara, A. Kondo, Takehisa Iwai, N. Yamada, Tomohiro Ogawa, Takao Kobayashi, M. Mo, Y. Yamashita
Background: To date, there are no large-scale data on the association between D-dimer levels at admission and the occurrence of venous thromboembolism (VTE) in Japanese patients with coronavirus disease 2019 (COVID-19). Methods and Results: The CLOT-COVID study was a retrospective, multicenter cohort study enrolling consecutive hospitalized patients with COVID-19 across 16 centers in Japan from April 2021 to September 2021. Among 2,894 enrolled patients, 2,771 (96%) had D-dimer levels measured at admission. Patients were divided into 3 groups based on tertiles of D-dimer levels at admission (1st tertile, D-dimer ≤0.5 μg/mL, n=949; 2nd tertile, D-dimer 0.51–1.09 μg/mL, n=894; 3rd tertile, D-dimer ≥1.1 μg/mL, n=928). The higher the tertile group, the more severe the COVID-19 status at admission. The incidence of VTE during hospitalization was highest in the 3rd tertile group (1st tertile, 0.3%; 2nd tertile, 0.3%; 3rd tertile, 3.6%; P<0.001). Even after adjusting for confounders in the multivariable logistic regression model, the higher D-dimer levels in the 3rd tertile (≥1.1 μg/mL) were independently associated with a higher risk of VTE during hospitalization (adjusted odds ratio 4.83 [95% confidence interval 1.93–12.11; P<0.001]; reference=1st tertile). Conclusions: Higher D-dimer levels at admission were associated with a higher risk of VTE events during hospitalization in Japanese patients with COVID-19. This could be helpful in determining patient-specific anticoagulation management strategies for COVID-19 in Japan.
{"title":"D-Dimer Values and Venous Thromboembolism in Patients With COVID-19 in Japan ― From the CLOT-COVID Study ―","authors":"N. Ikeda, S. Yachi, M. Takeyama, Y. Nishimoto, I. Tsujino, J. Nakamura, N. Yamamoto, Hiroko Nakata, S. Ikeda, Michihisa Umetsu, S. Aikawa, H. Hayashi, H. Satokawa, Yoshinori Okuno, Eriko Iwata, Yoshito Ogihara, A. Kondo, Takehisa Iwai, N. Yamada, Tomohiro Ogawa, Takao Kobayashi, M. Mo, Y. Yamashita","doi":"10.1253/circrep.CR-22-0022","DOIUrl":"https://doi.org/10.1253/circrep.CR-22-0022","url":null,"abstract":"Background: To date, there are no large-scale data on the association between D-dimer levels at admission and the occurrence of venous thromboembolism (VTE) in Japanese patients with coronavirus disease 2019 (COVID-19). Methods and Results: The CLOT-COVID study was a retrospective, multicenter cohort study enrolling consecutive hospitalized patients with COVID-19 across 16 centers in Japan from April 2021 to September 2021. Among 2,894 enrolled patients, 2,771 (96%) had D-dimer levels measured at admission. Patients were divided into 3 groups based on tertiles of D-dimer levels at admission (1st tertile, D-dimer ≤0.5 μg/mL, n=949; 2nd tertile, D-dimer 0.51–1.09 μg/mL, n=894; 3rd tertile, D-dimer ≥1.1 μg/mL, n=928). The higher the tertile group, the more severe the COVID-19 status at admission. The incidence of VTE during hospitalization was highest in the 3rd tertile group (1st tertile, 0.3%; 2nd tertile, 0.3%; 3rd tertile, 3.6%; P<0.001). Even after adjusting for confounders in the multivariable logistic regression model, the higher D-dimer levels in the 3rd tertile (≥1.1 μg/mL) were independently associated with a higher risk of VTE during hospitalization (adjusted odds ratio 4.83 [95% confidence interval 1.93–12.11; P<0.001]; reference=1st tertile). Conclusions: Higher D-dimer levels at admission were associated with a higher risk of VTE events during hospitalization in Japanese patients with COVID-19. This could be helpful in determining patient-specific anticoagulation management strategies for COVID-19 in Japan.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"40 1","pages":"215 - 221"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86525523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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