Northern clinics of Istanbul最新文献

REV-ERB α/β proteins play critical roles in circadian rhythm regulation and are considered to be specialized members of the nuclear receptor family. These so-called "orphan" proteins, whose endogenous ligands were initially unidentified, have become exogenously interferable through synthetic agents with the discovery of their endogenous ligands. This feature has made them an important target for clinical research in recent years. Unlike other nuclear receptors, the unique structure of REV-ERB proteins allows them to perform only transcription inhibition, which makes them even more intriguing. This review summarizes the structural features of REV-ERB α/β proteins and their role in the circadian cycle. We also discuss findings in the literature on the function of REV-ERB α/β proteins in the metabolic and immune systems, emphasizing their importance in these systems.

[This retracts the article DOI: 10.14744/nci.2019.95676.].

Objective: The role of magnesium in glucose homeostasis, its effects on glycemic control and the causal relationship between them have been the subject of many studies. In this direction, in our study, we aimed to investigate the relationship between serum magnesium (Mg) levels and hemoglobin A1c (HbA1c) and insulin resistance.

Methods: Based on their HbA1c levels, 305 participants were split into 3 groups: 121 were in the control group, 85 were in the prediabetes group, and 99 were in the diabetes group. Serum magnesium levels were measured in these three groups. The correlation between Mg and fasting plasma glucose, fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) was also investigated. In addition, patients' demographic data, blood pressure, smoking habits and basic biochemical data were also included in the analysis.

Results: There was a significant statistical difference in terms of serum magnesium levels among all the groups (p<0.001). A strong negative correlation was found between serum magnesium levels and HbA1c (r=-0.316, p<0.001). There was also a weak negative relationship between Mg and serum fasting glucose, insulin, and HOMA-IR (r=-0.167 p=0.004, r=-0.167 p=0.003, and r=-0.198 p=0.001, respectively).

Conclusion: We observed a statistically significant negative correlation between serum magnesium levels and HbA1c in our study. According to this finding, it would be useful to assess magnesium levels in patients with high HbA1c levels. However, due to conflicting results among studies investigating the relationship between magnesium, glycemic control and insulin sensitivity with increasing interest, more comprehensive, prospective studies with longer follow-up periods are needed.

Endometriosis is an estrogen-dependent benign disease that generally affects women at childbearing age. Despite its high incidence, pathogenesis of endometriosis is poorly clarified. There are several theories explaining the mechanism of disease such as retrograde menstruation, coelomic metaplasia, vascular and lymphatic metastasis. While endometriosis has been described in many intra- and extra-abdominal organs including the ovaries, omentum, colon, liver, lungs and brain, parenchymal splenic endometriosis is a rare situation. In recent years, with reported cases, this rare condition came onto the scene. We also wanted to present our case and question the idea of splenic immunity against endometriosis according to current literature. From now on, splenic endometriosis can be thought of as a differential diagnosis for unidentified lesions of spleen.

Objective: Elective splenectomy is often performed due to hematological diseases. In this study, we aimed to investigate the splenectomy procedures performed in our clinic under emergency and elective conditions by analyzing the surgical techniques applied, surgical indications, and the clinical and demographic data of the patients, while seeking to discuss this subject, which holds a significant place in general surgical practice, in light of current literature.

Methods: Patients who underwent splenectomy surgery in the general surgery clinic of a tertiary care hospital between September 2016 and September 2024 were included in the study. Clinical and demographic data of the patients were collected retrospectively through the hospital information management system records.

Results: The mean age of 89 patients included in the study was 41.0±18.8 years (18-76 years). The male/female ratio was 1.3/1. The most common indication for splenectomy was trauma (38.2%). This was followed by mass (29.2%), splenomegaly (14.6%), and immune thrombocytopenic purpura (ITP) (14.6%). Of the patients, 62.9% underwent open surgery, while 37.1% were operated on using the laparoscopic technique. Of the patients, 57.3% underwent elective surgery, while emergency surgery was planned for 42.7%.

Conclusion: While splenectomy is a life-saving intervention in emergency conditions, it has become the most important treatment in some hematological diseases. Firstly, accurate surgical indication and the selection of an appropriate surgical technique tailored to the patient are of critical importance. There are still controversial issues in the current literature regarding the indications for splenectomy and the surgical technique to be applied.

Objective: Achalasia is a movement disorder of the esophagus that continues with chest pain, dysphagia, weight loss, regurgitation of undigested foods, recurrent aspiration and night cough.

Methods: Weight loss, presence of dysphagia, presence of retrosternal pain and regurgitation were recorded before POEM treatment and preoperative Eckardt Score was calculated and recorded. Patients were recorded at the 6^th month after POEM treatment recording weight loss, dysphagia presence, retrosternal pain and regurgitation presence and calculating postoperative Eckardt score.

Results: The change between the postoperative and preoperative values of the patients was calculated as ∆ value. As a result of the examination, no significant difference was found between the values ∆weight loss, ∆dysphagia, ∆retrosternal pain, ∆regurgitation and ∆Eckardt score and gender variable (respectively, p=0.112; p=0.412; p=0.619; p=0.171; p=0.092). Postoperative weight loss, dysphagia, retrosternal pain, regurgitation and Eckardt score values were found to be lower than preoperative values. (respectively, p<0.001;p<0.001; p<0.001; p<0.001; p<0.001).

Conclusion: Peroral endoscopic myotomy treatment is an effective treatment method with its being more reliable, lower complication risk, being less invasive and with postprocedural and clinical results.

Objective: The primary objective of our meticulously designed study is to thoroughly investigate and delineate the extent to which individuals afflicted with seborrheic dermatitis, particularly those exhibiting facial manifestations of this dermatological condition, experience significant psychological distress that may adversely impact their self-perception as measured by the Social Appearance Anxiety Scale (SAAS), while simultaneously comparing these findings against a group of healthy individuals serving as controls.

Methods: In the framework of our research, we meticulously recruited a sample comprising 120 individuals diagnosed with seborrheic dermatitis characterized by facial involvement, whose ages ranged from 18 to 65 years, alongside 118 healthy control participants who were strategically matched for key demographic variables, including age, gender, and educational attainment to ensure the integrity of our comparative analysis. Both the patient participants and the healthy controls underwent a systematic administration of a range of validated psychometric tools, particularly the SAAS and the Hospital Anxiety and Depression (HAD) scale. Further, the Dermatology Life Quality Index (DLQI) and Visual Analog Scales (VAS) were exclusively utilized for the subset of individuals within the patient population.

Results: Through comprehensive statistical analysis, the mean scores acquired from the Social Appearance Anxiety Scale (SAAS) for the patient and control groups were 52.10 and 21.35 points, respectively. Accordingly, it was concluded that the average SAAS score observed in the patient group was substantially higher than that recorded in the control group, with a p-value of less than 0.01 reflecting a statistically significant observation.

Conclusion: The presence of seborrheic dermatitis lesions located on visible areas of the skin engenders a notable degree of anxiety among affected individuals, primarily stemming from concerns regarding their physical appearance. This investigation underscores the critical need for individuals experiencing such dermatological manifestations to receive holistic treatment that addresses their psychiatric and dermatological needs.

Objective: This study aims to evaluate the changes in posterior segment parameters that affect visual prognosis in patients with central retinal vein occlusion (CRVO).

Methods: This retrospective study included 58 eyes of 58 CRVO patients. Best-corrected visual acuity (BCVA), intraocular pressure, central macular thickness (CMT), hyperreflective foci (HRF), ellipsoid zone (EZ) loss, disorganization of retinal inner layers (DRIL), intraretinal cystic changes, posterior vitreous detachment (PVD), and macular superficial and deep vascular density (VD), as well as superficial and deep foveal avascular zone (FAZ) areas, were assessed at baseline and 3 months follow-up after treatment. The treatments (intravitreal injections and laser) received were recorded.

Results: The mean age was 63.02±9.91 years, 37 (63.8%) were female, and 39 (67.3%) were classified as having non-ischemic CRVO. The mean baseline BCVA was 0.64±0.85 logMAR; at 3 months, it improved to 0.39±0.65 logMAR (p<0.001). The mean baseline CMT was 478.9±82.6 µm, and at 3 months, it reduced to 288.56±72.39 µm (p<0.001). At baseline, HRF in 31% of eyes, EZ disruption in 44.8% of eyes, DRIL in 17.2% of eyes, intraretinal cysts in 55.2% of eyes, and PVD in 43.1% of eyes. A significant decrease in BCVA was observed in patients with EZ loss (p<0.001), while the presence of intraretinal cysts had significant impact on CMT (p=0.007). Furthermore, a statistically significant negative correlation was observed between foveal and superior VD in both the superficial and deep capillary plexus (SCP, DCP) and changes in BCVA (logMAR). In contrast, a positive correlation was found between superficial FAZ area and BCVA (logMAR). Additionally, a statistically significant positive correlation was noted between foveal VD in both the SCP and DCP and changes in CMT.

Conclusion: The study emphasizes the importance of structural and vascular changes in predicting functional outcomes and suggests the utility of optical coherence tomography (OCT) and OCT angiography in early visual prognosis and treatment planning.

Objective: Osteoarthritis (OA) is a prevalent and disabling joint condition that affects millions worldwide, particularly in the knee joint, and it presents limited therapeutic options. Platelet-rich plasma (PRP) and hyaluronic acid (HA) have emerged as promising intra-articular treatments. This study aimed to compare the effects of single-dose PRP and HA on pain, functionality, and stiffness in patients with knee OA over a 12-week follow-up period.

Methods: A retrospective analysis was conducted on 64 patients who underwent single-dose intra-articular HA or PRP treatment for knee OA between December 2021 and June 2022. Pain and functional outcomes were assessed using the Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores. Patient satisfaction was evaluated using a Likert scale. Appropriate statistical analyses were performed to compare treatment outcomes and p<0.05 was considered statistically significant.

Results: Both PRP and HA treatments led to significant improvements in pain, functionality, and stiffness over the 12-week follow-up period. VAS pain scores decreased significantly in both groups, but a greater reduction was observed in the HA group. Additionally, the HA group exhibited superior improvement in the WOMAC physical function score at the 4-week mark (p=0.047).

Conclusion: This study is another novel contribution to the growing literature on treatment of PRP and HA treatments for knee OA, where we highlighted the potential benefits of single-dose HA in alleviating pain and enhancing physical function.