Objectives: Chronic kidney disease (CKD) complicated by secondary hyperparathyroidism (SHPT) is associated with an increased risk of fragility fractures. Etelcalcetide (EC) is a treatment for SHPT that reduces serum parathyroid hormone (PTH) levels. However, the effects of combined treatment with osteoporosis drugs such as teriparatide (TPTD) remain unclear. This study investigates the combined effects of EC and TPTD on bone in CKD model rats.
Methods: The CKD model was established in 8-week-old male Wistar rats by feeding them a 0.75% adenine diet for 4 weeks. At 20 weeks of age, the rats were divided into 4 groups (N = 9-10 in each group): CKD group (vehicle administration), TPTD group (30 μg/kg, 3 times/week), EC group (0.6 mg/kg, daily), and Comb group (TPTD and EC combined). EC was injected for 12 weeks starting at 20 weeks of age, and TPTD was injected for 8 weeks starting at 24 weeks of age. After treatment, the followings were evaluated: bone mineral density, bone strength, biochemical tests, bone and fat histomorphometry, and micro-computed tomography.
Results: In CKD model rats, the combination of EC and TPTD was more effective in increasing cortical bone thickness and bone strength and inhibiting porosity. In addition, the combined treatment decreased bone marrow adiposity and fibrosis, and it increased bone mass and improved bone microstructure in trabecular bone.
Conclusions: With the observed benefits such as improved bone mass, bone strength, structural properties, and bone marrow adiposity, combination therapy may be a potential way to improve bone fragility in CKD.
{"title":"Teriparatide and etelcalcetide improve bone, fibrosis, and fat parameters in chronic kidney disease model rats.","authors":"Shun Igarashi, Yuji Kasukawa, Koji Nozaka, Hiroyuki Tsuchie, Kazunobu Abe, Hikaru Saito, Ryo Shoji, Fumihito Kasama, Shuntaro Harata, Kento Okamoto, Keita Oya, Naohisa Miyakoshi","doi":"10.1016/j.afos.2023.11.002","DOIUrl":"10.1016/j.afos.2023.11.002","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic kidney disease (CKD) complicated by secondary hyperparathyroidism (SHPT) is associated with an increased risk of fragility fractures. Etelcalcetide (EC) is a treatment for SHPT that reduces serum parathyroid hormone (PTH) levels. However, the effects of combined treatment with osteoporosis drugs such as teriparatide (TPTD) remain unclear. This study investigates the combined effects of EC and TPTD on bone in CKD model rats.</p><p><strong>Methods: </strong>The CKD model was established in 8-week-old male Wistar rats by feeding them a 0.75% adenine diet for 4 weeks. At 20 weeks of age, the rats were divided into 4 groups (N = 9-10 in each group): CKD group (vehicle administration), TPTD group (30 μg/kg, 3 times/week), EC group (0.6 mg/kg, daily), and Comb group (TPTD and EC combined). EC was injected for 12 weeks starting at 20 weeks of age, and TPTD was injected for 8 weeks starting at 24 weeks of age. After treatment, the followings were evaluated: bone mineral density, bone strength, biochemical tests, bone and fat histomorphometry, and micro-computed tomography.</p><p><strong>Results: </strong>In CKD model rats, the combination of EC and TPTD was more effective in increasing cortical bone thickness and bone strength and inhibiting porosity. In addition, the combined treatment decreased bone marrow adiposity and fibrosis, and it increased bone mass and improved bone microstructure in trabecular bone.</p><p><strong>Conclusions: </strong>With the observed benefits such as improved bone mass, bone strength, structural properties, and bone marrow adiposity, combination therapy may be a potential way to improve bone fragility in CKD.</p>","PeriodicalId":94349,"journal":{"name":"Osteoporosis and sarcopenia","volume":"9 4","pages":"121-130"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10874735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139907270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-27DOI: 10.1002/9781119597896.ch10
J. M. Bauer, C. Sieber
{"title":"Sarcopenia, Frailty, and Intrinsic Capacity","authors":"J. M. Bauer, C. Sieber","doi":"10.1002/9781119597896.ch10","DOIUrl":"https://doi.org/10.1002/9781119597896.ch10","url":null,"abstract":"","PeriodicalId":94349,"journal":{"name":"Osteoporosis and sarcopenia","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78910433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-27DOI: 10.1002/9781119597896.ch3
L. Ferrucci, Marta Zampino, Paul M. Coen, B. Goodpaster
{"title":"The Role of Mitochondria in Age‐Related Sarcopenia","authors":"L. Ferrucci, Marta Zampino, Paul M. Coen, B. Goodpaster","doi":"10.1002/9781119597896.ch3","DOIUrl":"https://doi.org/10.1002/9781119597896.ch3","url":null,"abstract":"","PeriodicalId":94349,"journal":{"name":"Osteoporosis and sarcopenia","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83137441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-27DOI: 10.1002/9781119597896.ch23
T. Cederholm, J. M. Bauer, A. Cruz-Jentoft
{"title":"Nutritional Approaches to Treat Sarcopenia","authors":"T. Cederholm, J. M. Bauer, A. Cruz-Jentoft","doi":"10.1002/9781119597896.ch23","DOIUrl":"https://doi.org/10.1002/9781119597896.ch23","url":null,"abstract":"","PeriodicalId":94349,"journal":{"name":"Osteoporosis and sarcopenia","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87803703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-27DOI: 10.1002/9781119597896.ch17
P. Cawthon, William J Evans
{"title":"Deuterated Creatine Dilution to Assess Muscle Mass (D3‐Cr Muscle Mass) in Humans","authors":"P. Cawthon, William J Evans","doi":"10.1002/9781119597896.ch17","DOIUrl":"https://doi.org/10.1002/9781119597896.ch17","url":null,"abstract":"","PeriodicalId":94349,"journal":{"name":"Osteoporosis and sarcopenia","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84109231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-27DOI: 10.1002/9781119597896.ch24
F. Landi, R. Calvani, A. Picca, E. Marzetti
{"title":"Beta‐hydroxy‐beta‐methylbutyrate (HMB) and Sarcopenia","authors":"F. Landi, R. Calvani, A. Picca, E. Marzetti","doi":"10.1002/9781119597896.ch24","DOIUrl":"https://doi.org/10.1002/9781119597896.ch24","url":null,"abstract":"","PeriodicalId":94349,"journal":{"name":"Osteoporosis and sarcopenia","volume":"GE-23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72623135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-27DOI: 10.1002/9781119597896.ch21
C. Beaudart, J. Reginster, O. Bruyère, A. Geerinck
{"title":"Quality of Life and Sarcopenia","authors":"C. Beaudart, J. Reginster, O. Bruyère, A. Geerinck","doi":"10.1002/9781119597896.ch21","DOIUrl":"https://doi.org/10.1002/9781119597896.ch21","url":null,"abstract":"","PeriodicalId":94349,"journal":{"name":"Osteoporosis and sarcopenia","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77766978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-27DOI: 10.1002/9781119597896.ch7
J. Woo
{"title":"Adverse Outcomes and Functional Consequences of Sarcopenia","authors":"J. Woo","doi":"10.1002/9781119597896.ch7","DOIUrl":"https://doi.org/10.1002/9781119597896.ch7","url":null,"abstract":"","PeriodicalId":94349,"journal":{"name":"Osteoporosis and sarcopenia","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73393816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-27DOI: 10.1002/9781119597896.ch14
Hidenori Arai
{"title":"Sarcopenia and Other Chronic Organ Diseases","authors":"Hidenori Arai","doi":"10.1002/9781119597896.ch14","DOIUrl":"https://doi.org/10.1002/9781119597896.ch14","url":null,"abstract":"","PeriodicalId":94349,"journal":{"name":"Osteoporosis and sarcopenia","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75829387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-27DOI: 10.1002/9781119597896.ch22
M. Peterson, J. Serra
{"title":"Exercise Interventions to Prevent and Improve Sarcopenia","authors":"M. Peterson, J. Serra","doi":"10.1002/9781119597896.ch22","DOIUrl":"https://doi.org/10.1002/9781119597896.ch22","url":null,"abstract":"","PeriodicalId":94349,"journal":{"name":"Osteoporosis and sarcopenia","volume":"163 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75194989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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