The EPMA journal最新文献

英文中文

Body fluid multiomics in 3PM-guided ischemic stroke management: health risk assessment, targeted protection against health-to-disease transition, and cost-effective personalized approach are envisaged. 体液多组学在 3PM 指导下的缺血性中风管理中的应用：健康风险评估、有针对性地防止从健康到疾病的转变以及具有成本效益的个性化方法。

IF 6 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

The EPMA journal

Pub Date : 2024-08-29 eCollection Date: 2024-09-01 DOI: 10.1007/s13167-024-00376-2

Ruofei Chen, Xiaoyan Wang, Na Li, Olga Golubnitschaja, Xianquan Zhan

Because of its rapid progression and frequently poor prognosis, stroke is the third major cause of death in Europe and the first one in China. Many independent studies demonstrated sufficient space for prevention interventions in the primary care of ischemic stroke defined as the most cost-effective protection of vulnerable subpopulations against health-to-disease transition. Although several studies identified molecular patterns specific for IS in body fluids, none of these approaches has yet been incorporated into IS treatment guidelines. The advantages and disadvantages of individual body fluids are thoroughly analyzed throughout the paper. For example, multiomics based on a minimally invasive approach utilizing blood and its components is recommended for real-time monitoring, due to the particularly high level of dynamics of the blood as a body system. On the other hand, tear fluid as a more stable system is recommended for a non-invasive and patient-friendly holistic approach appropriate for health risk assessment and innovative screening programs in cost-effective IS management. This article details aspects essential to promote the practical implementation of highlighted achievements in 3PM-guided IS management.

Supplementary information: The online version contains supplementary material available at 10.1007/s13167-024-00376-2.

脑卒中是欧洲第三大死因，在中国则是第一大死因，因为其进展迅速，预后往往不佳。许多独立研究表明，缺血性脑卒中初级治疗中的预防干预措施有足够的空间，可为脆弱亚人群提供最具成本效益的保护，防止从健康到疾病的转变。尽管多项研究发现了体液中特异的 IS 分子模式，但这些方法都尚未纳入 IS 治疗指南。本文全面分析了各种体液的优缺点。例如，基于微创方法的多组学利用血液及其成分进行实时监测是值得推荐的，因为血液作为人体系统具有特别高的动态水平。另一方面，泪液作为一种更稳定的系统，建议采用无创、方便患者的整体方法，适合于健康风险评估和创新性筛查计划，以实现具有成本效益的信息系统管理。本文详细介绍了在 3PM 指导的 IS 管理中促进重点成果实际应用的重要方面：在线版本包含补充材料，可在 10.1007/s13167-024-00376-2。

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引用次数: 0

Tangled quest of post-COVID-19 infection-caused neuropathology and what 3P nano-bio-medicine can solve? 新型冠状病毒感染后神经病理学的纠结探索和3P纳米生物医学能解决什么?

The EPMA journal

Pub Date : 2022-06-01 DOI: 10.1007/s13167-022-00285-2

N. Hamdy, Fatma H. Shaker, X. Zhan, Emad B. Basalious

引用次数: 2

Methods to evaluate vascular function: a crucial approach towards predictive, preventive, and personalised medicine 评估血管功能的方法:预测、预防和个性化医疗的关键途径

The EPMA journal

Pub Date : 2022-05-20 DOI: 10.1007/s13167-022-00280-7

C. Sena, Lino Gonçalves, R. Seiça

引用次数: 8

Mitochondrial health quality control: measurements and interpretation in the framework of predictive, preventive, and personalized medicine 线粒体健康质量控制:预测、预防和个性化医学框架中的测量和解释

The EPMA journal

Pub Date : 2022-05-12 DOI: 10.1007/s13167-022-00281-6

Lenka Koklesová, Alena Mazurakova, Marek Samec, E. Kudela, K. Biringer, P. Kubatka, O. Golubnitschaja

引用次数: 22

Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care 植物化学物质的抗乳腺癌作用:初级、二级和三级护理

The EPMA journal

Pub Date : 2022-04-14 DOI: 10.1007/s13167-022-00277-2

Alena Mazurakova, Lenka Koklesová, Marek Samec, E. Kudela, K. Kajo, V. Skuciova, S. Csizmár, V. Mestanova, M. Péč, M. Adamkov, R. Al-Ishaq, K. Šmejkal, F. Giordano, Dietrich Büsselberg, K. Biringer, O. Golubnitschaja, P. Kubatka

引用次数: 29

Prostate cancer treatment costs increase more rapidly than for any other cancer—how to reverse the trend? 前列腺癌的治疗费用比其他癌症增长得更快——如何扭转这一趋势?

The EPMA journal

Pub Date : 2022-03-01 DOI: 10.1007/s13167-022-00276-3

J. Ellinger, A. Alajati, P. Kubatka, F. Giordano, M. Ritter, V. Costigliola, O. Golubnitschaja

引用次数: 22

Evaluation of thermal sensitivity is of potential clinical utility for the predictive, preventive, and personalized approach advancing metabolic syndrome management 评估热敏性对于预测、预防和个性化的方法推进代谢综合征的管理具有潜在的临床应用价值

The EPMA journal

Pub Date : 2022-02-18 DOI: 10.1007/s13167-022-00273-6

Sujeong Mun, Kihyun Park, Siwoo Lee

引用次数: 2

Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients 以T2DM患者为例，泪液代谢表型作为个体化用药的预后工具

The EPMA journal

Pub Date : 2021-12-02 DOI: 10.1007/s13167-022-00272-7

Julia Brunmair, A. Bileck, D. Schmidl, G. Hagn, S. Meier‐Menches, Nikolaus Hommer, A. Schlatter, C. Gerner, G. Garhöfer

引用次数: 9

Nomogram prediction for the 3-year risk of type 2 diabetes in healthy mainland China residents 中国大陆健康居民3年2型糖尿病发病风险的Nomogram预测

The EPMA journal

Pub Date : 2019-08-06 DOI: 10.1007/s13167-019-00181-2

Kun Wang, Meihua Gong, Songpu Xie, Meng Zhang, Huabo Zheng, Xiaofang Zhao, Chengyun Liu

引用次数: 32

Inappropriate modeling of chronic and complex disorders: How to reconsider the approach in the context of predictive, preventive and personalized medicine, and translational medicine. 慢性和复杂疾病的不适当建模：如何在预测性、预防性和个性化医学以及转化医学的背景下重新考虑该方法。

The EPMA journal

Pub Date : 2019-07-31 eCollection Date: 2019-09-01 DOI: 10.1007/s13167-019-00176-z

Soroush Seifirad, Vahid Haghpanah

Preclinical investigations such as animal modeling make the basis of clinical investigations and subsequently patient care. Predictive, preventive, and personalized medicine (PPPM) not only highlights a patient-tailored approach by choosing the right medication, the right dose at the right time point but it as well essentially requires early identification, by the means of complex and state-of-the-art technologies of unmanifested pathological processes in an individual, in order to deliver targeted prevention early enough to reverse manifestation of a pathology. Such an approach can be achieved by taking into account clinical, pathological, environmental, and psychosocial characteristics of the patients or an individual who has a suboptimal health condition. Inappropriate modeling of chronic and complex disorders, in this context, may diminish the predictive potential and slow down the development of PPPM and consequently modern healthcare. Therefore, it is the common goal of PPPM and translational medicine to find the solution for the problem we present in our review. Both, translational medicine and PPPM in parallel, essentially need accurate surrogates for misleading animal models. This study was therefore undertaken to provide shreds of evidence against the validity of animal models. Limitations of current animal models and drug development strategies based on animal modeling have been systematically discussed. Finally, a variety of potential surrogates have been suggested to change the unfavorable situation in medical research and consequently in healthcare.

临床前研究，如动物模型，是临床研究和后续患者护理的基础。预测性、预防性和个性化医学（PPPM）不仅强调了通过在正确的时间点选择正确的药物、正确的剂量来为患者量身定制的方法，而且还基本上需要通过复杂和最先进的技术来早期识别个体的未列明的病理过程，以便尽早提供有针对性的预防以逆转病理学的表现。这种方法可以通过考虑患者或健康状况不佳的个人的临床、病理、环境和心理社会特征来实现。在这种情况下，对慢性和复杂疾病的不适当建模可能会降低预测潜力，减缓PPPM的发展，从而减缓现代医疗保健的发展。因此，找到我们在综述中提出的问题的解决方案是PPPM和转化医学的共同目标。同时，转化医学和PPPM本质上都需要准确的替代品来建立误导性的动物模型。因此，这项研究旨在为动物模型的有效性提供零星的证据。系统地讨论了当前动物模型的局限性和基于动物模型的药物开发策略。最后，已经提出了各种潜在的代孕者来改变医学研究以及医疗保健领域的不利局面。

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引用次数: 20

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