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A cross-sectional survey on the effects of ambient temperature and humidity on health outcomes in individuals with chronic respiratory disease 关于环境温度和湿度对慢性呼吸道疾病患者健康影响的横断面调查
Samantha Mekhuri, S. Quach, Caroline Barakat, Winnie Sun, Mika L Nonoyama
Rationale Extremes of temperature and humidity are associated with adverse respiratory symptoms, reduced lung function, and increased exacerbations among individuals living with chronic obstructive pulmonary disease (COPD). Objectives To describe the reported effects of temperature and humidity extremes on the health outcomes, health status and physical activity (PA) in individuals living with COPD. Methods A cross-sectional self-reported survey collected the effects on health status (COPD Assessment Test [CAT]), PA, and health outcomes in 1) moderate/ideal (14 to 21°C, 30 to 50% relative humidity [RH]), 2) hot and humid (≥ 25°C, > 50% RH) and 3) cold and dry (≤ 5°C, < 30% RH) weather conditions. Participants were ≥ 40 years old with COPD or related chronic respiratory diseases (e.g., asthma, sleep apnea, interstitial lung disease, lung cancer) and residing in Canada for ≥ 1 year. Negative responders to weather extremes were a priori defined as having a change of ≥ 2 points in the CAT. Main Results Thirty-six participants responded; the mean age (SD) was 65 (11) years, and 23 (64%) were females. Compared to ideal conditions, 23 (66%) and 24 (69%) were negatively affected by cold/dry and hot/humid weather, respectively. Health status was significantly lower, and PA amount and difficulty level were reduced in hot/humid and cold/dry conditions compared with ideal conditions. The number of exacerbations in hot/humid was significantly higher compared to ideal conditions. Conclusions More participants were negatively affected by extremes of weather: health status worsened, PA decreased, and frequency of exacerbations was higher compared to ideal. Future prospective studies should directly and objectively investigate different combinations of extreme temperature and humidity levels on symptoms and PA to understand their long-term health outcomes.
在慢性阻塞性肺疾病(COPD)患者中,极端温度和湿度与不良呼吸道症状、肺功能下降和加重加重有关。目的描述极端温度和湿度对慢性阻塞性肺病患者健康结局、健康状况和身体活动(PA)的影响。方法采用横断面自我报告调查,收集1)中等/理想(14 ~ 21℃,30 ~ 50%相对湿度[RH])、2)湿热(≥25℃,> 50% RH)和3)寒冷干燥(≤5℃,< 30% RH)天气条件对健康状况(COPD评估测试[CAT])、PA和健康结局的影响。参与者年龄≥40岁,患有慢性阻塞性肺病或相关慢性呼吸系统疾病(如哮喘、睡眠呼吸暂停、间质性肺疾病、肺癌),在加拿大居住≥1年。对极端天气的负反应者被先验地定义为在CAT中变化≥2点。主要结果36名参与者回复;平均年龄65(11)岁,女性23例(64%)。与理想条件相比,23(66%)和24(69%)分别受到寒冷/干燥和炎热/潮湿天气的负面影响。与理想条件相比,热/湿和冷/干条件下的健康状况显著降低,PA量和难度降低。与理想条件相比,炎热/潮湿条件下的恶化次数明显更高。结论:更多的参与者受到极端天气的负面影响:与理想情况相比,健康状况恶化,PA下降,恶化频率更高。未来的前瞻性研究应直接和客观地调查极端温度和湿度水平对症状和PA的不同组合,以了解其长期健康结果。
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引用次数: 0
Impact of telephone follow-up on COPD outcomes in pulmonary rehabilitation patients: A randomized clinical trial 电话随访对肺康复患者慢性阻塞性肺疾病疗效的影响:随机临床试验
Stefanie Tonguino Rosero, Juan Carlos Ávila Valencia, Jhonatan Betancourt Peña
Background The educational component is a comprehensive part of Pulmonary Rehabilitation (PR), and telephone follow-up (TFU) is an alternative to reinforce face-to-face education. The objective was to determine the effect of telephone follow-up on educational needs, dyspnea, quality of life and functional capacity in Chronic Obstructive Pulmonary Disease (COPD) patients undergoing PR. Methods Double-blind randomized controlled clinical trial in patients with COPD in a PR program in Cali-Colombia, allocation by randomization tables. All patients received 24 sessions of PR, which included face-to-face education sessions. In addition, the experimental group received telephone calls twice a week to reinforce the face-to-face educational content. The Lung Information Needs Questionnaire (LINQ) was used to measure disease knowledge, the Saint George’s Respiratory Questionnaire to measure quality of life, the modified Medical Research Council (mMRC) scale to measure dyspnea, and the 6-minute walking test (6MWT) to measure functional capacity. Results Thirty-four patients were randomized and 31 were analyzed. PR group with conventional education (PRTE) n=15 and PR group with education plus telephone follow-up (PRTETFU) n=16. Significant improvement from baseline to endpoint in both groups: LINQ (PRTE 4±1.1, p=0.003, PRTETFU 5.8±10.6, p=0.000), mMRC (PRTE 1.6±0.3, p=0.000, PRTETFU 0.6±0.3, p=0.036) and functional capacity (PM6M: PRTE 45.9m±16.1, p=0.013, PRTETFU 62.8m±21.4, p=0.010). Analysis showed differences between groups for changes in LINQ knowledge domain after intervention, with greater improvement for PRTETFU (p=0.018). Discussion The TFU is an alternative to reinforce the education. This study demonstrated greater positive effects for the autonomous management of the pathology. Conclusion Adding educational reinforcement through phone calls to patients with COPD during PR leads to improved knowledge and skills for managing the disease.
教育内容是肺康复(PR)的一个综合部分,电话随访(TFU)是加强面对面教育的一种选择。目的是确定电话随访对接受PR的慢性阻塞性肺疾病(COPD)患者的教育需求、呼吸困难、生活质量和功能能力的影响。方法在加州-哥伦比亚的一个PR项目中对COPD患者进行双盲随机对照临床试验,采用随机化表分配。所有患者均接受了24次PR,包括面对面的教育。此外,实验组每周接受两次电话,加强面对面的教学内容。采用肺信息需求问卷(LINQ)测量疾病知识,采用圣乔治呼吸问卷(Saint George’s Respiratory Questionnaire)测量生活质量,采用改良的医学研究委员会(Medical Research Council, mMRC)量表测量呼吸困难,采用6分钟步行测试(6MWT)测量功能能力。结果随机选取34例,分析31例。PR组常规教育组(PRTE) 15例,PR组教育加电话随访组(PRTETFU) 16例。两组从基线到终点均有显著改善:LINQ (PRTE 4±1.1,p=0.003, PRTETFU 5.8±10.6,p=0.000)、mMRC (PRTE 1.6±0.3,p=0.000, PRTETFU 0.6±0.3,p=0.036)和功能容量(PM6M: PRTE 45.9m±16.1,p=0.013, PRTETFU 62.8m±21.4,p=0.010)。分析显示,干预后各组间LINQ知识域的变化存在差异,其中PRTETFU的改善更大(p=0.018)。TFU是加强教育的另一种选择。本研究证明了对病理自主管理的更大积极作用。结论在PR期间,通过电话对COPD患者加强教育,可以提高对疾病管理的知识和技能。
{"title":"Impact of telephone follow-up on COPD outcomes in pulmonary rehabilitation patients: A randomized clinical trial","authors":"Stefanie Tonguino Rosero, Juan Carlos Ávila Valencia, Jhonatan Betancourt Peña","doi":"10.29390/001c.90520","DOIUrl":"https://doi.org/10.29390/001c.90520","url":null,"abstract":"Background The educational component is a comprehensive part of Pulmonary Rehabilitation (PR), and telephone follow-up (TFU) is an alternative to reinforce face-to-face education. The objective was to determine the effect of telephone follow-up on educational needs, dyspnea, quality of life and functional capacity in Chronic Obstructive Pulmonary Disease (COPD) patients undergoing PR. Methods Double-blind randomized controlled clinical trial in patients with COPD in a PR program in Cali-Colombia, allocation by randomization tables. All patients received 24 sessions of PR, which included face-to-face education sessions. In addition, the experimental group received telephone calls twice a week to reinforce the face-to-face educational content. The Lung Information Needs Questionnaire (LINQ) was used to measure disease knowledge, the Saint George’s Respiratory Questionnaire to measure quality of life, the modified Medical Research Council (mMRC) scale to measure dyspnea, and the 6-minute walking test (6MWT) to measure functional capacity. Results Thirty-four patients were randomized and 31 were analyzed. PR group with conventional education (PRTE) n=15 and PR group with education plus telephone follow-up (PRTETFU) n=16. Significant improvement from baseline to endpoint in both groups: LINQ (PRTE 4±1.1, p=0.003, PRTETFU 5.8±10.6, p=0.000), mMRC (PRTE 1.6±0.3, p=0.000, PRTETFU 0.6±0.3, p=0.036) and functional capacity (PM6M: PRTE 45.9m±16.1, p=0.013, PRTETFU 62.8m±21.4, p=0.010). Analysis showed differences between groups for changes in LINQ knowledge domain after intervention, with greater improvement for PRTETFU (p=0.018). Discussion The TFU is an alternative to reinforce the education. This study demonstrated greater positive effects for the autonomous management of the pathology. Conclusion Adding educational reinforcement through phone calls to patients with COPD during PR leads to improved knowledge and skills for managing the disease.","PeriodicalId":9533,"journal":{"name":"Canadian Journal of Respiratory Therapy: CJRT = Revue Canadienne de la Thérapie Respiratoire : RCTR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138594404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies to achieve adherence to prone positioning in awake COVID-19 patients with high-flow nasal oxygen. A case series 高流量鼻吸氧下清醒COVID-19患者坚持俯卧位的策略案例系列
M. Busico, M. M. Laiz, J. Urrutia, Maria Emilia Amado, D. Villalba, S. Saavedra, Adrián Gallardo, A. Thille
Introduction The use of high-flow nasal oxygen (HFNO) is a simple method that can reduce intubation in patients with hypoxemic acute respiratory failure (ARF). Early and prolonged prone position has demonstrated benefits on mortality in mechanically ventilated patients and on intubation in awake patients with ARF. However, strategies to achieve adherence to awake prone positioning (APP) have not been previously described. Case and outcomes We present six patients with ARF due to COVID-19 treated with HFNO and APP. The median (p25–75) of PaFiO2 upon admission was 121 (112–175). The average duration of APP on the first day was 16 h (SD 5 h). Duration (median p25–75) in APP for the following 20 days was 13 (10–18) h/day. Several strategies such as the presence of a health care team, recreational activities, adaptation of the circadian rhythm, oral nutritional support, and analgesics were used to improve prone tolerance. None of the patients suffered from delirium, all were ambulating on discharge from the ICU and none require intubation. Conclusion The case series presented show the feasibility of prolonged use of HFNO and APP in patients with COVID-19 and severe persistent hypoxemia and described strategies to enhance adherence.
高流量鼻吸氧(HFNO)是低氧性急性呼吸衰竭(ARF)患者减少插管的一种简便方法。早期和延长俯卧位已被证明对机械通气患者的死亡率和ARF清醒患者的插管有好处。然而,以前没有描述过坚持清醒俯卧位(APP)的策略。病例和结果我们报告了6例经HFNO和APP治疗的COVID-19所致ARF患者。入院时PaFiO2的中位数(p25-75)为121(112-175)。第一天APP的平均持续时间为16 h (SD 5 h),随后20天APP的持续时间(p25-75)为13 (10-18)h/d。一些策略,如卫生保健团队的存在,娱乐活动,适应昼夜节律,口服营养支持和止痛药被用来改善俯卧耐受性。所有患者均无谵妄,出院时均可走动,均无需插管。结论本病例系列显示了COVID-19合并严重持续性低氧血症患者长期使用HFNO和APP的可行性,并描述了增强依从性的策略。
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引用次数: 1
A survey on the attitudinal differences between acute and community settings 急性环境与社区环境态度差异调查
Cael Field
Introduction While challenges facing community and acute care practitioners have been studied elsewhere, this is not the case for respiratory therapists (RTs). This study aimed to examine attitudinal differences amongst RTs in British Columbia regarding challenges faced by acute and community settings. Methods A 40-item anonymous online survey was sent to members of the British Columbia Society or Respiratory Therapists. Of the 40 questions, 11 were relevant to the study’s aim. Results Of 1024 invitations, 197 (19.2%) responded. One-hundred and seventeen (59.4%) self-identified as working in acute care settings, 53 (26.9%) in community settings, and 27 (13.7%) as “other”. Stress- and interpersonal-related challenges showed statistically significant differences (P ≤ 0.05) based on work setting. Acute care had the highest percentage of responses for challenges related to technology, stress, inter-professional collaboration, and training. Community settings had the highest percentage in challenges related to independence and education. Both being equal received the highest percentage in challenges related to problem-solving, interpersonal, communication, and resource management. Discussion While attitudinal differences exist, they are not extreme. It did not appear that respondents’ primary motivation was to vote along “party lines”. Conclusions The setting an RT works in can influence attitudes related to stress and interpersonal challenges. Despite this, one setting is not universally more challenging. Acute care settings can have greater technological, inter-professional, and training-related challenges. Community settings can have greater independence and education-related challenges. Both settings can provide similar challenges with problem-solving, communication, and resource management.
虽然社区和急症护理从业者面临的挑战已经在其他地方进行了研究,但呼吸治疗师(RTs)的情况并非如此。本研究旨在考察不列颠哥伦比亚省RTs在急性和社区环境中所面临的挑战的态度差异。方法向不列颠哥伦比亚省呼吸治疗师协会会员发送40项匿名在线调查。在40个问题中,有11个与研究目的相关。结果在1024份邀请中,197份(19.2%)得到回应。117人(59.4%)自认为在急症护理机构工作,53人(26.9%)在社区环境中工作,27人(13.7%)为“其他”。压力相关挑战和人际相关挑战在不同工作环境中的差异有统计学意义(P≤0.05)。急症护理对与技术、压力、跨专业合作和培训相关的挑战的回应比例最高。社区环境在与独立和教育相关的挑战中所占比例最高。在解决问题、人际关系、沟通和资源管理方面的挑战中,两者的比例都是最高的。态度上的差异虽然存在,但并不极端。调查显示,受访者的主要动机并不是按照“党派路线”投票。结论RT工作环境对压力态度和人际挑战有影响。尽管如此,并不是所有的场景都更具挑战性。急性护理环境可能有更大的技术、跨专业和培训相关的挑战。社区环境可能具有更大的独立性和与教育相关的挑战。这两种设置在解决问题、沟通和资源管理方面都会带来类似的挑战。
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引用次数: 0
Winning Posters from the Canadian Society of Respiratory Therapists 2022 Annual Conference 来自加拿大呼吸治疗师协会2022年年会的获奖海报
J. Brown, R. Floro, A. Lam, T. Nguyen, M. Patel, J. Paul, T. Peacock
Canadian Respiratory Therapist COVID-19 vaccination uptake rates and responses were investigated with a look at the reasons behind any delays or non-vaccinations as well as other demographics, attitudes, or factors that may be shown to play a role. An anonymous survey using SurveyMonkey® on vaccination uptake rates, responses, and attitudes was available to Student, Graduate, and Registered Respiratory Therapists in Canada from July to October of 2021. A total of 1066 surveys (8.4% of target population) were started, 983 in English and 83 in French with 1013 completed fully and included in the data analysis. Canadian RT Vaccination uptake rates were compared to those of all Canadian healthcare workers which showed that 90.42% of the surveyed RT population in Canada received their vaccination right away compared to the posted rate at the time of 86.27% for all Canadian Healthcare Workers. Pearson Chi-Square Tests were performed to evaluate association between vaccination status and other categorical parameters evaluated in the survey. There was a significant (P = 0.013) association between early vaccination and age, a significant (P = 0.036) association between vaccination status and participants’ response on whether or not they have a family member or know someone who has had COVID-19, a significant (P < 0.001) association between vaccination status and attitudes towards trusting science to develop safe, effective, new vaccines, and a significant (P < 0.001) association between vaccination status and attitudes towards trusting the Ministry of Health to ensure that vaccines are safe. There was no significant association between vaccination status and gender, province/territory of residency/work, level of education, level of involvement with COVID-19 patients. The results suggest that the RT groups across Canada had higher early vaccination uptake rates than the general Healthcare worker groups and that age, relationship to people with COVID-19 and trust in science played a significant role in their vaccination uptake rates.
对COVID-19疫苗接种率和反应进行了调查,研究了任何延误或未接种疫苗背后的原因,以及其他可能发挥作用的人口统计学、态度或因素。2021年7月至10月,加拿大的学生、研究生和注册呼吸治疗师使用SurveyMonkey®进行了一项关于疫苗接种率、反应和态度的匿名调查。总共开展了1066项调查(占目标人群的8.4%),其中英语调查983项,法语调查83项,其中1013项完全完成并纳入数据分析。加拿大RT疫苗接种率与所有加拿大卫生保健工作者的接种率进行了比较,结果表明,加拿大90.42%的接受调查的RT人群立即接种了疫苗,而当时所有加拿大卫生保健工作者的接种率为86.27%。采用Pearson卡方检验来评估疫苗接种状况与调查中评估的其他分类参数之间的关系。早期接种疫苗与年龄之间存在显著相关性(P = 0.013),接种疫苗状况与参与者是否有家庭成员或认识某人感染COVID-19的回答之间存在显著相关性(P = 0.036),接种疫苗状况与相信科学能够开发安全、有效的新疫苗的态度之间存在显著相关性(P < 0.001)。疫苗接种状况与信任卫生部确保疫苗安全的态度之间存在显著(P < 0.001)关联。疫苗接种状况与性别、居住/工作省/地区、教育水平、与COVID-19患者的接触程度无显著相关性。结果表明,加拿大各地的RT组的早期疫苗接种率高于普通医护人员组,年龄、与COVID-19患者的关系以及对科学的信任在他们的疫苗接种率中发挥了重要作用。
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引用次数: 0
Proceedings from the Canadian Society of Respiratory Therapists Annual Conference May 13–14, 2022 加拿大呼吸治疗师协会年会论文集,2022年5月13-14日
T. Tessier
Background: The long-term impact of COVID-19 is still unknown. Objective: This study aimed to explore post COVID-19 effect on patients’ chest computed tomography (CT), lung function, respiratory symptoms, fatigue, functional capacity, health-related quality of life (HRQoL) and the ability to return to work beyond 3 months post-infection. Methods: A systematic search was performed on PubMed, Web of Science and Ovid MEDLINE on May 22, 2021, to identify studies that reported persistent effects of COVID-19 beyond 3 months follow-up. Data on the proportion of patients who had the outcome were collected and analyzed using a one-group meta-analysis. Results: Data were extracted from 24 articles that presented information on a total of 5323 post COVID-19 adults between 3 and 6 months after symptoms onset or hospital discharge. The pooled prevalence of CT abnormalities was 59% (95% CI 4473, I2 = 96%), abnormal lung function 39% (95% CI 24–55, I2 = 94%), fatigue 38% (95% CI 27–49, I2 = 98%), dyspnea 32% (95% CI 24–40, I2 = 98%), chest paint/tight-ness 16% (95% CI 12–21, I2 = 94%), and cough 13%, (95% CI 9–17, I2 = 94%). Decreased functional capacity and HRQoL were found in 36% (95% CI 22–49, I2 = 97%) and 52% (95% CI 33–71, they may be vaccine hesitant despite acknowledging that vaccination is necessary. This presentation will present an ethics methodology approach to encourage collaboration between opposing groups. Reasons for both vaccine hesitancy and vaccine support will be presented. The goal is to provide respiratory students and professionals with additional tools to approach vaccine-hesitant patients so that future confrontations are col-laborative and proactive. Recommended methods on how to approach and challenging patients on their values can help guide difficult discus-sions around vaccinations and mistrust in healthcare. The findings from this case series reveal that the pres-ence of ventilator-associated pneumonia in SARS-CoV-2 patients is a source of significant mortality. This study strengthens the importance of non-invasive mechanical ventilation strategies and also high-lights the need for careful infection control surveillance in invasive mechanical ventilation. Due to the high rates of VAP and associated increased mortality, uprating antibiotic/antifungal therapy selec-tion is also paramount in caring for SARS-CoV-2 cases admitted to the ICU. steps therapeutic algorithm for VV-ECMO ARDS 1. an optimization of mechanical ventilation before VV-ECMO consideration; 2. VV-ECMO indications; 3. start, maintenance and weaning phases of VV-ECMO; 4. post decannulation. The complex interaction between a patient, a VV-ECMO machine, and a mechanical ventilator as well as challenges of respiratory monitoring be
背景:COVID-19的长期影响尚不清楚。目的:本研究旨在探讨COVID-19感染后3个月对患者胸部CT、肺功能、呼吸系统症状、疲劳、功能能力、健康相关生活质量(HRQoL)和重返工作能力的影响。方法:于2021年5月22日在PubMed、Web of Science和Ovid MEDLINE上进行系统检索,以确定报告COVID-19在3个月随访后持续影响的研究。采用单组荟萃分析收集并分析了达到上述结果的患者比例的数据。结果:数据从24篇文章中提取,这些文章提供了5323名COVID-19后成人在症状出现或出院后3至6个月的信息。CT异常的总患病率为59% (95% CI 4473, I2 = 96%),肺功能异常39% (95% CI 24-55, I2 = 94%),疲劳38% (95% CI 27-49, I2 = 98%),呼吸困难32% (95% CI 24-40, I2 = 98%),胸漆/胸闷16% (95% CI 12-21, I2 = 94%),咳嗽13% (95% CI 9-17, I2 = 94%)。36% (95% CI 22-49, I2 = 97%)和52% (95% CI 33-71)的患者功能能力和HRQoL下降,尽管承认有必要接种疫苗,但他们可能对疫苗犹豫不决。本报告将介绍一种伦理方法论方法,以鼓励对立团体之间的合作。将介绍对疫苗犹豫和支持疫苗的原因。目标是为呼吸学学生和专业人员提供额外的工具来接近疫苗犹豫的患者,以便未来的对抗是合作和积极主动的。关于如何接近和挑战患者价值观的推荐方法可以帮助指导围绕疫苗接种和医疗保健不信任的困难讨论。该病例系列的研究结果表明,SARS-CoV-2患者出现呼吸机相关肺炎是导致严重死亡率的一个原因。本研究强调了无创机械通气策略的重要性,也强调了在有创机械通气中进行仔细的感染控制监测的必要性。由于VAP的高发生率和相关的死亡率增加,在护理ICU收治的SARS-CoV-2病例时,提高抗生素/抗真菌治疗的选择也至关重要。VV-ECMO ARDS的治疗算法考虑VV-ECMO前机械通气的优化;2. VV-ECMO迹象;3.VV-ECMO的启动、维持和脱机阶段;4. 后拔管。患者、VV-ECMO机和机械呼吸机之间复杂的相互作用以及呼吸监测的挑战
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引用次数: 0
Late diagnosis of COVID-19 in a 34-year-old man in a hypercoagulable state: A case report 34岁高凝状态男性晚期诊断COVID-19 1例
D. Desdiani
Background Late diagnosis of COVID-19 in young patients in a hypercoagulable state can cause a high mortality rate. Clinical manifestations of COVID-19 include respiratory and extrapulmonary symptoms such as a hypercoagulable state, increased transaminase enzymes, and multiple-organ failure. Case and outcomes A 34-year-old male presented to the emergency room after 3 days of high fever, weakness, and flatulence. The patient had thrombocytopenia and elevated liver transaminase enzymes and was initially diagnosed with dengue hemorrhagic fever. He was given hydration intravenous fluids, oxygen, antipyretic, and hepatoprotector. On day 4, the patient was diagnosed with COVID-19 and received therapy to decrease the Alanine transaminase and Aspartate transaminase levels. While waiting for outsourced D dimer and prothrombin time results, the patient was given low molecular weight heparin (LMWH) on day 5. On day 13, his condition deteriorated with cephalgia and shortness of breath, but the patient’s family refused intubation. The chest CT scan revealed large ground-glass opacities in both lungs. The patient was given additional medications, such as Meropenem, Dexamethasone, and Remdesivir. On day 15, the patient passed away. Discussion Intermediate LMWH dosage seems to be associated with a lower mortality incidence than standard Deep Vein Thrombosis (DVT) prophylaxis in hospitalized COVID-19 patients. However, due to the late COVID-19 diagnosis, the patient was not given LMWH at the beginning of treatment. Conclusion A hypercoagulable state is partly responsible for the high mortality rate of COVID-19 patients. Early detection and management of the hypercoagulable state, including the use of LMWH, can decrease the severity of COVID-19 symptoms.
背景年轻高凝患者COVID-19的晚期诊断可导致高死亡率。COVID-19的临床表现包括呼吸和肺外症状,如高凝状态、转氨酶升高和多器官衰竭。病例和结果一名34岁男性在3天的高热、虚弱和胀气后被送往急诊室。患者有血小板减少症和肝转氨酶升高,最初诊断为登革出血热。给予静脉补液、吸氧、退烧药和护肝药。第4天诊断为COVID-19,并接受降低丙氨酸转氨酶和天冬氨酸转氨酶水平的治疗。在等待外包D二聚体和凝血酶原时间结果的同时,患者在第5天给予低分子肝素(LMWH)。第13天病情恶化,出现头痛、呼吸急促,但患者家属拒绝插管。胸部CT扫描显示双肺大面积磨玻璃影。患者给予额外的药物治疗,如美罗培南、地塞米松和瑞德西韦。第15天,病人去世了。在住院的COVID-19患者中,低分子肝素的中间剂量似乎与较低的深静脉血栓形成(DVT)预防相关。然而,由于COVID-19诊断较晚,患者在治疗开始时未给予低分子肝素。结论高凝状态是COVID-19患者高死亡率的原因之一。早期发现和管理高凝状态,包括使用低分子肝素,可以降低COVID-19症状的严重程度。
{"title":"Late diagnosis of COVID-19 in a 34-year-old man in a hypercoagulable state: A case report","authors":"D. Desdiani","doi":"10.29390/cjrt-2021-028","DOIUrl":"https://doi.org/10.29390/cjrt-2021-028","url":null,"abstract":"Background Late diagnosis of COVID-19 in young patients in a hypercoagulable state can cause a high mortality rate. Clinical manifestations of COVID-19 include respiratory and extrapulmonary symptoms such as a hypercoagulable state, increased transaminase enzymes, and multiple-organ failure. Case and outcomes A 34-year-old male presented to the emergency room after 3 days of high fever, weakness, and flatulence. The patient had thrombocytopenia and elevated liver transaminase enzymes and was initially diagnosed with dengue hemorrhagic fever. He was given hydration intravenous fluids, oxygen, antipyretic, and hepatoprotector. On day 4, the patient was diagnosed with COVID-19 and received therapy to decrease the Alanine transaminase and Aspartate transaminase levels. While waiting for outsourced D dimer and prothrombin time results, the patient was given low molecular weight heparin (LMWH) on day 5. On day 13, his condition deteriorated with cephalgia and shortness of breath, but the patient’s family refused intubation. The chest CT scan revealed large ground-glass opacities in both lungs. The patient was given additional medications, such as Meropenem, Dexamethasone, and Remdesivir. On day 15, the patient passed away. Discussion Intermediate LMWH dosage seems to be associated with a lower mortality incidence than standard Deep Vein Thrombosis (DVT) prophylaxis in hospitalized COVID-19 patients. However, due to the late COVID-19 diagnosis, the patient was not given LMWH at the beginning of treatment. Conclusion A hypercoagulable state is partly responsible for the high mortality rate of COVID-19 patients. Early detection and management of the hypercoagulable state, including the use of LMWH, can decrease the severity of COVID-19 symptoms.","PeriodicalId":9533,"journal":{"name":"Canadian Journal of Respiratory Therapy: CJRT = Revue Canadienne de la Thérapie Respiratoire : RCTR","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89788012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A survey of physicians’ opinions about the treatment of subsegmental pulmonary embolism 医生对亚节段性肺栓塞治疗的看法调查
Mahdokht Parsirad, B. Rahimi, S. Peiman, J. Zebardast, Elham Zangene
Introduction The aim of this study was to survey the attitudes of internists, cardiologists, and pulmonologists regarding treatment or no treatment of isolated subsegmental pulmonary embolism (ISSPE) with anticoagulant drugs. Methods Qualified physicians were asked to select their management options from a questionnaire that included a patient scenario with subsegmental pulmonary embolism (SSPE) and negative past medical history of thromboembolism. Results A total of 113 physicians responded to the survey. Of these, 8.8% preferred not to treat patients without further evaluation; 15% decided not to treat, but follow-up the patient with a serial lower-limb colour Doppler ultrasonography; 1.7% preferred anticoagulant treatment only during hospitalization and follow-up without medication; 5% preferred anticoagulant treatment for less than 3 months; and 34.5% chose a 3–6-month treatment with anticoagulation. Furthermore, 24% of physicians opted for anticoagulant treatment for more than 6 months, and 9.7% left the decision up to the patient. Opting not to treat was an option selected by more board-certified faculty members specialized in cardiology, internal medicine, and pulmonology compared with residents (p = 0.038). Willingness to provide anticoagulant therapy in the internal medicine, cardiology and pulmonology groups was 56.6%, 37.3% and 6%, respectively (p = 0.007). Conclusion The majority of physicians surveyed prefer anticoagulant therapy in patients with SSPE.
本研究的目的是调查内科医生、心脏科医生和肺科医生对使用抗凝药物治疗或不治疗孤立性亚节段性肺栓塞(ISSPE)的态度。方法要求合格的医生从一份调查问卷中选择他们的治疗方案,调查问卷包括亚节段性肺栓塞(SSPE)患者的情况和阴性的血栓栓塞病史。结果共有113名医生参与调查。其中,8.8%的人在没有进一步评估的情况下不愿治疗患者;15%的患者决定不治疗,但对患者进行连续下肢彩色多普勒超声随访;1.7%的人在住院期间和随访期间只选择抗凝治疗而不选择药物治疗;5%首选抗凝治疗少于3个月;34.5%的患者选择3 - 6个月的抗凝治疗。此外,24%的医生选择抗凝治疗超过6个月,9.7%的医生将决定权留给患者。与住院医师相比,更多的董事会认证的心脏病学、内科和肺病学专业教师选择不治疗(p = 0.038)。内科组、心脏科组和肺科组提供抗凝治疗的意愿分别为56.6%、37.3%和6% (p = 0.007)。结论接受调查的大多数医生倾向于对SSPE患者进行抗凝治疗。
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引用次数: 0
Chronic obstructive pulmonary disease patients’ experience using Trelegy as compared with other inhalers 慢性阻塞性肺疾病患者使用Trelegy与其他吸入器的比较
H. Mashaal, Joshua Fogel, N. Sayedy, Ruchi Jalota Sahota, J. Akella
Introduction Trelegy is a combination inhaler that is often reported to offer benefits over multiple inhalers. We compared Trelegy use with multiple inhalers for adherence, symptoms, medication beliefs, and medication attitudes. Methods This cross-sectional survey of 58 patients compared the patient’s experience with Trelegy (n = 18) versus any other inhaler (n = 40). Outcome variables consisted of Test of the Adherence to Inhalers scale, the Chronic obstructive pulmonary disease Assessment Test (CAT) scale, attitude items from the St. George’s Respiratory Questionnaire, the Beliefs about Medicines Questionnaire (BMQ)-necessity subscale, and the BMQ-concerns subscale. Results We found that patients using Trelegy had greater CAT symptoms (M = 19.8, SD = 7.75) in comparison with the any other inhaler group (M = 15.7, SD = 11.10; P = 0.04). We did not find any difference between the groups for adherence or any of the medication attitudes or beliefs. CAT score was positively correlated with the number of months patients were on their current inhaler (rs = 0.29, P < 0.05) and their use of a rescue inhaler (rs = 0.42, P < 0.01). Patients with more concern about their medications were negatively correlated with the use of a rescue inhaler (rs = −0.31, P < 0.05). Discussion We found that patients using Trelegy had greater symptoms in comparison with the any other inhaler group, but did not differ for adherence, medication attitudes, or medication beliefs. Conclusion We recommend that clinicians should regularly re-evaluate their Trelegy recommendations, as Trelegy use may not be the best therapy for certain patients. Also, a study with a larger sample size can be beneficial to confirm these findings.
Trelegy是一种组合吸入器,经常被报道比多种吸入器更有好处。我们比较了Trelegy与多种吸入器的使用依从性、症状、用药信念和用药态度。方法对58例患者进行横断面调查,比较患者使用Trelegy (n = 18)和其他吸入器(n = 40)的经验。结果变量包括吸入器依从性测试量表、慢性阻塞性肺疾病评估测试(CAT)量表、圣乔治呼吸问卷中的态度项目、药物信念问卷(BMQ)-必要性子量表和BMQ-关注子量表。结果与其他吸入器组(M = 15.7, SD = 11.10)相比,使用Trelegy的患者CAT症状更严重(M = 19.8, SD = 7.75);P = 0.04)。我们没有发现两组之间的依从性或任何药物态度或信念有任何差异。CAT评分与患者使用当前吸入器的月数(rs = 0.29, P < 0.05)和使用抢救吸入器的月数(rs = 0.42, P < 0.01)呈正相关。患者对用药的担忧程度与抢救吸入器的使用呈负相关(rs = - 0.31, P < 0.05)。我们发现使用Trelegy的患者与其他任何吸入器组相比有更大的症状,但在依从性、用药态度或用药信念方面没有差异。结论我们建议临床医生应定期重新评估他们的Trelegy建议,因为Trelegy使用可能不是某些患者的最佳治疗方法。此外,更大样本量的研究可能有助于证实这些发现。
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引用次数: 0
Prediction for the maximum inspiratory pressure value from the thoracic expansion measurement in Indonesian healthy young adults 印度尼西亚健康青年胸廓扩张测量预测最大吸气压力值
M. Moeliono, D. M. Sari, Taufiq Nashrulloh
Background The diaphragm is the primary muscle responsible for breathing. Weakness in the diaphragm will result in breathing difficulties. The micro-RPM (respiratory pressure meter) is a non-invasive testing device to measure respiratory muscle strength, which is not always feasible, while thoracic expansion measurements are easy to do. Aim This study constructs a prediction formula for a maximal inspiratory pressure (MIP) value from thoracic expansion measurements. Methods This study was quantitative with a cross-sectional design. Participants were healthy adults aged 20–40 years, with normal Mini-Mental State Examinations, body mass index, spirometry, and moderate activity levels. The tests performed were MIP and thoracic expansion measurements at three levels: axilla (L1), the fourth intercostal space (L2), and at processus xiphoideus (L3). The data were analyzed using an unpaired t-test and multivariate. Results The mean MIP for males (81.51 ± 13.90 cmH2O) was significantly greater than females (63.17 ± 15.89 cmH2O) (P = 0.0001). These findings were not different with the Chinese, Indian, Mangalorean, and Malaysian populations because they are all of Asian ethnicity. Thoracic expansion L2 (r = 0.463, P = 0.0001) and L3 (r = 0.502, P = 0.0001) were moderately correlated with MIP, whereas thoracic expansion L2, L3 combined with gender had a weak effect on MIP. The prediction formula was: MIP = 56.802 + 2.387 + L2 + 13.904 + Gender * and MIP = 53.289+ 3.561 + L3 + 9.504 + Gender *, * 0 = female; 1 = male. Conclusions A prediction formula for MIP can be made using the thoracic expansion variable with gender as a determinant factor. A quick and easy measurement of thoracic expansion can be used as a mean of screening respiratory muscle strength in patient care.
膈肌是负责呼吸的主要肌肉。膈肌无力会导致呼吸困难。micro-RPM(呼吸压力计)是一种测量呼吸肌力量的非侵入性测试设备,并非总是可行,而胸廓扩张测量则很容易做到。目的建立胸廓扩张测量的最大吸气压力(MIP)预测公式。方法采用横断面设计进行定量研究。参与者为20-40岁的健康成年人,具有正常的迷你精神状态检查、体重指数、肺活量测定和中度活动水平。所做的测试是MIP和三个水平的胸廓扩张测量:腋窝(L1)、第四肋间隙(L2)和剑突肌(L3)。使用非配对t检验和多变量分析数据。结果男性的平均MIP(81.51±13.90 cmH2O)显著高于女性(63.17±15.89 cmH2O) (P = 0.0001)。这些发现与中国人、印度人、芒果人和马来西亚人没有什么不同,因为他们都是亚洲种族。L2胸廓扩张(r = 0.463, P = 0.0001)和L3胸廓扩张(r = 0.502, P = 0.0001)与MIP中度相关,L2胸廓扩张、L3胸廓扩张合并性别对MIP影响较弱。预测公式为:MIP = 56.802 + 2.387 + L2 + 13.904 +性别*,MIP = 53.289+ 3.561 + L3 + 9.504 +性别*,* 0 =女性;1 =男性。结论胸椎扩张变量以性别为决定因素,可建立MIP的预测公式。一种快速简便的胸廓扩张测量方法可作为筛查患者呼吸肌力的一种手段。
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引用次数: 2
期刊
Canadian Journal of Respiratory Therapy: CJRT = Revue Canadienne de la Thérapie Respiratoire : RCTR
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