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A Case Series on Pregnant Patients with Mild Covid-19 Infection and Signs of Severe Placental Insufficiency. 轻度Covid-19感染伴重度胎盘功能不全的孕妇病例系列分析
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2023-01-01 DOI: 10.1155/2023/2018551
A Ivert, C Lindblad Wollmann, K Pettersson

In this case series, we present five cases of pregnant women who sought medical attention for reduced fetal movements with an ongoing mild maternal Covid-19 infection at a Stockholm hospital in Spring of 2021. At the time of admission, the patients were in gestational week between 24 + 0 and 33 + 5. Abdominal ultrasound at the hospital showed no fetal movements, and cardiotocography (CTG) was pathological. All women delivered via cesarean section within 24 hours after admission. Placental pathology in all cases showed massive perivillous fibrin deposition and extensive histiocytic intervillositis. All placentas were Covid-19 polymerase chain reaction (PCR) positive. The infants were Covid-19 PCR negative. Consistent with other published case reports, we hypothesize that Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect the placenta resulting in massive perivillous fibrin deposition and histiocytic intervillositis leading to acute placental insufficiency and fetal hypoxia. The absence of intrauterine growth restriction also augments the theory of an acute onset of placental insufficiency due to the Covid-19 infection.

在本病例系列中,我们介绍了5例孕妇,她们于2021年春季在斯德哥尔摩一家医院因胎儿运动减少而寻求医疗照顾,并伴有持续的轻度母体Covid-19感染。入院时,患者孕周为24 + 0 ~ 33 + 5周。在医院的腹部超声显示没有胎动,心脏造影(CTG)是病理的。所有妇女均在入院后24小时内剖宫产。所有病例的胎盘病理均显示大量绒毛周围纤维蛋白沉积和广泛的组织细胞绒毛间炎。所有胎盘均为Covid-19聚合酶链反应(PCR)阳性。婴儿Covid-19 PCR阴性。与其他已发表的病例报告一致,我们假设严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)可影响胎盘,导致大量绒毛周围纤维蛋白沉积和组织细胞绒毛间炎,导致急性胎盘功能不全和胎儿缺氧。没有宫内生长受限也增强了Covid-19感染导致胎盘功能不全急性发作的理论。
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引用次数: 0
Small Bowel Obstruction in Postpartum Vaginal Delivery due to Prior Abdominal Adhesions Case Report. 先前腹部粘连致产后阴道分娩小肠梗阻病例报告。
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2023-01-01 DOI: 10.1155/2023/6563205
Liubin Yang, Lydia Kao

Intestinal obstruction rarely occurs after uncomplicated vaginal deliveries. Here, we present a case of a multiparous woman with a history of prior appendectomy presenting with generalized, nonspecific abdominal pain that was out of proportion to exam findings. Initial abdominal X-ray was nonspecific, and subsequent computed tomography (CT) abdomen showed closed small bowel obstruction requiring surgical repair. We present a case of intestinal obstruction occurring within 24 hours of uncomplicated vaginal delivery with a risk factor of a prior appendectomy surgery and the use of CT abdomen and pelvis to expedite diagnose.

无并发症的阴道分娩后很少发生肠梗阻。在这里,我们提出了一个病例,多产妇女与既往阑尾切除术的历史,目前的广泛性,非特异性腹痛,是不成比例的检查结果。最初的腹部x线无特异性,随后的腹部计算机断层扫描(CT)显示闭合性小肠阻塞需要手术修复。我们报告一例无并发症阴道分娩后24小时内发生肠梗阻的病例,其危险因素是先前的阑尾切除术和使用腹部和骨盆CT来加快诊断。
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引用次数: 0
Emergency Obstetric Hysterectomy after Conservative Management of Placenta Accreta. 急诊产科子宫切除术后保守处理胎盘增生。
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2023-01-01 DOI: 10.1155/2023/2420333
T Loukopoulos, A Zikopoulos, M Plachoura, A Galani, K Zikopoulos, E Kolibianakis

Background: Obstetric hemorrhage is a frequent and life-threatening complication of either vaginal or cesarean delivery. It can be due to many causes, one of which is placenta accreta, the abnormal invasion of the placenta into the myometrial wall of uterus. Ultrasonography is the first line diagnostic method that can lead to the diagnosis of placenta accreta although, the depth of penetration is estimated by magnetic resonance imaging. Placenta accreta is a life-threatening situation requiring an experienced health care team for its management. Hysterectomy is usually performed although, conservative management might be preferred in carefully selected cases. Case Presentation. A 32-year-old woman (G2, P0) who had an inconsistently monitored pregnancy appeared at a regional hospital with contractions at 39th week of gestation. In her first pregnancy, she was subjected to cesarean section due to delay in second stage of labor and unfortunately her child died due to sudden cardiac death. During C-section, placenta accreta was identified. Given her previous history and her desire to maintain fertility, conservative management was initially planned to preserve her uterus. However, due to persisting vaginal bleeding immediately after delivery an emergency hysterectomy was performed.

Conclusion: Conservative management of placenta accreta can be considered in some special cases with the aim to spare fertility. However, if bleeding cannot be controlled during the immediate postpartum period, emergency hysterectomy is unavoidable. A specialized multidisciplinary medical team is required to optimize management.

背景:产科出血是阴道或剖宫产中常见的危及生命的并发症。它可能是由许多原因引起的,其中之一是胎盘增生,胎盘异常侵入子宫肌壁。超声检查是诊断胎盘增生的第一线诊断方法,但穿透深度是通过磁共振成像来估计的。胎盘增生是一种危及生命的情况,需要有经验的医疗团队进行管理。子宫切除术通常进行,虽然保守管理可能优先在精心挑选的情况下。案例演示。一名32岁妇女(G2, P0)妊娠监测不一致,在妊娠第39周出现宫缩。在她第一次怀孕时,由于第二产程延迟,她接受了剖宫产手术,不幸的是她的孩子因心脏性猝死而死亡。在剖腹产时,发现了胎盘增生。考虑到她的既往病史和她希望保持生育能力,最初计划保守治疗以保留她的子宫。然而,由于分娩后阴道持续出血,紧急进行了子宫切除术。结论:在某些特殊情况下,可考虑保守处理胎盘,以避免生育。然而,如果出血不能在产后立即控制,紧急子宫切除术是不可避免的。需要一个专业的多学科医疗团队来优化管理。
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引用次数: 0
Bilateral Ovarian Serous Borderline Tumor with Non-Invasive Endometrial Implants. 双侧卵巢浆液性交界性肿瘤伴无创子宫内膜植入物。
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2023-01-01 DOI: 10.1155/2023/4845887
Melissa Bou Malham, Jordy Mehawej, Andreas Filippaios, Christina Kushnir, Paulette Mhawech-Fauceglia

Herein, we are presenting a case of a 33-year-old woman who presented to the emergency department complaining of persistent lower abdominal pain of one-day duration. Physical examination revealed abdominal tenderness with right lower quadrant rebound tenderness. Computed tomography abdomen/pelvis showed a 6 cm possible necrotic mass of the left ovary with moderate amount of complex ascites. A laparoscopic left oophorectomy with bilateral salpingectomy, right ovarian biopsy, and appendectomy were performed without complications. The cut surface of the left ovary showed a 9.7 cm × 8 cm × 4 cm ovarian mass, and the cut surface revealed multiple gray-tan friable papillary excrescence. Microscopic evaluation showed findings consistent with left and right ovarian serous borderline tumor (SBT). Subsequently, a tumor staging was conducted with total laparoscopic hysterectomy, pelvic and periaortic lymph node dissection, and omentectomy. The endometrium sections showed several small foci of SBT within the endometrial stroma, consistent with non-invasive implants of the endometrium. The omentum and lymph nodes were all negative for malignancy. SBTs associated with endometrial implants are very rare with only one case reported in the literature. Their existence can cause diagnostic challenges, and they should be acknowledged for early diagnosis and to plan for patient's treatment and outcome.

在此,我们提出的情况下,一个33岁的妇女谁提出了急诊科抱怨持续的下腹部疼痛一天的时间。体格检查发现腹部压痛并右下腹反跳痛。腹部/骨盆计算机断层扫描显示左侧卵巢可能有6厘米坏死肿块,伴中度复杂腹水。腹腔镜左卵巢切除术合并双侧输卵管切除术、右卵巢活检和阑尾切除术均无并发症。左侧卵巢切面可见9.7 cm × 8 cm × 4 cm卵巢肿块,切面可见多发灰褐色易碎乳头状赘生物。镜检显示左、右卵巢浆液交界性肿瘤(SBT)。随后,通过全腹腔镜子宫切除术、盆腔和腹主动脉周围淋巴结清扫和网膜切除术对肿瘤进行分期。子宫内膜切片显示子宫内膜间质内有几个小的SBT灶,与子宫内膜非侵入性植入一致。网膜及淋巴结均为阴性。与子宫内膜植入相关的sbt是非常罕见的,文献中只有一例报道。它们的存在可能会导致诊断上的挑战,它们应该在早期诊断中得到承认,并为患者的治疗和结果制定计划。
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引用次数: 0
Meckel's Diverticulum: The “Great Mimic” but Often a Forgotten Cause of Acute Abdomen during Pregnancy 梅克尔憩室:“伟大的模仿者”,但经常被遗忘的原因急性腹部在怀孕期间
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2022-06-07 DOI: 10.1155/2022/2383075
Beatriz Féria, M. Trindade, M. J. Palma, J. Figueiredo, F. Passos
Meckel's diverticulitis is an extremely rare event during pregnancy. Its diagnosis is often difficult and can result in higher maternal and fetal morbimortality. We describe a case of a 40-year-old healthy pregnant woman at 33 weeks of gestation who presented with abdominal pain and tender abdomen, leukocytosis, and elevated PCR. The imagiological exams were not conclusive. After an urgent caesarean section due to worsening of clinical status and nonreassuring fetal well-being, a laparotomy revealed a distended, necrotic, and perforated Meckel's diverticulum.
梅克尔氏憩室炎在怀孕期间极为罕见。它的诊断通常很困难,并可能导致更高的孕产妇和胎儿死亡率。我们描述了一例40岁的健康孕妇在妊娠33周谁提出腹痛和腹部压痛,白细胞增多,和PCR升高。影像学检查没有结论。由于临床状况恶化和胎儿健康状况不稳定,在紧急剖腹产后,剖腹检查发现梅克尔憩室膨胀、坏死和穿孔。
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引用次数: 2
Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism 地中海贫血与促性腺功能减退症的关系
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2022-05-19 DOI: 10.1155/2022/4655249
A. Vidal, C. Dhakal
Thalassaemic syndromes are among the most common haemoglobinopathies and are associated with high morbidity and mortality. Because of the various treatments, a secondary endocrinopathy due to iron overload—haemosiderosis—can occur, causing hypopituitarism leading to hypogonadotropic hypogonadism (HH) and infertility. We present a case of secondary amenorrhoea in a patient with beta-thalassaemia and a history of multiple therapies in her adolescence, such as multiple transfusions, chemotherapy, and allogeneic bone marrow transplantation, who presented with HH and premature ovarian insufficiency.
地中海贫血综合征是最常见的血红蛋白病之一,与高发病率和高死亡率有关。由于不同的治疗方法,可发生由铁超载引起的继发性内分泌病变- - -血红素沉着病,引起垂体功能减退,导致促性腺功能减退(HH)和不孕。我们报告了一个继发性闭经的病例,该患者患有-地中海贫血,并在其青春期有多种治疗史,如多次输血,化疗和异基因骨髓移植,她表现为HH和卵巢早衰。
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引用次数: 2
Rotational Thromboelastometry-Guided Venoarterial Extracorporeal Membrane Oxygenation in the Treatment of Amniotic Fluid Embolism. 旋转血栓弹力仪引导静脉动脉体外膜肺氧合治疗羊水栓塞。
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2022-05-18 eCollection Date: 2022-01-01 DOI: 10.1155/2022/9658708
Jillian K Wothe, Elizabeth Elfstrand, Michael R Mooney, Donald D Wothe

Amniotic fluid embolism (AFE) is a rare and often fatal complication of pregnancy that occurs during the puerperium. The low incidence of AFE has resulted in few large studies, which makes evidence-based management of AFE challenging. The use of extracorporeal membrane oxygenation (ECMO) has been reported but is limited by availability and challenges managing anticoagulation. In this report, we detail the case of a 29-year-old female who suffered from an AFE leading to cardiac arrest and disseminated intravascular coagulopathy. She was treated with protocolized A-OK (adenosine, ondansetron, and ketorolac), emergency c-section, cardiopulmonary resuscitation, massive blood transfusion, and rotational thromboelastometry-guided ECMO, allowing her to forgo initial anticoagulation. After a prolonged rehabilitation with initial poor neurological status, she made a complete recovery. In this report, we describe the protocols that contributed to her recovery and detail management of complicated AFE for other clinicians.

羊水栓塞(AFE)是发生在产褥期的一种罕见且经常致命的妊娠并发症。AFE的低发病率导致很少有大型研究,这使得AFE的循证管理具有挑战性。体外膜肺氧合(ECMO)的使用已有报道,但受到抗凝治疗的可用性和挑战的限制。在本报告中,我们详细介绍了一名29岁女性的病例,她患有AFE,导致心脏骤停和弥漫性血管内凝血病。她接受了原协议A-OK(腺苷、昂丹司琼和酮咯酸)、紧急剖腹产、心肺复苏、大量输血和旋转血栓弹性测量术指导的ECMO治疗,从而放弃了最初的抗凝治疗。经过长期的康复和最初的神经系统状况不佳,她完全康复了。在本报告中,我们描述了有助于她的康复的方案,并为其他临床医生详细管理复杂的AFE。
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引用次数: 1
A Case of Preeclampsia with Uterine Necrosis after Uterine Artery Embolization for Postpartum Hemorrhage 子宫动脉栓塞治疗产后出血后子痫前期合并子宫坏死1例
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2022-05-17 DOI: 10.1155/2022/2859766
Midori Yoshikawa, T. Seyama, T. Iriyama, S. Sayama, T. Fujii, Masatake Toshimitsu, Moto Nakaya, R. Kurokawa, Eisuke Shibata, T. Watadani, K. Kumasawa, T. Nagamatsu, K. Koga, Y. Osuga
Uterine necrosis is a rare complication in uterine artery embolization (UAE) for postpartum hemorrhage (PPH). Preeclampsia (PE) is a condition characterized with systemic endothelial damage and intravascular volume depletion. Whether a patient with PE is at high risk for uterine necrosis after UAE for PPH has been unknown. A 30-year-old primipara woman was diagnosed with PE based on hypertension and proteinuria during delivery. UAE was performed for PPH after forceps delivery. After UAE, the patient presented with pleural effusion and massive ascites as well as persistent fever unresponsive to antibiotics. Ultrasonography and contrast-enhanced magnetic resonance imaging (MRI) led to the diagnosis of uterine necrosis, for which we performed total laparoscopic hysterectomy. It should be kept in mind that patients with PE associated with massive ascites may be at high risk for uterine necrosis after UAE due to decreased uterine perfusion. Therefore, it is important to pay attention to persistent symptoms such as fever and abdominal pain after UAE to diagnose uterine necrosis.
子宫坏死是子宫动脉栓塞治疗产后出血(PPH)的一种罕见并发症。先兆子痫(PE)是一种以全身内皮损伤和血管内容量减少为特征的疾病。PE患者在PPH UAE后是否有子宫坏死的高风险尚不清楚。一位30岁初产妇在分娩时因高血压和蛋白尿被诊断为PE。产钳分娩后PPH行UAE。UAE后,患者出现胸腔积液和大量腹水以及持续发热,对抗生素无反应。超声检查和增强磁共振成像(MRI)导致子宫坏死的诊断,为此我们进行了全腹腔镜子宫切除术。需要注意的是,PE合并大量腹水的患者,由于子宫灌注减少,UAE后子宫坏死的风险较高。因此,要注意UAE后持续出现发热、腹痛等症状,以诊断子宫坏死。
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引用次数: 1
More than an Incidentaloma: The Nonreportable NIPT 不只是偶发瘤:不可报告的NIPT
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2022-04-30 DOI: 10.1155/2022/2496057
Allison M Jay, Brian Mason, D. Lebovic, P. Chuba
Noninvasive prenatal testing (NIPT), which utilizes a maternal blood sample to detect fetal gender and screen for fetal aneuploidy (abnormal chromosomes), is widely used in obstetrics to screen for Trisomies 21, 18, and 13. Per the literature, approximately 0.3% of pregnant woman's results are nonreportable. Reasons include low fetal fraction, insufficient DNA, vanishing twin, twin pregnancy, clonal mosaicism, and maternal neoplasia. Here, we describe a 25-year-old G2P1 pregnant woman who had two nonreportable NIPT results and subsequently was diagnosed with lymphoma. We discuss the importance of clinical exam in correlation with the results to offer comprehensive evaluation of the patient with a nonreportable finding, given malignancy occurs in 1/1000 pregnant women. This report overviews proposed management guidelines for pregnant women with a nonreportable result and helps to address discomfort the treating physician may feel in discussing this result with their patient.
无创产前检测(NIPT)利用母体血液样本检测胎儿性别并筛查胎儿非整倍体(异常染色体),广泛用于产科筛查21、18和13三体。根据文献,大约0.3%的孕妇的结果是不可报告的。原因包括胎儿分数低、DNA不足、双胞胎消失、双胎妊娠、克隆嵌合和母体肿瘤。在这里,我们描述了一位25岁的G2P1孕妇,她有两个不可报告的NIPT结果,随后被诊断为淋巴瘤。鉴于恶性肿瘤发生率为1/1000孕妇,我们讨论了临床检查的重要性与结果的相关性,以提供对未报告发现的患者的全面评估。本报告概述了未报告结果的孕妇的建议管理指南,并有助于解决治疗医生在与患者讨论这一结果时可能感到的不适。
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引用次数: 0
Appearances Are Deceptive: Two Case Reports in Teenagers on the Conservative Laparoscopic Surgery for Adnexal Torsion with Apparent Infarction 外表具有欺骗性:两例青少年保守腹腔镜手术治疗伴有明显梗死的附件扭转
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2022-04-27 DOI: 10.1155/2022/1798599
A. Jayawardane, M. Patabendige, C. Gunathilaka
Introduction. Torsion of the ovary, tube, or both is estimated to be responsible for 2-7% of all gynaecological emergencies. Oophorectomy is commonly performed for adnexal torsion with a possible negative impact on fertility in women of reproductive age. Case Presentations. We report two cases of teenage girls presented with adnexal torsion describing their laparoscopy features. Detorsion without additional surgical intervention could save their ovaries. Discussion. Detorsion is a more conservative surgical approach that should be considered in all younger women with ovarian torsion.
介绍。卵巢、输卵管或两者的扭转估计占所有妇科急诊的2-7%。卵巢切除术通常用于附件扭转,可能对育龄妇女的生育能力产生负面影响。例演示。我们报告两例十几岁的女孩提出附件扭转描述他们的腹腔镜特征。不加手术干预的卵巢扭曲可以挽救卵巢。讨论。卵巢扭转是一种更保守的手术方法,应考虑所有卵巢扭转的年轻女性。
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引用次数: 0
期刊
Case Reports in Obstetrics and Gynecology
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