Pub Date : 2021-10-23DOI: 10.9734/bpi/cacs/v6/1927c
M. Khan
The present study examines the effect of multimedia dissolution profile on the drug release of sustained release hydrophilic matrices of zidovudine containing combination of different grades of hydroxypropyl methylcellulose. Zidovudine the first anti-HIV compound approved for clinical use is widely used for the treatment of AIDS either alone or in combination with other antiviral agents. Matrices were prepared using combination of different grades of HPMC viz, HPMCK4M and HPMCK15M to sustain the release of the drug. Multimedia dissolution studies were performed to mimic the in-vivo condition by doing in-vitro test. The pH/buffer selection is based on the exposure of drug from stomach to intestine/colon. The study ensures the impact of pH changes on dissolution and release of drug substance for absorption. Matrices also provide quite regulated release of the drug zidovudine over an extended period of time.
{"title":"Investigating the Influence of pH on Drug Release from Zidovudine Matrices Containing Different Grades of Hydroxypropyl Methyl Cellulose","authors":"M. Khan","doi":"10.9734/bpi/cacs/v6/1927c","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v6/1927c","url":null,"abstract":"The present study examines the effect of multimedia dissolution profile on the drug release of sustained release hydrophilic matrices of zidovudine containing combination of different grades of hydroxypropyl methylcellulose. Zidovudine the first anti-HIV compound approved for clinical use is widely used for the treatment of AIDS either alone or in combination with other antiviral agents. Matrices were prepared using combination of different grades of HPMC viz, HPMCK4M and HPMCK15M to sustain the release of the drug. Multimedia dissolution studies were performed to mimic the in-vivo condition by doing in-vitro test. The pH/buffer selection is based on the exposure of drug from stomach to intestine/colon. The study ensures the impact of pH changes on dissolution and release of drug substance for absorption. Matrices also provide quite regulated release of the drug zidovudine over an extended period of time.","PeriodicalId":9701,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 6","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89265807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-23DOI: 10.9734/bpi/cacs/v6/1988c
F. Allouche
{"title":"Determining the Synthesis of Pyrazoles via Multi-Component Reaction and Cyclization Cascade of Hydrazono Ugi Adducts","authors":"F. Allouche","doi":"10.9734/bpi/cacs/v6/1988c","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v6/1988c","url":null,"abstract":"","PeriodicalId":9701,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 6","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86120635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-23DOI: 10.9734/bpi/cacs/v6/4285f
Akira Nose
{"title":"Water has the Capability of Reducing the Alcohol-Stimulative Taste of Spirits","authors":"Akira Nose","doi":"10.9734/bpi/cacs/v6/4285f","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v6/4285f","url":null,"abstract":"","PeriodicalId":9701,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 6","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88455964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-23DOI: 10.9734/bpi/cacs/v6/4925f
J. I. Onwuemeka, F. Eze, I. Ndukwe
{"title":"Determination of Chemically Desposited ZnO Thin Films for Possible Device Applications","authors":"J. I. Onwuemeka, F. Eze, I. Ndukwe","doi":"10.9734/bpi/cacs/v6/4925f","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v6/4925f","url":null,"abstract":"","PeriodicalId":9701,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 6","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79219011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-23DOI: 10.9734/bpi/cacs/v6/5051f
K. Laxmi
{"title":"Determining the Properties of Phenobarbital an Antiepileptic Drug Using Chemcalise Software","authors":"K. Laxmi","doi":"10.9734/bpi/cacs/v6/5051f","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v6/5051f","url":null,"abstract":"","PeriodicalId":9701,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 6","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87160648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-23DOI: 10.9734/bpi/cacs/v6/14554d
L. Pinard, C. Batiot-Dupeyrat
{"title":"Non-thermal Plasma for Coke Elimination in an Aged Hydrotreating Catalyst: Comparison with a Coked Zeolite","authors":"L. Pinard, C. Batiot-Dupeyrat","doi":"10.9734/bpi/cacs/v6/14554d","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v6/14554d","url":null,"abstract":"","PeriodicalId":9701,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 6","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86927156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-23DOI: 10.9734/bpi/cacs/v6/4828f
U. V. Babu, M. Ramakrishan, M. Nagamani
{"title":"Study on Modeling with Multilayer Perceptron for Detection of Fuel Adulteration Using Python Programming","authors":"U. V. Babu, M. Ramakrishan, M. Nagamani","doi":"10.9734/bpi/cacs/v6/4828f","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v6/4828f","url":null,"abstract":"","PeriodicalId":9701,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 6","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80028929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-23DOI: 10.9734/bpi/cacs/v6/5306f
K. Priya, J. Moses, T. Sasikala
{"title":"Determination of Anti-bacterial Effect, Anti- odour Effect, uv- protection Factor and XRD on Formic Acid Treated Modal and Cotton Fabric","authors":"K. Priya, J. Moses, T. Sasikala","doi":"10.9734/bpi/cacs/v6/5306f","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v6/5306f","url":null,"abstract":"","PeriodicalId":9701,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 6","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82018011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-23DOI: 10.9734/bpi/cacs/v6/5300f
Y. Yuasa
{"title":"Determining the Practical Synthesis and Purification of cis-11-Octadecenoic Acid: A Component of Inhibition of Endotoxin Response","authors":"Y. Yuasa","doi":"10.9734/bpi/cacs/v6/5300f","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v6/5300f","url":null,"abstract":"","PeriodicalId":9701,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 6","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75207402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-23DOI: 10.9734/bpi/cacs/v6/5052f
P. Mittal, Manoj Kumar Pachouri
{"title":"Structural and Biocidal Studies of Monobutyltin (IV) Derivatives of 1-Hydroxy-2-Naphthoic Acid","authors":"P. Mittal, Manoj Kumar Pachouri","doi":"10.9734/bpi/cacs/v6/5052f","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v6/5052f","url":null,"abstract":"","PeriodicalId":9701,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 6","volume":"155 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74054558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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