Nan Chen, Chaokun Li, Shangteng Liao, Jinglong Chen, Xingxing Ma, Qiuling Song
A protocol for the synthesis of α-mono/disubstituted tetrahydropyrans (THPs) with vinyl cyclic ethers and potassium trifluorob-orates was achieved in the presence of Brønsted acid and Lewis acid under mild reaction conditions. The oxonium ions intermediates, produced from various readily available vinyl cyclic ethers, were attacked by the nucleophile to form the desired α-alkenylation products. This strategy could be an alternative approach to modify a series of modules that are of broad utility in natural products and fine chemicals.
{"title":"Brønsted Acid-Mediated Selective α-Alkenylation of 3,4-Dihydropyrans","authors":"Nan Chen, Chaokun Li, Shangteng Liao, Jinglong Chen, Xingxing Ma, Qiuling Song","doi":"10.1039/d4qo00541d","DOIUrl":"https://doi.org/10.1039/d4qo00541d","url":null,"abstract":"A protocol for the synthesis of α-mono/disubstituted tetrahydropyrans (THPs) with vinyl cyclic ethers and potassium trifluorob-orates was achieved in the presence of Brønsted acid and Lewis acid under mild reaction conditions. The oxonium ions intermediates, produced from various readily available vinyl cyclic ethers, were attacked by the nucleophile to form the desired α-alkenylation products. This strategy could be an alternative approach to modify a series of modules that are of broad utility in natural products and fine chemicals.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A three-component reaction of aldehyde-derived hydrazones with DABSO and aryldiazonium tetrafluoroborates is described. By using organic DABSO as the source of SO2, this straightforward sulfonylation tactic provides an elegant access to (E)-sufonylated hydrazones in moderate to excellent yields. Moreover, the sulfonylation of hydrazones can also be achieved under photocatalyzed conditions by using sulfonyl chlorides as the active sulfonylating reagents.
{"title":"Direct C−H Sulfonylation of Hydrazones Involving the Insertion of SO2","authors":"Mengzhao Yu, Shuizhen Lin, Shuoshuo Zhang, Xinkui Lin, Xiaolei Huang","doi":"10.1039/d4qo00835a","DOIUrl":"https://doi.org/10.1039/d4qo00835a","url":null,"abstract":"A three-component reaction of aldehyde-derived hydrazones with DABSO and aryldiazonium tetrafluoroborates is described. By using organic DABSO as the source of SO2, this straightforward sulfonylation tactic provides an elegant access to (E)-sufonylated hydrazones in moderate to excellent yields. Moreover, the sulfonylation of hydrazones can also be achieved under photocatalyzed conditions by using sulfonyl chlorides as the active sulfonylating reagents.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A concise protocol for the construction of axially chiral biaryls via Pd-catalyzed direct C-H arylation of 1-arylisoquinoline N-oxides through kinetic resolution using commercially available, cost-effective, and bench-stable chiral mono-protected amino acid have been uncovered. The high conformational stability of the axially chiral products in different solvents and at high temperatures, as observed from the experimental studies and DFT calculations, shows their excellent stability.
{"title":"Synthesis of Axially Chiral Biaryls via Pd(II)-Catalysed Direct C(sp2)-H Arylation","authors":"Diksha Parmar, Rohit Kumar, Sarthi ., Akhilesh Kumar Sharma, Upendra Sharma","doi":"10.1039/d4qo00958d","DOIUrl":"https://doi.org/10.1039/d4qo00958d","url":null,"abstract":"A concise protocol for the construction of axially chiral biaryls via Pd-catalyzed direct C-H arylation of 1-arylisoquinoline N-oxides through kinetic resolution using commercially available, cost-effective, and bench-stable chiral mono-protected amino acid have been uncovered. The high conformational stability of the axially chiral products in different solvents and at high temperatures, as observed from the experimental studies and DFT calculations, shows their excellent stability.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The elucidation of exact reaction mechanisms, especially for the purpose of determining the origin of regio-and diastereo-selectivity, is essential for furthering the development of substituent divergent reactions. In this study, density functional theory calculations were carried out to elucidate the mechanism and thereby, the origin of regio- and diastereo-selectivity, of the divergent [3+2] annulation of an aldimine with alkenes catalyzed by the rare-earth metal scandium (Sc). The reaction mechanism was found to consist of the generation of active species, C(sp3)-H activation, alkene insertion, ring-closure, and protonation processes. The alkene insertion process was found to determine the regio- and diastereoselectivity of the reaction. The main role of the amine is to lower the positive charge of the Sc atom, thereby weakening and cleaving the Sc-C(sp3) bond, before forming an Sc-C(sp2) bond forms during the alkene insertion process. These results provide valuable insights into the reactions catalyzed by rare-earth metals.
{"title":"Elucidating the mechanism and origin of diastereoselectivity in scandium-catalyzed β-C(sp3)-H activation and transformation of an aliphatic aldimine","authors":"Yiran Zhang, Yang Wang","doi":"10.1039/d4qo00567h","DOIUrl":"https://doi.org/10.1039/d4qo00567h","url":null,"abstract":"The elucidation of exact reaction mechanisms, especially for the purpose of determining the origin of regio-and diastereo-selectivity, is essential for furthering the development of substituent divergent reactions. In this study, density functional theory calculations were carried out to elucidate the mechanism and thereby, the origin of regio- and diastereo-selectivity, of the divergent [3+2] annulation of an aldimine with alkenes catalyzed by the rare-earth metal scandium (Sc). The reaction mechanism was found to consist of the generation of active species, C(sp3)-H activation, alkene insertion, ring-closure, and protonation processes. The alkene insertion process was found to determine the regio- and diastereoselectivity of the reaction. The main role of the amine is to lower the positive charge of the Sc atom, thereby weakening and cleaving the Sc-C(sp3) bond, before forming an Sc-C(sp2) bond forms during the alkene insertion process. These results provide valuable insights into the reactions catalyzed by rare-earth metals.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sulfur dioxide (SO2), as an atmospheric pollutant, has been increasingly attracting the interest of scientists regarding its chemical utilization. Vicinal sulfonyl-functionalization of alkenes through SO2 insertion offers an innovative method to introduce both sulfonyl and other functional groups into a single molecule. This approach boosts compound diversity while eliminating the need for multi-step operations. On the other hand, asymmetric construction of quaternary all-carbon stereocenters remains a persistent synthetic challenge. In particular, methods for the synthesis of chiral sulfones bearing an all-carbon quaternary stereocenter are rare. Herein, we present a copper-catalyzed vicinal cyano-arylsulfonylation of acrylamides via the insertion of sulfur dioxide (SO2), providing an easy access to achieve this goal with minimally functionalized starting materials. The reaction proceeds under mild conditions through a verified single-electron-transfer (SET) mechanism with excellent enantioselectivity (mostly >99% ee), good functional group tolerance, and a broad substrate scope (>50 examples). Notably, this four-component reaction is applicable to the direct chiral functionalization of amino acid and peptide derivatives.
{"title":"Access to Chiral Sulfones with An All-Carbon Quaternary Stereocenter from Sulfur Dioxide","authors":"Chunxi Huang, Xuemei Zhang, Liping Luo, Xiuwen Jia, Jian Liao, Zhong Lian","doi":"10.1039/d4qo00671b","DOIUrl":"https://doi.org/10.1039/d4qo00671b","url":null,"abstract":"Sulfur dioxide (SO2), as an atmospheric pollutant, has been increasingly attracting the interest of scientists regarding its chemical utilization. Vicinal sulfonyl-functionalization of alkenes through SO2 insertion offers an innovative method to introduce both sulfonyl and other functional groups into a single molecule. This approach boosts compound diversity while eliminating the need for multi-step operations. On the other hand, asymmetric construction of quaternary all-carbon stereocenters remains a persistent synthetic challenge. In particular, methods for the synthesis of chiral sulfones bearing an all-carbon quaternary stereocenter are rare. Herein, we present a copper-catalyzed vicinal cyano-arylsulfonylation of acrylamides via the insertion of sulfur dioxide (SO2), providing an easy access to achieve this goal with minimally functionalized starting materials. The reaction proceeds under mild conditions through a verified single-electron-transfer (SET) mechanism with excellent enantioselectivity (mostly >99% ee), good functional group tolerance, and a broad substrate scope (>50 examples). Notably, this four-component reaction is applicable to the direct chiral functionalization of amino acid and peptide derivatives.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao-Hong Wei, Ya-Wen Xue, Chun-Yuan Bai, Xuan Liu, Xiao-Hong Wang, Yanbin Wang, Qiong Su
A Lewis acid-catalyzed phosphinoylation and halogenation of α,β-unsaturated ketones to synthesize γ-halo allylic phosphonates is described. This transformation consists of a phospha-Michael addition, unimolecular elimination dehydration cascade reaction for the introduction of versatile groups (−P(O)R3R4 and −X) in the resulting γ-substituent allylic phosphonates with high regio- and stereoselectively.
{"title":"Lewis acid-catalyzed phosphinoylation and halogenation of α,β-unsaturated ketones: Access to γ-halo allylic phosphonates","authors":"Xiao-Hong Wei, Ya-Wen Xue, Chun-Yuan Bai, Xuan Liu, Xiao-Hong Wang, Yanbin Wang, Qiong Su","doi":"10.1039/d4qo00748d","DOIUrl":"https://doi.org/10.1039/d4qo00748d","url":null,"abstract":"A Lewis acid-catalyzed phosphinoylation and halogenation of α,β-unsaturated ketones to synthesize γ-halo allylic phosphonates is described. This transformation consists of a phospha-Michael addition, unimolecular elimination dehydration cascade reaction for the introduction of versatile groups (−P(O)R3R4 and −X) in the resulting γ-substituent allylic phosphonates with high regio- and stereoselectively.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An efficient method for a domino [3+2] cycloaddition/deamination/imine hydrolysis reaction of D-A cyclopropane with inexpensive thiourea catalyzed by Lu(OTf)3 has been developed. A series of spiro-γ-thiolactone oxidized indole compounds with potential biological activity were obtained up to 98% yields. Experiments to investigate the mechanism showed that γ-thiolactone products were from the hydrolysis of the imine intermediate. In addition, the asymmetric catalytic synthesis of D-A cyclopropane and thiourea has been successfully developed to afford the spiro-γ-thiolactone compounds in good enantioselectivity (up to 98% ee). The utility of this method was showcased by the facile transformation and biological activity of products.
{"title":"A Domino [3+2] Cycloaddition/Deamination/Imine Hydrolysis Reaction of Cyclopropyl Spirooxindoles with Thiourea for Access to Spiro-γ-thiolactone oxindoles","authors":"Hai-Ting Wang, Xiao-Lin Wen, Xiao-Lin Xu, Dong-Chao Wang, Hai-Ming Guo","doi":"10.1039/d4qo00833b","DOIUrl":"https://doi.org/10.1039/d4qo00833b","url":null,"abstract":"An efficient method for a domino [3+2] cycloaddition/deamination/imine hydrolysis reaction of D-A cyclopropane with inexpensive thiourea catalyzed by Lu(OTf)3 has been developed. A series of spiro-γ-thiolactone oxidized indole compounds with potential biological activity were obtained up to 98% yields. Experiments to investigate the mechanism showed that γ-thiolactone products were from the hydrolysis of the imine intermediate. In addition, the asymmetric catalytic synthesis of D-A cyclopropane and thiourea has been successfully developed to afford the spiro-γ-thiolactone compounds in good enantioselectivity (up to 98% ee). The utility of this method was showcased by the facile transformation and biological activity of products.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141326826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aryl radicals are important and versatile active intermediates in synthetic chemistry, and the chemical conversions involved are regarded as perfect complements to the transition-metal-catalyzed arylation reactions. The formation of aryl radicals is mainly achieved through reductive systems. Electrocatalysis has a safe and controllable potential range that can easily attain a reduction potential beyond the range of chemical reductants and excited photocatalysts, offering a synthetically attractive and environmentally friendly alternative for the production of aryl radicals. Remarkable achievements in the electrochemical functionalization of aryl radicals have been reported. This review primarily focuses on the generation of aryl radicals via electroreduction strategy, and systematically elaborates on synthetic applications, scope, and limitations of the substrates. A full spectrum of aryl radical precursors applied in the electroreduction strategy is reviewed, including aryl halides, aryl diazonium salts, arylazo sulfones, aryl amines, nitroarenes, aryl quaternary ammonium salts, aryl triflates, and aryl thianthrenium salts.
{"title":"Electroreduction Strategy: A Sustainable Tool for Generation of Aryl Radicals","authors":"Xiao-Qing Xie, Wei Zhou, Ruchun Yang, Xian-Rong Song, Mu-Jia Luo, Qiang Xiao","doi":"10.1039/d4qo00846d","DOIUrl":"https://doi.org/10.1039/d4qo00846d","url":null,"abstract":"Aryl radicals are important and versatile active intermediates in synthetic chemistry, and the chemical conversions involved are regarded as perfect complements to the transition-metal-catalyzed arylation reactions. The formation of aryl radicals is mainly achieved through reductive systems. Electrocatalysis has a safe and controllable potential range that can easily attain a reduction potential beyond the range of chemical reductants and excited photocatalysts, offering a synthetically attractive and environmentally friendly alternative for the production of aryl radicals. Remarkable achievements in the electrochemical functionalization of aryl radicals have been reported. This review primarily focuses on the generation of aryl radicals via electroreduction strategy, and systematically elaborates on synthetic applications, scope, and limitations of the substrates. A full spectrum of aryl radical precursors applied in the electroreduction strategy is reviewed, including aryl halides, aryl diazonium salts, arylazo sulfones, aryl amines, nitroarenes, aryl quaternary ammonium salts, aryl triflates, and aryl thianthrenium salts.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi Zhou, Yong Qin He, Xia Nie, Lin Lu, Xian-Rong Song, Zhao-Zhao Zhou, Wan-Fa Tian, Qiang Xiao
An unexcepted Ir/Co dual catalytic hydroacylation of electron-deficient alkenes overcoming redox potential limitations is reported. In this protocol, Co(I) species are generated via photoreduction using Ir[dF(CF3)ppy]2dtbbpy, which excited state has an oxidative potential (Eox = -0.89 V vs SCE) close to or lower than the reduction potential of several effective salen-Co(II) catalysts (Co-1~Co-5: ECo(II)/Co(I) = -0.80 to -1.36 V vs SCE). The nucleophilic Co(I) species catalyzes the fragmentation of carboxylic anhydrides to release acyl radical, which were subsequently captured by electron-deficient alkenes.
本研究报告介绍了一种克服氧化还原电位限制的未接受过的 Ir/Co 双催化缺电子烯烃加氢酰化反应。在该方案中，Co(I) 物种是通过使用 Ir[dF(CF3)ppy]2dtbbpy 进行光反应生成的，其激发态的氧化电位（Eox = -0.89 V vs SCE）接近或低于几种有效的沙林-Co(II) 催化剂的还原电位（Co-1~Co-5：ECo(II)/Co(I) = -0.80 至 -1.36 V vs SCE）。亲核的 Co(I) 物种催化羧酸酐碎裂，释放出酰基，随后被缺电子的烯捕获。
{"title":"Ir/Co Dual Catalyzed Hydroacylation of Electron-Deficient Alkenes Overcoming Redox Potential Limitations","authors":"Yi Zhou, Yong Qin He, Xia Nie, Lin Lu, Xian-Rong Song, Zhao-Zhao Zhou, Wan-Fa Tian, Qiang Xiao","doi":"10.1039/d4qo00778f","DOIUrl":"https://doi.org/10.1039/d4qo00778f","url":null,"abstract":"An unexcepted Ir/Co dual catalytic hydroacylation of electron-deficient alkenes overcoming redox potential limitations is reported. In this protocol, Co(I) species are generated via photoreduction using Ir[dF(CF3)ppy]2dtbbpy, which excited state has an oxidative potential (Eox = -0.89 V vs SCE) close to or lower than the reduction potential of several effective salen-Co(II) catalysts (Co-1~Co-5: ECo(II)/Co(I) = -0.80 to -1.36 V vs SCE). The nucleophilic Co(I) species catalyzes the fragmentation of carboxylic anhydrides to release acyl radical, which were subsequently captured by electron-deficient alkenes.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recent research has developed a Cu/Ru dual catalysis system for the hydroalkylation of racemic allylic alcohols and racemic ketimine esters. This method is distinguished by its ability to stereodivergently generate 1,4-nonadjacent stereocenters. This study employs density functional theory calculations to elucidate how copper and ruthenium synergistically drive this transformation and to reveal why this dual-catalyst system is more efficient than systems using either copper or ruthenium independently. The findings show how different combinations of chiral catalysts influence the formation of two stereogenic centers. We highlight the critical roles of noncovalent interactions and steric effects in determining the most energetically favorable transition states for each catalyst combination. Additionally, this study elucidates the significant role of potassium phosphate (K3PO4) in enhancing the reaction efficiency. Specifically, K3PO4 facilitates the dehydrogenation and hydrogenation processes across all three stages of the catalytic cycle. We also explore the reaction’s chemoselectivity by computing the formation mechanisms of three potential by-products and analyzing the driving forces behind the generation of the desired product. These mechanistic insights can support advancements in stereodivergent synthesis using cooperative bimetallic catalysis.
{"title":"Copper/Ruthenium Relay Catalysis for Stereodivergent Construction of 1,4-Nonadjacent Stereocenters: Mechanistic Investigation Using DFT Calculations","authors":"Congcong Huang, Biyao Yang, Keying Zhang, Juan Li","doi":"10.1039/d4qo00780h","DOIUrl":"https://doi.org/10.1039/d4qo00780h","url":null,"abstract":"Recent research has developed a Cu/Ru dual catalysis system for the hydroalkylation of racemic allylic alcohols and racemic ketimine esters. This method is distinguished by its ability to stereodivergently generate 1,4-nonadjacent stereocenters. This study employs density functional theory calculations to elucidate how copper and ruthenium synergistically drive this transformation and to reveal why this dual-catalyst system is more efficient than systems using either copper or ruthenium independently. The findings show how different combinations of chiral catalysts influence the formation of two stereogenic centers. We highlight the critical roles of noncovalent interactions and steric effects in determining the most energetically favorable transition states for each catalyst combination. Additionally, this study elucidates the significant role of potassium phosphate (K3PO4) in enhancing the reaction efficiency. Specifically, K3PO4 facilitates the dehydrogenation and hydrogenation processes across all three stages of the catalytic cycle. We also explore the reaction’s chemoselectivity by computing the formation mechanisms of three potential by-products and analyzing the driving forces behind the generation of the desired product. These mechanistic insights can support advancements in stereodivergent synthesis using cooperative bimetallic catalysis.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141315672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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