Daniel C. Reuman, Jonathan A. Walter, Lawrence W. Sheppard, Vadim A. Karatayev, Ethan S. Kadiyala, Amanda C. Lohmann, Thomas L. Anderson, Nat J. Coombs, Kyle J. Haynes, Lauren M. Hallett, Max C. N. Castorani
Spatial synchrony, the tendency for temporal fluctuations in an ecological variable to be positively associated in different locations, is a widespread and important phenomenon in ecology. Understanding of the nature and mechanisms of synchrony, and how synchrony is changing, has developed rapidly over the past 2 decades. Many recent developments have taken place through the study of long-term data sets. Here, we review and synthesise some important recent advances in spatial synchrony, with a focus on how long-term data have facilitated new understanding. Longer time series do not just facilitate better testing of existing ideas or more precise statistical results; more importantly, they also frequently make possible the expansion of conceptual paradigms. We discuss several such advances in our understanding of synchrony, how long-term data led to these advances, and how future studies can continue to improve the state of knowledge.
{"title":"Insights Into Spatial Synchrony Enabled by Long-Term Data","authors":"Daniel C. Reuman, Jonathan A. Walter, Lawrence W. Sheppard, Vadim A. Karatayev, Ethan S. Kadiyala, Amanda C. Lohmann, Thomas L. Anderson, Nat J. Coombs, Kyle J. Haynes, Lauren M. Hallett, Max C. N. Castorani","doi":"10.1111/ele.70112","DOIUrl":"https://doi.org/10.1111/ele.70112","url":null,"abstract":"<p>Spatial synchrony, the tendency for temporal fluctuations in an ecological variable to be positively associated in different locations, is a widespread and important phenomenon in ecology. Understanding of the nature and mechanisms of synchrony, and how synchrony is changing, has developed rapidly over the past 2 decades. Many recent developments have taken place through the study of long-term data sets. Here, we review and synthesise some important recent advances in spatial synchrony, with a focus on how long-term data have facilitated new understanding. Longer time series do not just facilitate better testing of existing ideas or more precise statistical results; more importantly, they also frequently make possible the expansion of conceptual paradigms. We discuss several such advances in our understanding of synchrony, how long-term data led to these advances, and how future studies can continue to improve the state of knowledge.</p>","PeriodicalId":161,"journal":{"name":"Ecology Letters","volume":"28 4","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ele.70112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Precise frequency detection is one of the key problems to be solved in a high-accuracy transfer of time and frequency. The solution to this problem is helpful in improving the precision of the phase noise measurement, atomic frequency standard, and time synchronization, which plays a strong role in the whole precision measurement physics fields. A high-accuracy frequency detection and analysis based on adaptive frequency standard tracking are proposed for time–frequency signal processing without frequency normalization. First, an adaptive frequency standard signal is generated by using an FPGA to control the DDS based on the measured signal. This signal can achieve phase comparison with the measured signal under any frequency relationships including complex and large-frequency difference relationships, widening a frequency measurement range. Second, the frequency standard signal is put off by the delay chains. The rough time delaying can generate many phase coincidences, which can shorten the gate switch time to achieve fast time response. The finer delaying can provide a very high measurement resolution without transforming the frequency relationships between the measured and reference signals. And then, a differential synchronization is performed between the measured and reference signals after shaping and conditioning the two signals. The obtained optimal phase coincidences, that is, fuzzy zone edge pulses, are used as the gate signals. A precise frequency measurement for the measured signals can then be realized by counting the measured and reference signals without gap in the gate time. The testing results show that the frequency measurement accuracy of the system can reach 1.7 × 10−13/s.
{"title":"High-Accuracy Frequency Detection and Analysis via Adaptive Frequency Standard Tracking","authors":"Baoqiang Du, Zhengze Xiao, Lanqin Tan","doi":"10.1049/sil2/8914468","DOIUrl":"https://doi.org/10.1049/sil2/8914468","url":null,"abstract":"<div>\u0000 <p>Precise frequency detection is one of the key problems to be solved in a high-accuracy transfer of time and frequency. The solution to this problem is helpful in improving the precision of the phase noise measurement, atomic frequency standard, and time synchronization, which plays a strong role in the whole precision measurement physics fields. A high-accuracy frequency detection and analysis based on adaptive frequency standard tracking are proposed for time–frequency signal processing without frequency normalization. First, an adaptive frequency standard signal is generated by using an FPGA to control the DDS based on the measured signal. This signal can achieve phase comparison with the measured signal under any frequency relationships including complex and large-frequency difference relationships, widening a frequency measurement range. Second, the frequency standard signal is put off by the delay chains. The rough time delaying can generate many phase coincidences, which can shorten the gate switch time to achieve fast time response. The finer delaying can provide a very high measurement resolution without transforming the frequency relationships between the measured and reference signals. And then, a differential synchronization is performed between the measured and reference signals after shaping and conditioning the two signals. The obtained optimal phase coincidences, that is, fuzzy zone edge pulses, are used as the gate signals. A precise frequency measurement for the measured signals can then be realized by counting the measured and reference signals without gap in the gate time. The testing results show that the frequency measurement accuracy of the system can reach 1.7 × 10<sup>−13</sup>/s.</p>\u0000 </div>","PeriodicalId":56301,"journal":{"name":"IET Signal Processing","volume":"2025 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/sil2/8914468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In article number 2400910, Junhwan Choi, Hocheon Yoo, and co-workers present floating gate devices with tunable characteristics based on the parylene tunneling dielectric layer (TDL) thickness. Thin TDLs enable tunneling, while thicker layers exhibit photomemory with robust retention and flexibility on paper substrates.
{"title":"Tunneling Dielectric Thickness-Dependent Behaviors in Transistors Based on Sandwiched Small Molecule and Insulating Layer Structures (Adv. Electron. Mater. 5/2025)","authors":"Dong Hyun Lee, Yunchae Jeon, Junhwan Choi, Hocheon Yoo","doi":"10.1002/aelm.202570014","DOIUrl":"https://doi.org/10.1002/aelm.202570014","url":null,"abstract":"<p><b>Tunneling Dielectric Thickness</b></p><p>In article number 2400910, Junhwan Choi, Hocheon Yoo, and co-workers present floating gate devices with tunable characteristics based on the parylene tunneling dielectric layer (TDL) thickness. Thin TDLs enable tunneling, while thicker layers exhibit photomemory with robust retention and flexibility on paper substrates.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":110,"journal":{"name":"Advanced Electronic Materials","volume":"11 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aelm.202570014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abraam Rezkalla, Ahmad Nouri, Fadi Hadya, Islam Rajab, Emile Doss
Coronary embolism (CE) is a rare yet significant contributor to acute myocardial infarction (AMI), particularly in younger patients. We report a 42-year-old male who experienced an AMI following recent cocaine use. Investigations revealed a left ventricular apical thrombus, identified as the source of a distal embolus occluding the right coronary artery (RCA). Cocaine is known for its thrombogenic effects, promoting thrombus formation through mechanisms such as vasoconstriction and increased platelet aggregation. This unique situation highlights the critical interplay between cocaine use, left ventricular thrombus formation, and the resultant coronary artery embolism, contributing to myocardial ischemia. The patient underwent successful aspiration thrombectomy, restoring coronary blood flow without the need for stenting. This case underscores the importance of recognizing CE as a potential etiology of AMI, particularly in the context of substance abuse, advocating for heightened awareness among clinicians regarding the complexities of managing thromboembolic events.
{"title":"Successful Aspiration Thrombectomy for Cocaine-Induced Right Coronary Artery Embolism Secondary to Left Ventricular Thrombus: A Case Report and Literature Review","authors":"Abraam Rezkalla, Ahmad Nouri, Fadi Hadya, Islam Rajab, Emile Doss","doi":"10.1002/ccr3.70432","DOIUrl":"https://doi.org/10.1002/ccr3.70432","url":null,"abstract":"<p>Coronary embolism (CE) is a rare yet significant contributor to acute myocardial infarction (AMI), particularly in younger patients. We report a 42-year-old male who experienced an AMI following recent cocaine use. Investigations revealed a left ventricular apical thrombus, identified as the source of a distal embolus occluding the right coronary artery (RCA). Cocaine is known for its thrombogenic effects, promoting thrombus formation through mechanisms such as vasoconstriction and increased platelet aggregation. This unique situation highlights the critical interplay between cocaine use, left ventricular thrombus formation, and the resultant coronary artery embolism, contributing to myocardial ischemia. The patient underwent successful aspiration thrombectomy, restoring coronary blood flow without the need for stenting. This case underscores the importance of recognizing CE as a potential etiology of AMI, particularly in the context of substance abuse, advocating for heightened awareness among clinicians regarding the complexities of managing thromboembolic events.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 5","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coarse-graining (CG) is transforming the study of molecular systems, allowing researchers to explore by computer simulations larger and more complex structures than ever before. Continued advancements in CG techniques are making simulations more efficient, establishing this approach as a cornerstone for designing innovative materials and eco-friendly alternatives to traditional plastics. Additionally, CG methods are becoming indispensable for unraveling the complexities and functional mechanisms of large-scale macromolecular machines within cells. Yet, crafting an effective coarse-grained model demands a nuanced understanding of its advantages and limitations. Faster simulations come at the cost of molecular detail and accuracy in some properties, so that it is essential to balance computational efficiency with the specific needs of the system one wants to simulate. By asking the right questions, researchers can select models that offer the desired benefits while managing trade-offs. This article delves into the potential of different CG models and the compromises inherent in their adoption, highlighting their role in shaping the future of material science and biophysics.
{"title":"Everything You Want to Know About Coarse-Graining and Never Dared to Ask: Macromolecules as a Key Example","authors":"Marina G. Guenza","doi":"10.1002/wcms.70022","DOIUrl":"https://doi.org/10.1002/wcms.70022","url":null,"abstract":"<p>Coarse-graining (CG) is transforming the study of molecular systems, allowing researchers to explore by computer simulations larger and more complex structures than ever before. Continued advancements in CG techniques are making simulations more efficient, establishing this approach as a cornerstone for designing innovative materials and eco-friendly alternatives to traditional plastics. Additionally, CG methods are becoming indispensable for unraveling the complexities and functional mechanisms of large-scale macromolecular machines within cells. Yet, crafting an effective coarse-grained model demands a nuanced understanding of its advantages and limitations. Faster simulations come at the cost of molecular detail and accuracy in some properties, so that it is essential to balance computational efficiency with the specific needs of the system one wants to simulate. By asking the right questions, researchers can select models that offer the desired benefits while managing trade-offs. This article delves into the potential of different CG models and the compromises inherent in their adoption, highlighting their role in shaping the future of material science and biophysics.</p>","PeriodicalId":236,"journal":{"name":"Wiley Interdisciplinary Reviews: Computational Molecular Science","volume":"15 2","pages":""},"PeriodicalIF":16.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/wcms.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yansong Bai, Xueping Gu, Shaoyan Li, Tong Liu, Yingshan Wang
In power system restoration (PSR), networks with various voltage levels have different decision-making constraints and restoration characteristics. Specifically, the restoration plan for the lower voltage level network is more adaptable to uncertainty of wind power output, owing to its greater flexibility. First, the restoration scheme decision-making is divided into two parts for the main network level (MNL) and the regional network level (RNL) respectively, according to the voltage levels. Second, a hierarchical coordinated optimisation model is established based on a two-stage framework. In the first stage, the plants/lines restoration sequence of the MNL and the subsystem partitioning scheme are determined. Furthermore, the plants/lines restoration sequence of the RNL and the restoration power scheduling scheme of the MNL and RNL are obtained in the second stage of optimisation, which can be flexibly adjusted to adapt to uncertain wind power outputs. The coordination and allocation of frequency regulation resources across subsystems are considered. Finally, the nested column and constraint generation algorithm is applied to solve the two-stage robust model. Case studies using the IEEE standard and a provincial system in China show that the algorithm converges in 2–3 iterations. Compared to non-hierarchical approaches, the proposed method improves cumulative restored energy by 2% and 5.3% in case 1 and case 2, respectively, while maintaining robustness against wind power uncertainty, highlighting its effectiveness in multi-level PSR.
{"title":"Hierarchical Coordinated Optimisation of the Restoration Decision-Making for Multi-Voltage-Level Power Systems With Wind Power Integration","authors":"Yansong Bai, Xueping Gu, Shaoyan Li, Tong Liu, Yingshan Wang","doi":"10.1049/gtd2.70075","DOIUrl":"https://doi.org/10.1049/gtd2.70075","url":null,"abstract":"<p>In power system restoration (PSR), networks with various voltage levels have different decision-making constraints and restoration characteristics. Specifically, the restoration plan for the lower voltage level network is more adaptable to uncertainty of wind power output, owing to its greater flexibility. First, the restoration scheme decision-making is divided into two parts for the main network level (MNL) and the regional network level (RNL) respectively, according to the voltage levels. Second, a hierarchical coordinated optimisation model is established based on a two-stage framework. In the first stage, the plants/lines restoration sequence of the MNL and the subsystem partitioning scheme are determined. Furthermore, the plants/lines restoration sequence of the RNL and the restoration power scheduling scheme of the MNL and RNL are obtained in the second stage of optimisation, which can be flexibly adjusted to adapt to uncertain wind power outputs. The coordination and allocation of frequency regulation resources across subsystems are considered. Finally, the nested column and constraint generation algorithm is applied to solve the two-stage robust model. Case studies using the IEEE standard and a provincial system in China show that the algorithm converges in 2–3 iterations. Compared to non-hierarchical approaches, the proposed method improves cumulative restored energy by 2% and 5.3% in case 1 and case 2, respectively, while maintaining robustness against wind power uncertainty, highlighting its effectiveness in multi-level PSR.</p>","PeriodicalId":13261,"journal":{"name":"Iet Generation Transmission & Distribution","volume":"19 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/gtd2.70075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ki-Hwan Kim, Dae-Hee Seo, Im-Yeong Lee, Su-Hyun Kim
Private set intersection (PSI) is a privacy-preserving scheme that computes the intersection of two datasets without leaking any other information. Additionally, there is multiparty private set intersection (MPSI) to extend the number of parties for computing the intersection of multiple private datasets. In the traditional PSI and MPSI studies, protocol parties input their private datasets, and one or all of them can compute the intersection. However, there are some scenarios where an inputless external party requires the intersection between private datasets of other parties. Thus, the external party PSI protocols have been recently studied for applications such as pandemic contact tracing, computing human genome information and evaluating policy effects. However, they are limited in applications because the external party can compute the intersection of two datasets. In this paper, we propose a new external party compute-MPSI (EPC-MPSI) protocols that allow an external party to compute the intersection of multiple datasets. We provide the extension of the number of parties and solve the limitation of prior external party PSI protocols. In addition, we analyze the correctness, security and the efficiency in terms of communication and computation costs compared to the prior traditional MPSI protocols.
{"title":"A Study on New EPC-MPSI for an Inputless External Party to Compute the Intersection of Multiple Private Datasets","authors":"Ki-Hwan Kim, Dae-Hee Seo, Im-Yeong Lee, Su-Hyun Kim","doi":"10.1049/cmu2.70038","DOIUrl":"https://doi.org/10.1049/cmu2.70038","url":null,"abstract":"<p>Private set intersection (PSI) is a privacy-preserving scheme that computes the intersection of two datasets without leaking any other information. Additionally, there is multiparty private set intersection (MPSI) to extend the number of parties for computing the intersection of multiple private datasets. In the traditional PSI and MPSI studies, protocol parties input their private datasets, and one or all of them can compute the intersection. However, there are some scenarios where an inputless external party requires the intersection between private datasets of other parties. Thus, the external party PSI protocols have been recently studied for applications such as pandemic contact tracing, computing human genome information and evaluating policy effects. However, they are limited in applications because the external party can compute the intersection of two datasets. In this paper, we propose a new external party compute-MPSI (EPC-MPSI) protocols that allow an external party to compute the intersection of multiple datasets. We provide the extension of the number of parties and solve the limitation of prior external party PSI protocols. In addition, we analyze the correctness, security and the efficiency in terms of communication and computation costs compared to the prior traditional MPSI protocols.</p>","PeriodicalId":55001,"journal":{"name":"IET Communications","volume":"19 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/cmu2.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Si Heon Lim, Geunwoo Kim, Sungjin Cho, Yeong Kwon Kim, Eun Bee Ko, Seon Yeon Choi, Jung A Heo, Daegun Kim, Hocheon Yoo, So-Yeon Lee, YongJoo Kim, Pil-Ryung Cha, Dong Yun Lee, Sunghun Lee, Byung Chul Jang, Yeonhoo Kim, Hyun Ho Kim
Nanostructured Transition Metal Oxides
In article number 2418407, Hyun Ho Kim and co-workers present a universal and ultrafast method for synthesizing nanostructured transition metal oxides (NTMOs) through the induced solidification of microdroplets, enabling rapid production within a minute. Since NTMOs can be directly grown on substrates in ambient air without requiring high-purity carrier gases, this approach facilitates industrial-friendly mass production.
{"title":"Ultrafast and Universal Synthetic Route for Nanostructured Transition Metal Oxides Directly Grown on Substrates (Adv. Mater. 16/2025)","authors":"Si Heon Lim, Geunwoo Kim, Sungjin Cho, Yeong Kwon Kim, Eun Bee Ko, Seon Yeon Choi, Jung A Heo, Daegun Kim, Hocheon Yoo, So-Yeon Lee, YongJoo Kim, Pil-Ryung Cha, Dong Yun Lee, Sunghun Lee, Byung Chul Jang, Yeonhoo Kim, Hyun Ho Kim","doi":"10.1002/adma.202570125","DOIUrl":"https://doi.org/10.1002/adma.202570125","url":null,"abstract":"<p><b>Nanostructured Transition Metal Oxides</b></p><p>In article number 2418407, Hyun Ho Kim and co-workers present a universal and ultrafast method for synthesizing nanostructured transition metal oxides (NTMOs) through the induced solidification of microdroplets, enabling rapid production within a minute. Since NTMOs can be directly grown on substrates in ambient air without requiring high-purity carrier gases, this approach facilitates industrial-friendly mass production.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 16","pages":""},"PeriodicalIF":27.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adma.202570125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frederik Dencker Wisborg MD, Nora Olsen El Caidi MD, Ida Arentz Taraldsen MD, Sandra Tonning MD, Aginsha Kandiah MD, Mohammed El-Sheikh MD, Hashmat S. Z. Bahrami MD, Ove Andersen MDD, MSc, Line Jee Hartmann Rasmussen MSc, PhD, Jens Hove MD, MSc, PhD, Ulrik Dixen MD, PhD, Johannes Grand MD, MPH, PhD
Background
Atrial fibrillation (AF) is associated with a higher incidence of stroke, heart failure, and mortality. Risk assessment of clinical outcomes in patients hospitalized acutely with AF remains a challenge.
Purpose
To investigate if soluble urokinase plasminogen activator receptor (suPAR) levels at admission to the Emergency Department (ED) are associated with 1-year all-cause mortality in patients admitted with AF.
Methods
A prospective cohort study of patients consecutively admitted to the medical ED of a university hospital in Copenhagen, Denmark, between 2020 and 2022 with symptoms of COVID-19. Patients were included if they were admitted with AF as the primary or secondary diagnosis. All patients had suPAR measured at the index admission, and follow-up was up to 1 year. The association between suPAR and 1-year mortality was investigated with multivariate Cox regression. We adjusted for age, sex, smoking, C-reactive protein, creatinine, hemoglobin, albumin, and comorbidities.
Results
Of the 7,258 patients included during the period, 362 (5.0%) patients were admitted with AF as the primary or secondary diagnosis. Due to missing data, 23 (6.4%) patients were excluded. Among the remaining 339 patients, 68 (20.1%) patients were dead at follow-up. The multivariate Cox regression showed that elevated suPAR was independently associated with an increased risk of 1-year mortality, with a hazard ratio of 1.12 (95% confidence interval: 1.05–1.20, p < 0.001).
Conclusion
Elevated suPAR levels were significantly associated with 1-year all-cause mortality in patients acutely admitted with AF to the ED.
{"title":"Soluble urokinase plasminogen activator receptor (suPAR) as a prognostic biomarker in acutely admitted patients with atrial fibrillation","authors":"Frederik Dencker Wisborg MD, Nora Olsen El Caidi MD, Ida Arentz Taraldsen MD, Sandra Tonning MD, Aginsha Kandiah MD, Mohammed El-Sheikh MD, Hashmat S. Z. Bahrami MD, Ove Andersen MDD, MSc, Line Jee Hartmann Rasmussen MSc, PhD, Jens Hove MD, MSc, PhD, Ulrik Dixen MD, PhD, Johannes Grand MD, MPH, PhD","doi":"10.1002/joa3.70077","DOIUrl":"https://doi.org/10.1002/joa3.70077","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Atrial fibrillation (AF) is associated with a higher incidence of stroke, heart failure, and mortality. Risk assessment of clinical outcomes in patients hospitalized acutely with AF remains a challenge.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To investigate if soluble urokinase plasminogen activator receptor (suPAR) levels at admission to the Emergency Department (ED) are associated with 1-year all-cause mortality in patients admitted with AF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective cohort study of patients consecutively admitted to the medical ED of a university hospital in Copenhagen, Denmark, between 2020 and 2022 with symptoms of COVID-19. Patients were included if they were admitted with AF as the primary or secondary diagnosis. All patients had suPAR measured at the index admission, and follow-up was up to 1 year. The association between suPAR and 1-year mortality was investigated with multivariate Cox regression. We adjusted for age, sex, smoking, C-reactive protein, creatinine, hemoglobin, albumin, and comorbidities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 7,258 patients included during the period, 362 (5.0%) patients were admitted with AF as the primary or secondary diagnosis. Due to missing data, 23 (6.4%) patients were excluded. Among the remaining 339 patients, 68 (20.1%) patients were dead at follow-up. The multivariate Cox regression showed that elevated suPAR was independently associated with an increased risk of 1-year mortality, with a hazard ratio of 1.12 (95% confidence interval: 1.05–1.20, <i>p</i> < 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Elevated suPAR levels were significantly associated with 1-year all-cause mortality in patients acutely admitted with AF to the ED.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/joa3.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lalechère, E., Marrec, R., & Lenoir, J. (2025). A Non-Equilibrium Species Distribution Model Reveals Unprecedented Depth of Time Lag Responses to Past Environmental Change Trajectories. Ecology Letters, 28(1), e70040. https://doi.org/10.1111/ele.70040
In the ‘Material and Methods’ section and in the ‘Results’ section, the assertation that the distribution of the residual errors followed a normal distribution was unnecessary to assess model validity. This may lead to some confusion about the family of distribution that was used. As stated in the article, we relied on the binomial distribution.
We apologize for this mistake.
{"title":"Correction to “A Non-Equilibrium Species Distribution Model Reveals Unprecedented Depth of Time Lag Responses to Past Environmental Change Trajectories”","authors":"","doi":"10.1111/ele.70123","DOIUrl":"https://doi.org/10.1111/ele.70123","url":null,"abstract":"<p>\u0000 <span>Lalechère, E.</span>, <span>Marrec, R.</span>, & <span>Lenoir, J.</span> (<span>2025</span>). <span>A Non-Equilibrium Species Distribution Model Reveals Unprecedented Depth of Time Lag Responses to Past Environmental Change Trajectories</span>. <i>Ecology Letters</i>, <span>28</span>(<span>1</span>), e70040. https://doi.org/10.1111/ele.70040\u0000 </p><p>In the ‘Material and Methods’ section and in the ‘Results’ section, the assertation that the distribution of the residual errors followed a normal distribution was unnecessary to assess model validity. This may lead to some confusion about the family of distribution that was used. As stated in the article, we relied on the binomial distribution.</p><p>We apologize for this mistake.</p>","PeriodicalId":161,"journal":{"name":"Ecology Letters","volume":"28 4","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ele.70123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}