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Ensayos clínicos en UCI: «Más allá del valor p» UCI临床试验:“超越p值”
Pub Date : 2025-01-01 DOI: 10.1016/j.acci.2024.08.011
Jose Correa Guerrero
Of the frequentist methods in statistics, the “p-values” when interpreting the results do not inform about the effect size, they are based only on the 5% threshold to declare a real effect in the hypothesis test, and at the same time do not provide probabilistic information. That is why it is important to consider other alternatives or statistical methods in the current context. Bayesian inference or approach as this alternative method addresses the above limitations by having the ability to directly estimate the probability of a significant clinical benefit, and allowing researchers to quantify the influence of prior information on the interpretation of the final results, in order to provide temporary solutions to the problem of significance in the frequentist framework. As a general objective we will review the Bayesian approach or inference trying to address these limitations, some aspects such as statistical and mathematical formulas are beyond the scope of this review.
在统计学中的频率主义方法中,解释结果时的“p值”并不告知效应大小,它们仅基于5%的阈值来声明假设检验中的真实效应,同时不提供概率信息。这就是为什么在当前情况下考虑其他替代方法或统计方法是很重要的。贝叶斯推理或方法作为一种替代方法,通过能够直接估计显著临床获益的概率来解决上述局限性,并允许研究人员量化先验信息对最终结果解释的影响,以便为频率论框架中的显著性问题提供临时解决方案。作为一个总体目标,我们将回顾贝叶斯方法或试图解决这些局限性的推理,一些方面,如统计和数学公式超出了本综述的范围。
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引用次数: 0
Descripción de la Kocuria kristinae como agente causal de choque distributivo por sepsis en enfermedad pélvica inflamatoria en una paciente inmunocompetente: reporte de caso Kristinae作为免疫能力患者炎症性骨盆疾病中脓毒症分布性休克的致病因子的描述:病例报告
Pub Date : 2025-01-01 DOI: 10.1016/j.acci.2024.10.009
Jorge Eliecer Pinzón Bernal , Lina María Castro Rojas , Pedro Fernando Giraldo , Abel Yurialdy Espinoza Rios , Peter Vergara Ramírez
Kocuria kristinae is a gram-positive catalase-positive cocci-type microorganism that can normally be isolated from the skin and oral cavity of humans. It is not usually related to the production of infections, however, in recent years it has been found. important isolates of it that generate infections on immunocompromised patients around the world.
Pelvic inflammatory disease is a common entity in our environment, it includes a wide range of infectious processes that compromise the female genital tract that can compromise the endometrium, fallopian tubes, ovaries and even the peritoneum at the pelvic level, it is predominant in women of fertile age and sexually active. The germs commonly associated with the genesis of pelvic inflammatory disease are mainly Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium. However, it is important to keep in mind that up to the time of the review in our environment no cases of pelvic inflammatory disease secondary to K. kristinae have been documented in both immunosuppressed and immunocompetent patients, which is why the case report in question about an immunocompetent patient who presented a case of these characteristics becomes vitally important.
kristinae是一种革兰氏阳性过氧化氢酶阳性的球菌型微生物,通常可以从人类的皮肤和口腔中分离出来。它通常与感染的产生无关,但近年来已被发现。对世界各地免疫功能低下患者产生感染的重要分离株。盆腔炎是我们生活环境中常见的一种疾病,它包括多种感染过程,损害女性生殖道,可损害子宫内膜、输卵管、卵巢甚至骨盆水平的腹膜,主要发生在育龄和性活跃的女性中。通常与盆腔炎发生有关的细菌主要是沙眼衣原体、淋病奈瑟菌和生殖支原体。然而,重要的是要记住,在我们的研究环境中,到目前为止,还没有在免疫抑制和免疫正常的患者中记录到继发于kristina k的盆腔炎病例,这就是为什么有关具有这些特征的免疫正常患者的病例报告变得至关重要的原因。
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引用次数: 0
Rotura del septum ventricular como complicación del infarto agudo de miocardio con elevación del segmento ST: reporte de un caso 心室隔膜破裂作为急性ST段抬高心肌梗死的并发症:1例报告
Pub Date : 2025-01-01 DOI: 10.1016/j.acci.2024.10.001
Carlos Rebolledo Maldonado , Ricardo Luis Romero Figueroa , Mayra Manrique , Víctor Jaimes , Jorge Salazar Amaris , Claudia Pacheco Escorcia
Ventricular septal rupture as a mechanical complication after acute myocardial infarction (AMI) is rare after the use of fibrinolytic drugs, but highly fatal. It should be suspected in patients with dyspnea, chest pain, pansystolic murmur in the left sternal border and cardiogenic shock, confirming the defect, location and size through echocardiography and color Doppler. Surgical management remains the best therapeutic option compared to medical management. We present a case report of an elderly male patient with arterial hypertension who developed an anterolateral ST segment elevation myocardial infarction. Fibrinolysis with alteplase was performed and subsequently coronary angiography plus rescue percutaneous coronary intervention in the first 24 hours in the anterior descending artery. On the fourth day after the onset of the clinical picture, ventricular septal rupture was documented, leading to cardiogenic shock and subsequent death.
室间隔破裂作为急性心肌梗死(AMI)后使用纤溶药物的机械并发症是罕见的,但高度致命。当患者出现呼吸困难、胸痛、左胸骨缘全收缩期杂音和心源性休克时应予以怀疑,通过超声心动图和彩色多普勒确认缺损、部位和大小。与药物治疗相比,手术治疗仍然是最好的治疗选择。我们提出一个病例报告的老年男性患者动脉高血压谁发展的前外侧ST段抬高心肌梗死。用阿替普酶进行纤溶,随后在前降支的前24小时进行冠状动脉造影和经皮冠状动脉介入治疗。在临床表现出现后的第四天,室间隔破裂被记录下来,导致心源性休克和随后的死亡。
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引用次数: 0
Role of ultrasonography in the evaluation of dysphagia in critically ill patients: A narrative review 超声波检查在重症患者吞咽困难评估中的作用:叙述性综述
Pub Date : 2025-01-01 DOI: 10.1016/j.acci.2024.09.004
Juan Sanjuan , Emanuel Cruz , María Paula Uchima-Vera , Alan Andrés Camargo-Rojasc , Gustavo Adolfo Villegas-Gomez
Dysphagia, defined as difficulty in swallowing, significantly impacts critically ill patients, especially those in intensive care units (ICUs). It can arise from neuromuscular disorders or mechanical obstructions, often exacerbated by prolonged mechanical ventilation and other medical interventions. Dysphagia poses risks such as aspiration pneumonia, malnutrition, and prolonged hospital stays. Early detection and intervention are crucial. A comprehensive literature search was conducted using PubMed, SCOPUS, and SPRINGER databases from December 2023 to February 2024. Search terms included “screening,” “dysphagia,” “ICU,” “ultrasonography,” “swallowing function,” and “deglutition disorders.” The search yielded 43 relevant articles, which were subjected to narrative analysis. Traditional dysphagia assessment methods include bedside evaluations, swallow tests, and instrumental strategies like video fluoroscopic swallowing study (VFSS) and fiberoptic endoscopic evaluation of swallowing (FEES). Ultrasonography (US) emerges as a promising, non-invasive alternative for evaluating swallowing function. US can assess tongue and hyolaryngeal movements, and upper esophageal sphincter function, offering real-time feedback and aiding in diagnosis and therapeutic planning. Despite its benefits, US lacks standardized protocols and comprehensive diagnostic criteria, necessitating further research. Ultrasonography shows significant potential in evaluating and managing dysphagia in critically ill patients due to its non-invasive nature and real-time feedback capabilities. However, variations in techniques and the need for standardized diagnostic criteria present challenges. Future research should focus on standardizing ultrasound parameters and refining diagnostic criteria to enhance its reliability and accuracy. Despite these challenges, ultrasonography remains a promising tool for dysphagia assessment and intervention.
吞咽困难,定义为吞咽困难,严重影响危重患者,特别是重症监护病房(icu)的患者。它可由神经肌肉疾病或机械阻塞引起,通常因长时间机械通气和其他医疗干预而加剧。吞咽困难会带来吸入性肺炎、营养不良和住院时间延长等风险。早期发现和干预至关重要。从2023年12月至2024年2月,对PubMed、SCOPUS和施普林格数据库进行了全面的文献检索。搜索词包括“筛查”、“吞咽困难”、“ICU”、“超声检查”、“吞咽功能”和“吞咽障碍”。搜索得到了43篇相关文章,并对其进行了叙述分析。传统的吞咽困难评估方法包括床边评估、吞咽测试和仪器策略,如视频透视吞咽研究(VFSS)和纤维内镜吞咽评估(FEES)。超声检查(US)是一种很有前途的、非侵入性的吞咽功能评估方法。US可以评估舌、喉运动和上食管括约肌功能,提供实时反馈,帮助诊断和治疗计划。尽管有好处,但美国缺乏标准化的方案和全面的诊断标准,需要进一步的研究。超声检查由于其非侵入性和实时反馈能力,在评估和治疗危重患者的吞咽困难方面显示出巨大的潜力。然而,技术的变化和对标准化诊断标准的需求带来了挑战。未来的研究应着眼于规范超声参数,完善诊断标准,提高其可靠性和准确性。尽管存在这些挑战,超声检查仍然是吞咽困难评估和干预的一个很有前途的工具。
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引用次数: 0
Sepsis and septic shock associated with tuberculosis “Landouzy's tifobacilosis”: A dark and unpredictable enemy – From pathophysiology to clinical implications 与结核病 "Landouzy's tifobacilosis "相关的败血症和脓毒性休克:难以预测的黑暗敌人--从病理生理学到临床意义
Pub Date : 2025-01-01 DOI: 10.1016/j.acci.2024.06.002
Jose Dario Portillo-Miño , José Leonel Zambrano-Urbano , Diego Fernando Taramuel-Gómez , Franco Andrés Montenegro-Coral , Nasly Violedy Ipia Ordoñez , Luis Guillermo Andino-Bucheli , Leopoldo Javier Eraso-García , Hector Fabio Sanchez-Galvez , Jorge Ignacio Martínez-Díaz
Sepsis and septic shock associated with tuberculosis are such critical diseases that are life-threatening to the patient. TB bacteremia has been associated with sepsis and septic shock, especially in immunosuppressed patients with high mortality. In this sense, it has been seen that 1 in 4 patients infected with human immunodeficiency virus (HIV) hospitalized for sepsis had TB bacteremia. Acute forms of tuberculosis can progress in severity and between 1 and 3% of cases require an Intensive Care Unit (ICU) and high mortality. Given this scenario, the authors consider it pertinent to carry out this Review article, which allows a diagnostic and therapeutic approach to this acute form of TB to provide key aspects of the disease that are decisive in saving the lives of patients in critical condition.
脓毒症和脓毒性休克是危及患者生命的危重疾病。结核菌血症与败血症和感染性休克有关,特别是在死亡率高的免疫抑制患者中。从这个意义上说,已经看到4个感染人类免疫缺陷病毒(HIV)的患者中有1个因败血症住院。急性结核病的严重程度可能会恶化,1%至3%的病例需要重症监护病房(ICU),死亡率很高。鉴于这种情况,作者认为开展这篇综述文章是有必要的,它允许对这种急性结核的诊断和治疗方法提供该疾病的关键方面,这些方面对于挽救危重患者的生命具有决定性意义。
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引用次数: 0
Tormenta tiroidea: abordaje diagnóstico y terapéutico 甲状腺风暴:诊断和治疗方法
Pub Date : 2025-01-01 DOI: 10.1016/j.acci.2024.10.010
José Correa-Guerrero , Hugo Corrales Santander , Jorge Yepes Caro , Jesús Bello Simanca , Luis Rodríguez Arrieta , Alejandro Castellanos Pinedo , Elguis Rodríguez Garizabalo , Carmelo Dueñas Castell
Thyroid storm (TT) is a rare but potentially fatal condition if not detected and treated promptly. It is characterized by severe clinical manifestations at the level of the central nervous system, cardiovascular system, and gastrointestinal system, associated with elevated levels of free triiodothyronine (T3) and free thyroxine (T4). Infections and/or treatment discontinuation are the most frequent triggers. Identifying the triggering factor, reducing circulating levels of thyroid hormones, and admission to an intensive care unit become the cornerstone of treatment. In this review, based on a clinical scenario, we will provide information regarding the diagnostic and therapeutic approach to TT.
甲状腺风暴(TT)是一种罕见但潜在致命的疾病,如果不及时发现和治疗。以中枢神经系统、心血管系统、胃肠系统等临床表现严重为特点,伴有游离三碘甲状腺原氨酸(T3)、游离甲状腺素(T4)水平升高。感染和/或停止治疗是最常见的诱因。确定触发因素,降低循环甲状腺激素水平,并进入重症监护病房成为治疗的基石。在这篇综述中,基于临床情况,我们将提供有关TT的诊断和治疗方法的信息。
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引用次数: 0
Rabdomiólisis asociada a fenoverina: reporte de caso 与苯诺维林有关的Rabdomiolysis:案例报告
Pub Date : 2025-01-01 DOI: 10.1016/j.acci.2024.07.003
Felipe Arturo Valenzo Hernández , Sofía Jiménez Lomas , Martín Iván Patiño Rosillo , Dulce Guadalupe Márquez Jiménez
Rhabdomyolysis is a syndrome characterized by muscle destruction and the release of intracellular contents into the plasma, this being one of the main potential causes of nephrotoxicity. Being a syndrome, its etiology is diverse; however, little has been described about rhabdomyolysis secondary to the consumption of HMG-CoA reductase inhibitor drugs such as Phenoverine.
The case of a 54-year-old female patient with no significant history is described, with a clinical picture characterized by asthenia, adynamia, muscle pain, arthralgia, and serum creatine kinase (CPK) of 53,032 IU/L, after the consumption of Phenoverine, complying with diagnostic criteria for rhabdomyolysis secondary to drug use. After the initial evaluation, conservative management was established, based on nephroprotective measures, presenting satisfactory improvement, with resolution of rhabdomyolysis and acute kidney injury.
The objective of this article is to report the case of rhabdomyolysis secondary to the use of this frequently used antispasmodic agent, and of which this complication is underestimated, which can become so serious and leave permanent kidney damage as a consequence.
横纹肌溶解是一种以肌肉破坏和细胞内内容物释放到血浆为特征的综合征,这是肾毒性的主要潜在原因之一。作为一种综合征,其病因多种多样;然而,关于HMG-CoA还原酶抑制剂药物(如Phenoverine)引起的横纹肌溶解的报道很少。本文报告一例54岁女性患者,无明显病史,临床表现为服用Phenoverine后乏力、乏力、肌肉疼痛、关节痛,血清肌酸激酶(CPK) 53032 IU/L,符合药物继发性横纹肌溶解诊断标准。初步评估后,在肾保护措施的基础上建立保守治疗,改善满意,横纹肌溶解和急性肾损伤得到解决。本文的目的是报道使用这种常用的抗痉挛药物继发横纹肌溶解的病例,这种并发症被低估了,它可能变得如此严重,并留下永久性肾损害的后果。
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引用次数: 0
Infección por Clostridioides difficile en el adulto 成人艰难梭菌感染
Pub Date : 2025-01-01 DOI: 10.1016/j.acci.2024.08.008
Fabián Muñoz Ramírez , Santiago Morón-Serrano

Purpose

This review aims to provide clear and precise information about Clostridioides difficile infection (CDI), with the goal of enabling physicians to understand it and proceed with timely diagnosis and treatment.

Data Sources and Study Selection

Databases such as PubMed, Ovid, SciELO, Embase, and MEDLINE were consulted, along with general web searches and references previously known to the authors. Studies, guidelines, and reviews addressing the epidemiology, diagnosis, treatment, and prevention of CDI were included.

Data Extraction and Synthesis

Data were extracted from studies analyzing clinical presentation, diagnostic methods, and therapeutic options. The data synthesis aimed to provide a comprehensive view of best practices based on current evidence.

Conclusions

CDI is a significant cause of gastrointestinal disease in healthcare settings, particularly following antibiotic use. Its incidence is increasing, even in young people without risk factors. Diagnosis is based on clinical suspicion and the detection of C. difficile toxins or toxigenic genes using molecular biology techniques or enzyme immunoassays. This review emphasizes the importance of rapid detection and the implementation of effective therapies to reduce associated morbidity.
目的通过对艰难梭菌感染(clostridiides difficile, CDI)的研究,为临床医师提供准确、清晰的信息,以便及时诊断和治疗。数据来源和研究选择参考了PubMed、Ovid、SciELO、Embase和MEDLINE等数据库,以及作者已知的一般网络搜索和参考文献。包括研究、指南和综述,涉及CDI的流行病学、诊断、治疗和预防。数据提取和综合数据提取自分析临床表现、诊断方法和治疗方案的研究。数据综合旨在根据现有证据提供最佳做法的全面看法。结论scdi是医疗机构中胃肠道疾病的重要原因,特别是在抗生素使用后。即使在没有危险因素的年轻人中,其发病率也在增加。诊断是基于临床怀疑和使用分子生物学技术或酶免疫分析检测艰难梭菌毒素或产毒基因。这篇综述强调了快速检测和实施有效治疗以减少相关发病率的重要性。
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引用次数: 0
Monitoreo neurológico multimodal en cuidado intensivo 重症监护中的多模式神经监测
Pub Date : 2025-01-01 DOI: 10.1016/j.acci.2024.10.005
Jaime Sarmiento-Calderón , Diana Borré-Naranjo , Carmelo Dueñas-Castell
There are multiple monitoring strategies for the follow-up of patients with brain injuries admitted to the intensive care unit (ICU). These strategies begin with a neurological assessment, include imaging studies, and culminate with the implementation of cutting-edge, high-definition technologies. Clinical outcomes depend on the interpretation of the generated data. Neuromonitoring has received increasing attention in recent years. Current scientific evidence recommends practice standards for the use of neuromonitoring in critically ill patients, emphasizing the need to standardize technologies, efforts, and training necessary to integrate and interpret information from multimodal neuromonitoring (NMM). The future of neuromonitoring is oriented towards the integration and innovation of invasive and non-invasive NMM techniques. In terms of intracranial pressure (ICP), monitoring with an intraventricular catheter remains the reference technique or gold standard. Additionally, technologies for measuring cerebral oxygenation, ultrasonographic evaluations such as transcranial Doppler, optic nerve sheath measurement, and emerging techniques such as automated pupillometry and near-infrared spectroscopy (NIRS), should motivate intensivists to understand their foundation and interpretation, as well as their application to generate treatment strategies, monitor them, and impact better clinical outcomes. This review offers an updated assessment of the status of various neuromonitoring modalities and their use in different scenarios, highlighting the advantages and limitations of each method for implementation, emphasizing their utility in the ICU.
对于入住重症监护病房(ICU)的脑损伤患者,有多种随访监测策略。这些策略从神经学评估开始,包括影像学研究,最终采用尖端的高清技术。临床结果取决于对生成数据的解释。近年来,神经监测受到越来越多的关注。目前的科学证据建议在危重患者中使用神经监测的实践标准,强调需要标准化技术、努力和必要的培训,以整合和解释来自多模式神经监测(NMM)的信息。神经监测的未来是面向整合和创新的侵入性和非侵入性NMM技术。在颅内压(ICP)方面,使用脑室内导管监测仍然是参考技术或金标准。此外,测量脑氧合的技术,超声评估如经颅多普勒,视神经鞘测量,以及新兴技术如自动瞳孔测量和近红外光谱(NIRS),应该激励强化医生了解它们的基础和解释,以及它们在制定治疗策略,监测它们的应用,并影响更好的临床结果。本综述对各种神经监测模式的现状及其在不同情况下的应用进行了最新评估,强调了每种实施方法的优点和局限性,强调了它们在ICU中的应用。
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引用次数: 0
Meningoencefalitis por reactivación del virus de varicela zóster sin erupción cutánea en paciente inmunocomprometido: reporte de caso y revisión de la literatura 免疫受损患者中带状水痘病毒活动性脑膜炎无皮疹:病例报告和文献综述
Pub Date : 2025-01-01 DOI: 10.1016/j.acci.2024.10.011
Hans Altamar Polo , Izeth Sallas Rodríguez , Adriana Gamboa Dallos , Carlos Rebolledo Maldonado
We present an interesting case of acute meningoencephalitis due to reactivation of the varicella zoster virus in an immunocompromised patient in the absence of dermatomal neuralgia or skin lesions attributable to varicella zoster virus.
我们提出了一个有趣的急性脑膜脑炎病例,由于水痘带状疱疹病毒在免疫功能低下的病人的再激活,在没有皮肤神经痛或皮肤病变归因于水痘带状疱疹病毒。
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引用次数: 0
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Acta Colombiana de Cuidado Intensivo
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