Chinese Journal of Natural Medicines最新文献

英文中文

Research progress of small-molecule natural medicines for the treatment of ischemic stroke

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2025-01-01 DOI: 10.1016/S1875-5364(25)60801-6

Liu Kui, Wang Ling, Pang Tao

Stroke is the second leading cause of disability and mortality worldwide, imposing a substantial socioeconomic burden on individuals and healthcare systems. Annually, approximately 14 million people experience stroke, with ischemic stroke comprising nearly 85% of cases, of which 10% to 20% involve large vessel occlusions. Currently, recombinant tissue plasminogen activator (tPA) remains the only approved pharmacological intervention. However, its utility is limited due to a narrow therapeutic window and low recanalization rates, making it applicable to only a minority of patients. Therefore, there is an urgent need for novel therapeutic strategies, including pharmacological advancements and combinatory treatments. Small-molecule natural medicines, particularly those derived from traditional Chinese herbs, have demonstrated significant therapeutic potential in ischemic stroke management. These compounds exert multiple neuroprotective effects, such as antioxidation, anti-inflammatory action, and inhibition of apoptosis, all of which are critical in mitigating stroke-induced cerebral damage. This review comprehensively examines the pathophysiology of acute ischemic stroke (AIS) and highlights the recent progress in the development of small-molecule natural medicines as promising therapeutic agents for cerebral ischemic stroke.

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引用次数: 0

Natural-derived drug carriers (NDDCs) for precision therapy 用于精准治疗的天然药物载体（nddc）。

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-12-01 DOI: 10.1016/S1875-5364(24)60748-X

Wei HE , Yujie SHI , Ding QU

引用次数: 0

Advances in the combination of stem cell exosomes with medical devices-the new direction for combination products 干细胞外泌体与医疗器械结合的研究进展——结合产品的新方向。

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-12-01 DOI: 10.1016/S1875-5364(24)60637-0

Yuewen ZHAI, Fang HE, Ji FANG, Siwen LI

Exosomes (exos), nanoscale extracellular vesicles, play a critical role in tissue development and function. Stem cell-derived exos, containing various tissue repair components, show promise as natural therapeutic agents in disease treatment and regenerative medicine. However, challenges persist in their application, particularly in targeted delivery and controlled release, which are crucial for enhancing their biological efficacy. The integration of medical devices may provide a superior platform for improving drug bioavailability. Consequently, the combination products of stem cell-derived exos and medical devices present novel opportunities for expanding the therapeutic potential of exosomes. This review offers a comprehensive overview of the current research frontier in stem cell-derived exos combined with medical devices and discusses the prospective challenges and future prospects in this field.

外泌体（exos）是纳米级细胞外囊泡，在组织发育和功能中起着关键作用。干细胞衍生的外显子含有多种组织修复成分，有望成为疾病治疗和再生医学的天然治疗剂。然而，它们的应用仍然存在挑战，特别是在靶向给药和控释方面，这对提高它们的生物功效至关重要。医疗器械的集成可以为提高药物的生物利用度提供一个优越的平台。因此，干细胞衍生的外泌体和医疗器械的组合产品为扩大外泌体的治疗潜力提供了新的机会。本文综述了目前干细胞衍生外显子与医疗器械结合的研究前沿，并讨论了该领域的潜在挑战和未来前景。

引用次数: 0

Traditional Chinese medicine-based drug delivery systems for anti-tumor therapies 基于中药的抗肿瘤药物传递系统。

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-12-01 DOI: 10.1016/S1875-5364(24)60746-6

Ling YANG , Yani WANG , Xietao YE , Qiaoming LIU , Ding QU , Yan CHEN

The treatment of tumors continues to be significantly challenging. The presence of multiple modalities, including surgery, radiation, chemotherapy and immunotherapy, the therapeutic outcomes remain limited and are often associated with adverse effects and inconsistent efficacy across cancer types. Recent studies have highlighted the potential of active components from traditional Chinese medicine (TCM) for their anti-cancer properties, which are attributable to multi-targeted mechanisms and broad pharmacological actions. Despite this potential, TCM-derived compounds are commonly limited by poor water solubility, low bioavailability, and suboptimal targeting. Currently, it is believed that advances in nanotechnology could address these limitations. Nanoparticles (NPs), which possess properties such as enhanced bioavailability, controlled release and precise targeting, have been used to improve the therapeutic efficacy of TCM components in cancer therapy. This review discusses the use of NPs for the delivery of active TCM compounds via organic-inorganic nanocarriers, highlighting innovative strategies that enhance the effectiveness of TCM-based anti-tumor components to provide insights into improving clinical outcomes while advancing the modernization and global application of TCM in oncology.

肿瘤的治疗仍然具有很大的挑战性。包括手术、放疗、化疗和免疫治疗在内的多种治疗方式的存在，治疗结果仍然有限，并且通常与不良反应和不同癌症类型的疗效不一致有关。近年来的研究强调了中药活性成分的抗癌潜力，这种抗癌特性可归因于多靶点机制和广泛的药理作用。尽管有这种潜力，但中药衍生的化合物通常受水溶性差、生物利用度低和非最佳靶向性的限制。目前，人们相信纳米技术的进步可以解决这些限制。纳米颗粒（NPs）具有生物利用度高、释放可控和靶向性强等特点，已被用于提高中药成分在癌症治疗中的疗效。这篇综述讨论了NPs通过有机-无机纳米载体传递中药活性化合物的应用，重点介绍了提高中药抗肿瘤成分有效性的创新策略，为改善临床结果提供见解，同时推进中医药在肿瘤领域的现代化和全球应用。

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引用次数: 0

Approved natural products-derived nanomedicines for disease treatment 经批准用于疾病治疗的天然产品衍生纳米药物。

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-12-01 DOI: 10.1016/S1875-5364(24)60726-0

Xiaotong LI , Yaoyao LAI , Guanghan WAN , Jiahui ZOU , Wei HE , Pei YANG

In recent years, there has been an increasing emphasis on exploring innovative drug delivery approaches due to the limitations of conventional therapeutic strategies, such as inadequate drug targeting, insufficient therapeutic efficacy, and significant adverse effects. Nanomedicines have emerged as a promising solution with notable advantages, including extended drug circulation, targeted delivery, and improved bioavailability, potentially enhancing the clinical treatment of various diseases. Natural products/materials-derived nanomedicines, characterized by their natural therapeutic efficacy, superior biocompatibility, and safety profile, play a crucial role in nanomedicine-based treatments. This review provides a comprehensive overview of currently approved natural products-derived nanomedicines, emphasizing the essential properties of natural products-derived drug carriers, their applications in clinical diagnosis and treatment, and the current therapeutic potential and challenges. The aim is to offer guidance for the application and further development of these innovative therapeutic approaches.

近年来，由于传统治疗策略的局限性，如药物靶向性不足、治疗效果不足、不良反应明显等，人们越来越重视探索创新的给药途径。纳米药物已成为一种有前景的解决方案，具有显著的优势，包括延长药物循环，靶向递送和提高生物利用度，可能增强各种疾病的临床治疗。天然产物/材料衍生的纳米药物以其天然的治疗效果、优越的生物相容性和安全性等特点，在纳米医学治疗中发挥着至关重要的作用。本文综述了目前批准的天然产物衍生纳米药物，重点介绍了天然产物衍生药物载体的基本特性、在临床诊断和治疗中的应用以及目前的治疗潜力和挑战。目的是为这些创新治疗方法的应用和进一步发展提供指导。

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引用次数: 0

Transdermal delivery of natural products against atopic dermatitis 经皮输送天然产品对抗特应性皮炎。

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-12-01 DOI: 10.1016/S1875-5364(24)60681-3

Minghui LI , Yihua XU , Yanan YU , Wanshu LI , Lixia CHEN , Bo ZHAO , Yuli GAO , Jianqing GAO , Hangjuan LIN

Atopic dermatitis (AD) is a chronic inflammatory skin condition. Natural products have gained traction in AD treatment due to their accessibility, low toxicity, and favorable pharmacological properties. However, their application is primarily constrained by poor solubility, instability, and limited permeability. The transdermal drug delivery system (TDDS) offers potential solutions for transdermal delivery, enhanced penetration, improved efficacy, and reduced toxicity of natural drugs, aligning with the requirements of modern AD treatment. This review examines the application of hydrogels, microneedles (MNs), liposomes, nanoemulsions, and other TDDS-carrying natural products in AD treatment, with a primary focus on their effects on penetration and accumulation in the skin. The aim is to provide valuable insights into the treatment of AD and other dermatological conditions.

特应性皮炎（AD）是一种慢性皮肤炎症。天然产物因其可及性、低毒性和良好的药理特性而在阿尔茨海默病治疗中获得了广泛的应用。然而，它们的应用主要受到溶解度差、不稳定性和渗透率有限的限制。经皮给药系统（TDDS）为天然药物的经皮给药、增强穿透性、提高疗效和降低毒性提供了潜在的解决方案，符合现代AD治疗的要求。本文综述了水凝胶、微针（MNs）、脂质体、纳米乳液和其他携带tdds的天然产物在AD治疗中的应用，主要关注了它们对皮肤渗透和积累的影响。目的是为阿尔茨海默病和其他皮肤病的治疗提供有价值的见解。

引用次数: 0

Glycyrrhizic acid-based multifunctional nanoplatform for tumor microenvironment regulation 基于甘草酸的肿瘤微环境调控多功能纳米平台。

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-12-01 DOI: 10.1016/S1875-5364(24)60685-0

Meng XIAO , Zhiqing GUO , Yating YANG , Chuan HU , Qian CHENG , Chen ZHANG , Yihan WU , Yanfen CHENG , Wui Lau Man BENSON , Sheung Mei Ng SHAMAY , George Pak-Heng LEUNG , Jingjing LI , Huile GAO , Jinming ZHANG

Natural compounds demonstrate unique therapeutic advantages for cancer treatment, primarily through direct tumor suppression or interference with the tumor microenvironment (TME). Glycyrrhizic acid (GL), a bioactive ingredient derived from the medicinal herb Glycyrrhiza uralensis Fisch., and its sapogenin glycyrrhetinic acid (GA), have been recognized for their ability to inhibit angiogenesis and remodel the TME. Consequently, the combination of GL with other therapeutic agents offers superior therapeutic benefits. Given GL's amphiphilic structure, self-assembly capability, and liver cancer targeting capacity, various GL-based nanoscale drug delivery systems have been developed. These GL-based nanosystems exhibit angiogenesis suppression and TME regulation properties, synergistically enhancing anti-cancer effects. This review summarizes recent advances in GL-based nanosystems, including polymer-drug micelles, drug-drug assembly nanoparticles (NPs), liposomes, and nanogels, for cancer treatment and tumor postoperative care, providing new insights into the anti-cancer potential of natural compounds. Additionally, the review discusses existing challenges and future perspectives for translating GL-based nanosystems from bench to bedside.

天然化合物在癌症治疗中表现出独特的治疗优势，主要是通过直接抑制肿瘤或干扰肿瘤微环境（TME）。Glycyrrhizic acid （GL）是一种从甘草中提取的生物活性成分。，及其皂苷元甘草酸（GA），已被认为具有抑制血管生成和重塑TME的能力。因此，GL与其他治疗剂联合使用可提供更好的治疗效果。鉴于GL的两亲性结构、自组装能力和肝癌靶向能力，各种基于GL的纳米给药系统已经被开发出来。这些基于gl的纳米系统具有抑制血管生成和调节TME的特性，协同增强抗癌作用。本文综述了基于凝胶的纳米系统的最新进展，包括聚合物-药物胶束，药物-药物组装纳米颗粒（NPs），脂质体和纳米凝胶，用于癌症治疗和肿瘤术后护理，为天然化合物的抗癌潜力提供了新的见解。此外，该综述还讨论了将基于gl的纳米系统从实验室转化为临床的现有挑战和未来前景。

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引用次数: 0

Natural-derived porous nanocarriers for the delivery of essential oils 天然衍生的用于输送精油的多孔纳米载体。

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-12-01 DOI: 10.1016/S1875-5364(24)60731-4

Hongxin CHEN , Xiaoyu SU , Yijuan LUO , Yan LIAO , Fengxia WANG , Lizhen HUANG , Aiguo FAN , Jing LI , Pengfei YUE

Essential oils (EOs) are natural, volatile substances derived from aromatic plants. They exhibit multiple pharmacological effects, including antibacterial, anticancer, anti-inflammatory, and antioxidant properties, with broad application prospects in health care, food, and agriculture. However, the instability of volatile components, which are susceptible to deterioration under light, heat, and oxygen exposure, as well as limited water solubility, have significantly impeded the development and application of EOs. Porous nanoclays are natural clay minerals with a layered structure. They possess unique structural characteristics such as large pore size, regular distribution, and tunable particle size, which are extensively utilized in drug delivery, adsorption separation, reaction catalysis, and other fields. Natural-derived porous nanoclays have garnered considerable attention for the encapsulation and delivery of EOs. This review comprehensively summarizes the structure, types, and properties of natural-derived porous nanoclays, focusing on the structural characteristics of porous nanoclays such as montmorillonite, palygorskite, halloysite, kaolinite, vermiculite, and natural zeolite. It also examines research advances in their delivery of EOs and explores engineering strategies to enhance the delivery of EOs by natural-derived porous nanoclays. Finally, various applications of natural-derived porous nanoclays for EOs in antibacterial, food preservation, repellent, and insecticide aspects are presented, providing a reference for the development and application of EOs.

精油（EOs）是从芳香植物中提取的天然挥发性物质。具有抗菌、抗癌、抗炎、抗氧化等多种药理作用，在保健、食品、农业等领域具有广阔的应用前景。然而，挥发性成分的不稳定性，在光、热、氧暴露下容易变质，以及有限的水溶性，严重阻碍了EOs的开发和应用。多孔纳米粘土是具有层状结构的天然粘土矿物。它们具有孔径大、分布规则、粒度可调等独特的结构特点，广泛应用于药物输送、吸附分离、反应催化等领域。天然衍生的多孔纳米粘土已经引起了相当大的关注，用于EOs的封装和输送。本文综述了天然多孔纳米粘土的结构、类型和性质，重点介绍了蒙脱土、坡高岭土、高岭土、高岭土、蛭石和天然沸石等多孔纳米粘土的结构特征。它还检查了他们的研究进展，在交付EOs和探索工程策略，以提高天然衍生的多孔纳米粘土的交付EOs。最后介绍了天然多孔纳米粘土在抗菌、食品保鲜、驱避、杀虫等方面的应用，为环氧树脂的开发和应用提供参考。

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引用次数: 0

Natural endogenous material-based vehicles for delivery of macromolecular drugs 天然内源性大分子药物递送载体。

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-12-01 DOI: 10.1016/S1875-5364(24)60742-9

An LU , Kang DU , Meng WANG , Zehang ZHU , Lei LEI , Yujie SHI

Natural endogenous materials (NEMs), such as cell and cell derivatives, polysaccharide, protein and peptide, and nucleic acid-derived vectors, often exhibit biocompatibility, biodegradability and natural homing ability, which can minimize adverse reactions in vivo and have the potential to improve drug delivery efficacy. Currently, a variety of drug delivery systems (DDSs) based on NEMs have been constructed for macromolecules to address the challenges posed by their inherent large size, intricate structure, low permeability, and susceptibility to harsh environments. The aim of this article is to provide a comprehensive overview of various delivery strategies that predominantly utilize NEMs as carriers for macromolecular delivery. By thoroughly discussing the pros and cons of NEM-based DDSs, we hope to provide valuable insights into future innovations in pharmaceutical science, with a focus on improving therapeutic outcomes through advanced drug formulations.

天然内源性材料（nem），如细胞及其衍生物、多糖、蛋白质和多肽、核酸衍生载体等，往往具有生物相容性、生物可降解性和天然归巢能力，可以最大限度地减少体内不良反应，具有提高给药效果的潜力。目前，各种基于nem的大分子给药系统（dds）已经被构建，以解决其固有的大尺寸、复杂的结构、低渗透性和对恶劣环境的敏感性所带来的挑战。本文的目的是提供各种递送策略的全面概述，主要利用nem作为大分子递送的载体。通过深入讨论基于nem的dds的优缺点，我们希望为制药科学的未来创新提供有价值的见解，重点是通过先进的药物配方改善治疗效果。

引用次数: 0

Active herbal ingredients and drug delivery design for tumor therapy: a review 肿瘤治疗的有效草药成分和给药设计综述。

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-12-01 DOI: 10.1016/S1875-5364(24)60741-7

Jing HAN , Yanxi SHEN , Ruiying CAO , Weiren WANG , Jinao DUAN , Jialun DUAN , Chunjie BAO

Active herbal ingredients are gaining recognition for their potent anti-tumor efficacy, attributable to various mechanisms including tumor cell inhibition, immune system activation, and tumor angiogenesis inhibition. Recent studies have revealed that numerous anti-tumor herbal ingredients, such as ginsenosides, ursolic acid, oleanolic acid, and Angelica sinensis polysaccharides, can be utilized to develop smart drug carriers like liposomes, micelles, and nanoparticles. These carriers can deliver active herbal ingredients and co-deliver anti-tumor drugs to enhance drug accumulation at tumor sites, thereby improving anti-tumor efficacy. This study provides a comprehensive analysis of the mechanisms by which these active herbal ingredients-derived carriers enhance therapeutic outcomes. Additionally, it highlights the structural properties of these active herbal ingredients, demonstrating how their unique features can be strategically employed to design smart drug carriers with improved anti-tumor efficacy. The insights presented aim to serve as a reference and guide future innovations in the design and application of smart drug carriers for cancer therapy that leverage active herbal ingredients.

有效的草药成分因其强大的抗肿瘤功效而得到认可，这可归因于多种机制，包括肿瘤细胞抑制、免疫系统激活和肿瘤血管生成抑制。最近的研究表明，许多抗肿瘤的草药成分，如人参皂苷、熊果酸、齐墩果酸和当归多糖，可以用来开发智能药物载体，如脂质体、胶束和纳米颗粒。这些载体可以传递有效的草药成分，并共同传递抗肿瘤药物，增强药物在肿瘤部位的蓄积，从而提高抗肿瘤疗效。本研究提供了一个全面的机制分析，通过这些活性草药成分衍生载体提高治疗效果。此外，它还强调了这些活性草药成分的结构特性，展示了如何策略性地利用它们的独特特征来设计具有提高抗肿瘤功效的智能药物载体。所提出的见解旨在作为参考和指导未来利用活性草药成分设计和应用癌症治疗的智能药物载体的创新。

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