Chinese Journal of Natural Medicines最新文献_第5页

Activation of LONP1 by 84-B10 alleviates aristolochic acid nephropathy via re-establishing mitochondrial and peroxisomal homeostasis 84-B10 激活 LONP1 可通过重建线粒体和过氧化物酶体平衡缓解马兜铃酸肾病

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-09-01 DOI: 10.1016/S1875-5364(24)60608-4

Xinyue XU , Wenping ZHU , Mengqiu MIAO , Mi BAI , Jiaojiao FAN , Yujia NIU , Yuting LI , Aihua ZHANG , Zhanjun JIA , Mengqiu WU

Pharmaceutical formulations derived from Aristolochiaceae herbs, which contain aristolochic acids (AAs), are widely used for medicinal purposes. However, exposure to these plants and isolated AAs is linked to renal toxicity, known as AA nephropathy (AAN). Currently, the mechanisms underlying AAN are not fully understood, leading to unsatisfactory treatment strategies. In this study, we explored the protective role of 84-B10 (5-[[2-(4-methoxyphenoxy)-5-(trifluoromethyl) phenyl] amino]-5-oxo-3-phenylpentanoic acid) against AAN. RNA-seq analysis revealed that the mitochondrion and peroxisome were the most affected cellular components following 84-B10 treatment in AAN mice. Consistently, 84-B10 treatment preserved mitochondrial ultrastructure, restored mitochondrial respiration, enhanced the expression of key transporters (carnitine palmitoyltransferase 2) and enzymes (acyl-Coenzyme A dehydrogenase, medium chain) involved in mitochondrial fatty acid β-oxidation, and reduced mitochondrial ROS generation in both aristolochic acid I (AAI)-challenged mice kidneys and cultured proximal tubular epithelial cells. Additionally, 84-B10 treatment increased the expression of key transporters (ATP binding cassette subfamily D) and rate-limiting enzymes (acyl-CoA oxidase 1) involved in peroxisomal fatty acid β-oxidation and restored peroxisomal redox balance. Knocking down LONP1 expression diminished the protective effects of 84-B10 against AAN, suggesting LONP1-dependent protection. In conclusion, our study provides evidence that AAN is associated with significant disturbances in both mitochondrial and peroxisomal functions. The LONP1 activator 84-B10 demonstrates therapeutic potential against AAN, likely by maintaining homeostasis in both mitochondria and peroxisomes.

从含有马兜铃酸（AAs）的马兜铃科草药中提取的药物配方被广泛用于医疗目的。然而，接触这些植物和分离出的 AAs 会引起肾毒性，即 AA 肾病（AAN）。目前，AAN 的发病机制尚未完全明了，导致治疗策略不尽人意。在这项研究中，我们探讨了 84-B10（5-[[2-（4-甲氧基苯氧基）-5-（三氟甲基）苯基]氨基]-5-氧代-3-苯基戊酸）对 AAN 的保护作用。RNA-seq分析显示，线粒体和过氧物酶体是AAN小鼠经84-B10治疗后受影响最大的细胞成分。一致的是，84-B10 治疗保留了线粒体的超微结构，恢复了线粒体呼吸，提高了参与线粒体脂肪酸 β 氧化的关键转运体（肉碱棕榈酰基转移酶 2）和酶（酰基辅酶 A 脱氢酶，中链）的表达，并减少了马兜铃酸 I（AAI）挑战小鼠肾脏和培养的近端肾小管上皮细胞中线粒体 ROS 的生成。此外，84-B10 还能增加参与过氧化物酶体脂肪酸 β 氧化的关键转运体（ATP 结合盒亚族 D）和限速酶（酰基-CoA 氧化酶 1）的表达，并恢复过氧化物酶体的氧化还原平衡。敲除 LONP1 的表达会降低 84-B10 对 AAN 的保护作用，这表明保护作用依赖于 LONP1。总之，我们的研究提供了证据，证明 AAN 与线粒体和过氧化物酶体功能的显著紊乱有关。LONP1 激活剂 84-B10 可能通过维持线粒体和过氧物酶体的平衡，对 AAN 具有治疗潜力。

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引用次数: 0

Antibacterial and cytotoxic metabolites produced by Streptomyces tanashiensis BYF-112 isolated from Odontotermes formosanus 从甲壳虫体内分离出的田桥链霉菌 BYF-112 产生的抗菌和细胞毒性代谢物

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-09-01 DOI: 10.1016/S1875-5364(24)60720-X

Jun WU , Tao SONG , Le ZHANG , Zhongdi HUANG , Fang HUANG , Caiping YIN , Shuxiang ZHANG , Xinhua LIU , Yinglao ZHANG

Chemical investigations of the termite-associated Streptomyces tanashiensis BYF-112 resulted in the discovery of four novel alkaloid derivatives: vegfrecines A and B (1 and 2), exfoliazone A (3), and venezueline H (7), in addition to nine known metabolites (4−6, 8−13). The structures of these compounds were elucidated through comprehensive spectroscopic analysis and comparison with existing literature data. Antibacterial assays revealed that viridomycin A (11) exhibited potent antibacterial activity against Staphylococcus aureus, with a zone of inhibition (ZOI) of 12.67 mm, in comparison to a ZOI of 17.67 mm for the positive control gentamicin sulfate. Viridomycin A (11) showed moderate activity against Micrococcus tetragenus and Pseudomonas syringae pv. actinidae, with ZOI values of 15.50 and 14.33 mm, respectively, which were inferior to those of gentamicin sulfate (34.67 and 24.00 mm). Viridomycin F (12) also exhibited moderate antibacterial effects against S. aureus, M. tetragenus, and P. syringae pv. actinidae, with ZOI values of 8.33, 16.50, and 10.83 mm, respectively. Cytotoxicity assays demonstrated that viridobruunine A (5), exfoliazone (6), viridomycin A (11), and X-14881E (13) exhibited significant cytotoxicity against human malignant melanoma (A375), ovarian cancer (SKOV-3), and gastric cancer (MGC-803) cell lines, with IC₅₀ values ranging from 4.61 to 19.28 μmol·L⁻¹. Furthermore, bioinformatic analysis of the complete genome of S. tanashiensis suggested a putative biosynthetic gene cluster (BGC) responsible for the production of compounds 1−12. These findings indicate that the secondary metabolites of insect-associated S. tanashiensis BYF-112 hold promise as potential sources of novel antibacterial and anticancer agents.

通过对与白蚁相关的链霉菌（Streptomyces tanashiensis BYF-112）进行化学研究，发现了四种新型生物碱衍生物：vegfrecines A 和 B（1 和 2）、efoliazone A（3）和 venezueline H（7），此外还有九种已知的代谢物（4-6、8-13）。通过全面的光谱分析以及与现有文献数据的比较，这些化合物的结构得以阐明。抗菌试验显示，病毒霉素 A (11) 对金黄色葡萄球菌具有很强的抗菌活性，抑制区（ZOI）为 12.67 毫米，而阳性对照硫酸庆大霉素的抑制区（ZOI）为 17.67 毫米。病毒霉素 A（11）对四联微球菌和鞘氨醇假单胞菌 pv. actinidae 具有中等活性，ZOI 值分别为 15.50 和 14.33 毫米，低于硫酸庆大霉素（34.67 和 24.00 毫米）。病毒霉素 F (12) 对金黄色葡萄球菌、四联霉素霉菌和金黄色葡萄球菌也有中等程度的抗菌效果，ZOI 值分别为 8.33、16.50 和 10.83 mm。细胞毒性试验表明，viridobruunine A (5)、efoliazone (6)、viridomycin A (11) 和 X-14881E (13) 对人类恶性黑色素瘤（A375）、卵巢癌（SKOV-3）和胃癌（MGC-803）细胞系具有显著的细胞毒性，IC50 值范围为 4.61 至 19.28 μmol-L-1。此外，对 S. tanashiensis 完整基因组的生物信息学分析表明，一个假定的生物合成基因簇（BGC）负责生产 1-12 号化合物。这些研究结果表明，昆虫伴生 S. tanashiensis BYF-112 的次级代谢产物有望成为新型抗菌剂和抗癌剂的潜在来源。

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引用次数: 0

Macrocyclic trichothecenes from Myrothecium verrucaria PA 57 and their cytotoxic activity 来自疣霉菌 PA 57 的大环单端孢霉烯及其细胞毒性活性

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-09-01 DOI: 10.1016/S1875-5364(24)60573-X

Jisong MO , Yufen TAN , Wenjing AI , Yunyun LI , Yiyun YUAN , Yueping JIANG , Kangping XU , Guishan TAN , Wenxuan WANG , Jing LI , Shao LIU

Four novel macrocyclic trichothecenes, termed mytoxins D−G (1−4), along with four known analogs (5−8), were isolated from the ethyl acetate extract of fermented rice inoculated with the fungus Myrothecium verrucaria PA57. Each compound features a tricyclic 12,13-epoxytrichothec-9-ene (EPT) core. Notably, mytoxin G (4) represents the first instance of a macrocyclic trichothecene incorporating a glucosyl unit within the trichothecene structure. The structures of the newly identified compounds were elucidated through comprehensive spectroscopic analysis combined with quantum chemical calculations. All isolated compounds demonstrated cytotoxic activity against the CAL27 and HCT116 cell lines, which are models for human oral squamous cell carcinoma and colorectal cancer, respectively. Specifically, mytoxin D (1) and mytoxin F (3) exhibited pronounced cytotoxic effects against both cancer cell lines, with IC₅₀ values ranging from 3 to 6 nmol·L⁻¹. Moreover, compounds 1 and 3 were found to induce apoptosis in HCT116 cells by activating caspase-3.

从接种了疣霉属真菌 PA57 的发酵大米的乙酸乙酯提取物中分离出了四种新型大环单端孢霉烯，即霉菌毒素 D-G（1-4）以及四种已知的类似物（5-8）。每种化合物都以三环 12,13-环氧单端孢霉烯-9-烯（EPT）为核心。值得注意的是，Mytoxin G（4）首次代表了在单端孢霉烯结构中包含一个葡萄糖基单元的大环单端孢霉烯。通过综合光谱分析和量子化学计算，阐明了新发现化合物的结构。所有分离出的化合物都对 CAL27 和 HCT116 细胞系具有细胞毒性活性，这两种细胞系分别是人类口腔鳞状细胞癌和结肠直肠癌的模型。具体来说，肌毒素 D（1）和肌毒素 F（3）对这两种癌细胞株都有明显的细胞毒性作用，IC50 值介于 3 至 6 nmol-L-1 之间。此外，化合物 1 和 3 还能通过激活 caspase-3 诱导 HCT116 细胞凋亡。

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引用次数: 0

Natural medicine can substitute antibiotics in animal husbandry: protective effects and mechanisms of rosewood essential oil against Salmonella infection 天然药物可在畜牧业中替代抗生素：花梨木精油对沙门氏菌感染的保护作用和机制

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-09-01 DOI: 10.1016/S1875-5364(24)60576-5

Lanqiao WANG , Juan FANG , Heng WANG , Baoyu ZHANG , Nan WANG , Xinyu YAO , He LI , Jiazhang QIU , Xuming DENG , Bingfeng LENG , Jianfeng WANG , Wenxi TAN , Qiaoling ZHANG

Aniba rosaeodora essential oil (RO) has been traditionally used in natural medicine as a substitute for antibiotics due to its notable antidepressant and antibacterial properties. Salmonella, a prevalent pathogen in foodborne illnesses, presents a major challenge to current antibiotic treatments. However, the antibacterial efficacy and mechanisms of action of RO against Salmonella spp. remain underexplored. This study aims to elucidate the chemical composition of RO, evaluate its antibacterial activity and mechanisms against Salmonella in vitro, and further delineate its anti-inflammatory mechanisms in vivo during Salmonella infection. Gas chromatography-mass spectrometry (GC-MS) was utilized to characterize the chemical constituents of RO. The antibacterial activity of RO was assessed using minimal inhibitory concentration (MIC) and time-kill assays. Various biochemical assays were employed to uncover the potential bactericidal mechanisms. Additionally, mouse and chick models of Salmonella infection were established to investigate the prophylactic effects of RO treatment. RO exhibited significant antibacterial activity against both Gram-positive and Gram-negative bacteria, with an MIC of 4 mg·mL⁻¹ for Salmonella spp. RO treatment resulted in bacterial damage through the disruption of lipid and purine metabolism. Moreover, RO reduced injury and microbial colonization in infected mice and chicks. RO treatment also modulated the host inflammatory response by inhibiting proinflammatory pathways. In conclusion, our findings demonstrate that RO is effective against Salmonella infection, highlighting its potential as an alternative to antibiotics for antibacterial therapy.

Aniba rosaeodora 精油（RO）具有显著的抗抑郁和抗菌特性，传统上一直被天然药物用作抗生素的替代品。沙门氏菌是食源性疾病中的一种常见病原体，对目前的抗生素治疗方法构成了巨大挑战。然而，RO 对沙门氏菌的抗菌效果和作用机制仍未得到充分探索。本研究旨在阐明 RO 的化学成分，评估其在体外对沙门氏菌的抗菌活性和作用机制，并进一步阐明其在沙门氏菌感染过程中的体内抗炎机制。气相色谱-质谱法（GC-MS）被用来表征 RO 的化学成分。使用最小抑菌浓度（MIC）和时间致死试验评估了 RO 的抗菌活性。还采用了各种生化试验来揭示潜在的杀菌机制。此外，还建立了小鼠和小鸡沙门氏菌感染模型，以研究 RO 治疗的预防效果。RO 对革兰氏阳性菌和革兰氏阴性菌都有明显的抗菌活性，对沙门氏菌的 MIC 为 4 mg-mL-1。此外，RO 还能减少受感染小鼠和雏鸡的损伤和微生物定植。RO 处理还通过抑制促炎途径调节宿主炎症反应。总之，我们的研究结果表明 RO 能有效抑制沙门氏菌感染，突出了其作为抗生素替代品进行抗菌治疗的潜力。

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引用次数: 0

Discovery of antitumor diterpenoids from Casearia graveolens targeting VEGFR-2 to inhibit angiogenesis 从 Casearia graveolens 中发现靶向 VEGFR-2 的抗肿瘤二萜类化合物，从而抑制血管生成

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-09-01 DOI: 10.1016/S1875-5364(24)60566-2

Sibei WANG , Yuhui LIU , Yue LIANG , Yaru XI , Yupeng ZHAI , Dongho LEE , Jing XU , Yuanqiang GUO

Eight novel clerodane diterpenoids (1−8) were isolated from the twigs of Casearia graveolens. Their structures were elucidated through comprehensive nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and electronic circular dichroism (ECD) analyses. In addition to structural determination, surface plasmon resonance (SPR) assays were conducted to investigate molecular interactions, revealing that compound 8 exhibited high affinity for vascular endothelial growth factor receptor 2 (VEGFR2), a key regulator of tumor angiogenesis. Subsequent in vivo experiments demonstrated that compound 8 effectively inhibited angiogenesis and displayed significant antitumor activity by suppressing tumor proliferation and metastasis in zebrafish xenograft models. These findings suggest that compound 8 holds promise as an anticancer lead compound targeting VEGFR-2 to obstruct tumor angiogenesis.

从Casearia graveolens的小枝中分离出了八种新型萜类化合物（1-8）。通过全面的核磁共振（NMR）、高分辨率电喷雾质谱（HR-ESI-MS）和电子圆二色性（ECD）分析，阐明了它们的结构。除了结构测定外，还进行了表面等离子体共振（SPR）测定以研究分子相互作用，结果表明化合物 8 对血管内皮生长因子受体 2（VEGFR2）具有很高的亲和力，而血管内皮生长因子受体 2 是肿瘤血管生成的关键调节因子。随后的体内实验表明，化合物 8 能有效抑制血管生成，并在斑马鱼异种移植模型中通过抑制肿瘤增殖和转移而显示出显著的抗肿瘤活性。这些研究结果表明，化合物 8 有望成为以 VEGFR-2 为靶点阻碍肿瘤血管生成的抗癌先导化合物。

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引用次数: 0

Discovery and characterization of naturally occurring covalent inhibitors of SARS-CoV-2 Mpro from the antiviral herb Ephedra 从抗病毒草药麻黄中发现天然的 SARS-CoV-2 Mpro 共价抑制剂并确定其特性

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-09-01 DOI: 10.1016/S1875-5364(24)60577-7

Qing HU , Yiwen ZHANG , Pengcheng CHEN , Yani ZHANG , Guanghao ZHU , Wei LIU , Chaoran WANG , Shuilian ZHENG , Nonger SHEN , Haonan WANG , Ping HUANG , Guangbo GE

The Chinese herb Ephedra (also known as Mahuang) has been extensively utilized for the prevention and treatment of coronavirus-induced diseases, including coronavirus disease 2019 (COVID-19). However, the specific anti-SARS-CoV-2 compounds and mechanisms have not been fully elucidated. The main protease (M^pro) of SARS-CoV-2 is a highly conserved enzyme responsible for proteolytic processing during the viral life cycle, making it a critical target for the development of antiviral therapies. This study aimed to identify naturally occurring covalent inhibitors of SARS-CoV-2 M^pro from Ephedra and to investigate their covalent binding sites. The results demonstrated that the non-alkaloid fraction of Ephedra (ENA) exhibited a potent inhibitory effect against the SARS-CoV-2 M^pro effect, whereas the alkaloid fraction did not. Subsequently, the chemical constituents in ENA were identified, and the major constituents’ anti-SARS-CoV-2 M^pro effects were evaluated. Among the tested constituents, herbacetin (HE) and gallic acid (GA) were found to inhibit SARS-CoV-2 M^pro in a time- and dose-dependent manner. Their combination displayed a significant synergistic effect on this key enzyme. Additionally, various techniques, including inhibition kinetic assays, chemoproteomic methods, and molecular dynamics simulations, were employed to further elucidate the synergistic anti-M^pro mechanisms of the combination of HE and GA. Overall, this study deciphers the naturally occurring covalent inhibitors of SARS-CoV-2 M^pro from Ephedra and characterizes their synergistic anti-M^pro synergistic effect, providing robust evidence to support the anti-coronavirus efficacy of Ephedra.

中草药麻黄（又名麻黄）已被广泛用于预防和治疗冠状病毒引起的疾病，包括冠状病毒病 2019（COVID-19）。然而，具体的抗SARS-CoV-2化合物和机制尚未完全阐明。SARS-CoV-2 的主要蛋白酶（Mpro）是一种高度保守的酶，负责病毒生命周期中的蛋白水解处理，因此是开发抗病毒疗法的关键靶点。本研究旨在从麻黄中鉴定天然存在的 SARS-CoV-2 Mpro 共价抑制剂，并研究其共价结合位点。结果表明，麻黄的非生物碱部分（ENA）对 SARS-CoV-2 Mpro 的作用有很强的抑制作用，而生物碱部分则没有。随后，对ENA中的化学成分进行了鉴定，并评估了主要成分的抗SARS-CoV-2 Mpro作用。在测试的成分中，发现香草素（HE）和没食子酸（GA）对 SARS-CoV-2 Mpro 的抑制作用具有时间和剂量依赖性。它们的组合对这种关键酶有明显的协同作用。此外，还采用了多种技术，包括抑制动力学测定、化学蛋白组学方法和分子动力学模拟，进一步阐明了 HE 和 GA 组合的协同抗 Mpro 机制。总之，本研究解读了麻黄中天然存在的SARS-CoV-2 Mpro共价抑制剂，并描述了其协同抗Mpro的增效作用，为麻黄的抗冠状病毒功效提供了有力的证据支持。

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引用次数: 0

Cytotoxic lignans from the roots and rhizomes of Diphylleia sinensis, a China’s endemic plant species 中国特有植物--中华二仙草根茎中的细胞毒性木脂素

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-09-01 DOI: 10.1016/S1875-5364(24)60721-1

Yanjun SUN , Chen ZHAO , Hongyun BAI , Meng LI , Junmin WANG , Zhiyou HAO , Weisheng FENG

Eight novel arylnaphthalide lactone lignans, designated as diphylignan A−H (1−8), and a new dibenzyltyrolactone lignan, designated as diphylignan I (9), were isolated from the roots and rhizomes of Diphylleia sinensis, along with two additional novel natural products (11 and 14) and four known metabolites (10, 12, 13, 15). The structural and stereochemical characterization of these compounds was accomplished using NMR spectroscopy and electronic circular dichroism (ECD) analysis. The cytotoxic activities of all isolated compounds were assessed against A-549 and SMMC-7721 cell lines. Notably, compound 2 demonstrated the most significant cytotoxicity, with IC₅₀ values of 10.27 and 11.58 µmol·L⁻¹ against A-549 and SMMC-7721 cell lines, respectively, exhibiting greater potency than the positive control, cisplatin.

从中华二仙草的根部和根茎中分离出了八种新型芳基萘内酯木质素（命名为二木质素 A-H（1-8））和一种新型二苄基内酯木质素（命名为二木质素 I（9）），以及另外两种新型天然产物（11 和 14）和四种已知代谢物（10、12、13、15）。这些化合物的结构和立体化学特征是通过核磁共振光谱和电子圆二色性（ECD）分析完成的。评估了所有分离化合物对 A-549 和 SMMC-7721 细胞系的细胞毒性活性。值得注意的是，化合物 2 的细胞毒性最为显著，对 A-549 和 SMMC-7721 细胞株的 IC50 值分别为 10.27 和 11.58 µmol-L-1，显示出比阳性对照顺铂更强的效力。

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引用次数: 0

Approved drugs and natural products at clinical stages for treating Alzheimer’s disease 已获批准的治疗阿尔茨海默病的药物和处于临床阶段的天然产品

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-08-01 DOI: 10.1016/S1875-5364(24)60606-0

Yajing MA , Sufang LIU , Qingfeng ZHOU , Zhonghua LI , Zhijian ZHANG , Bin YU

Alzheimer’s disease (AD) remains the foremost cause of dementia and represents a significant unmet healthcare need globally. The complex pathogenesis of AD, characterized by various pathological and physiological events, has historically challenged the development of anti-AD drugs. However, recent breakthroughs in AD drug development, including the approvals of aducanumab, lecanemab, and sodium oligomannate (GV-971), have ended a nearly two-decade hiatus in the introduction of new AD drugs. These developments have addressed long-standing challenges in AD drug development, marking a substantial shift in the therapeutic landscape of AD. Moreover, natural products (NPs) have shown promise in AD drug research, with several currently under clinical investigation. Their distinct properties and mechanisms of action offer new avenues to complement and enhance existing AD treatment approaches. This review article aims to provide an overview of the recent advancements and prospects in AD therapeutics, focusing on both NPs and approved drugs.

阿尔茨海默病（AD）仍然是痴呆症的首要病因，也是全球尚未满足的重大医疗需求。阿兹海默症的发病机制复杂，以各种病理和生理事件为特征，因此抗阿兹海默症药物的开发一直面临挑战。然而，最近在抗注意力缺失症药物开发方面取得的突破，包括阿杜单抗、利卡尼单抗和寡甘氨酸钠（GV-971）的获批，结束了近二十年来注意力缺失症新药迟迟未能问世的局面。这些研发成果解决了 AD 药物研发中长期存在的难题，标志着 AD 治疗领域发生了重大转变。此外，天然产物（NPs）在注意力缺失症药物研究中也大有可为，目前有几种天然产物正在进行临床研究。它们与众不同的特性和作用机制为补充和加强现有的AD治疗方法提供了新的途径。这篇综述文章旨在概述AD疗法的最新进展和前景，重点关注NPs和已获批准的药物。

引用次数: 0

Taohong Siwu Decoction: a classical Chinese prescription for treatment of orthopedic diseases 桃红四物汤：治疗骨科疾病的经典中药方剂

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-08-01 DOI: 10.1016/S1875-5364(24)60581-9

Yunzhen SHI , Shengpeng WANG , Disi DENG , Yitao WANG

The pathogenesis of orthopedic diseases is intimately linked to blood stasis, frequently arising from damage to primary and secondary blood channels. This disruption can lead to “blood leaving the meridians” or Qi stagnation, resulting in blood stasis syndrome. Taohong Siwu Decoction (THSWD) is a renowned classical Chinese medicinal formula extensively used to promote blood circulation and mitigate blood stasis. Clinical studies have demonstrated its significant therapeutic effects on various orthopedic conditions, particularly its anti-inflammatory and analgesic properties, as well as its efficacy in preventing deep vein thrombosis post-surgery. Despite these findings, research on THSWD remains fragmented, and its interdisciplinary impact is limited. This review aims to provide a comprehensive evaluation of the efficacy and pharmacological mechanisms of THSWD in treating common orthopedic diseases. Additionally, we employ bibliometric analysis to explore research trends and hotspots related to THSWD. We hope this review will enhance the recognition and application of THSWD in orthopedic treatments and guide future research into its pharmacological mechanisms.

骨科疾病的发病机理与血瘀密切相关，通常是由于主次血脉受损所致。这种破坏可导致 "血出经络 "或气滞，从而引发血瘀综合征。桃红四物汤（THSWD）是著名的经典中药方剂，被广泛用于活血化瘀。临床研究表明，桃红四物汤对各种骨科疾病具有显著的治疗效果，尤其是其消炎镇痛的功效，以及预防术后深静脉血栓形成的功效。尽管有这些发现，但有关 THSWD 的研究仍很零散，其跨学科影响也很有限。本综述旨在全面评估 THSWD 治疗常见骨科疾病的疗效和药理机制。此外，我们还采用文献计量分析法探讨了 THSWD 的相关研究趋势和热点。我们希望这篇综述能提高人们对 THSWD 在骨科治疗中的认识和应用，并指导未来对其药理机制的研究。

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引用次数: 0

Cancer statistics and trends in China: the potential of natural product application 中国癌症统计数据和趋势：天然产品的应用潜力

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines

Pub Date : 2024-08-01 DOI: 10.1016/S1875-5364(24)60649-7

Ting LI , Muyang HUANG , Jinjian LU

引用次数: 0