Pub Date : 1989-10-01DOI: 10.1016/0738-1751(89)90021-X
Charles E. Cherubin
{"title":"Penetration of antibiotics into the CSF and the treatment of meningitis: Personal commentary and review of selected agents— part 1","authors":"Charles E. Cherubin","doi":"10.1016/0738-1751(89)90021-X","DOIUrl":"https://doi.org/10.1016/0738-1751(89)90021-X","url":null,"abstract":"","PeriodicalId":100101,"journal":{"name":"Antimicrobic Newsletter","volume":"6 10","pages":"Pages 77-84"},"PeriodicalIF":0.0,"publicationDate":"1989-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0738-1751(89)90021-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91764500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1989-09-01DOI: 10.1016/0738-1751(89)90027-0
D. Amsterdam
{"title":"The development of resistance during antimicrobial therapy","authors":"D. Amsterdam","doi":"10.1016/0738-1751(89)90027-0","DOIUrl":"10.1016/0738-1751(89)90027-0","url":null,"abstract":"","PeriodicalId":100101,"journal":{"name":"Antimicrobic Newsletter","volume":"6 9","pages":"Pages 72-74"},"PeriodicalIF":0.0,"publicationDate":"1989-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0738-1751(89)90027-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90619441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1989-09-01DOI: 10.1016/0738-1751(89)90028-2
Eugene A. Gorzynski
{"title":"Interactions between microorganisms, antimicrobics, and cells","authors":"Eugene A. Gorzynski","doi":"10.1016/0738-1751(89)90028-2","DOIUrl":"10.1016/0738-1751(89)90028-2","url":null,"abstract":"","PeriodicalId":100101,"journal":{"name":"Antimicrobic Newsletter","volume":"6 9","pages":"Pages 74-75"},"PeriodicalIF":0.0,"publicationDate":"1989-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0738-1751(89)90028-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84930485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1989-08-01DOI: 10.1016/0738-1751(89)90015-4
James H. Jorgensen
{"title":"Antimicrobial susceptibility testing of Haemophilus influenzae: An update","authors":"James H. Jorgensen","doi":"10.1016/0738-1751(89)90015-4","DOIUrl":"10.1016/0738-1751(89)90015-4","url":null,"abstract":"","PeriodicalId":100101,"journal":{"name":"Antimicrobic Newsletter","volume":"6 8","pages":"Pages 65-68"},"PeriodicalIF":0.0,"publicationDate":"1989-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0738-1751(89)90015-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83186979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1989-08-01DOI: 10.1016/0738-1751(89)90014-2
Roy Cleeland, Harry Albrecht, George Beskid, Kakong Chan, James Christenson, Nafsika Georgopapadakou, Dennis Keith, David Pruess, Edwina Squires, Chung Chen Wei, Manfred Weigele
Ro 23-9424 represents the culmination of an idea put forth by O'Callaghan et al4 in 1976. They proposed that a cephalosporin could act as a carrier for a second antibacterial with the total molecule functioning as a single antibacterial until separated by opening of the ß-lactam ring by a ß-lactamase or, as we now know, the target penicillin-sensitive enzymes. It is important to note that in spite of the ester linkage, hydrolysis of Ro 23-9424 in animals to the components is minimal and the elimination kinetics are those of a single molecule with a pharmacokinetic profile of the cephalosporin component. The results of our preliminary toxicology studies in rats and dogs also suggest that this compound will have a safety profile similar to that of the cephalosporin component. This would allow parenteral administration of the quinolone component, fleroxacin, at a much higher dosage than is possible with the free quinolone.
Ro 23-9424 represents the first of a new class of antibacterials. The major constraint in designing new compounds within this class will only be the ingenuity of the pharmaceutical chemist.
{"title":"Dual-action antibacterials: A concept newly realized for antibacterial chemotherapy","authors":"Roy Cleeland, Harry Albrecht, George Beskid, Kakong Chan, James Christenson, Nafsika Georgopapadakou, Dennis Keith, David Pruess, Edwina Squires, Chung Chen Wei, Manfred Weigele","doi":"10.1016/0738-1751(89)90014-2","DOIUrl":"10.1016/0738-1751(89)90014-2","url":null,"abstract":"<div><p>Ro 23-9424 represents the culmination of an idea put forth by O'Callaghan et al<sup>4</sup> in 1976. They proposed that a cephalosporin could act as a carrier for a second antibacterial with the total molecule functioning as a single antibacterial until separated by opening of the ß-lactam ring by a ß-lactamase or, as we now know, the target penicillin-sensitive enzymes. It is important to note that in spite of the ester linkage, hydrolysis of Ro 23-9424 in animals to the components is minimal and the elimination kinetics are those of a single molecule with a pharmacokinetic profile of the cephalosporin component. The results of our preliminary toxicology studies in rats and dogs also suggest that this compound will have a safety profile similar to that of the cephalosporin component. This would allow parenteral administration of the quinolone component, fleroxacin, at a much higher dosage than is possible with the free quinolone.</p><p>Ro 23-9424 represents the first of a new class of antibacterials. The major constraint in designing new compounds within this class will only be the ingenuity of the pharmaceutical chemist.</p></div>","PeriodicalId":100101,"journal":{"name":"Antimicrobic Newsletter","volume":"6 8","pages":"Pages 61-65"},"PeriodicalIF":0.0,"publicationDate":"1989-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0738-1751(89)90014-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79484266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1989-07-01DOI: 10.1016/0738-1751(89)90019-1
Ronald N. Jones
{"title":"Critical assessment of the newer non-quinolone oral antimicrobial agents","authors":"Ronald N. Jones","doi":"10.1016/0738-1751(89)90019-1","DOIUrl":"10.1016/0738-1751(89)90019-1","url":null,"abstract":"","PeriodicalId":100101,"journal":{"name":"Antimicrobic Newsletter","volume":"6 7","pages":"Pages 53-60"},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0738-1751(89)90019-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84662377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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