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Spinal mediators of nociceptive neurotransmission and hyperalgesia 痛觉神经传递和痛觉过敏的脊髓介质
APS Journal
Pub Date : 1993-12-01 Epub Date: 2005-08-01 DOI: 10.1016/S1058-9139(05)80257-8
George L. Wilcox

The synaptic mechanisms of nociception, hyperalgesia, allodynia, opioid tolerance, and neuropathic pain in the spinal cord dorsal horn are explored. The characteristics of the transmitters conveying excitation and the mechanisms that can enhance synaptic efficacy in the spinal nociceptive system after prolonged stimulation are examined, and a possible sequence of events that could contribute to progressive development, after intense or pathologic stimulation, of enhanced neuronal responsiveness from initial synaptic plasticity and hyperalgesia to subsequent neurotoxicity and neuropathic pain is described. The progression includes neurokinins and excitatory amino acids as neurotransmitters acting at neurokinins and excitatory amino acids receptors and evoking the production of nitric oxide by spinal interneurons. Finally, the importance of spinal blood flow as an affected function and an effective participant is discussed.

突触机制的痛觉，痛觉过敏，异常性疼痛，阿片耐受性和神经性疼痛在脊髓背角的探讨。我们研究了在长时间刺激后，传递兴奋的递质的特性和增强脊髓痛觉系统突触效能的机制，并描述了在强烈或病理性刺激后，从最初的突触可塑性和痛觉过敏到随后的神经毒性和神经性疼痛，促进神经元反应性增强的可能事件序列。这一过程包括神经激肽和兴奋性氨基酸作为神经递质作用于神经激肽和兴奋性氨基酸受体，并引起脊髓中间神经元产生一氧化氮。最后，讨论了脊髓血流作为受影响功能和有效参与者的重要性。
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引用次数: 29
On the significance of viscerosomatic convergence 论脏体会聚的意义
APS Journal
Pub Date : 1993-12-01 Epub Date: 2005-08-01 DOI: 10.1016/S1058-9139(05)80251-7
Karen J. Berkley

Viscerosomatic convergence is a surprisingly common inducible feature of the response properties of neurons throughout the central nervous system. It indicates an extensive potential overlap between neuronal domains that process interoceptive information and those that process exteroceptive and proprioceptive information. This potential for overlap suggests that responses of individual neurons serve different functions at different times depending on the current pattern of activity in other neurons throughout the nervous system. Within such a dynamic scheme, skin and skeletal muscle have access to interoceptive control mechanisms and take variable advantage of that access for different purposes, for example, for shunting blood supply to tissues that need it. Similarly, viscera have access to exteroceptive control mechanisms and use them flexibly as needed. One important use would be to employ the exteroceptive domain's efficient protective mechanisms when a viscus is under threat. Visceral and referred pain would thus be byproducts of this opportunistic tactic.

内脏躯体趋同是整个中枢神经系统神经元反应特性的一个令人惊讶的共同诱导特征。这表明处理内感受信息的神经元域与处理外感受和本体感受信息的神经元域之间存在广泛的潜在重叠。这种潜在的重叠表明，单个神经元的反应在不同的时间发挥不同的功能，这取决于整个神经系统中其他神经元的当前活动模式。在这样一个动态机制中，皮肤和骨骼肌可以进入内感受控制机制，并根据不同的目的利用这种控制机制，例如，将血液供应分流到需要它的组织。同样，内脏也有外部感知控制机制，并根据需要灵活地使用它们。一个重要的用途是，当黏液受到威胁时，利用外感受域的有效保护机制。因此，内脏和牵涉性疼痛将是这种机会主义策略的副产品。
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引用次数: 2
Scientific meeting update 科学会议更新
APS Journal
Pub Date : 1993-12-01 Epub Date: 2005-08-01 DOI: 10.1016/S1058-9139(05)80262-1
MD, FAPA David A. Fishbain (chair, associate professor of psychiatry and neurological surgery) , PhD Brian Cutler (research associate in the department of neurological surgery)
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引用次数: 0
IASP global news IASP全球新闻
APS Journal
Pub Date : 1993-12-01 Epub Date: 2005-08-01 DOI: 10.1016/S1058-9139(05)80263-3
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引用次数: 0
Viscerosomatic convergence Viscerosomatic收敛
APS Journal
Pub Date : 1993-12-01 Epub Date: 2005-08-01 DOI: 10.1016/S1058-9139(05)80253-0
Fernando Cervero
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引用次数: 0
Pleasure in pursuit of answers 追求答案的乐趣
APS Journal
Pub Date : 1993-12-01 Epub Date: 2005-08-01 DOI: 10.1016/S1058-9139(05)80256-6
Karen J. Berkley
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引用次数: 0
True believer, with questions 真正的信徒，带着疑问
APS Journal
Pub Date : 1993-12-01 Epub Date: 2005-08-01 DOI: 10.1016/S1058-9139(05)80248-7
John D. Loeser
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引用次数: 1
Vascular compression is the cause of trigeminal neuralgia 血管受压是三叉神经痛的病因
APS Journal
Pub Date : 1993-12-01 Epub Date: 2005-08-01 DOI: 10.1016/S1058-9139(05)80246-3
Peter J. Jannetta

Trigeminal neuralgia is discussed from the standpoint of etiology, pathophysiology, and surgical treatment. The author presents the hypothesis of cranial nerve vascular compression as the cause of trigeminal neuralgia from a historic perspective, with a comprehensive review of the literature from its earliest efforts through the present.

从病因学、病理生理学和外科治疗的角度讨论三叉神经痛。作者从历史的角度提出颅神经血管压迫是三叉神经痛的原因的假设，并从最早的努力到现在的文献进行了全面的回顾。
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引用次数: 28
Are we clear on the meaning of viscerosomatic convergence? 我们清楚脏腑合一的含义了吗?
APS Journal
Pub Date : 1993-12-01 Epub Date: 2005-08-01 DOI: 10.1016/S1058-9139(05)80254-2
Alan Randich
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引用次数: 1
Evolution of ideas on viscerosomatic convergence in the central nervous system and its role in referred pain and hyperalgesia 中枢神经系统脏体趋同思想的演变及其在牵涉性疼痛和痛觉过敏中的作用
APS Journal
Pub Date : 1993-12-01 Epub Date: 2005-08-01 DOI: 10.1016/S1058-9139(05)80252-9
D. Albe-Fessard
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引用次数: 0
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