Pub Date : 2021-06-15DOI: 10.12114/J.ISSN.1007-9572.2021.00.528
Jue Liu, Wannian Liang, Min Liu, Weizhong Yang, Xia Liu, Jing Wu, Yadong Wang, G. Shan, H. Han, Lei Zhou
{"title":"Development of the COVID-19 Cluster Containment Evaluation System Using the Emergency Management Theory","authors":"Jue Liu, Wannian Liang, Min Liu, Weizhong Yang, Xia Liu, Jing Wu, Yadong Wang, G. Shan, H. Han, Lei Zhou","doi":"10.12114/J.ISSN.1007-9572.2021.00.528","DOIUrl":"https://doi.org/10.12114/J.ISSN.1007-9572.2021.00.528","url":null,"abstract":"","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46299604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-15DOI: 10.12114/J.ISSN.1007-9572.2021.00.056
M. Ai, Tong-Zeng Li, Longyu Zhang, Hui Xu, D. Mou, Lian-chun Liang
Background: Since April 2020, the number of newly diagnosed cases and death cases of COVID-19 have decreased significantly in China but increased rapidly abroad Early diagnosis and treatment are of great concern to improving the prognosis of COVID-19 patients Objective: To investigate the clinical features and prognostic risk factors of adult patients with COVID-19, offering a reference for clinical diagnosis and treatment of this disease Methods: A retrospective design was used Participants were 93 adult cases of COVID-19 who were treated in Beijing Youan Hospital between January and February 2020 They were categorized into common, severe and critical types by the most serious conditions during hospitalization, in accordance with the Diagnosis and Treatment Protocol for COVID-19(Trial Version 7)issued by the National Health Commission of the People's Republic of China Indications such as general information, major clinical manifestations, baseline laboratory parameters, APACHE II and SOFA scores within 24 hours of admission, imaging findings, comorbidities and complications, treatments and outcomes were collected Results: There were 57 cases of common type(61 3%), 22 of severe type(23 7%)and 14 of critical type(15 0%) The male ratio was slighter higher in critical group, and female ratio was slighter higher in other groups, but sex composition showed no significant differences across the groups(P>0 05) The median age for common, severe and critical groups was 45 0, 62 0 and 81 0 years, respectively, showing significant differences(P0 05) Dyspnea occurred in all severe or critical cases, showing a higher incidence than common cases(100 0% vs 31 6%)(P<0 05) The incidence of lymphocytopenia in critical group was 100%, which was significantly higher than that in common group(49 1%)or severe group(59 1%)(P<0 05) Acute liver injury was the most common complication(58 1%)in all cases, but its incidence was obviously increased in severe group (77 3%) or critical group(92 9%), than that of common group(42 1%)(P<0 05) Chinese medicine therapy was used in 75 3% of all cases, but the severe cases had a higher rate of treating with Chinese medicine than critical cases(90 9% vs 50 0%, P<0 05) The rate of corticosteroid use in severe cases(63 6%)or critical cases(64 3%)was significantly increased than that of common cases(5 3%)(P<0 05) Six patients(6 5%)were treated with invasive ventilation, but only 1 of them(16 7%)was successfully extubated ultimately Nine patients(9 7%)died in hospital due to all causes Logistic regression analysis revealed that age ≥74 years〔OR(95%CI)=33 714(3 021, 376 211), P=0 004〕and baseline SOFA≥2 5〔OR(95%CI)=15 447(1 331, 179 260), P=0 029〕were independent risk factors for in-hospital death Conclusion: COVID-19 mainly manifests as respiratory infections Severe patients are apt to appear tissue injury and dysfunction of organs like liver, kidney and heart, etc The majority of patients have a favorable outcome Age and baseline SOFA sc
{"title":"Clinical Features and Prognostic Risk Factors of COVID-19 in Adults: a Retrospective Analysis of 93 Cases","authors":"M. Ai, Tong-Zeng Li, Longyu Zhang, Hui Xu, D. Mou, Lian-chun Liang","doi":"10.12114/J.ISSN.1007-9572.2021.00.056","DOIUrl":"https://doi.org/10.12114/J.ISSN.1007-9572.2021.00.056","url":null,"abstract":"Background: Since April 2020, the number of newly diagnosed cases and death cases of COVID-19 have decreased significantly in China but increased rapidly abroad Early diagnosis and treatment are of great concern to improving the prognosis of COVID-19 patients Objective: To investigate the clinical features and prognostic risk factors of adult patients with COVID-19, offering a reference for clinical diagnosis and treatment of this disease Methods: A retrospective design was used Participants were 93 adult cases of COVID-19 who were treated in Beijing Youan Hospital between January and February 2020 They were categorized into common, severe and critical types by the most serious conditions during hospitalization, in accordance with the Diagnosis and Treatment Protocol for COVID-19(Trial Version 7)issued by the National Health Commission of the People's Republic of China Indications such as general information, major clinical manifestations, baseline laboratory parameters, APACHE II and SOFA scores within 24 hours of admission, imaging findings, comorbidities and complications, treatments and outcomes were collected Results: There were 57 cases of common type(61 3%), 22 of severe type(23 7%)and 14 of critical type(15 0%) The male ratio was slighter higher in critical group, and female ratio was slighter higher in other groups, but sex composition showed no significant differences across the groups(P>0 05) The median age for common, severe and critical groups was 45 0, 62 0 and 81 0 years, respectively, showing significant differences(P0 05) Dyspnea occurred in all severe or critical cases, showing a higher incidence than common cases(100 0% vs 31 6%)(P<0 05) The incidence of lymphocytopenia in critical group was 100%, which was significantly higher than that in common group(49 1%)or severe group(59 1%)(P<0 05) Acute liver injury was the most common complication(58 1%)in all cases, but its incidence was obviously increased in severe group (77 3%) or critical group(92 9%), than that of common group(42 1%)(P<0 05) Chinese medicine therapy was used in 75 3% of all cases, but the severe cases had a higher rate of treating with Chinese medicine than critical cases(90 9% vs 50 0%, P<0 05) The rate of corticosteroid use in severe cases(63 6%)or critical cases(64 3%)was significantly increased than that of common cases(5 3%)(P<0 05) Six patients(6 5%)were treated with invasive ventilation, but only 1 of them(16 7%)was successfully extubated ultimately Nine patients(9 7%)died in hospital due to all causes Logistic regression analysis revealed that age ≥74 years〔OR(95%CI)=33 714(3 021, 376 211), P=0 004〕and baseline SOFA≥2 5〔OR(95%CI)=15 447(1 331, 179 260), P=0 029〕were independent risk factors for in-hospital death Conclusion: COVID-19 mainly manifests as respiratory infections Severe patients are apt to appear tissue injury and dysfunction of organs like liver, kidney and heart, etc The majority of patients have a favorable outcome Age and baseline SOFA sc","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":"196-204"},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44578841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.12114/j.issn.1007-9572.2021.00.293
L. Piterman
{"title":"Thinking, Judgement and Decision Making in the Prevention and Control of COVID-19","authors":"L. Piterman","doi":"10.12114/j.issn.1007-9572.2021.00.293","DOIUrl":"https://doi.org/10.12114/j.issn.1007-9572.2021.00.293","url":null,"abstract":"","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":"3171-3174"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66051971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.12114/j.issn.1007-9572.2021.01.302
J. Dai, B. Lin, X. Sun
Background: In the early stage of COVID-19, the colloidal gold method was the first to be approved by the National Medical Products Administration for clinical use, but the interfering factors of false positive antibody test results are still unclear. Objective: To explore how to analyze and interpret the positive results of COVID-19 antibody test in clinical practice. Methods: A total of 8 678 patients simultaneously submitted for SARS-CoV-2 IgM/IgG antibody and nucleic acid in Peking University International Hospital from March to June 2020 for retrospective analysis were included in the inretrospective analysis. The epidemiological history, clinical manifestations and laboratory indicators(including SARS-CoV-2 IgM/IgG antibody and nucleic acid, rheumatoid factor, complement, immunoglobulin). The colloidal gold method was used to detect the SARS-CoV-2 IgM/IgG antibody, and the positive check of the antibody was performed by the magnetic particle chemiluminescence method. RT-PCR method was adopted to detect SARS-CoV-2 nucleic acid. The heterophilic antibody blocking tube(HBT)was used to process the specimens that were positive by the colloidal gold method, and then the test was performed again. Results: (1)Among the 8 678 patient specimens submitted for examination, 8 677 were negative for SARS-CoV-2 nucleic acid detection, of which 25 cases(0.288%)were positive for SARS-CoV-2 IgM antibody detected by colloidal gold method, SARS-CoV-2 -5 patients(0.058%)with IgG antibody positive, and 0 patients with SARS-CoV-2 IgM and SARS-CoV-2 IgG antibodies at the same time.(2)Thirty patients who tested positive for SARS-CoV-2 antibody by colloidal gold method had no epidemiological history, and at the same time, the results of SARS-CoV-2 nucleic acid test were negative. The possibility of SARS-CoV-2 infection or previous SARS-CoV-2 infection was ruled out. Among them, 10 patients with positive SARS-CoV-2 IgM antibody were still positive after more than 2 times of dynamic monitoring, and the remaining 20 patients were not clinically active monitored.(3)The false positive rate of SARS-CoV-2 IgM antibody detected by colloidal gold method was 0.288%, and the false positive rate of SARS-CoV-2 IgG antibody was 0.058%. After HBT was used to process the SARS-CoV-2 colloidal gold-positive specimens, among the 25 SARS-CoV-2 IgM antibody-positive specimens, except for 1 case which was still positive, the other results became negative;the results of 5 specimens with positive SARS-CoV-2 IgG antibody were still positive.(4)The rheumatoid factor, complement and immunoglobulin levels of 30 SARS-CoV-2 antibody-positive patients were within the normal reference range. Conclusion: The SARS-CoV-2 antibody test results may have false positives. The majority of SARS-CoV-2 IgM antibody positives are caused by heterophilic antibody interference. Those with SARS-CoV-2 IgG antibody positive may also have other potentially unknown interference factors. Heterophile antibodies interfer
{"title":"Exploration on the Detection Results of 2019 Novel Coronavirus Antibodies in the Real World","authors":"J. Dai, B. Lin, X. Sun","doi":"10.12114/j.issn.1007-9572.2021.01.302","DOIUrl":"https://doi.org/10.12114/j.issn.1007-9572.2021.01.302","url":null,"abstract":"Background: In the early stage of COVID-19, the colloidal gold method was the first to be approved by the National Medical Products Administration for clinical use, but the interfering factors of false positive antibody test results are still unclear. Objective: To explore how to analyze and interpret the positive results of COVID-19 antibody test in clinical practice. Methods: A total of 8 678 patients simultaneously submitted for SARS-CoV-2 IgM/IgG antibody and nucleic acid in Peking University International Hospital from March to June 2020 for retrospective analysis were included in the inretrospective analysis. The epidemiological history, clinical manifestations and laboratory indicators(including SARS-CoV-2 IgM/IgG antibody and nucleic acid, rheumatoid factor, complement, immunoglobulin). The colloidal gold method was used to detect the SARS-CoV-2 IgM/IgG antibody, and the positive check of the antibody was performed by the magnetic particle chemiluminescence method. RT-PCR method was adopted to detect SARS-CoV-2 nucleic acid. The heterophilic antibody blocking tube(HBT)was used to process the specimens that were positive by the colloidal gold method, and then the test was performed again. Results: (1)Among the 8 678 patient specimens submitted for examination, 8 677 were negative for SARS-CoV-2 nucleic acid detection, of which 25 cases(0.288%)were positive for SARS-CoV-2 IgM antibody detected by colloidal gold method, SARS-CoV-2 -5 patients(0.058%)with IgG antibody positive, and 0 patients with SARS-CoV-2 IgM and SARS-CoV-2 IgG antibodies at the same time.(2)Thirty patients who tested positive for SARS-CoV-2 antibody by colloidal gold method had no epidemiological history, and at the same time, the results of SARS-CoV-2 nucleic acid test were negative. The possibility of SARS-CoV-2 infection or previous SARS-CoV-2 infection was ruled out. Among them, 10 patients with positive SARS-CoV-2 IgM antibody were still positive after more than 2 times of dynamic monitoring, and the remaining 20 patients were not clinically active monitored.(3)The false positive rate of SARS-CoV-2 IgM antibody detected by colloidal gold method was 0.288%, and the false positive rate of SARS-CoV-2 IgG antibody was 0.058%. After HBT was used to process the SARS-CoV-2 colloidal gold-positive specimens, among the 25 SARS-CoV-2 IgM antibody-positive specimens, except for 1 case which was still positive, the other results became negative;the results of 5 specimens with positive SARS-CoV-2 IgG antibody were still positive.(4)The rheumatoid factor, complement and immunoglobulin levels of 30 SARS-CoV-2 antibody-positive patients were within the normal reference range. Conclusion: The SARS-CoV-2 antibody test results may have false positives. The majority of SARS-CoV-2 IgM antibody positives are caused by heterophilic antibody interference. Those with SARS-CoV-2 IgG antibody positive may also have other potentially unknown interference factors. Heterophile antibodies interfer","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66052607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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