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Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes最新文献

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Transport of proteins across membranes — a paradigm in transition 蛋白质跨膜运输-过渡中的范例
Pub Date : 1995-12-20 DOI: 10.1016/0304-4157(95)00009-7
Lois Isenman , Charles Liebow , Stephen Rothman
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引用次数: 24
The role of the MDR protein in altered drug translocation across tumor cell membranes MDR蛋白在改变药物跨肿瘤细胞膜转运中的作用
Pub Date : 1995-12-20 DOI: 10.1016/0304-4157(95)00013-5
Paul D. Roepe
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引用次数: 77
The epithelial mucin, MUC1, of milk, mammary gland and other tissues 乳、乳腺和其他组织的上皮黏液蛋白MUC1
Pub Date : 1995-12-20 DOI: 10.1016/0304-4157(95)00014-3
Stuart Patton , Sandra J. Gendler , Andrew P. Spicer
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引用次数: 280
Cumulative contents 累积的内容
Pub Date : 1995-12-20 DOI: 10.1016/0304-4157(95)90000-4
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引用次数: 0
Signalling and transport through the nuclear membrane 通过核膜传递信号和运输
Pub Date : 1995-12-20 DOI: 10.1016/0304-4157(95)00015-1
Péter Csermely, Tamás Schnaider, Ildikó Szántó
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引用次数: 53
Molecular and functional properties of mitochondrial benzodiazepine receptors 线粒体苯二氮卓类受体的分子和功能特性
Pub Date : 1995-12-20 DOI: 10.1016/0304-4157(95)00016-X
Karl E. Krueger
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引用次数: 99
Intracellular membranes in the synthesis, transport, and metabolism of proteoglycans 蛋白聚糖的合成、运输和代谢过程中的细胞膜
Pub Date : 1995-12-20 DOI: 10.1016/0304-4157(95)00011-9
Jeremiah E. Silbert , Geetha Sugumaran
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引用次数: 77
Forces and factors that contribute to the structural stability of membrane proteins 促进膜蛋白结构稳定性的力量和因素
Pub Date : 1995-07-17 DOI: 10.1016/0304-4157(94)00161-6
Tuomas Haltia, Ernesto Freire

While a considerable amount of literature deals with the structural energetics of water-soluble proteins, relatively little is known about the forces that determine the stability of membrane proteins. Similarly, only a few membrane protein structures are known at atomic resolution, although new structures have recently been described. In this article, we review the current knowledge about the structural features of membrane proteins. We then proceed to summarize the existing literature regarding the thermal stability of bacteriorhodopsin, cytochrome-c oxidase, the band 3 protein, Photosystem II and porins. We conclude that a fundamental difference between soluble and membrane proteins is the high thermal stability of intrabilayer secondary structure elements in membrane proteins. This property manifests itself as incomplete unfolding, and is reflected in the observed low enthalpies of denaturation of most membrane proteins. By contrast, the extramembranous parts of membrane proteins may behave much like soluble proteins. A brief general account of thermodynamics factors that contribute to the stability of water soluble and membrane proteins is presented.

虽然相当多的文献涉及水溶性蛋白的结构能量学,但对决定膜蛋白稳定性的力的了解相对较少。同样,只有少数膜蛋白结构在原子分辨率上是已知的,尽管最近有新的结构被描述。本文就膜蛋白结构特征的研究进展作一综述。然后,我们对现有的关于细菌紫质、细胞色素c氧化酶、带3蛋白、光系统II和孔蛋白的热稳定性的文献进行了总结。我们得出结论,可溶性蛋白和膜蛋白之间的根本区别是膜蛋白层内二级结构元件的高热稳定性。这一特性表现为不完全展开,并反映在大多数膜蛋白的低变性焓中。相比之下,膜蛋白的膜外部分可能表现得很像可溶性蛋白。简要介绍了影响水溶性和膜蛋白稳定性的热力学因素。
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引用次数: 34
Mannose 6-phosphate receptors in sorting and transport of lysosomal enzymes 甘露糖6-磷酸受体在溶酶体酶的分选和转运中的作用
Pub Date : 1995-07-17 DOI: 10.1016/0304-4157(95)00004-B
Annette Hille-Rehfeld
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引用次数: 241
Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport 肝胆有机化合物分泌;膜运输的分子机制
Pub Date : 1995-07-17 DOI: 10.1016/0304-4157(95)00006-D
Ronald P.J. Oude Elferink , Dirk K.F. Meijer , Folkert Kuipers , Peter L.M. Jansen , Albert K. Groen , Geny M.M. Groothuis
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引用次数: 406
期刊
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes
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