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The establishment of a telemedicine center during the COVID-19 pandemic at a tertiary care hospital in Pakistan 在2019冠状病毒病大流行期间,在巴基斯坦一家三级医疗医院建立了远程医疗中心
Pub Date : 2021-01-01 DOI: 10.1016/j.ceh.2021.11.002
Fibhaa Syed , Muhammad Hassan , Aamir Shehzad , Salman Shafi Koul , Mohammad Ali Arif , Rebecca Susan Dewey , Tanwir Khaliq

Background

Telemedicine involves the innovative application of technology to provide remote patient healthcare services especially those relating to emergency care and contagious disease spread. Telemedicine is less developed in low-and-middle-income countries like Pakistan and there is little published literature on its function and efficiency. Our institution was established to triage patients with COVID-19 symptoms to ease the load on emergency departments.

Objective

To conduct an analysis of the first month of function of a telemedicine/tele-triage center in Pakistan. To determine in which ways it was beneficial to hospital management during the COVID-19 pandemic.

Methods

This study was carried out at the newly established telemedicine/tele-triage center at the Shaheed Zulfiqar Ali Bhutto Medical University (SZABMU) in Islamabad Pakistan between the 26th March and the 25th April 2020. Data were collected over telephone interview using a proforma to provide each caller with a C-Score (a C-score of >3 indicated observe at home 3–5-indicated home isolation with confirmatory testing and >5 indicated testing and transfer to hospital) representing their COVID-19 risk and informing the nature of the advice given to them. Data were presented using descriptive statistics.

Results

The center received total of 857 calls. Fever cough dyspnea and flu were present in 327(38.2%) 268(31.3%) 107(12.5%) and 124(14.5%) callers respectively. Based on the completion of the proforma 774(90.3%) callers had a C-Score of > 75(8.8%) callers had a C-Score of 3–5 and 8 (0.9%) callers had a C-Score of >5. We recommended COVID-19 testing in 83 patients (9.68%) based on C-score. Out of these 83 patients 64 underwent testing and only 1 tested positive for COVID-19.

Conclusion

In a one-month period the center was able to support patients by providing a triage service thereby preventing numerous unnecessary hospital visits and helping to protect healthcare professionals during a global pandemic. Telemedicine has great potential to help patient populations in low-and-middle-income countries.

远程医疗涉及创新应用技术,提供远程患者保健服务,特别是与紧急护理和传染病传播有关的服务。远程医疗在巴基斯坦等低收入和中等收入国家欠发达,关于其功能和效率的已发表文献很少。我们机构的成立是为了分流有COVID-19症状的患者,以减轻急诊科的负担。目的对巴基斯坦某远程医疗/远程分诊中心第一个月的运行情况进行分析。确定在COVID-19大流行期间哪些方面有利于医院管理。方法本研究于2020年3月26日至4月25日在巴基斯坦伊斯兰堡Shaheed Zulfiqar Ali Bhutto医科大学(SZABMU)新建立的远程医疗/远程分诊中心进行。通过电话访谈收集数据,采用形式表格为每个呼叫者提供C-Score (C-Score为>3表示在家观察,3 - 5表示在家隔离并进行确认性检测,>5表示进行检测并转院),代表他们的COVID-19风险,并告知向他们提供的建议的性质。数据采用描述性统计。结果中心共受理来电857次。发热、咳嗽、呼吸困难和流感分别为327例(38.2%)、268例(31.3%)、107例(12.5%)和124例(14.5%)。根据完成的形式表,774(90.3%)呼叫者的C-Score为>75名(8.8%)来电者的C-Score为3-5,8名(0.9%)来电者的C-Score为5。我们建议83例(9.68%)患者根据C-score进行COVID-19检测。在这83名患者中,64人接受了检测,只有1人的COVID-19检测呈阳性。在一个月的时间里,该中心能够通过提供分诊服务来支持患者,从而避免了大量不必要的医院就诊,并在全球大流行期间帮助保护医疗保健专业人员。远程医疗在帮助低收入和中等收入国家的患者群体方面具有巨大潜力。
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引用次数: 2
Role of portable and wearable sensors in era of electronic healthcare and medical internet of things 便携式和可穿戴传感器在电子医疗和医疗物联网时代的作用
Pub Date : 2021-01-01 DOI: 10.1016/j.ceh.2021.11.001
Jianan Hui , Hongju Mao
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引用次数: 1
A national program to support self-management for patients with a chronic condition in primary care: A social return on investment analysis 支持初级保健中慢性病患者自我管理的国家项目:投资的社会回报分析
Pub Date : 2021-01-01 DOI: 10.1016/j.ceh.2021.02.001
Esther Talboom-Kamp , Pim Ketelaar , Anke Versluis

Background

Chronic care patients can play an important role in the self-management of their disease; however, large-scale implementation of self-management has been challenging. To aid and stimulate self-management in primary care, a Dutch cooperation supported healthcare providers in primary care, through collective healthcare groups, who wanted to implement and execute a self-management program. The program aimed to increase the quality of life (QoL) in people with a chronic condition and simultaneously reduce healthcare costs.

Objective

The aim of this study was to assess the public value of the self-management program that was available for approximately 375.000 chronically ill patients.

Methods

A Social Return on Investment analysis was carried out. The analysis is based on the principles of a cost-benefit analysis, and attributes monetary value to the social return of the self-management program in primary care.

Results

The analysis of the self-management program showed that each euro invested translated to a social return of 4.90 euros per patient per year (measured over 5 years). This result was mainly caused by an increase in QoL and a decrease in healthcare costs. Importantly, the results show that costs and benefits were inequitably distributed across the relevant stakeholders.

Discussion

The results show that self-management support programs in primary care can provide a social return on investment. There is a clear need for lasting support for healthcare providers, both material and non-material, to enable successful implementation of self-management programs in practice.

慢性护理患者在疾病自我管理中可以发挥重要作用;然而,大规模实施自我管理一直具有挑战性。为了帮助和促进初级保健中的自我管理,荷兰的一个合作组织通过集体医疗保健团体支持初级保健中的医疗保健提供者,他们希望实施和执行自我管理方案。该项目旨在提高慢性病患者的生活质量(QoL),同时降低医疗成本。目的本研究的目的是评估自我管理计划的公共价值,该计划适用于大约375,000名慢性病患者。方法进行社会投资回报率分析。该分析基于成本效益分析的原则,并将货币价值归因于初级保健中自我管理计划的社会回报。结果自我管理计划的分析表明,每投资一欧元,每位患者每年(超过5 年)的社会回报为4.90欧元。这一结果主要是由于生活质量的提高和医疗成本的降低。重要的是,研究结果表明,成本和收益在相关利益相关者之间分配不均。结果表明,基层医疗自我管理支持项目能够提供社会投资回报。显然需要对医疗保健提供者提供持久的物质和非物质支持,以便在实践中成功实施自我管理计划。
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引用次数: 5
The successes and lessons of a Dutch University Hospitals’ eHealth program: An evaluation study protocol 荷兰大学医院电子健康项目的成功与教训:评估研究方案
Pub Date : 2021-01-01 DOI: 10.1016/j.ceh.2020.12.002
Anneloek Rauwerdink , Marise J. Kasteleyn , Niels H. Chavannes , Marlies P. Schijven , On behalf of the steering committee of the Citrien fund program eHealth

Background

University Hospitals (UHs) are key players in contributing to a sustainable health care system. In the Netherlands the eight UHs joined forces from 2016 till 2018 within the Citrien fund (CF) – program eHealth to develop sustainable eHealth solutions by carrying out 32 research projects.

Objective

The objective of this study was to develop an evaluation study protocol that would be capable of evaluating the first Dutch University Hospitals eHealth program in depth.

Methods

To develop the protocol three consecutive steps were carried out: 1) a rapid review to find suitable eHealth evaluation frameworks and eHealth project progress indicators, 2) assessment of the selected eHealth evaluation frameworks to determine the most suitable framework to evaluate CF - program eHealth, and 3) development of a mixed-methods study to evaluate eHealth project progress indicators in relation to the 32 eHealth research projects.

Results

The ‘Commonwealth Scientific and Industrial Research Organization (CSIRO) framework for evaluating telehealth trials or programs’ was deemed most suitable for evaluating CF - program eHealth. The aspects planning, needs assessment, policy/organization, technology, ethics, legal, and finance, were considered useful indicators for monitoring the progress of an eHealth project, and therefore incorporated into the survey.

Conclusion

The developed evaluation study protocol will be used to evaluate the first Dutch University Hospitals’ eHealth program, the CF – program eHealth, and therewith contribute to maximizing successful uptake of eHealth solutions. Also, the selected set of eHealth project performance indicators could be used by researchers or policymakers to securely monitor the progress of eHealth projects.

大学医院(UHs)是促进可持续卫生保健系统的关键参与者。在荷兰,从2016年到2018年,八所大学在Citrien基金(CF)的电子健康计划下合作,通过开展32个研究项目来开发可持续的电子健康解决方案。本研究的目的是制定一项评估研究方案,能够深入评估荷兰大学医院的第一个电子健康计划。方法为了制定方案,进行了三个连续的步骤:1)快速审查,以找到合适的电子健康评估框架和电子健康项目进度指标;2)评估选定的电子健康评估框架,以确定最适合评估CF -计划电子健康的框架;3)开发混合方法研究,以评估与32个电子健康研究项目相关的电子健康项目进度指标。结果“联邦科学与工业研究组织(CSIRO)远程医疗试验或项目评估框架”被认为最适合评估CF -项目电子健康。规划、需求评估、政策/组织、技术、道德、法律和财务等方面被认为是监测电子卫生项目进展的有用指标,因此纳入了调查。结论所开发的评估研究方案将用于评估第一个荷兰大学医院的电子健康计划,CF -计划电子健康,从而有助于最大限度地成功采用电子健康解决方案。此外,研究人员或政策制定者可以使用选定的电子卫生项目绩效指标集来安全地监测电子卫生项目的进展。
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引用次数: 1
Coronavirus disease-2019 and its current scenario – A review 2019冠状病毒病及其当前情况综述
Pub Date : 2021-01-01 DOI: 10.1016/j.ceh.2021.09.002
Showkat Ahmad Bhat, Gurjinder Singh, Waseem F. Bhat, Kumudini Borole, Ashraf Ali Khan

Coronaviruses are enveloped non-segmented positive-sense RNA viruses belonging to the family Coronaviridae. The human coronavirus infections are mild; the epidemics of the two β-coronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have caused more than ten thousand cumulative cases in the past twodecades. There is a new public health crisis threatening the world with the emergence and spread of 2019 novel coronavirus (2019-nCoV). The virus originated in bats and was transmitted to humans through yet unknown intermediary animals in Wuhan, Hubei province in China during the month of December 2019. Till date around 7,823,289 reported cases of coronavirus disease 2019 (COVID-2019) and 431,541 reported deaths till date. The disease is transmitted by inhalation or contact with infected droplets with incubation period of 2–14 days. The symptoms are usually fever, sore throat, dry cough, breathlessness, fatigue while many people are asymptomatic. Coronavirus (2019-nCoV) may progress to pneumonia, acute respiratory distress syndrome (ARDS) and can cause multi-organ dysfunction. Currently diagnosis is done by demonstration of the virus in respiratory secretions by special molecular tests like real-time reverse-transcription–polymerase-chain-reaction (RT-PCR), Radiological examinations (chest CT). Common laboratory tests like white cell counts and C-reactive protein (CRP) and measure symptoms can be used as preliminary screening at large scale after lock down the area or country. Treatment is essentially supportive; role of antiviral agents is yet to be established. It is paramount to implement infection control practices by infection source controlling, transmission route blocking, and susceptible population protection. Early preventive measures can be home isolation of suspected cases and those with mild illnesses and strict infection control measures at hospitals that include contact and droplet precautions. The worldwide impact of this Coronavirus new epidemic is yet uncertain.

冠状病毒是冠状病毒科的包膜非节段正义RNA病毒。人类冠状病毒感染是轻微的;严重急性呼吸综合征冠状病毒(SARS-CoV)和中东呼吸综合征冠状病毒(MERS-CoV)这两种β-冠状病毒的流行在过去二十年中累计造成了一万多例病例。随着2019年新型冠状病毒(2019- ncov)的出现和传播,一场新的公共卫生危机威胁着世界。该病毒起源于蝙蝠,并于2019年12月在中国湖北省武汉市通过尚不清楚的中间动物传播给人类。到目前为止,报告的2019年冠状病毒病(COVID-2019)病例约为7823289例,死亡病例约为431541例。该病通过吸入或接触受感染飞沫传播,潜伏期为2-14天。症状通常是发烧,喉咙痛,干咳,呼吸困难,疲劳,而许多人是无症状的。冠状病毒(2019-nCoV)可发展为肺炎、急性呼吸窘迫综合征(ARDS),并可导致多器官功能障碍。目前的诊断是通过实时逆转录聚合酶链反应(RT-PCR)、放射检查(胸部CT)等特殊分子检测在呼吸道分泌物中证实病毒。白细胞计数、c反应蛋白(CRP)等常规实验室检测和症状测量可作为封锁地区或国家后的大规模初步筛查。治疗基本上是支持性的;抗病毒药物的作用尚未确定。通过控制传染源、阻断传播途径和保护易感人群实施感染控制措施至关重要。早期预防措施可以是在家中隔离疑似病例和轻症患者,并在医院采取严格的感染控制措施,包括接触和飞沫预防措施。这种新型冠状病毒的全球影响尚不确定。
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引用次数: 2
Systematic development of an mHealth app to prevent healthcare-associated infections by involving patients: ‘Participatient’ 系统开发移动医疗应用程序,通过让患者参与来预防医疗相关感染:“参与患者”
Pub Date : 2021-01-01 DOI: 10.1016/j.ceh.2021.03.001
Robbert G. Bentvelsen , Rosalie van der Vaart , Karin Ellen Veldkamp , Niels H. Chavannes

Introduction

In hospital care, urinary catheters are frequently used, causing a substantial risk for catheter-associated urinary tract infections (CAUTI). Patient awareness and evaluation of appropriateness of their catheter through mHealth could decrease these healthcare-associated infections. However, patient engagement via mHealth in infection prevention is still limited. Therefore, we describe the systematic development and usability evaluation of the mHealth intervention Participatient, to prevent CAUTI, aiming for optimal adoption of the app in the clinical setting.

Method

The CeHRes roadmap was used as development guideline, operationalizing phases for (1) contextual inquiry (observations and interviews), (2) value specification (interviews with probing) and (3) design in multiple steps and in co-creation with end-users. During phases 1 and 2, semi-structured interviews were conducted with fifteen patients and three nurses. The design phase was combined with the minimum viable product development strategy, with a focus on early cyclic steps of prototyping.

Results

In phase 1, patients acknowledged the risks of catheter use. Patients in phase 2 valued endorsement of a mHealth application by healthcare workers and reported to own a smartphone. Both patients and nurses recognized the need for useful modules in the app besides catheter care. Based on the needs and values as found in phase 2, the Participation app was developed. Based on usability tests in phase 3, content, text size, plain language, and navigation structures were further amended, and images were added.

Conclusion

This study provides real-world insight in the developmental strategy for mHealth interventions by involving both patients and care providers. Development of an app using thorough needs-assessment provided understanding for its content and design. By developing an app providing patients with reliable information and daily checklists, we aim to provide a tailored tool for communication and awareness on catheter use for the whole ward, and a potential blueprint for mHealth development.

导读:在医院护理中,导尿管经常被使用,导致导尿管相关性尿路感染(CAUTI)的重大风险。患者通过移动健康了解和评估导管的适当性可以减少这些医疗保健相关感染。然而,患者通过移动医疗参与感染预防的情况仍然有限。因此,我们描述了移动医疗干预系统的开发和可用性评估,以预防CAUTI,旨在优化应用程序在临床环境中的采用。方法以CeHRes路线图作为开发指南,实施以下阶段:(1)语境调查(观察和访谈),(2)价值规范(探究访谈)和(3)多步骤设计和与最终用户共同创造。在第一阶段和第二阶段,对15名患者和3名护士进行了半结构化访谈。设计阶段与最小可行产品开发策略相结合,重点放在原型的早期循环步骤上。结果在第一阶段,患者承认导管使用的风险。第二阶段的患者重视医护人员对移动医疗应用程序的认可,并报告说他们拥有一部智能手机。患者和护士都意识到除了导管护理之外,应用程序还需要有用的模块。基于第二阶段发现的需求和价值,开发了参与应用程序。基于阶段3的可用性测试,进一步修改了内容、文本大小、简单语言和导航结构,并添加了图像。本研究通过涉及患者和护理提供者,为移动医疗干预的发展策略提供了现实世界的见解。使用全面的需求评估来开发应用程序,为其内容和设计提供了理解。通过开发一款为患者提供可靠信息和每日检查清单的应用程序,我们的目标是为整个病房的导管使用沟通和意识提供量身定制的工具,并为移动健康发展提供潜在的蓝图。
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引用次数: 0
Short message services interventions for chronic disease management: A systematic review 短信服务干预慢性疾病管理:系统综述
Pub Date : 2021-01-01 DOI: 10.1016/j.ceh.2020.11.004
Martha Chioma Ebuenyi , Kyma Schnoor , Anke Versluis , Eline Meijer , Niels H. Chavannes

Introduction

The burden of chronic diseases has continued to grow globally. Technology has been used successfully in the management of chronic conditions through diagnosis, monitoring and education. This review aims to collate available evidence to evaluate the role of short message services (SMS), as an intervention, in patient participation in disease management of three common chronic diseases, i.e., Human Immunodeficiency Virus (HIV), Diabetes Mellitus (DM) and Chronic Obstructive Pulmonary Disease (COPD).

Materials and method

The review identified eight eligible studies in PubMed, Google Scholar and Cochrane library that assessed the effect of SMS interventions on self-management in HIV, DM and COPD. Outcomes of interest included adherence to the self-management plan, lifestyle modification (e.g., exercise and diet), clinical outcomes (e.g body mass index, blood glucose level, blood pressure), knowledge of disease, feasibility, acceptability, usability, and cost-effectiveness.

Results

Adherence, knowledge about their disease conditions, and feasibility/acceptability were assessed in eight, six and three studies, respectively. Improvements from pre- to post-intervention in adherence and clinical outcomes (including body mass index and blood glucose level) were recorded in eight and three studies. Patients reported having knowledge about their conditions and were willing to continue with the intervention (patient acceptability and usability). However, some patients complained they could not send response messages either due to technical issues or forgetfulness and no analysis of cost-effectiveness.

Conclusion

Chronic conditions require long-term care and patients can be active participants in their care plan to improve their health. SMS interventions have been used successfully to encourage patient self-management, patient awareness, and treatment adherence in HIV, COPD, and DM. The SMS intervention has been applied in various research designs and disease conditions. Patients’ adherence and clinical conditions changed from pre- to post-intervention; however, more research is needed to elucidate the effect of SMS interventions in different countries, socioeconomic status and age groups, and chronic diseases.

慢性疾病的负担在全球范围内持续增长。通过诊断、监测和教育,技术已成功地用于慢性病的管理。本综述旨在整理现有证据,以评估短信服务(SMS)作为一种干预措施,在患者参与三种常见慢性疾病(即人类免疫缺陷病毒(HIV)、糖尿病(DM)和慢性阻塞性肺疾病(COPD)的疾病管理中的作用。材料和方法本综述在PubMed、谷歌Scholar和Cochrane图书馆中筛选了8项符合条件的研究,评估了SMS干预对HIV、DM和COPD患者自我管理的影响。关注的结果包括遵守自我管理计划、生活方式改变(如运动和饮食)、临床结果(如体重指数、血糖水平、血压)、疾病知识、可行性、可接受性、可用性和成本效益。结果分别在8项、6项和3项研究中评估了依从性、对疾病状况的了解以及可行性/可接受性。从干预前到干预后依从性和临床结果(包括体重指数和血糖水平)的改善分别记录在8项和3项研究中。患者报告了解自己的病情并愿意继续进行干预(患者可接受性和可用性)。然而,一些患者抱怨由于技术问题或遗忘以及没有对成本效益进行分析,他们无法发送响应信息。结论慢性疾病需要长期护理,患者可积极参与其护理计划以改善其健康状况。SMS干预已成功用于鼓励艾滋病、慢性阻塞性肺病和糖尿病患者的自我管理、患者意识和治疗依从性。SMS干预已应用于各种研究设计和疾病条件。干预前后患者依从性和临床状况发生变化;然而,需要更多的研究来阐明短信干预在不同国家、社会经济地位和年龄组以及慢性病中的影响。
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引用次数: 7
An anatomization on breast cancer detection and diagnosis employing multi-layer perceptron neural network (MLP) and Convolutional neural network (CNN) 多层感知器神经网络(MLP)和卷积神经网络(CNN)在乳腺癌检测诊断中的应用解剖
Pub Date : 2021-01-01 DOI: 10.1016/j.ceh.2020.11.002
Meha Desai , Manan Shah

This paper aims to review Artificial neural networks, Multi-Layer Perceptron Neural network (MLP) and Convolutional Neural network (CNN) employed to detect breast malignancies for early diagnosis of breast cancer based on their accuracy in order to identify which method is better for the diagnosis of breast cell malignancies. Deep comparison of functioning of each network and its designing is performed and then analysis is done based on the accuracy of diagnosis and classification of breast malignancy by the network to decide which network outperforms the other. CNN is found to give slightly higher accuracy than MLP for diagnosis and detection of breast cancer. There still is the need to carefully analyse and perform a thorough research that uses both these methods on the same data set under same conditions in order identify the architecture that gives better accuracy.

本文旨在通过对人工神经网络、多层感知器神经网络(multilayer Perceptron neural network, MLP)和卷积神经网络(Convolutional neural network, CNN)用于乳腺恶性肿瘤检测的准确性进行综述,以确定哪种方法更适合乳腺细胞恶性肿瘤的诊断。对每个网络的功能和设计进行了深入的比较,然后根据网络对乳腺恶性肿瘤的诊断和分类的准确性进行分析,以确定哪个网络优于其他网络。发现CNN在诊断和检测乳腺癌方面的准确性略高于MLP。仍然需要仔细分析和执行彻底的研究,在相同的条件下对相同的数据集使用这两种方法,以确定提供更高准确性的体系结构。
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引用次数: 141
Application of artificial intelligence in renal disease 人工智能在肾脏疾病中的应用
Pub Date : 2021-01-01 DOI: 10.1016/j.ceh.2021.11.003
Lijing Yao , Hengyuan Zhang , Mengqin Zhang , Xing Chen , Jun Zhang , Jiyi Huang , Lu Zhang

Artificial intelligence (AI) has been applied widely in almost every area of our daily lives, due to the growth of computing power, advances in methods and techniques, and the explosion of data, it also plays a critical role in academic disciplines, medicine is not an exception. AI can augment the intelligence of clinicians in diagnosis, prognosis, and treatment decisions. Kidney disease causes great economic burden worldwide, with both acute kidney injury and chronic kidney disease bringing about high morbidity and mortality. Outstanding challenges in nephrology may be addressed by leveraging big data and AI. In this review, we summarized advances in machine learning (ML), artificial neural network (ANN), convolution neural network (CNN) and deep learning (DL), with a special focus on acute kidney injury (AKI), chronic kidney disease (CKD), end-stage renal disease (ESRD), dialysis, kidney transplantation and nephropathology. AI may not be anticipated to replace the nephrologists’ medical decision-making for now, but instead assisting them in providing optimal personalized therapy for patients.

人工智能(AI)已经广泛应用于我们日常生活的几乎每个领域,由于计算能力的增长,方法和技术的进步,以及数据的爆炸式增长,它在学术学科中也起着至关重要的作用,医学也不例外。人工智能可以增强临床医生在诊断、预后和治疗决策方面的智能。肾脏疾病在世界范围内造成了巨大的经济负担,无论是急性肾损伤还是慢性肾脏疾病都具有很高的发病率和死亡率。利用大数据和人工智能可以解决肾脏病学中的突出挑战。本文综述了机器学习(ML)、人工神经网络(ANN)、卷积神经网络(CNN)和深度学习(DL)的研究进展,重点介绍了急性肾损伤(AKI)、慢性肾病(CKD)、终末期肾病(ESRD)、透析、肾移植和肾脏病理学等方面的研究进展。人工智能目前可能不会取代肾病学家的医疗决策,而是帮助他们为患者提供最佳的个性化治疗。
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引用次数: 7
An anatomization on breast cancer detection and diagnosis employing multi-layer perceptron neural network (MLP) and Convolutional neural network (CNN) 多层感知器神经网络(MLP)和卷积神经网络(CNN)在乳腺癌检测诊断中的应用解剖
Pub Date : 2020-11-24 DOI: 10.1016/j.ceh.2020.11.002
Meha D. Desai, Manan Shah
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引用次数: 157
期刊
Clinical eHealth
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