Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section最新文献

Acoustic P300 was recorded from Fz, Cz and Pz by means of an `odd-ball' paradigm in 44 non-demented de novo Parkinson's disease patients (PD) or PD patients under treatment withdrawal, and in 31 age-matched normal subjects, to evaluate whether a P300 latency increase was present in PD patients. The influence of age and disease stage on latency was successively verified by subgrouping PD patients according to different age (`young' or `old') and disease stage (`early' or `advanced'). PD patient data were compared to data of normal subjects subgrouped into `young' and `old' or, to eliminate the age-dependent shift of latency, this latter was adjusted to 60 years in all the examined subjects. A significant increase of latency has been found in Fz and Cz in the `old' group of PD patients (n=23) but not in the `young' group (n=21) utilising both methods. Moreover, a significant latency increase was also present in Fz and Cz in the group of `advanced' PD patients (n=8), but not in the group of `early' PD patients (n=36) utilising age-adjusted measurements. When the `early' PD patient group was divided into `young' (n=20) and `old' (n=16), the `early old' group displayed significantly increased latencies in Fz compared with normal subjects. Abnormal P300 latencies were observed, at least in one electrode, by analysing the raw data, in 5.0% of the `early young', 43.7% of the `early old' and up to 62.7% of the `advanced' patients. Fz represented the site in which abnormal P300 latencies were most often observed. Moreover, in the total group of PD patients, the P300 delay was significant only on the frontal (Fz) site when compared with normal subjects. The reported findings were interpreted as if PD produces a sort of `accelerated effect of age' on the cognitive functions, presumably produced by a mechanism different from that producing motor impairment since no clear correlation could be detected between P300 latency and motor score. The frontal impairment of P300 is in line with previous neuropsychological findings obtained in these patients. Considering that about 30% of PD patients develop dementia during their disease progression, a border-line or abnormal P300 latency observed at disease onset may represent a predictive marker of this evolution.

A multi-start downhill simplex method is examined as a global minimization technique for fitting multidipole, spatio-temporal magnetoencephalography (MEG) data. This procedure has been performed on both simulated and empirical human visual data, known to exhibit complex field patterns due to multiple sources. Unlike some other non-linear fitting techniques the multi-start downhill simplex method does not require users to provide initial guesses for the dipole parameters, hence the fitting procedure is less time-consuming, more objective, and user-friendly. In addition, this method offers more than one adequate solution thus providing a range of uncertainty for the estimated parameters. The Multi-start downhill simplex method is used to fit the non-linear dipole spatial parameters, while the linear temporal parameters are fit using a separate linear fitting procedure. Singular value decomposition (SVD) is also used in order to improve the procedure for determining the adequate number of modeled dipoles.

Waveform analyses of flash visual evoked potentials (VEPs) in neurologically normal preterm infants (postconceptional age 31–42 weeks) were performed using an autoregressive moving average (ARMA) model to interpret the evoked potentials as dynamic high-order responses to natural and experimental stimulation. Averaged VEP waveforms obtained were decomposed into 7–11 component impulse response waveforms by an ARMA component wave analysis. Based on the histogram of damping frequencies of different component impulse response waveforms, the waveforms were divided into 6 groups. All characteristic values in Group IV (6.5–12.0 Hz), such as the energy, the percent energy and the damping time of component impulse responses, changed significantly with increasing postconceptional age. Among the component impulse responses, neuronal networks generating impulse responses classified into Group IV appeared to be important to the developmental change of VEPs in preterm infants. The identification of an impulse response component with a dominant frequency which undergoes a well-identified change with age might prove to be a useful tool for discriminating between normal and abnormal changes in the VEP with age in preterm infants and could aid in the early diagnosis of abnormalities.

Neurogenic motor evoked potential (NMEP) monitoring, which basically represents a monitoring of both motor and somatosensory tracts, has been proposed as a warning system in preventing neural damage during spinal surgery. The aim of this study was to report our clinical experience in 112 consecutive patients undergoing surgery for spinal deformity, and to emphasize the interest of NMEP monitoring. NMEPs were elicited in each patient by electrical stimulation of the spinal cord via needle electrodes placed by the surgeon in the rostral part of the surgical field, and recorded from the right and left sciatic nerves. Concomitantly, somatosensory evoked potentials (SSEPs) were obtained using a standard method. No false-negative cases of intra-operative spinal cord damage were reported. In 3 patients, both NMEPs and SSEPs suddenly disappeared during specific surgical manipulations of the vertebral implants. In these patients, the level of the lesion was easily recognized by moving the stimulating electrodes of NMEPs along the spinal cord, allowing the surgeon to perform laminectomy at the appropriate vertebral level. Spinal cord decompression was a success in two patients, the last unfortunately being paraplegic. Two additional patients exhibited transient reduction in NMEP amplitude at the insertion of a rod while SSEPs did not change significantly. In these two cases, the surgeon modified his procedure according to the NMEP changes, possibly avoiding a neurological complication. Each time evoked potentials were significantly altered, significant information was more rapidly acquired with NMEPs than with SSEPs. These results suggest that NMEPs can be used as primary choice for detecting impeding lesion of the spinal cord during critical steps of spinal surgery.

The P300 component of the event-related brain potential (ERP) was elicited with auditory and visual stimuli in separate experiments. Each study compared an oddball paradigm that presented both target and standard stimuli with a single-stimulus paradigm that presented a target but no standard stimuli. Subjects were instructed in different conditions either to ignore the stimuli, press a response key to the target, or maintain a mental count of the targets. For the passive ignore conditions, P300 amplitude from the single-stimulus paradigm was larger than that from the oddball paradigm. For the active tasks, P300 amplitude from the oddball paradigm was larger than that from the single-stimulus paradigm. For the press and count conditions, P300 amplitude and latency were highly similar for the oddball and single-stimulus procedures. The findings suggest that the single-stimulus paradigm can provide reliable cognitive measures in clinical/applied testing for both passive and active response conditions.

In this study, short latency (t<12.7 ms) vestibular evoked potentials (VsEPs) in response to linear acceleration impulses were recorded in 37 rats. A new technique (based on a solenoid) was used for generating linear force impulses that were delivered to the animal's head. The impulse had a maximal peak acceleration of 12 g. During the impulse, the displacement was 50 μm (at 4 g) and the rise time was 1.0 ms. A stimulation rate of 2/s was usually used. The VsEPs (averaged responses to 128 stimulations, digital filter: 300–1500 Hz) were recorded with electrodes on pinna and vertex, and were composed of 4–6 clear waves with mean amplitudes (for a 4 g stimulus) of 1–5 μV. The VsEPs were resistant to white noise masking, and were significantly suppressed (P<0.05) following bilateral application of a saturated KCl solution to the inner ear, showing that contributions of the auditory and somatosensory systems are negligible. The latency of the response decreased as a power law function of stimulus magnitude, and the amplitude of the first wave increased as a sigmoid function of stimulus magnitude. VsEP responses were still present at the lowest intensities attainable (0.06–0.4 g) and reached saturation at 9 g. The amplitude of the later components was reduced when stimulus rate was elevated to 20/s. These results suggest that VsEPs in response to linear accelerations are similar in their nature to VsEPs in response to angular acceleration impulses that were previously recorded. These VsEPs to linear accelerations are most likely initiated in the otolith organs.

The influence of stimulus duration on auditory evoked potentials (AEPs) was examined for tones varying randomly in duration, location, and frequency in an auditory selective attention task. Stimulus duration effects were isolated as duration difference waves by subtracting AEPs to short duration tones from AEPs to longer duration tones of identical location, frequency and rise time. This analysis revealed that AEP components generally increased in amplitude and decreased in latency with increments in signal duration, with evidence of longer temporal integration times for lower frequency tones. Different temporal integration functions were seen for different N1 subcomponents. The results suggest that different auditory cortical areas have different temporal integration times, and that these functions vary as a function of tone frequency.

The present study investigates the differential behavior of laser evoked brain potentials (LEPs), late auditory evoked potentials (AEP) and the endogenous P300 in response to morphine treatment, examined in 6 chronic pain patients. The main result was that in parallel with marked clinical pain relief, amplitudes of the long latency LEP positivity (P400) were significantly reduced under morphine. One patient suffering from extremely painful osteoporosis for 20 years exhibited a large middle latency component (N170) which was prominently attenuated by morphine. In contrast to LEP amplitude reductions, auditory N1 and P2 potentials appeared either unchanged or even enlarged during morphine treatment. Also P300 amplitude was slightly increased under morphine. Reaction time and mood scales also failed to indicate any sedation. Obviously, LEPs reflected specifically the analgesic morphine effect in this study, while stability or enhancement of AEPs and P300 during morphine treatment indicated lack of sedation or even improved perception and concentration due to the removal of persistent pain as a disruptive perceptual-cognitive stressor.