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High-quality nutrition counselling for hypercholesterolemia by public health nurses in rural areas does not affect total blood cholesterol 农村地区公共卫生护士对高胆固醇血症的高质量营养咨询对总血胆固醇没有影响
Pub Date : 2005-01-01 DOI: 10.1016/S1462-9410(03)00072-X
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引用次数: 1
No association between mobile phone usage and development of acoustic neuroma 手机使用与听神经瘤的发展无关联
Pub Date : 2004-08-01 DOI: 10.1016/J.EHBC.2004.05.007
L. Hardell
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引用次数: 2
Hormone replacement therapy is not safe for breast cancer survivors 激素替代疗法对乳腺癌幸存者来说并不安全
Pub Date : 2004-08-01 DOI: 10.1016/J.EHBC.2004.05.004
R. Vassilopoulou-sellin
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引用次数: 0
Laparoscopic hysterectomy is not cost effective compared with vaginal hysterectomy 与阴道子宫切除术相比,腹腔镜子宫切除术不具有成本效益
Pub Date : 2004-08-01 DOI: 10.1016/J.EHBC.2004.05.014
B. Crawford
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引用次数: 2
Link between diagnostic X-rays and cancer uncertain☆ 诊断x光与癌症之间的联系尚不明确
Pub Date : 2004-08-01 DOI: 10.1016/J.EHBC.2004.05.011
J. Cameron
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引用次数: 4
Retaplase plus abciximab improves non-fatal outcomes, but not overall survival in people with diabetes and acute ST-segment elevation myocardial infarction Retaplase + abciximab可改善糖尿病合并急性st段抬高型心肌梗死患者的非致命性预后,但不能改善总生存率
Pub Date : 2004-08-01 DOI: 10.1016/j.ehbc.2004.05.001
Victor Serebruany MD, PhD (Commentary Author)

Question

In people with diabetes and ST-segment elevation myocardial infarction, is half-dose reteplase plus abciximab more effective than reteplase alone?

Study design

Secondary analysis of multicentre randomised controlled trial.

Main results

For mortality at 30 days or 1 year, there was no significant difference between groups (see Table 1). Reteplase plus abciximab significantly reduced the risk of reinfarction, or recurrent ischaemia or angina compared with reteplase alone.

Table 1 Clinical outcomes for people with diabetes and ST-segment myocardial infarction.
Reteplase alone (n=1299)Half-dose reteplase plus abciximab (n=1334)P value
Death within 30 days8.8%8.2%0.57
Death within 1 year13.0%12.4%0.64
Reinfarction4.3%2.5%0.01
Recurrent ischaemia/angina14.9%11.8%0.01

Authors’ conclusions

Although treatment with reteplase plus abciximab did not provide a survival benefit for people with diabetes and ST-segment elevation myocardial infarction compared with reteplase alone, nonfatal outcomes including reinfarction and recurrent ischaemia were substantially reduced.

问题在糖尿病和ST段抬高型心肌梗死患者中,半剂量的雷普酶加阿昔单抗是否比单独使用雷普酶更有效?研究设计多中心随机对照试验的二次分析。主要结果对于30天或1年的死亡率,各组之间没有显著差异(见表1)。与单独使用瑞替普酶相比,瑞替普蛋白酶联合阿昔单抗显著降低了再梗死、复发性缺血或心绞痛的风险。表1糖尿病和ST段心肌梗死患者的临床结果。单独使用雷普酶(n=1299)半剂量雷普酶加阿昔单抗(n=1334)P值30天内死亡8.8%8.2%0.57 1年内死亡13.0%12.4%0.64再梗死4.3%2.5%0.01复发性缺血/血管痉挛14.9%11.8%0.01作者的结论尽管与单独使用瑞替普酶,包括再梗死和复发性缺血在内的非致命性结果显著降低。
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引用次数: 0
H. pylori eradication does not reduce gastric cancer incidence in a high-risk area of China 幽门螺杆菌根除并不能降低中国高风险地区胃癌的发病率
Pub Date : 2004-08-01 DOI: 10.1016/j.ehbc.2004.05.005
Bor-Shyang Sheu MD (Commentary Author), Xi-Zhang Lin MD (Commentary Author)

Question

Does treating H. Pylori reduce the incidence of gastric cancer?

Study

Randomised placebo-controlled trial.

Main results

At 7.5 years, incidence of gastric cancer was not significantly different between groups (treatment: 0.86%, n=7; placebo: 1.35%, n=11; p=0.33). In people without precancerous lesions at baseline, risk of gastric cancer was significantly lower for treatment compared with placebo (incidence of gastric cancer: treatment n=0; placebo n=6; p=0.02) but there was no difference among people with precancerous lesions (n=7 and 5, respectively). Smoking (hazard ratio [HR] 6.2, 95% CI 2.3 to 16.5) and older age (HR per 1 year 1.10, 95% CI 1.05 to 1.15) were independent predictors of gastric cancer risk.

Authors’ conclusions

Incidence of gastric cancer was similar between H. pylori eradication and placebo groups over 7.5 years of follow-up. However, it was significantly reduced in a subgroup of people without precancerous lesions at baseline.

问题治疗幽门螺杆菌能降低癌症的发病率吗?研究随机安慰剂对照试验。主要结果7.5年时,各组癌症发生率无显著差异(治疗组:0.86%,n=7;安慰剂组:1.35%,n=11;p=0.33),与安慰剂相比,治疗癌症的风险显著降低(癌症的发病率:治疗n=0;安慰剂n=6;p=0.02),但癌前病变患者之间没有差异(分别为n=7和5)。吸烟(危险比[HR]6.2,95%CI 2.3-16.5)和年龄较大(每1年HR 1.10,95%CI 1.05-1.15)是癌症风险的独立预测因素。作者的结论在7.5年的随访中,根除幽门螺杆菌组和安慰剂组的癌症发病率相似。然而,在基线时没有癌前病变的亚组中,它显著降低。
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引用次数: 2
Hormone replacement therapy is not safe for breast cancer survivors 激素替代疗法对乳腺癌幸存者来说并不安全
Pub Date : 2004-08-01 DOI: 10.1016/j.ehbc.2004.05.004
Rena Vassilopoulou-Sellin MD (Commentary Author)

Question

Is hormone replacement therapy safe for women with previous breast cancer?

Study design

Randomised controlled trial (interim analysis).

Main results

In 345 women surviving breast cancer, there were more new breast cancer events in women taking HRT for menopausal symptoms compared with women receiving symptomatic treatment without hormones at a median of 2 years follow-up (absolute risk for new breast cancer: 26/174 [14%] with HRT vs 8/171 [5%] with no HRT; relative hazard 3.5, 95% CI 1.5 to 8.1).

Authors’ conclusions

In women surving breast cancer, those who received HRT for menopausal symptoms were at a higher risk of developing new breast cancers compared with those who received symptomatic treatment without hormones. These findings led to the termination of the trial.

问题:激素替代疗法对既往患有癌症的女性安全吗?研究设计随机对照试验(中期分析)。主要结果在345例癌症患者中,在中位2年的随访中,因更年期症状而服用激素替代疗法的女性与未服用激素的有症状治疗的女性相比,有更多的新乳腺癌症事件(新乳腺癌症的绝对风险:使用激素替代疗法时为26/174[14%],而未使用激素替代治疗时为8/171[5];相对风险3.5,95%CI 1.5至8.1),那些因更年期症状而接受激素替代疗法的人与那些接受无激素症状治疗的人相比,患新乳腺癌的风险更高。这些发现导致审判终止。
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引用次数: 0
After a stroke, ability with daily tasks of living improves after therapy based rehabilitation services 中风后,日常生活能力在康复治疗后得到改善
Pub Date : 2004-08-01 DOI: 10.1016/j.ehbc.2004.05.018
Michael Power MB, FRCP (Commentary Author)

Question

Do post-discharge rehabilitation services change recovery after stroke?

Study design

Systematic review with meta-analysis.

Main results

Fourteen trials met inclusion criteria; 12 trials comparing therapy-based rehabilitation services were included in the meta-analysis (occupational therapy = 6 trials, physiotherapy = 2 trials and mixed services = 4 trials). At a median follow-up of 6 months, therapy-based rehabilitation services reduced the risk of deterioration in ability to undertake daily living tasks compared with control, (OR 0.72, 95% CI 0.57 to 0.92). Ability to carry out extended activities of daily living significantly improved in people undergoing therapy-based rehabilitation services compared with control (mean difference 0.17 95% CI 0.04 to 0.30). When similar categories of therapy were compared, only occupational therapy significantly reduced deterioration rate (occupational therapy: OR 0.73, 95% CI 0.55 to 0.96; physiotherapy OR 0.67, 95% CI 0.24 to 1.89; mixed services OR 0.72, 95% CI 0.41 to 1.27). Data were inconclusive with respect to mood, quality of life, need for long-term care and hospital readmission.

Authors’ conclusions

People discharged to their homes after stroke are less likely to deteriorate if therapy-based rehabilitation services are provided compared with usual care or no routine intervention.

问题出院后的康复服务会改变中风后的恢复吗?研究设计采用荟萃分析的系统综述。主要结果四项试验符合纳入标准;荟萃分析包括12项比较基于治疗的康复服务的试验(职业治疗=6项试验,物理治疗=2项试验,混合服务=4项试验)。在6个月的中位随访中,与对照组相比,基于治疗的康复服务降低了承担日常生活任务能力恶化的风险,(OR 0.72,95%CI 0.57至0.92)。与对照组相比,接受基于治疗的康复服务的人进行延长日常生活活动的能力显著提高(平均差异0.17,95%CI 0.04至0.30)。当比较类似类别的治疗时,只有职业治疗显著降低了恶化率(职业治疗:OR 0.73,95%CI 0.55至0.96;物理治疗OR 0.67,95%CI 0.24至1.89;混合服务OR 0.72,95%CI 0.41至1.27)。情绪、生活质量、长期护理需求和再次入院方面的数据不确定。作者的结论:与常规护理或不进行常规干预相比,如果提供基于治疗的康复服务,中风后出院回家的人病情恶化的可能性较小。
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引用次数: 3
Attending a single care site associated with improved glycaemic control in people with diabetes 参加单一护理地点与改善糖尿病患者的血糖控制有关
Pub Date : 2004-08-01 DOI: 10.1016/j.ehbc.2004.05.016
Peter Harvey (Commentary Author)

Question

Does continuity of care improve control of clinical risk factors in people with diabetes?

Study design

Cross-sectional community-based survey.

Main results

85.5% of participants had continuity of care (single care site and usual provider), 9.3% had a single care site but different providers, and 5.2% had no usual source of care. Good glycaemic control was more likely with continuity of care or single care site compared with no usual source of care (continuity of care: OR 4.62, 95% CI 2.02 to 10.60; single care site: OR 6.13, 95% CI 2.08 to 18.04). There were no significant differences between groups with a usual site. There was no increased likelihood of good control of blood pressure or lipid level among groups.

Authors’ conclusions

There is evidence that good glycaemic control is more likely among people whose diabetic care is provided from one site, regardless of whether it is provided by the same practitioner.

问题连续性护理是否能改善糖尿病患者临床风险因素的控制?研究设计基于社区的横断面调查。主要结果8.5%的参与者有连续的护理(单一护理点和常规提供者),9.3%的参与者有单一护理点但不同的提供者,5.2%的参与者没有常规护理来源。与没有通常的护理来源相比,连续性护理或单一护理地点更有可能实现良好的血糖控制(连续性护理:or 4.62,95%CI 2.02至10.60;单一护理地点:or 6.13,95%CI 2.08至18.04)。具有通常护理地点的组间无显著差异。各组之间血压或脂质水平得到良好控制的可能性没有增加。作者的结论有证据表明,无论是否由同一位医生提供糖尿病护理,在一个地点提供糖尿病护理的人中,良好的血糖控制更有可能。
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引用次数: 1
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Evidence-based Healthcare
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