首页 > 最新文献

Chimica Oggi-chemistry Today最新文献

英文 中文
Collaboration as the best medicine 合作是最好的良药
Q4 Chemistry Pub Date : 2019-03-11 DOI: 10.17863/CAM.40948
J. Srai, C. Badman
Collaboration can be pivotal in making change happen. So how can new collaborative models be forged in areas where such relationships are not well established, but where change is required? In UK medicines manufacturing, there is an opportunity and a pressing need for progressive change. But there are also plenty of challenges and obstacles, particularly in a highly competitive and tightly regulated sector. A bold step forward has been taken through a collaborative £23m four-year project, ReMediES, involving 22 industry partners and 2 leading UK Universities. Dr Jag Srai and Professor Clive Badman, co-Directors of Project ReMediES discuss how the project has forged a model for change through collaboration.
协作是实现变革的关键。那么,在这种关系尚未建立,但又需要变革的领域,如何建立新的协作模式呢?在英国药品制造业,有机会和迫切需要进行渐进式变革。但也存在许多挑战和障碍,尤其是在一个竞争激烈、监管严格的行业。一项耗资2300万英镑、为期四年的合作项目“补救措施”向前迈出了大胆的一步,该项目涉及22个行业合作伙伴和2所英国顶尖大学。项目补救的联合主任Jag Srai博士和Clive Badman教授讨论了该项目如何通过合作打造了一个变革模式。
{"title":"Collaboration as the best medicine","authors":"J. Srai, C. Badman","doi":"10.17863/CAM.40948","DOIUrl":"https://doi.org/10.17863/CAM.40948","url":null,"abstract":"Collaboration can be pivotal in making change happen. So how can new collaborative models be forged in areas where such relationships are not well established, but where change is required? In UK medicines manufacturing, there is an opportunity and a pressing need for progressive change. But there are also plenty of challenges and obstacles, particularly in a highly competitive and tightly regulated sector. A bold step forward has been taken through a collaborative £23m four-year project, ReMediES, involving 22 industry partners and 2 leading UK Universities. Dr Jag Srai and Professor Clive Badman, co-Directors of Project ReMediES discuss how the project has forged a model for change through collaboration.","PeriodicalId":10052,"journal":{"name":"Chimica Oggi-chemistry Today","volume":"42 1","pages":"10-13"},"PeriodicalIF":0.0,"publicationDate":"2019-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83481843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biocatalytic hydrogen-borrowing cascades. 生物催化的借氢级联。
Q4 Chemistry Pub Date : 2017-09-01
Tanja Knaus, Francesco G Mutti

The exquisite chemoselectivity and the intrinsic compatibility of enzymes have been widely exploited during the past decade for the development of multi-step biocatalytic reactions in one-pot. In this context, hydrogen-borrowing cascades permit to maximise the atom-efficiency through the internal recycling of redox equivalents, which avoids the use of additional oxidants or reductants. Here, we describe the state-of-the-art in the field of biocatalytic hydrogen-borrowing cascades and provide a future perspective for a wider implementation in organic synthesis.

近十年来,酶的精细化学选择性和内在相容性被广泛地用于一锅多步生物催化反应的开发。在这种情况下,借氢级联可以通过氧化还原当量的内部循环来最大化原子效率,从而避免使用额外的氧化剂或还原剂。在这里,我们描述了生物催化借氢级联领域的最新技术,并为在有机合成中更广泛的实施提供了未来的视角。
{"title":"Biocatalytic hydrogen-borrowing cascades.","authors":"Tanja Knaus,&nbsp;Francesco G Mutti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The exquisite chemoselectivity and the intrinsic compatibility of enzymes have been widely exploited during the past decade for the development of multi-step biocatalytic reactions in one-pot. In this context, hydrogen-borrowing cascades permit to maximise the atom-efficiency through the internal recycling of redox equivalents, which avoids the use of additional oxidants or reductants. Here, we describe the state-of-the-art in the field of biocatalytic hydrogen-borrowing cascades and provide a future perspective for a wider implementation in organic synthesis.</p>","PeriodicalId":10052,"journal":{"name":"Chimica Oggi-chemistry Today","volume":"35 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837015/pdf/emss-76205.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35891907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why development of new HPLC column technology is still alive 为什么新的高效液相色谱柱技术还在发展
Q4 Chemistry Pub Date : 2013-01-01 DOI: 10.4172/2155-9872.S1.012
Joshua E. Young, Maria T. Matyska-Pesek, J. Pesek
{"title":"Why development of new HPLC column technology is still alive","authors":"Joshua E. Young, Maria T. Matyska-Pesek, J. Pesek","doi":"10.4172/2155-9872.S1.012","DOIUrl":"https://doi.org/10.4172/2155-9872.S1.012","url":null,"abstract":"","PeriodicalId":10052,"journal":{"name":"Chimica Oggi-chemistry Today","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74457807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Modeling G Protein-Coupled Receptors: a Concrete Possibility. G 蛋白偶联受体建模:一种具体的可能性。
Q4 Chemistry Pub Date : 2010-01-01
Stefano Costanzi

G protein-coupled receptors (GPCRs) are a large superfamily of membrane bound signaling proteins that are involved in the regulation of a wide range of physiological functions and constitute the most common target for therapeutic intervention. Due to the paucity of crystal structures, homology modeling has become a widespread technique for the construction of GPCR models, which have been applied to the study of their structure-function relationships and to the identification of lead ligands through virtual screening. Rhodopsin has been for years the only available template. However, recent breakthroughs in GPCR crystallography have led to the solution of the structures of a few additional receptors. In light of these newly elucidated crystal structures, we have been able to produce a substantial amount of data to demonstrate that accurate models of GPCRs in complex with their ligands can be constructed through homology modeling followed by fully flexible molecular docking. These results have been confirmed by our success in the first blind assessment of GPCR modeling and docking, organized in coordination with the solution of the X-ray structure of the adenosine A(2A) receptor. Taken together, these data indicate that: a) the transmembrane helical bundle can be modeled with considerable accuracy; b) predicting the binding mode of a ligand, although doable, is challenging; c) modeling of the extracellular and intracellular loops is still problematic.

G 蛋白偶联受体(GPCR)是一个庞大的膜结合信号蛋白超家族,参与调控多种生理功能,是最常见的治疗干预靶标。由于晶体结构的缺乏,同源建模已成为构建 GPCR 模型的一种广泛技术,并已应用于研究其结构与功能的关系,以及通过虚拟筛选确定先导配体。多年来,Rhodopsin 一直是唯一可用的模板。然而,最近在 GPCR 晶体学方面取得的突破性进展已经解决了另外一些受体的结构问题。根据这些新阐明的晶体结构,我们已经能够生成大量数据,证明通过同源建模和完全灵活的分子对接,可以构建 GPCR 与其配体复合的精确模型。我们在与腺苷 A(2A)受体 X 射线结构的解决协调组织的首次 GPCR 建模和对接盲评估中取得的成功也证实了这些结果。综合来看,这些数据表明:a)跨膜螺旋束的建模相当准确;b)预测配体的结合模式虽然可行,但具有挑战性;c)胞外环路和胞内环路的建模仍然存在问题。
{"title":"Modeling G Protein-Coupled Receptors: a Concrete Possibility.","authors":"Stefano Costanzi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>G protein-coupled receptors (GPCRs) are a large superfamily of membrane bound signaling proteins that are involved in the regulation of a wide range of physiological functions and constitute the most common target for therapeutic intervention. Due to the paucity of crystal structures, homology modeling has become a widespread technique for the construction of GPCR models, which have been applied to the study of their structure-function relationships and to the identification of lead ligands through virtual screening. Rhodopsin has been for years the only available template. However, recent breakthroughs in GPCR crystallography have led to the solution of the structures of a few additional receptors. In light of these newly elucidated crystal structures, we have been able to produce a substantial amount of data to demonstrate that accurate models of GPCRs in complex with their ligands can be constructed through homology modeling followed by fully flexible molecular docking. These results have been confirmed by our success in the first blind assessment of GPCR modeling and docking, organized in coordination with the solution of the X-ray structure of the adenosine A(2A) receptor. Taken together, these data indicate that: a) the transmembrane helical bundle can be modeled with considerable accuracy; b) predicting the binding mode of a ligand, although doable, is challenging; c) modeling of the extracellular and intracellular loops is still problematic.</p>","PeriodicalId":10052,"journal":{"name":"Chimica Oggi-chemistry Today","volume":"28 3","pages":"26-31"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022441/pdf/nihms226427.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29614681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Taxoid-Based Tumor-Targeting Drug Conjugates. 新型基于类taxoid的肿瘤靶向药物偶联物
Q4 Chemistry Pub Date : 2009-11-01
Manisha DAS, Edison Zuniga, Iwao Ojima

A long standing problem of conventional cancer chemotherapy is the lack of tumor specificity. Tumor-targeting drug delivery systems have been explored to overcome this problem. These systems combine a powerful cytotoxic anticancer agent with a tumor-targeting molecule via a suitable linker to form highly efficacious drug-conjugates. These conjugates can deliver potent cytotoxic drugs specifically to tumors and cancer cells with minimal systemic toxicity. This article describes the design, development and application of novel taxoid-based tumor-targeting drug-conjugates, which possess excellent specificity and efficacy in vitro and in vivo.

传统癌症化疗的一个长期存在的问题是缺乏肿瘤特异性。肿瘤靶向给药系统已被探索以克服这一问题。这些系统通过合适的连接物将强大的细胞毒性抗癌剂与肿瘤靶向分子结合,形成高效的药物偶联物。这些缀合物可以将有效的细胞毒性药物特异性地传递给肿瘤和癌细胞,并且具有最小的全身毒性。本文介绍了基于类taxoid的新型肿瘤靶向药物偶联物的设计、开发和应用,这些药物在体外和体内均具有良好的特异性和有效性。
{"title":"Novel Taxoid-Based Tumor-Targeting Drug Conjugates.","authors":"Manisha DAS,&nbsp;Edison Zuniga,&nbsp;Iwao Ojima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A long standing problem of conventional cancer chemotherapy is the lack of tumor specificity. Tumor-targeting drug delivery systems have been explored to overcome this problem. These systems combine a powerful cytotoxic anticancer agent with a tumor-targeting molecule via a suitable linker to form highly efficacious drug-conjugates. These conjugates can deliver potent cytotoxic drugs specifically to tumors and cancer cells with minimal systemic toxicity. This article describes the design, development and application of novel taxoid-based tumor-targeting drug-conjugates, which possess excellent specificity and efficacy in vitro and in vivo.</p>","PeriodicalId":10052,"journal":{"name":"Chimica Oggi-chemistry Today","volume":"27 6","pages":"54-56"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150549/pdf/nihms269849.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30060188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP). 靶向酸性病变组织:基于使用pH(低)插入肽(pHLIP)的新技术。
Q4 Chemistry Pub Date : 2009-03-01
Oleg A Andreev, Donald M Engelman, Yana K Reshetnyak

We discuss a peptide that targets cells in the acidic tissues that result from a range of pathological states, including tumours, and that can also translocate cell-impermeable cargo molecules across cell membranes in a pH-dependent manner. The technology is based on the interactions of a water-soluble membrane peptide, which we call pHLIP (pH (Low) Insertion Peptide), with the lipid bilayers of cell membranes. at the normal pH of healthy tissue it binds to cell surfaces, but at low pH pHLIP inserts as a monomer across the cell membrane to form a stable transmembrane helix. pHLIP holds promise for imaging and drug delivery applications.

我们讨论了一种针对酸性组织中由一系列病理状态(包括肿瘤)导致的细胞的肽,它也可以以ph依赖的方式跨细胞膜转运细胞不渗透的货物分子。这项技术是基于水溶性膜肽(我们称之为pHLIP(低pH插入肽))与细胞膜脂质双分子层的相互作用。在健康组织的正常pH值下,它与细胞表面结合,但在低pH值下,phillip作为单体插入细胞膜,形成稳定的跨膜螺旋。philips在成像和药物输送应用方面具有前景。
{"title":"Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP).","authors":"Oleg A Andreev,&nbsp;Donald M Engelman,&nbsp;Yana K Reshetnyak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We discuss a peptide that targets cells in the acidic tissues that result from a range of pathological states, including tumours, and that can also translocate cell-impermeable cargo molecules across cell membranes in a pH-dependent manner. The technology is based on the interactions of a water-soluble membrane peptide, which we call pHLIP (pH (Low) Insertion Peptide), with the lipid bilayers of cell membranes. at the normal pH of healthy tissue it binds to cell surfaces, but at low pH pHLIP inserts as a monomer across the cell membrane to form a stable transmembrane helix. pHLIP holds promise for imaging and drug delivery applications.</p>","PeriodicalId":10052,"journal":{"name":"Chimica Oggi-chemistry Today","volume":"27 2","pages":"34-37"},"PeriodicalIF":0.0,"publicationDate":"2009-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796806/pdf/nihms154890.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28617070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A life cycle approach to measuring sustainability 衡量可持续性的生命周期方法
Q4 Chemistry Pub Date : 2009-01-01 DOI: 10.1016/B978-0-12-409548-9.10036-3
A. Azapagic, H. Stichnothe
{"title":"A life cycle approach to measuring sustainability","authors":"A. Azapagic, H. Stichnothe","doi":"10.1016/B978-0-12-409548-9.10036-3","DOIUrl":"https://doi.org/10.1016/B978-0-12-409548-9.10036-3","url":null,"abstract":"","PeriodicalId":10052,"journal":{"name":"Chimica Oggi-chemistry Today","volume":"119 1","pages":"44-46"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90264799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Investigation of molecular recognition in biological systems using cellular membrane affinity chromatography. 利用细胞膜亲和层析技术研究生物系统中的分子识别。
Q4 Chemistry Pub Date : 2008-09-01
Irving W Wainer

Cellular membrane affinity chromatography (CMAC) columns have been created through the immobilization of cellular membrane fragments on liquid chromatographic supports. A CMAC column containing the human organic cation transporter, CMAC(hOCT1) column, has been used to study the stereoselective binding of competitive inhibitors. The chromatographic data obtained using the CMAC(hOCT1) column was to develop a pharmacophore model that described the stereoselectivity. The results indicate that a dynamic chiral recognition model based upon conformational adjustments between the inhibitors and hOCT1 is responsible for the observed steroeselectivity.

细胞膜亲和层析(CMAC)柱是通过将细胞膜片段固定在液相层析支持物上而制成的。含有人类有机阳离子转运体的 CMAC 柱(CMAC(hOCT1) 柱)被用于研究竞争性抑制剂的立体选择性结合。利用 CMAC(hOCT1) 柱获得的色谱数据建立了一个描述立体选择性的药效模型。结果表明,基于抑制剂和 hOCT1 之间构象调整的动态手性识别模型是观察到的立体选择性的原因。
{"title":"Investigation of molecular recognition in biological systems using cellular membrane affinity chromatography.","authors":"Irving W Wainer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cellular membrane affinity chromatography (CMAC) columns have been created through the immobilization of cellular membrane fragments on liquid chromatographic supports. A CMAC column containing the human organic cation transporter, CMAC(hOCT1) column, has been used to study the stereoselective binding of competitive inhibitors. The chromatographic data obtained using the CMAC(hOCT1) column was to develop a pharmacophore model that described the stereoselectivity. The results indicate that a dynamic chiral recognition model based upon conformational adjustments between the inhibitors and hOCT1 is responsible for the observed steroeselectivity.</p>","PeriodicalId":10052,"journal":{"name":"Chimica Oggi-chemistry Today","volume":"26 5 Suppl","pages":"19-22"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678806/pdf/nihms78847.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28164949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dimethyl carbonate as a green reagent 碳酸二甲酯作为绿色试剂
Q4 Chemistry Pub Date : 2007-05-15 DOI: 10.1002/9780470124086.CH4
P. Tundo
{"title":"Dimethyl carbonate as a green reagent","authors":"P. Tundo","doi":"10.1002/9780470124086.CH4","DOIUrl":"https://doi.org/10.1002/9780470124086.CH4","url":null,"abstract":"","PeriodicalId":10052,"journal":{"name":"Chimica Oggi-chemistry Today","volume":"1 1","pages":"77-102"},"PeriodicalIF":0.0,"publicationDate":"2007-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82888197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
High throughput synthesis of peptides and peptidomimetics. 高通量多肽和多肽模拟物的合成。
Q4 Chemistry Pub Date : 2006-01-01
Victor J Hruby, Josef Vagner

Peptide synthesis has been developed into one of the most efficient synthetic procedures in organic chemistry. The problems of orthogonal functional group protection and amide bond formation without racemization have been developed in a number of ingenious strategies. Optimization, in particular, has been achieved in stepwise solid phase synthesis. This in turn made possible the development of combinatorial synthesis allowing the synthesis of millions of peptide compounds of high purity in a few days. A variety of methodologies and strategies have been developed and continue to be developed to determine structures and to evaluate peptides and peptidomimetics. The development of methods for solid phase synthesis of a variety of organic and inorganic structures using similar strategies as in peptide synthesis are being vigorously pursued. However, existing instrumentation and technology is not sufficient to cover current demands for peptides, and thus new approaches and technologies for cost-effective synthesis of peptide arrays are needed.

肽合成已发展成为有机化学中最有效的合成方法之一。正交官能团保护和不外消旋形成酰胺键的问题已经在许多巧妙的策略中得到了发展。特别是在逐步固相合成中实现了优化。这反过来又使组合合成的发展成为可能,可以在几天内合成数百万种高纯度的肽化合物。各种方法和策略已经发展,并将继续发展,以确定结构和评价肽和肽拟物。人们正在大力发展固相合成各种有机和无机结构的方法,使用与肽合成类似的策略。然而,现有的仪器和技术不足以满足当前对肽的需求,因此需要新的方法和技术来经济高效地合成肽阵列。
{"title":"High throughput synthesis of peptides and peptidomimetics.","authors":"Victor J Hruby,&nbsp;Josef Vagner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Peptide synthesis has been developed into one of the most efficient synthetic procedures in organic chemistry. The problems of orthogonal functional group protection and amide bond formation without racemization have been developed in a number of ingenious strategies. Optimization, in particular, has been achieved in stepwise solid phase synthesis. This in turn made possible the development of combinatorial synthesis allowing the synthesis of millions of peptide compounds of high purity in a few days. A variety of methodologies and strategies have been developed and continue to be developed to determine structures and to evaluate peptides and peptidomimetics. The development of methods for solid phase synthesis of a variety of organic and inorganic structures using similar strategies as in peptide synthesis are being vigorously pursued. However, existing instrumentation and technology is not sufficient to cover current demands for peptides, and thus new approaches and technologies for cost-effective synthesis of peptide arrays are needed.</p>","PeriodicalId":10052,"journal":{"name":"Chimica Oggi-chemistry Today","volume":"24 4","pages":"18-21"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447911/pdf/nihms-54646.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27527002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Chimica Oggi-chemistry Today
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1