首页 > 最新文献

Geriatric Mental Health Care最新文献

英文 中文
Concerns of using the Mini-Cog to screen Chinese elders for possible dementia 使用Mini-Cog筛查中国老年人可能患痴呆症的担忧
Pub Date : 2015-12-01 DOI: 10.1016/j.gmhc.2016.03.001
Kar Choi Chan , Joel Sadavoy

Introduction

The Mini-Cog is an easy-to-administer and reliable short screen for possible dementia. It is said to have high sensitivity and specificity comparable to those of Mini Mental Status Examination (MMSE). It consists of a delayed-recall (DR) test and a distractor-clock-drawing test (CDT). A positive screen is defined as either a score of zero in the 3-item DR or a score of 1–2 in the DR combined with an abnormal CDT. The Mini-Cog is said to be relatively free of language, educational and cultural bias. However the utility of the Mini-Cog for screening ethnic elders with minimal or no education remains largely unexplored.

Methods

Ninety-six community-dwelling Chinese elders from 7 social-recreational programs in Toronto were recruited and screened by the Mini-Cog for possible dementia. The feasibility and limitations of using the Mini-Cog for screening were evaluated. Participants' feedback on the acceptability of the Mini-Cog and their resistance to future Mini-Cog screening were collected through evaluative questionnaires. Fisher Exact test was used to determine whether there was significant association between participants' refusal to attempt or complete the Mini-Cog and each of the pertinent variables namely 1) participants' literacy; 2) resistance to the Mini-Cog re-screening; 3) difficulty understanding the Mini-Cog instruction; and 4) performance on the DR part of the Mini-Cog.

Results

Of the 96 participants, 10 (10.4%) refused to attempt the CDT part of the Mini-Cog, and expressed difficulty in writing and drawing. Of those 10, 7 reported having no education and 3 minimal education. A highly significant association was found between participants' refusal to attempt CDT and illiteracy (p=7E−0; p<0.001). While participants' refusal to attempt the CDT part of the Mini-Cog appeared to be independent of their self-reported difficulty in understanding the Mini-Cog instruction or their actual DR score in screening, it was found to be significantly related to their resistance to future mini-Cog test (p=0.4958; p<0.05).

Conclusion

The results suggest that there may be limitations in the utility of the Mini-Cog for screening elders with minimal education. This concurs with earlier findings about the negative effect of illiteracy on CDT performance. Further study is needed to explore possible modifications to the distracter component of the Mini-Cog for elders who are illiterate or have a very low level of education.

Mini-Cog是一种易于管理和可靠的可能的痴呆短屏幕。据说它具有与迷你精神状态检查(MMSE)相当的高灵敏度和特异性。它由延迟回忆(DR)测试和干扰器时钟绘制测试(CDT)组成。阳性筛查定义为3项DR得分为0或DR得分为1-2并伴有异常CDT。据说,Mini-Cog相对来说没有语言、教育和文化偏见。然而,Mini-Cog在筛选受过很少教育或没有受过教育的少数民族老年人方面的效用在很大程度上仍未得到探索。方法从多伦多7个社会娱乐项目中招募96名居住在社区的华人老年人,通过Mini-Cog对可能的痴呆进行筛查。评估了使用Mini-Cog进行筛选的可行性和局限性。通过评估问卷收集参与者对Mini-Cog可接受性的反馈和对未来Mini-Cog筛查的抵制。使用Fisher精确检验来确定参与者拒绝尝试或完成Mini-Cog与每个相关变量之间是否存在显著关联,即1)参与者的读写能力;2)对Mini-Cog重筛的阻力;3)难以理解Mini-Cog指令;4) Mini-Cog的DR部分的性能。结果96例患者中有10例(10.4%)拒绝尝试Mini-Cog的CDT部分,并表现出书写和绘图困难。在这10人中,7人没有接受过教育,3人接受过最低程度的教育。参与者拒绝尝试CDT与文盲之间存在高度显著的关联(p=7E−0;术中,0.001)。虽然参与者拒绝尝试Mini-Cog的CDT部分似乎与他们自我报告的理解Mini-Cog指导的困难或他们在筛选中的实际DR分数无关,但发现它与他们对未来Mini-Cog测试的抵抗力显著相关(p=0.4958;术中,0.05)。结论Mini-Cog在低文化程度老年人筛查中的应用可能存在局限性。这与早期关于文盲对CDT表现的负面影响的发现相一致。需要进一步的研究来探索对Mini-Cog的干扰成分进行可能的修改,以适应文盲或教育水平很低的老年人。
{"title":"Concerns of using the Mini-Cog to screen Chinese elders for possible dementia","authors":"Kar Choi Chan ,&nbsp;Joel Sadavoy","doi":"10.1016/j.gmhc.2016.03.001","DOIUrl":"10.1016/j.gmhc.2016.03.001","url":null,"abstract":"<div><h3>Introduction</h3><p>The Mini-Cog is an easy-to-administer and reliable short screen for possible dementia. It is said to have high sensitivity and specificity comparable to those of Mini Mental Status Examination (MMSE). It consists of a delayed-recall (DR) test and a distractor-clock-drawing test (CDT). A positive screen is defined as either a score of zero in the 3-item DR or a score of 1–2 in the DR combined with an abnormal CDT. The Mini-Cog is said to be relatively free of language, educational and cultural bias. However the utility of the Mini-Cog for screening ethnic elders with minimal or no education remains largely unexplored.</p></div><div><h3>Methods</h3><p>Ninety-six community-dwelling Chinese elders from 7 social-recreational programs in Toronto were recruited and screened by the Mini-Cog for possible dementia. The feasibility and limitations of using the Mini-Cog for screening were evaluated. Participants' feedback on the acceptability of the Mini-Cog and their resistance to future Mini-Cog screening were collected through evaluative questionnaires. Fisher Exact test was used to determine whether there was significant association between participants' refusal to attempt or complete the Mini-Cog and each of the pertinent variables namely 1) participants' literacy; 2) resistance to the Mini-Cog re-screening; 3) difficulty understanding the Mini-Cog instruction; and 4) performance on the DR part of the Mini-Cog.</p></div><div><h3>Results</h3><p>Of the 96 participants, 10 (10.4%) refused to attempt the CDT part of the Mini-Cog, and expressed difficulty in writing and drawing. Of those 10, 7 reported having no education and 3 minimal education. A highly significant association was found between participants' refusal to attempt CDT and illiteracy (<em>p</em>=7E−0; <em>p</em>&lt;0.001). While participants' refusal to attempt the CDT part of the Mini-Cog appeared to be independent of their self-reported difficulty in understanding the Mini-Cog instruction or their actual DR score in screening, it was found to be significantly related to their resistance to future mini-Cog test (<em>p</em>=0.4958; <em>p</em>&lt;0.05).</p></div><div><h3>Conclusion</h3><p>The results suggest that there may be limitations in the utility of the Mini-Cog for screening elders with minimal education. This concurs with earlier findings about the negative effect of illiteracy on CDT performance. Further study is needed to explore possible modifications to the distracter component of the Mini-Cog for elders who are illiterate or have a very low level of education.</p></div>","PeriodicalId":100583,"journal":{"name":"Geriatric Mental Health Care","volume":"3 3","pages":"Pages 36-40"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gmhc.2016.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85563930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Antiepileptic medicine utilization in older people over a 9-year study period 一项为期9年的老年人抗癫痫药物使用研究
Pub Date : 2015-12-01 DOI: 10.1016/j.gmhc.2016.04.001
Prasad S. Nishtala, Chanaka Kaluarachchi

Background

The aim of this population-level study was to describe and characterize the utilization of AEDs in older people in New Zealand from 2005 to 2013.

Methods

De-identified individual level dispensing data for people aged 65 years and over for the period 2005–2013 were obtained from New Zealand Ministry of Health. AEDs were categorized using the ATC classification system of the WHOCC and Norwegian institute of public health. Utilization rates by year, age, sex, ethnicity and district health boards were measured as DDD per TOPD.

Results

The prevalence of AEDs utilization (DDD/TOPD) increased from 14.23 in 2005 to 14.39 in 2013. The newer AEDs increased from 0.64 in 2005 to 1.82 in 2013, but the prevalence for older AEDs decreased over the same study period from 13.59 to 12.57. AEDs utilization in males over the 9-year period was 17.18 (33.22% higher than females). Highest utilization was observed in those aged between 65 and 69 years, with average of 15.44 (28.88% higher than 85 plus age group). Sodium valproate followed by phenytoin and carbamazepine were the most common AEDs. Among the newer AEDs, gabapentin followed by lamotrigine was most frequently utilized.

Conclusion

Utilization of AEDs increased over the 9-year study period in older New Zealanders. The newer AEDs may have contributed to this increase. Further research is required to examine the utilization of AEDs by therapeutic indications.

本研究的目的是描述2005年至2013年新西兰老年人使用aed的情况。方法从新西兰卫生部获得2005-2013年65岁及以上人群的个人层面配药数据。采用世界卫生组织和挪威公共卫生研究所的ATC分类系统对aed进行分类。按年份、年龄、性别、种族和地区卫生局分列的使用率以每日每日用药/总每日用药来衡量。结果该院抗癫痫药使用率(DDD/TOPD)由2005年的14.23上升至2013年的14.39。新aed的患病率从2005年的0.64上升到2013年的1.82,但在同一研究期间,旧aed的患病率从13.59下降到12.57。9年期间,男性使用aed的比率为17.18%(比女性高33.22%)。65 ~ 69岁人群的使用率最高,平均为15.44,比85岁以上人群高28.88%。丙戊酸钠其次是苯妥英和卡马西平是最常见的AEDs。在较新的aed中,加巴喷丁和拉莫三嗪最常被使用。结论:在为期9年的研究期间,新西兰老年人对aed的使用有所增加。较新的aed可能促成了这一增长。需要进一步的研究来检查抗癫痫药的治疗指征。
{"title":"Antiepileptic medicine utilization in older people over a 9-year study period","authors":"Prasad S. Nishtala,&nbsp;Chanaka Kaluarachchi","doi":"10.1016/j.gmhc.2016.04.001","DOIUrl":"10.1016/j.gmhc.2016.04.001","url":null,"abstract":"<div><h3>Background</h3><p>The aim of this population-level study was to describe and characterize the utilization of AEDs in older people in New Zealand from 2005 to 2013.</p></div><div><h3>Methods</h3><p>De-identified individual level dispensing data for people aged 65 years and over for the period 2005–2013 were obtained from New Zealand Ministry of Health. AEDs were categorized using the ATC classification system of the WHOCC and Norwegian institute of public health. Utilization rates by year, age, sex, ethnicity and district health boards were measured as DDD per TOPD.</p></div><div><h3>Results</h3><p><span>The prevalence of AEDs utilization (DDD/TOPD) increased from 14.23 in 2005 to 14.39 in 2013. The newer AEDs increased from 0.64 in 2005 to 1.82 in 2013, but the prevalence for older AEDs decreased over the same study period from 13.59 to 12.57. AEDs utilization in males over the 9-year period was 17.18 (33.22% higher than females). Highest utilization was observed in those aged between 65 and 69 years, with average of 15.44 (28.88% higher than 85 plus age group). Sodium valproate<span> followed by phenytoin and </span></span>carbamazepine<span> were the most common AEDs. Among the newer AEDs, gabapentin<span> followed by lamotrigine was most frequently utilized.</span></span></p></div><div><h3>Conclusion</h3><p>Utilization of AEDs increased over the 9-year study period in older New Zealanders. The newer AEDs may have contributed to this increase. Further research is required to examine the utilization of AEDs by therapeutic indications.</p></div>","PeriodicalId":100583,"journal":{"name":"Geriatric Mental Health Care","volume":"3 3","pages":"Pages 41-46"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gmhc.2016.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85678700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Takotsubo Cardiomyopathy and emotion regulation: Risk and prevention 心肌病和情绪调节:风险和预防
Pub Date : 2015-12-01 DOI: 10.1016/j.gmhc.2015.12.001
Timothy R. Rice, Leon Hoffman
{"title":"Takotsubo Cardiomyopathy and emotion regulation: Risk and prevention","authors":"Timothy R. Rice,&nbsp;Leon Hoffman","doi":"10.1016/j.gmhc.2015.12.001","DOIUrl":"10.1016/j.gmhc.2015.12.001","url":null,"abstract":"","PeriodicalId":100583,"journal":{"name":"Geriatric Mental Health Care","volume":"3 3","pages":"Page 47"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gmhc.2015.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82934934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of depressive symptoms in the older population 老年人群抑郁症状的患病率
Pub Date : 2015-12-01 DOI: 10.1016/j.gmhc.2016.02.001
Man Hung , Anthony B. Crum , Jerry Bounsanga , Maren W. Voss , Wei Chen , Wendy C. Birmingham

Objectives

Depression is a major health risk factor among the older population, related to significant increases in total per person health care expenditures. Prior studies have shown significant regional variations in some clinical conditions. However, there has not been any study examining depressive symptoms across regions. The purpose of this study was to investigate the prevalence of the older population experiencing depressive symptoms across different regions in the United States.

Methods

Public data were obtained from the 2011–2014 National Health and Aging Trends Study, a longitudinal study that included a nationally representative sample of individuals aged 65 or older. Participants’ regions of residence were categorized by Northeast, Midwest, South and West census regions. A composite score of 3 or greater from the Personal Health Questionnaire-2 was used to indicate the presence of depressive symptoms. The comparison of proportion having depression across census regions were analyzed using chi-square tests.

Results

A total of 3863 participants over the age of 65 were included in this study. Of those, 1583 (41.0%) were male and 2757 (71.4%) were White. A majority of the participants (22.1%, n=852) were between 70 and 74 years old at the baseline year. Disparities in the prevalence of depressive symptoms were observed across different regions in the United States. From 2011 to 2014, depressive symptoms among this population significantly declined in the South (p<0.05) and increased significantly in the Midwest and West (p<0.05).

Conclusion

Understanding regional variations of depressive symptoms in older adults can inform the public regarding resource allocation and treatment models. By showing which areas of the US are more prone to depressive symptoms, local, state, and federal funding can be appropriated to the areas with the greatest need.

目的:抑郁症是老年人的主要健康风险因素,与人均医疗保健支出的显著增加有关。先前的研究表明,在某些临床情况下存在显著的地区差异。然而,目前还没有任何跨地区考察抑郁症状的研究。本研究的目的是调查美国不同地区经历抑郁症状的老年人口的患病率。公共数据来自2011-2014年国家健康与老龄化趋势研究,这是一项纵向研究,包括65岁或以上的全国代表性样本。参与者的居住地区按东北、中西部、南部和西部人口普查地区分类。个人健康问卷-2的综合得分为3分或更高,表明存在抑郁症状。采用卡方检验比较各人口普查地区患抑郁症的比例。结果本研究共纳入3863名65岁以上老年人。其中男性1583例(41.0%),白人2757例(71.4%)。大多数参与者(22.1%,n=852)在基线年的年龄在70 - 74岁之间。在美国不同地区观察到抑郁症状患病率的差异。2011 - 2014年,该人群抑郁症状在南部显著下降(p<0.05),在中西部和西部显著增加(p<0.05)。结论了解老年人抑郁症状的区域差异可以为资源分配和治疗模式提供依据。通过显示美国哪些地区更容易出现抑郁症状,地方、州和联邦政府就可以将资金拨给最需要的地区。
{"title":"Prevalence of depressive symptoms in the older population","authors":"Man Hung ,&nbsp;Anthony B. Crum ,&nbsp;Jerry Bounsanga ,&nbsp;Maren W. Voss ,&nbsp;Wei Chen ,&nbsp;Wendy C. Birmingham","doi":"10.1016/j.gmhc.2016.02.001","DOIUrl":"10.1016/j.gmhc.2016.02.001","url":null,"abstract":"<div><h3>Objectives</h3><p>Depression is a major health risk factor among the older population, related to significant increases in total per person health care expenditures. Prior studies have shown significant regional variations in some clinical conditions. However, there has not been any study examining depressive symptoms across regions. The purpose of this study was to investigate the prevalence of the older population experiencing depressive symptoms across different regions in the United States.</p></div><div><h3>Methods</h3><p>Public data were obtained from the 2011–2014 National Health and Aging Trends Study, a longitudinal study that included a nationally representative sample of individuals aged 65 or older. Participants’ regions of residence were categorized by Northeast, Midwest, South and West census regions. A composite score of 3 or greater from the Personal Health Questionnaire-2 was used to indicate the presence of depressive symptoms. The comparison of proportion having depression across census regions were analyzed using chi-square tests.</p></div><div><h3>Results</h3><p>A total of 3863 participants over the age of 65 were included in this study. Of those, 1583 (41.0%) were male and 2757 (71.4%) were White. A majority of the participants (22.1%, n=852) were between 70 and 74 years old at the baseline year. Disparities in the prevalence of depressive symptoms were observed across different regions in the United States. From 2011 to 2014, depressive symptoms among this population significantly declined in the South (p&lt;0.05) and increased significantly in the Midwest and West (p&lt;0.05).</p></div><div><h3>Conclusion</h3><p>Understanding regional variations of depressive symptoms in older adults can inform the public regarding resource allocation and treatment models. By showing which areas of the US are more prone to depressive symptoms, local, state, and federal funding can be appropriated to the areas with the greatest need.</p></div>","PeriodicalId":100583,"journal":{"name":"Geriatric Mental Health Care","volume":"3 3","pages":"Pages 29-35"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gmhc.2016.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83167666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Managing disruptive behaviours exhibited by older adults with mental health, addictions and neurocognitive conditions in Alberta: A mixed methods approach 管理阿尔伯塔省精神健康、成瘾和神经认知状况的老年人表现出的破坏性行为:一种混合方法
Pub Date : 2015-12-01 DOI: 10.1016/j.gmhc.2015.10.002
Suzette Brémault-Phillips , Tamara Germani , Lori-Ann R. Sacrey , Steven Friesen , Jennifer Lee

Responsive behaviours (RB's) are variable responses to an individual's environment that are disruptive to the person exhibiting the behaviour as well as to those around them. Throughout the community and continuing care service sectors, managing RB's in the resident population is an increasing concern. In Alberta at present, the magnitude or impact of RB's at a provincial level is unknown. This is significant as current healthcare policies, facilities, and programs are governed at this level. A symposium of health care providers, policy and decision makers, academics, and researchers with expertize in RB's was convened with two broad aims: (1) identify and discuss issues related to the provision of health care services for individuals across Alberta, who live and cope with RB's; and (2) to develop a plan to address this challenge across the continuum of care. The findings from the symposium highlight the readiness and need for a provincial framework/strategy to develop guiding principles to cope with RB's across conditions and ages.

反应性行为(RB)是对个人环境的可变反应,对表现出这种行为的人以及周围的人都是破坏性的。在整个社区和持续护理服务部门,管理常住人口中的RB是一个日益受到关注的问题。目前在艾伯塔省,RB在省一级的规模或影响是未知的。这一点很重要,因为当前的医疗保健政策、设施和项目都在这一级别进行管理。卫生保健提供者、政策制定者、决策者、学者和研究人员在RB's方面的专业知识召开了一次研讨会,其主要目的有两个:(1)确定和讨论与为阿尔伯塔省生活和应对RB's的个人提供卫生保健服务有关的问题;(2)制定一项计划,在整个护理过程中应对这一挑战。研讨会的调查结果强调了省级框架/战略的准备和必要性,以制定应对不同条件和年龄的RB的指导原则。
{"title":"Managing disruptive behaviours exhibited by older adults with mental health, addictions and neurocognitive conditions in Alberta: A mixed methods approach","authors":"Suzette Brémault-Phillips ,&nbsp;Tamara Germani ,&nbsp;Lori-Ann R. Sacrey ,&nbsp;Steven Friesen ,&nbsp;Jennifer Lee","doi":"10.1016/j.gmhc.2015.10.002","DOIUrl":"10.1016/j.gmhc.2015.10.002","url":null,"abstract":"<div><p>Responsive behaviours (RB's) are variable responses to an individual's environment that are disruptive to the person exhibiting the behaviour as well as to those around them. Throughout the community and continuing care service sectors, managing RB's in the resident population is an increasing concern. In Alberta at present, the magnitude or impact of RB's at a provincial level is unknown. This is significant as current healthcare policies<span>, facilities, and programs are governed at this level. A symposium of health care providers, policy and decision makers, academics, and researchers with expertize in RB's was convened with two broad aims: (1) identify and discuss issues related to the provision of health care services for individuals across Alberta, who live and cope with RB's; and (2) to develop a plan to address this challenge across the continuum of care. The findings from the symposium highlight the readiness and need for a provincial framework/strategy to develop guiding principles to cope with RB's across conditions and ages.</span></p></div>","PeriodicalId":100583,"journal":{"name":"Geriatric Mental Health Care","volume":"3 2","pages":"Pages 21-27"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gmhc.2015.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83945656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
‘Awakened Art Stories’—Rediscovering pictures by persons living with dementia utilising TimeSlips: A Pilot Study “觉醒的艺术故事”-利用TimeSlips重新发现痴呆症患者的照片:一项试点研究
Pub Date : 2015-12-01 DOI: 10.1016/j.gmhc.2015.10.001
Andrea Loizeau , Yvonne Kündig , Sandra Oppikofer

Introduction

‘Awakened Art Stories’ is the first creative expression intervention study for persons with dementia (PWD) and their caregivers. The study was conducted at the Kunsthaus Museum in Switzerland. The intervention utilised TimeSlips to encourage persons living with dementia to create stories about artwork in response to open-ended questions. The aim of this pilot study was to assess the efficacy and feasibility of an intervention through storytelling and a social gathering.

Materials and method

A mixed-method pre-post design using semi-structured interviews, written questionnaires, validated and adapted scales, and a self-generated observations' sheet as well as a visual analogue scale assessed the efficacy as well as the feasibility of the intervention. Participants were four PWDs and their caregivers as well as four volunteers, who supported the PWDs during the sessions. Qualitative data were analysed using thematic analyses and descriptive observations, as well as further feedback from participants, while a Wilcoxon signed-rank test was used to analyse quantitative data.

Results

The quantitative findings revealed a statistically significant, positive effect on PWDs' and caregivers' mood on the Smiley-Face Assessment Scale directly after the museum session (all participants: Z=−4.84, p<0.001; PWDs: Z=−3.57, p<0.001; Caregivers: Z=−3.34, p<0.001). On the Dementia Attitudes Scale, no significant differences in the caregivers' and volunteers' attitudes towards dementia were found. No significant differences were found on the Caregiver Burden Inventory either. Although the qualitative findings revealed via thematic analyses that while PWDs attributed their mood to the atmosphere, caregivers attributed it rather to social contacts. All caregivers and most of the volunteers reported a positive change in their attitude towards dementia. In addition, PWDs' reported that they welcomed the opportunity to contribute and express their thoughts. All participants were highly satisfied with their experience.

Conclusion

Despite the small sample size, the many benefits of making art accessible to PWDs and their caregivers, as well as the feasibility of an innovative intervention based on TimeSlips resulted in both quantitative and qualitative evidence.

“觉醒的艺术故事”是首个针对痴呆症患者及其照顾者的创造性表达干预研究。这项研究是在瑞士的Kunsthaus博物馆进行的。干预措施利用TimeSlips鼓励痴呆症患者创作关于艺术品的故事,以回应开放式问题。这项初步研究的目的是评估通过讲故事和社交聚会进行干预的有效性和可行性。材料和方法采用混合方法进行前后设计,采用半结构化访谈、书面问卷、经过验证和调整的量表、自行生成的观察表以及视觉模拟量表来评估干预的有效性和可行性。参加者包括四名残疾人士和他们的照顾者,以及四名在活动期间为残疾人士提供支援的义工。定性数据采用专题分析和描述性观察以及参与者的进一步反馈进行分析,而定量数据采用Wilcoxon符号秩检验进行分析。结果定量研究结果显示,在博物馆活动结束后,残疾人和照顾者的笑脸评估量表上的情绪有统计学显著的正向影响(所有参与者:Z= - 4.84, p<0.001;pwd: Z=−3.57,p<0.001;照顾者:Z=−3.34,p<0.001)。在痴呆症态度量表上,照顾者和志愿者对痴呆症的态度没有显著差异。在照顾者负担量表上也没有发现显著差异。虽然定性研究结果通过专题分析显示,虽然残疾人将他们的情绪归因于氛围,但护理人员将其归因于社会交往。所有护理人员和大多数志愿者都报告说,他们对痴呆症的态度发生了积极的变化。此外,残疾人士表示,他们欢迎有机会发表意见和表达意见。所有的参与者都对他们的经历非常满意。尽管样本量小,但让残疾人及其护理人员接触艺术的许多好处,以及基于TimeSlips的创新干预的可行性,都得到了定量和定性的证据。
{"title":"‘Awakened Art Stories’—Rediscovering pictures by persons living with dementia utilising TimeSlips: A Pilot Study","authors":"Andrea Loizeau ,&nbsp;Yvonne Kündig ,&nbsp;Sandra Oppikofer","doi":"10.1016/j.gmhc.2015.10.001","DOIUrl":"10.1016/j.gmhc.2015.10.001","url":null,"abstract":"<div><h3>Introduction</h3><p>‘Awakened Art Stories’ is the first creative expression intervention study for persons with dementia (PWD) and their caregivers. The study was conducted at the Kunsthaus Museum in Switzerland. The intervention utilised Time<em>Slips</em> to encourage persons living with dementia to create stories about artwork in response to open-ended questions. The aim of this pilot study was to assess the efficacy and feasibility of an intervention through storytelling and a social gathering.</p></div><div><h3>Materials and method</h3><p>A mixed-method pre-post design using semi-structured interviews, written questionnaires, validated and adapted scales, and a self-generated observations' sheet as well as a visual analogue scale assessed the efficacy as well as the feasibility of the intervention. Participants were four PWDs and their caregivers as well as four volunteers, who supported the PWDs during the sessions. Qualitative data were analysed using thematic analyses and descriptive observations, as well as further feedback from participants, while a Wilcoxon signed-rank test was used to analyse quantitative data.</p></div><div><h3>Results</h3><p>The quantitative findings revealed a statistically significant, positive effect on PWDs' and caregivers' mood on the Smiley-Face Assessment Scale directly after the museum session (all participants: <em>Z</em>=−4.84, <em>p</em>&lt;0.001; PWDs: <em>Z</em>=−3.57, <em>p</em>&lt;0.001; Caregivers: <em>Z</em>=−3.34, <em>p</em><span>&lt;0.001). On the Dementia Attitudes Scale, no significant differences in the caregivers' and volunteers' attitudes towards dementia were found. No significant differences were found on the Caregiver Burden Inventory either. Although the qualitative findings revealed via thematic analyses that while PWDs attributed their mood to the atmosphere, caregivers attributed it rather to social contacts. All caregivers and most of the volunteers reported a positive change in their attitude towards dementia. In addition, PWDs' reported that they welcomed the opportunity to contribute and express their thoughts. All participants were highly satisfied with their experience.</span></p></div><div><h3>Conclusion</h3><p>Despite the small sample size, the many benefits of making art accessible to PWDs and their caregivers, as well as the feasibility of an innovative intervention based on Time<em>Slips</em> resulted in both quantitative and qualitative evidence.</p></div>","PeriodicalId":100583,"journal":{"name":"Geriatric Mental Health Care","volume":"3 2","pages":"Pages 13-20"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gmhc.2015.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76862712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Emotional reaction in nursing home residents with dementia-associated apathy: A pilot study 老年痴呆症相关冷漠的养老院居民的情绪反应:一项初步研究
Pub Date : 2015-08-01 DOI: 10.1016/j.gmhc.2015.04.001
Yvonne Treusch , Julie Page , Cornelis van der Luijt , Mina Beciri , Rebeca Benitez , Maria Stammler , Valentine L. Marcar

Introduction

Conventionally apathy is defined as a symptom primarily characterized by loss of feelings and emotional display and is the most common behavioural symptom in dementia patients. Neuronal network of emotions has ceased to function in patients suffering from dementia associated apathy.

Objective and methods

We measured changes in skin conductance and heart rate from n=12 demented nursing home residents with clinical significant apathy (sumscore>40 in the Apathy Evaluation Scale, AES) to images taken from the International Affective Picture System (IAPS, Lang et al., 2008). Additionally we used autobiographical material to study the responsiveness of the neuronal network of emotions and the adequacy of somatic indicators to demonstrate emotional reactions in individuals diagnosed with dementia and apathy.

Results

Analysis of the EDA data revealed a significant difference in the change of skin conductance between the different image categories. The autobiographical material generated the largest change in skin conductance. Analysis of the heart rate did not yield any significant difference between the image categories.

Conclusions

Our findings demonstrate that the neuronal network underlying emotion is still responsive in patients diagnosed with dementia associated apathy, although residents don׳t seem to be involved emotionally from an extraneous visual focus. Non pharmacological therapy approaches should deal with individual, familiar, autobiographic material to ensure a high level of emotional response and therefore reduce apathy severity.

传统上,冷漠被定义为一种以丧失感觉和情绪表现为主要特征的症状,是痴呆患者中最常见的行为症状。在患有痴呆症相关冷漠的患者中,情绪神经网络已经停止运作。目的和方法我们测量了n=12名患有临床显著冷漠的痴呆养老院居民(冷漠评估量表,AES得分为40分)对国际情感图像系统(IAPS, Lang et al., 2008)图像的皮肤电导和心率的变化。此外,我们使用自传体材料来研究情绪神经元网络的反应性和躯体指标的充分性,以证明诊断为痴呆和冷漠的个体的情绪反应。结果EDA数据分析显示,不同图像类别的皮肤电导变化有显著差异。自传体材料对皮肤电导的影响最大。对心率的分析没有发现图像类别之间的任何显著差异。结论我们的研究结果表明,在诊断为痴呆相关冷漠的患者中,潜在情绪的神经网络仍然具有反应性,尽管患者似乎没有从外部视觉焦点中参与情绪。非药物治疗方法应该处理个体的、熟悉的、自传体的材料,以确保高水平的情绪反应,从而减少冷漠的严重程度。
{"title":"Emotional reaction in nursing home residents with dementia-associated apathy: A pilot study","authors":"Yvonne Treusch ,&nbsp;Julie Page ,&nbsp;Cornelis van der Luijt ,&nbsp;Mina Beciri ,&nbsp;Rebeca Benitez ,&nbsp;Maria Stammler ,&nbsp;Valentine L. Marcar","doi":"10.1016/j.gmhc.2015.04.001","DOIUrl":"10.1016/j.gmhc.2015.04.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Conventionally apathy is defined as a symptom primarily characterized by loss of feelings and emotional display and is the most common behavioural symptom in dementia patients. Neuronal network of emotions has ceased to function in patients suffering from dementia associated apathy.</p></div><div><h3>Objective and methods</h3><p>We measured changes in skin conductance and heart rate from <em>n</em>=12 demented nursing home residents with clinical significant apathy (sumscore&gt;40 in the Apathy Evaluation Scale, AES) to images taken from the International Affective Picture System (IAPS, <span>Lang et al., 2008</span>). Additionally we used autobiographical material to study the responsiveness of the neuronal network of emotions and the adequacy of somatic indicators to demonstrate emotional reactions in individuals diagnosed with dementia and apathy.</p></div><div><h3>Results</h3><p>Analysis of the EDA data revealed a significant difference in the change of skin conductance between the different image categories. The autobiographical material generated the largest change in skin conductance. Analysis of the heart rate did not yield any significant difference between the image categories.</p></div><div><h3>Conclusions</h3><p>Our findings demonstrate that the neuronal network underlying emotion is still responsive in patients diagnosed with dementia associated apathy, although residents don׳t seem to be involved emotionally from an extraneous visual focus. Non pharmacological therapy approaches should deal with individual, familiar, autobiographic material to ensure a high level of emotional response and therefore reduce apathy severity.</p></div>","PeriodicalId":100583,"journal":{"name":"Geriatric Mental Health Care","volume":"3 1","pages":"Pages 1-6"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gmhc.2015.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74815745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Mental disorder comorbidity and in-hospital mortality among patients with acute myocardial infarction 急性心肌梗死患者精神障碍合并症及住院死亡率
Pub Date : 2015-08-01 DOI: 10.1016/j.gmhc.2015.04.002
Minji Sohn , Daniela C. Moga , Jeffery Talbert

Objective

The purpose of this study was to examine the association between mental disorder comorbidity and in-hospital mortality, and whether subgroups of mental disorder comorbidity have differential impacts on in-hospital mortality in acute myocardial infarction (AMI) patients.

Methods

A cross-sectional study was conducted using the 2010 Nationwide Inpatient Sample (NIS) database of the Healthcare Cost and Utilization Project (HCUP). The study sample included discharges for which the primary diagnosis was AMI. As the primary exposure, the presence of any mental disorder comorbidity was identified as discharges for which one or more mental disorders listed as the non-primary diagnosis. The secondary exposure was subgroups of the mental disorder comorbidity (schizophrenia, major affective disorder, substance abuse, and other). The outcome of interest was in-hospital mortality. Logistic regression and resulting odds ratios (ORs) with associated 95% confidence intervals (CIs) were used to estimate the impact of mental disorder comorbidity on in-hospital death.

Results

A total of 42,416 discharges were included in the analysis. Of these, 16,140 (38%) had at least one diagnosis of a mental disorder. No significant differences were observed in in-hospital mortality between patients with and without mental disorder comorbidity. However, when the mental disorder comorbidity is specified into subgroups, the impact differentiated depending on the subgroup. More specifically, patients with schizophrenia were associated with increased in-hospital mortality (OR 1.72, 95% CI 1.02–2.90) and patients with substance abuse disorder were associated with decreased in-hospital mortality (OR 0.80, 95% CI 0.70–0.91). Major affective disorder and other mental disorders were not statistically significant.

Conclusions

Mental disorder comorbidity has a differential impact on post-AMI in-hospital mortality depending on the subgroup of mental disorders. We argue that mental disorder comorbidity should not be treated as a single category when assessing its impact on a health outcome.

目的探讨精神障碍共病与住院死亡率的关系,以及精神障碍共病亚组对急性心肌梗死(AMI)患者住院死亡率的差异影响。方法采用2010年医疗成本与利用项目(HCUP)全国住院患者样本(NIS)数据库进行横断面研究。研究样本包括最初诊断为AMI的出院患者。作为主要暴露,任何精神障碍共病的存在被确定为出院,其中一种或多种精神障碍被列为非主要诊断。二次暴露是精神障碍共病的亚组(精神分裂症、严重情感性障碍、药物滥用和其他)。我们关注的结果是住院死亡率。采用Logistic回归和相关95%置信区间(ci)的比值比(ORs)来估计精神障碍合并症对院内死亡的影响。结果共纳入42,416例出院病例。其中,16140人(38%)至少有一种精神障碍的诊断。有精神障碍合并症和无精神障碍合并症患者的住院死亡率无显著差异。然而,当精神障碍共病被划分为亚组时,其影响随亚组的不同而不同。更具体地说,精神分裂症患者与住院死亡率增加相关(OR 1.72, 95% CI 1.02-2.90),药物滥用障碍患者与住院死亡率降低相关(OR 0.80, 95% CI 0.70-0.91)。主要情感障碍和其他精神障碍无统计学意义。结论精神障碍共病对ami后住院死亡率的影响因精神障碍亚组而异。我们认为,在评估精神障碍共病对健康结果的影响时,不应将其视为单一类别。
{"title":"Mental disorder comorbidity and in-hospital mortality among patients with acute myocardial infarction","authors":"Minji Sohn ,&nbsp;Daniela C. Moga ,&nbsp;Jeffery Talbert","doi":"10.1016/j.gmhc.2015.04.002","DOIUrl":"10.1016/j.gmhc.2015.04.002","url":null,"abstract":"<div><h3>Objective</h3><p>The purpose of this study was to examine the association between mental disorder comorbidity and in-hospital mortality, and whether subgroups of mental disorder comorbidity have differential impacts on in-hospital mortality in acute myocardial infarction (AMI) patients.</p></div><div><h3>Methods</h3><p>A cross-sectional study was conducted using the 2010 Nationwide Inpatient Sample (NIS) database of the Healthcare Cost and Utilization Project (HCUP). The study sample included discharges for which the primary diagnosis was AMI. As the primary exposure, the presence of any mental disorder comorbidity was identified as discharges for which one or more mental disorders<span><span> listed as the non-primary diagnosis. The secondary exposure was subgroups of the mental disorder comorbidity (schizophrenia, major affective disorder, substance abuse, and other). The outcome of interest was in-hospital mortality. </span>Logistic regression and resulting odds ratios (ORs) with associated 95% confidence intervals (CIs) were used to estimate the impact of mental disorder comorbidity on in-hospital death.</span></p></div><div><h3>Results</h3><p>A total of 42,416 discharges were included in the analysis. Of these, 16,140 (38%) had at least one diagnosis of a mental disorder. No significant differences were observed in in-hospital mortality between patients with and without mental disorder comorbidity. However, when the mental disorder comorbidity is specified into subgroups, the impact differentiated depending on the subgroup. More specifically, patients with schizophrenia were associated with increased in-hospital mortality (OR 1.72, 95% CI 1.02–2.90) and patients with substance abuse disorder were associated with decreased in-hospital mortality (OR 0.80, 95% CI 0.70–0.91). Major affective disorder and other mental disorders were not statistically significant.</p></div><div><h3>Conclusions</h3><p>Mental disorder comorbidity has a differential impact on post-AMI in-hospital mortality depending on the subgroup of mental disorders. We argue that mental disorder comorbidity should not be treated as a single category when assessing its impact on a health outcome.</p></div>","PeriodicalId":100583,"journal":{"name":"Geriatric Mental Health Care","volume":"3 1","pages":"Pages 7-11"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gmhc.2015.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85307745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Needs assessment of elderly people living in Polish nursing homes 居住在波兰养老院的老年人需求评估
Pub Date : 2015-03-01 DOI: 10.1016/j.gmhc.2014.12.001
Justyna Mazurek , Dorota Szcześniak , Dorota Talarska , Katarzyna Wieczorowska-Tobis , Sylwia Kropińska , Hanna Kachaniuk , Joanna Rymaszewska

Introduction

Demographic aging of the Polish population is becoming a challenge for health and social policy, similarly to other European countries. It is also seen as one of the most important causes for developing formal long-term care.

Objective

The aim of this study was to analyse the complex needs of residents of nursing homes over 75 years old in different Polish cities from different perspectives and to explore the unmet need associations of health-related factors.

Material and methods

The sample consisted of 300 randomly selected people over 75 years old from different nursing homes in three metropolises: Wroclaw, Poznan and Lublin. The detailed needs were assessed using the CANE questionnaire and psychophysical condition was based on MMSE, GDS and BI.

Results

Comparison of needs examined from three different perspectives showed that nursing home residents reported significantly fewer problems than nursing home staff and rater and significantly more unmet needs than staff. The most common areas where unmet needs were reported were company/friends and psychological distress. Moreover, the more severe the depression and the worse the cognitive functions were, the more unmet needs were reported by nursing home residents.

Conclusions

In order to improve the care provided for elderly people, it seems necessary to promote knowledge concerning wider needs of elderly patients among the employees of different geriatric care facilites. Interventions to reduce senior׳s unmet needs should be targeted at organisational and medical assessment issues. Future studies with longitudinal follow-ups are required.

与其他欧洲国家一样,波兰人口老龄化正在成为卫生和社会政策面临的挑战。它也被视为发展正式长期护理的最重要原因之一。目的本研究旨在从不同角度分析波兰不同城市75岁以上养老院居民的复杂需求,并探讨未满足需求与健康相关因素的关联。材料和方法样本由300名随机选择的75岁以上老人组成,他们来自弗罗茨瓦夫、波兹南和卢布林三个大都市的不同养老院。使用CANE问卷评估详细需求,并基于MMSE、GDS和BI评估心理生理状况。结果三种不同角度的需求比较显示,养老院居民报告的问题明显少于养老院工作人员,未满足的需求明显多于养老院工作人员。最常见的未满足需求的领域是公司/朋友和心理困扰。此外,抑郁程度越重、认知功能越差的老人,其未满足需求的报告也越多。结论为提高老年护理水平,有必要在不同老年护理机构的工作人员中推广老年患者更广泛需求的知识。减少老年人未满足的需求的干预措施应针对组织和医疗评估问题。需要进一步的纵向随访研究。
{"title":"Needs assessment of elderly people living in Polish nursing homes","authors":"Justyna Mazurek ,&nbsp;Dorota Szcześniak ,&nbsp;Dorota Talarska ,&nbsp;Katarzyna Wieczorowska-Tobis ,&nbsp;Sylwia Kropińska ,&nbsp;Hanna Kachaniuk ,&nbsp;Joanna Rymaszewska","doi":"10.1016/j.gmhc.2014.12.001","DOIUrl":"10.1016/j.gmhc.2014.12.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Demographic aging of the Polish population is becoming a challenge for health and social policy, similarly to other European countries. It is also seen as one of the most important causes for developing formal long-term care.</p></div><div><h3>Objective</h3><p>The aim of this study was to analyse the complex needs of residents of nursing homes over 75 years old in different Polish cities from different perspectives and to explore the unmet need associations of health-related factors.</p></div><div><h3>Material and methods</h3><p>The sample consisted of 300 randomly selected people over 75 years old from different nursing homes in three metropolises: Wroclaw, Poznan and Lublin. The detailed needs were assessed using the CANE questionnaire and psychophysical condition was based on MMSE<span><span>, GDS and </span>BI.</span></p></div><div><h3>Results</h3><p><span>Comparison of needs examined from three different perspectives showed that nursing home residents reported significantly fewer problems than nursing home staff and rater and significantly more unmet needs than staff. The most common areas where unmet needs were reported were company/friends and </span>psychological distress. Moreover, the more severe the depression and the worse the cognitive functions were, the more unmet needs were reported by nursing home residents.</p></div><div><h3>Conclusions</h3><p>In order to improve the care provided for elderly people, it seems necessary to promote knowledge concerning wider needs of elderly patients among the employees of different geriatric care facilites. Interventions to reduce senior׳s unmet needs should be targeted at organisational and medical assessment issues. Future studies with longitudinal follow-ups are required.</p></div>","PeriodicalId":100583,"journal":{"name":"Geriatric Mental Health Care","volume":"2 3","pages":"Pages 9-15"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gmhc.2014.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80022635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Improvement in behavioral symptoms, motor impairment and activities of daily living in a patient with the behavioral variant of frontotemporal dementia under treatment with methylene blue 亚甲基蓝治疗额颞叶痴呆行为变异患者的行为症状、运动障碍和日常生活活动的改善
Pub Date : 2014-10-01 DOI: 10.1016/j.gmhc.2014.06.001
Georg Adler, Angelika E. Mautes

We report the effects of a treatment with methylene blue over 6 months in a 46-year-old male suffering from the behavioral variant of frontotemporal dementia. This treatment was initiated after the clinical status of the patient had deteriorated rapidly in the preceding months. After 4 months of treatment with methylene blue we observed a definite and lasting reduction of negative behavioral symptoms, an improvement in motor functions, particularly gait, and an improvement in basic activities of daily living. These improvements may be attributed to a disease-modifying effect of methylene blue, possibly mediated by its tau-filament dissolving properties.

我们报告亚甲基蓝治疗的效果超过6个月的46岁男性患有额颞叶痴呆的行为变异。这种治疗是在患者的临床状况在前几个月迅速恶化后开始的。用亚甲基蓝治疗4个月后,我们观察到负面行为症状明显而持久地减轻,运动功能,特别是步态得到改善,日常生活基本活动得到改善。这些改善可能归因于亚甲基蓝的疾病修饰作用,可能是由其tau丝溶解特性介导的。
{"title":"Improvement in behavioral symptoms, motor impairment and activities of daily living in a patient with the behavioral variant of frontotemporal dementia under treatment with methylene blue","authors":"Georg Adler,&nbsp;Angelika E. Mautes","doi":"10.1016/j.gmhc.2014.06.001","DOIUrl":"10.1016/j.gmhc.2014.06.001","url":null,"abstract":"<div><p><span>We report the effects of a treatment<span> with methylene blue<span> over 6 months in a 46-year-old male suffering from the behavioral variant of frontotemporal dementia. This treatment was initiated after the clinical status of the patient had deteriorated rapidly in the preceding months. After 4 months of treatment with methylene blue we observed a definite and lasting reduction of negative behavioral symptoms, an improvement in motor functions, particularly gait, and an improvement in basic </span></span></span>activities of daily living. These improvements may be attributed to a disease-modifying effect of methylene blue, possibly mediated by its tau-filament dissolving properties.</p></div>","PeriodicalId":100583,"journal":{"name":"Geriatric Mental Health Care","volume":"2 1","pages":"Pages 1-2"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gmhc.2014.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87994946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
期刊
Geriatric Mental Health Care
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1