Intelligent Pharmacy最新文献

Background

Arq is a traditional Unani liquid formulation. In this study we explored Arq-Makoh, Arq-Badiyan and Arq-Kasni for their pharmacological potential to alleviate the symptoms of hyperlipidaemia and obesity and develop an amalgamation with modern drugs that have clinically well reported antihyperlipidaemic and antiobesity potential.

Materials and methods

Rats were fed High Fat Diet for 4 weeks. 10 ​ml/kg of each of the three arqs were given alone and along with atorvastatin and orlistat daily for 28 days P.O. During the course of treatment body weight and food intake were carefully observed and after the end of the study, liver weight, heart weight, plasma lipid profile, blood glucose level, insulin and leptin level, serum lipase, lactate dehydrogenase, and antioxidant activity were studied in all treatment groups.

Result

Both Arqs and Atorvastatin and Orlistat significantly reduced body weight, lipid profile in HFD fed rats. Arqs when given along with Atorvastatin and Orlistat produced more significant decrease in the serum lipid profile, serum lipase, atherogenic index, lactate Dehydrogenase and TBARS compared with HFD Control group and elevated the levels of HDL-C and SOD. Apart from antihyperlipidaemic and antiobesity effects the treatment groups showed a significant reduction in elevated fasting blood glucose levels (as a result of HFD model used in the study). The above parameters were further confirmed by histopathological studies.

Conclusion

The present study indicates that Arq-Makoh, Arq-Badiyan and Arq-Kasni has lipid lowering potential and could potentiate the antihyperlipidaemic and antiobesity potential of Atorvastatin and Orlistat.

Viral outbreaks facilitated by global travel and modernity pose significant threats to global health. Influenza viruses, particularly α-influenza and β-influenza strains, have been plaguing human populations since time immemorial. Despite their long-standing impact, effective drugs are yet to be developed, and co-infection with these viruses can lead to severe health complications. In light of these challenges, this study aimed to investigate the potential antiviral molecules sourced from cyanobacteria and herbs. We conducted virtual screening using ligand-based docking to identify potential phytochemicals and cyanobacterial metabolites as candidates for further evaluation. Subsequently, pharmacophore modeling was employed to validate the binding modes of the selected compounds, followed by MM-GBSA calculations to assess their binding affinities and stabilities within the viral target. Among the molecules investigated, the cyanobacterial compound Symplocamide A (−8.042) demonstrated notable outcomes in docking than the herb molecules in the docked ligand. This finding suggests its potential as a therapeutic agent against influenza A virus proteins. Additionally, cyanobacterial molecules such as Lyngbyastatins 3 (−8.001), Lyngbyastatin G1 (−7.501), and Kempenopeptide (−6.128) exhibit stronger binding affinities and more potent docking scores, making them promising candidates for targeting viral proteins in potential therapeutic applications. The present study reveals the possibility of harnessing cyanobacterial molecules as novel antiviral agents against influenza viruses. Ultimately, we believe that this research will serve as a stepping stone in the quest for innovative drugs to combat respiratory diseases caused by viral infections.

Background

Silver nanoparticles (AgNP) are frequently utilized metallic nanoparticles in healthcare systems. In this investigation, AgNP was produced employing β-sitosterol and Woodfordia fruticosa gel for the purpose of ameliorating wound healing.

Methods

The characterization of AgNP was conducted via SEM and spectrophotometry analysis. Simultaneously, a solution with a concentration of 1 ​mM of silver nitrate was prepared by dissolving 16.99 ​mg of silver nitrate in 100 ​ml of distilled water. Subsequently, the API and the silver nitrate solution were utilized in the synthesis of silver nanoparticles. The physicochemical properties, stability, and morphology of the synthesized silver nanoparticles were evaluated through various techniques, such as zeta potential analysis and electron microscopy. These techniques were employed for the purpose of assessing the aforementioned properties. Following the gel preparation, an assessment of the gel was performed.

Result

The investigation successfully produced silver nanoparticles (AgNP) using β-sitosterol and Woodfordia fruticosa gel. To characterize the synthesized AgNP, various techniques were employed, including SEM and spectrophotometry analysis. A 1 ​mM solution of silver nitrate was prepared and used in the synthesis process, and the physicochemical properties, stability, and morphology of the AgNP were assessed through zeta potential analysis and electron microscopy.

Conclusion

The results of this study indicate the successful synthesis of silver nanoparticles using β-sitosterol and Woodfordia fruticosa gel. The characterization techniques, including SEM and spectrophotometry, confirmed the formation of AgNP. The analysis of physicochemical properties and stability, particularly through zeta potential analysis, provided valuable insights into the stability of the synthesized nanoparticles. These findings have significant implications in the context of wound healing. Silver nanoparticles have been widely studied for their potential wound healing properties due to their antimicrobial and anti-inflammatory characteristics. The utilization of natural compounds like β-sitosterol and botanical sources like Woodfordia fruticosa gel for the synthesis of AgNP is particularly promising as it may reduce potential toxicity and enhance the biocompatibility of these nanoparticles.

Microneedles (MN) have been used to deliver small molecular weight drugs, nucleotides, DNA, peptides, proteins, and even viruses that have been turned off. Over the past ten years, different kinds of MN have been made using several different production methods. Different kinds of materials have been used to make different shapes of microneedles. Using these MNs, different ways of putting drugs through the skin with microneedles have been tried. After a short introduction to microneedles for transdermal use, this review talks about the different kinds, how they are made, and recent improvements in MN delivery. In a separate part of this review, patents survey on MN using databases such as USPTO (United States Patent and Trademark Office), EPO (European Patent Office), and WIPO (World Intellectual Property Organization), etc. are discussed in detail. We talked about recent improvements to MN-based methods for getting drugs and vaccines to people. Because MN worked so well, there was a lot of interest in taking advantage of the opportunities, as patent data shows. With a current worldwide perspective, the current analysis confirms the overall evolution and unexplored areas of MN research and makes microneedle-based (trans)dermal drug delivery systems for effective therapeutic effects.

This review provides a concise overview of recent advances and future perspectives in co-processed excipients which is characterized by their synergistic combinations have become pivotal in pharmaceutical formulations. This review delves in to the latest innovations manufacturing techniques and applications of co-processed excipients. Emphasis is placed on enhanced functionality, and improved performance and the potential for addressing formulation challenges. The abstract concludes by highlighting the future prospects and emerging trends in this dynamic field ,offering valuable insights for researchers and pharmaceutical professionals alike.

Background

Revamp of liposomal preparation inimical ageing by using a splendid treasure of herbal drugs includes non-prescription and prescription upshot. Liposomal therapy stands at the forefront of cutting-edge cosmeceutical innovation. It involves a sophisticated, bi-layered delivery system designed for the precise infusion of walnut oil and tamarind seed oil into the skin. This innovative approach effectively combats the signs of ageing, whether they are the result of a sedentary lifestyle or genetic factors within one's family history.

Purpose

The current study focuses on exploring the area of traditional systems of medicine in the field of pharmaceuticals to achieve the combined effect of walnut oil [F1] and tamarind seed oil [F2] in the form of liposomal preparation against ageing.

Methods

Liposomes of walnut oil and tamarind seed oil were developed by using a rotary vacuum evaporator, and microscopy of the formulated liposomes was done using a Digicam microscope, which provided a microscopic view that both formulated liposomes are spherical, but F1 liposomes are more dense and tactile than F2, and the F2 liposomal formulation has more vesicles than F1. In-vitro drug release studies of F1 and F2 were done by diffusion cells while using a dialysis membrane with buffer medium 6.8. Further characterization techniques like SEM and FTIR were used to investigate the size range with the clear shape of the particles and to obtain a clear peak that matched the pure drug, which shows that it has retained its pharmacological properties. The final step was directed towards the preparation of topical anti-ageing cream by combining F1 and F2 to obtain the synergistic effect, and the formulation cream was successfully visualised under a projection microscope at a magnification of 10x, which reveals that spherically droplet vacuoles are present with a soft texture and a creamy, whitish colour. Last but not least, a 14-day animal study was conducted on female Swiss mice from the authorised animal laboratory departmental animal house at Integral University. The studies were conducted in 3 groups: G1 was given saline as a control, G2 was given Olay as a topical application, and G3 was given the test cream. The anti-ageing potential of the formulated cream was evaluated by skin compliance studies using UV exposure.

Results

Walnut oil and tamarind seed oil-based liposomes were formulated after placebo selection, i.e., F1 and F2, and the microscopic view of F1 sphere-shaped vesicles is larger, brighter, and more dense than F2, and the sphere-shaped vesicles of F1 and F2 contain phospholipid bilayers composed of soyalecthin, which helps to deliver drugs at a specific site. The pH of two formulations, F1 and F2, was determined by storing them at different temperatures, 350°C and 450°C. The pH resultant values were in the range of 5.8 to 6.9, which means that the fo