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Fatty acid hydratases for hydroxy fatty acid bioproduction 用于羟基脂肪酸生物生产的脂肪酸水合酶
Invention Disclosure
Pub Date : 2025-02-01 DOI: 10.1016/j.inv.2025.100037
Yu Chyuan Heng, Sandra Kittelmann
Hydroxy fatty acids are an emerging class of compounds with growing industrial and medicinal significance, yet their chemical synthesis remains challenging. Consequently, biological synthesis has been explored as an alternative approach, with fatty acid hydratases gaining considerable interest due to their mild reaction conditions and broad substrate and product ranges. The present invention introduces 21 fatty acid hydratases with varied regio-selectivity, substrate, and product scopes, and discloses methods of producing hydroxy fatty acids from unsaturated fatty acids using individual or combinations of these enzymes. The present invention offers a foundation for industrial-scale hydroxy fatty acid bioproduction, paving the way to broaden the availability and application of hydroxy fatty acids across various sectors.
羟基脂肪酸是一类新兴的化合物，具有日益增长的工业和医学意义，但它们的化学合成仍然具有挑战性。因此，生物合成已被探索作为一种替代方法，脂肪酸水合酶由于其温和的反应条件和广泛的底物和产物范围而引起了相当大的兴趣。本发明介绍了21种具有不同区域选择性、底物和产物范围的脂肪酸水合酶，并公开了使用这些酶的单独或组合从不饱和脂肪酸生产羟基脂肪酸的方法。本发明为工业规模的羟基脂肪酸生物生产奠定了基础，为扩大羟基脂肪酸在各个领域的可用性和应用铺平了道路。
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引用次数: 0
Invention Disclosure
Pub Date : 2025-01-01
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引用次数: 0
Invention Disclosure
Pub Date : 2025-01-01
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引用次数: 0
Invention Disclosure
Pub Date : 2025-01-01
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引用次数: 0
Invention Disclosure
Pub Date : 2025-01-01
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引用次数: 0
Invention Disclosure
Pub Date : 2025-01-01
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引用次数: 0
Invention Disclosure
Pub Date : 2025-01-01
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引用次数: 0
Invention Disclosure
Pub Date : 2025-01-01
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引用次数: 0
Invention Disclosure
Pub Date : 2025-01-01
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引用次数: 0
Invention Disclosure
Pub Date : 2025-01-01
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引用次数: 0
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