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Vision transformers in multi-modal brain tumor MRI segmentation: A review 多模式脑肿瘤MRI分割中的视觉变换器:综述
Pub Date : 2023-06-01 DOI: 10.1016/j.metrad.2023.100004
Pengyu Wang , Qiushi Yang , Zhibin He , Yixuan Yuan

Brain tumors have shown extreme mortality and increasing incidence during recent years, which bring enormous challenges for the timely diagnosis and effective treatment of brain tumors. Concretely, accurate brain tumor segmentation on multi-modal Magnetic Resonance Imaging (MRI) is essential and important since most normal tissues are unresectable in brain tumor surgery. In the past decade, with the explosive development of artificial intelligence technologies, a series of deep learning-based methods are presented for brain tumor segmentation and achieved excellent performance. Among them, vision transformers with non-local receptive fields show superior performance compared with the classical Convolutional Neural Networks (CNNs). In this review, we focus on the representative transformer-based works for brain tumor segmentation proposed in the last three years. Firstly, this review divides these transformer-based methods as the pure transformer methods and the hybrid transformer methods according to their transformer architectures. Then, we summarize the corresponding theoretical innovations, implementation schemes and superiorities to help readers better understand state-of-the-art transformer-based brain tumor segmentation methods. After that, we introduce the most commonly-used Brain Tumor Segmentation (BraTS) datasets, and comprehensively analyze and compare the performance of existing methods through multiple quantitative statistics. Finally, we discuss the current research challenges and describe the future research trends.

近年来,脑肿瘤死亡率极高,发病率不断上升,这给脑肿瘤的及时诊断和有效治疗带来了巨大挑战。具体来说,由于大多数正常组织在脑肿瘤手术中是不可切除的,因此在多模式磁共振成像(MRI)上准确分割脑肿瘤是至关重要的。在过去的十年里,随着人工智能技术的爆炸性发展,一系列基于深度学习的脑肿瘤分割方法被提出,并取得了优异的性能。其中,与经典的卷积神经网络(CNNs)相比,具有非局部感受野的视觉转换器表现出优越的性能。在这篇综述中,我们重点介绍了在过去三年中提出的用于脑肿瘤分割的具有代表性的基于变换器的工作。首先,本文根据变压器架构将这些基于变压器的方法分为纯变压器方法和混合变压器方法。然后,我们总结了相应的理论创新、实现方案和优势,以帮助读者更好地理解最先进的基于transformer的脑肿瘤分割方法。之后,我们介绍了最常用的脑肿瘤分割(BraTS)数据集,并通过多重定量统计对现有方法的性能进行了全面分析和比较。最后,我们讨论了当前的研究挑战,并描述了未来的研究趋势。
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引用次数: 0
Meta-Radiology: Sharing promising ideas, persisting innovative researches, and exploring new frontiers 元放射学:分享有希望的想法,坚持创新的研究,探索新的领域
Pub Date : 2023-06-01 DOI: 10.1016/j.metrad.2023.100002
Zhihong Li, Tianming Liu, Jun Liu
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引用次数: 1
Deep learning-based rigid motion correction for magnetic resonance imaging: A survey 基于深度学习的磁共振成像刚性运动校正研究综述
Pub Date : 2023-06-01 DOI: 10.1016/j.metrad.2023.100001
Yuchou Chang , Zhiqiang Li , Gulfam Saju , Hui Mao , Tianming Liu

Physiological and physical motions of the subjects, e.g., patients, are the primary sources of image artifacts in magnetic resonance imaging (MRI), causing geometric distortion, blurring, low signal-to-noise ratio, or ghosting. To overcome motion artifacts, various deep learning strategies, and models have been investigated to enable retrospective and prospective motion correction for MRI. This review article provides a survey on current deep learning-based rigid motion correction methods that have been used for MRI. Also, deep learning motion correction methods are compared to conventional motion correction methods and hybrid methods. Furthermore, we discuss the advantages and limitations of the current deep learning motion correction methods, leading to some suggestions for the future development of deep learning motion correction methods and their potential applications in improving clinical MRI.

受试者(例如患者)的生理和物理运动是磁共振成像(MRI)中图像伪影的主要来源,导致几何失真、模糊、低信噪比或重影。为了克服运动伪影,已经研究了各种深度学习策略和模型,以实现MRI的回顾性和前瞻性运动校正。这篇综述文章对目前用于MRI的基于深度学习的刚性运动校正方法进行了综述。此外,将深度学习运动校正方法与传统的运动校正方法和混合方法进行了比较。此外,我们讨论了当前深度学习运动校正方法的优势和局限性,为深度学习运动纠正方法的未来发展及其在改进临床MRI中的潜在应用提出了一些建议。
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引用次数: 2
Engineering exosomes as nanocarriers traverse the blood-brain barrier for theranostics against glioblastoma: Opportunities and challenges 工程外泌体作为纳米载体穿越血脑屏障治疗胶质母细胞瘤:机遇与挑战
Pub Date : 2023-06-01 DOI: 10.1016/j.metrad.2023.100006
Chang Li, Mohammad Javad Afshari, Jun Liu
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引用次数: 1
When brain-inspired AI meets AGI 当受大脑启发的人工智能遇到AGI时
Pub Date : 2023-06-01 DOI: 10.1016/j.metrad.2023.100005
Lin Zhao , Lu Zhang , Zihao Wu , Yuzhong Chen , Haixing Dai , Xiaowei Yu , Zhengliang Liu , Tuo Zhang , Xintao Hu , Xi Jiang , Xiang Li , Dajiang Zhu , Dinggang Shen , Tianming Liu

Artificial General Intelligence (AGI) has been a long-standing goal of humanity, with the aim of creating machines capable of performing any intellectual task that humans can do. To achieve this, AGI researchers draw inspiration from the human brain and seek to replicate its principles in intelligent machines. Brain-inspired artificial intelligence is a field that has emerged from this endeavor, combining insights from neuroscience, psychology, and computer science to develop more efficient and powerful AI systems. In this article, we provide a comprehensive overview of brain-inspired AI from the perspective of AGI. We begin with the current progress in brain-inspired AI and its extensive connection with AGI. We then cover the important characteristics for both human intelligence and AGI (e.g., scaling, multimodality, and reasoning). We discuss important technologies toward achieving AGI in current AI systems, such as in-context learning and prompt tuning. We also investigate the evolution of AGI systems from both algorithmic and infrastructural perspectives. Finally, we explore the limitations and future of AGI.

通用人工智能(AGI)一直是人类的一个长期目标,目的是创造能够执行人类所能完成的任何智力任务的机器。为了实现这一目标,AGI研究人员从人脑中汲取灵感,并试图在智能机器中复制其原理。以大脑为灵感的人工智能是这一努力中出现的一个领域,它结合了神经科学、心理学和计算机科学的见解,开发出更高效、更强大的人工智能系统。在这篇文章中,我们从AGI的角度对大脑启发的人工智能进行了全面的概述。我们从当前受大脑启发的人工智能的进展及其与AGI的广泛联系开始。然后,我们介绍了人类智能和AGI的重要特征(例如,缩放、多模态和推理)。我们讨论了在当前人工智能系统中实现AGI的重要技术,如上下文学习和即时调整。我们还从算法和基础设施的角度研究了AGI系统的演变。最后,我们探讨了AGI的局限性和未来。
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引用次数: 0
The impact of ChatGPT and LLMs on medical imaging stakeholders: Perspectives and use cases ChatGPT和llm对医学成像利益相关者的影响:观点和用例
Pub Date : 2023-06-01 DOI: 10.1016/j.metrad.2023.100007
Jiancheng Yang , Hongwei Bran Li , Donglai Wei

This study investigates the transformative potential of Large Language Models (LLMs), such as OpenAI ChatGPT, in medical imaging. With the aid of public data, these models, which possess remarkable language understanding and generation capabilities, are augmenting the interpretive skills of radiologists, enhancing patient-physician communication, and streamlining clinical workflows. The paper introduces an analytic framework for presenting the complex interactions between LLMs and the broader ecosystem of medical imaging stakeholders, including businesses, insurance entities, governments, research institutions, and hospitals (nicknamed BIGR-H). Through detailed analyses, illustrative use cases, and discussions on the broader implications and future directions, this perspective seeks to raise discussion in strategic planning and decision-making in the era of AI-enabled healthcare.

这项研究调查了大型语言模型(LLM)在医学成像中的变革潜力,如OpenAI ChatGPT。在公共数据的帮助下,这些模型具有非凡的语言理解和生成能力,增强了放射科医生的解释技能,增强了医患沟通,并简化了临床工作流程。本文介绍了一个分析框架,用于呈现LLM与更广泛的医疗成像利益相关者生态系统之间的复杂互动,包括企业、保险实体、政府、研究机构和医院(昵称为BIGR-H)。通过详细的分析、说明性的用例以及对更广泛的影响和未来方向的讨论,这一观点试图在人工智能医疗时代的战略规划和决策中引发讨论。
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引用次数: 3
Application of omics-based biomarkers in substance use disorders 基于组学的生物标志物在物质使用障碍中的应用
Pub Date : 2023-06-01 DOI: 10.1016/j.metrad.2023.100008
Longtao Yang , Lijie Zhang , Huiting Zhang , Jun Liu

Substance use disorder (SUD) is a type of addictive encephalopathy resulting from drug abuse, which leads to abnormal cerebral alterations indicating neurotoxicity that is manifested through various biomarkers. However, biological mechanisms underlying addiction are still not thoroughly explored. Omics approaches, including radiomics, connectomics, immunomics, transcriptomics, metabolomics, genomics, and proteomics, offer high-throughput means of discovering potential biological markers of SUDs. Nonetheless, omics research in addiction is dispersed, and summarization is needed to capture the general direction. This review provides an overview of omics application in SUDs and highlights dominant biomarkers that have been identified for predicting SUDs’ initiation, therapeutic responses, and targeting specific molecular targets of personalized treatment, which can help to improve the understanding of critical issues in drug addiction research.

物质使用障碍(SUD)是一种由药物滥用引起的成瘾性脑病,它会导致异常的大脑改变,表明通过各种生物标志物表现出的神经毒性。然而,成瘾的生物学机制仍然没有得到彻底的探索。组学方法,包括放射组学、连接组学、免疫组学、转录组学、代谢组学、基因组学和蛋白质组学,为发现SUD的潜在生物标志物提供了高通量手段。尽管如此,成瘾的组学研究是分散的,需要总结来把握总体方向。这篇综述概述了组学在SUDs中的应用,并强调了已确定的用于预测SUDs的启动、治疗反应和靶向个性化治疗的特定分子靶点的主要生物标志物,这有助于提高对药物成瘾研究中关键问题的理解。
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引用次数: 1
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Meta-Radiology
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