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OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation OPA1-Exon4b通过ATP调节肝癌细胞的迁移和侵袭
Mitochondrial Communications
Pub Date : 2023-01-01 DOI: 10.1016/j.mitoco.2022.08.001
Haite Tang , Zhijuan Hu , Liang Yang , Zifeng Ruan , Hao Wang , Yunhao Zhou , Feixiang Bao , Xingguo Liu

Optic Atrophy 1 (OPA1), a mitochondrial inner protein, is involved in both mitochondrial fusion dynamic and cell apoptosis. OPA1 Exon4b (OPA1-Exon4b) was reported to be downregulated in hepatocellular carcinoma (HCC). However, the relationship between OPA1-Exon4b and HCC remains unclear. Here we demonstrated that OPA1-Exon4b is related with migration using genome-wide transcriptome profiling. OPA1-Exon4b overexpression suppresses the migration and invasion, and cellular ATP production in HCC cells. The inhibition of migration and invasion by OPA1-Exon4b overexpression could be rescued by ATP addition, showing that OPA1-Exon4b suppresses the migration and invasion by decreasing ATP. We further demonstrated OPA1 overexpression induces the enlargement of mtDNA nucleoids in HCC cells. Thus, our study demonstrated a key role of OPA1-Exon4b to regulate the migration and invasion in HCC, which could provide a new prospect for the clinical diagnosis and therapy of HCC.

视神经萎缩1（OPA1）是一种线粒体内部蛋白，参与线粒体融合动力学和细胞凋亡。据报道，OPA1-Exon4b在肝细胞癌（HCC）中被下调。然而，OPA1-Exon4b与HCC之间的关系尚不清楚。在这里，我们使用全基因组转录组分析证明了OPA1-Exon4b与迁移有关。OPA1-Exon4b过表达抑制HCC细胞的迁移和侵袭以及细胞ATP的产生。OPA1-Exon4b过表达对迁移和侵袭的抑制可以通过添加ATP来挽救，表明OPA1-Exon 4b通过降低ATP来抑制迁移和侵袭。我们进一步证明了OPA1过表达诱导HCC细胞中mtDNA类核的扩增。因此，我们的研究证明了OPA1-Exon4b在HCC中调节迁移和侵袭的关键作用，这可能为HCC的临床诊断和治疗提供新的前景。
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引用次数: 0
The metabolism and function of phospholipids in Mitochondria 磷脂在线粒体中的代谢和功能
Mitochondrial Communications
Pub Date : 2023-01-01 DOI: 10.1016/j.mitoco.2022.10.002
Jun Dong , Fei Ye , Jiacheng Lin , He He, Zhiyin Song

Mitochondria are important organelles of eukaryotic cells and involved in a variety of cellular processes including oxidative phosphorylation for generating ATP, apoptosis, steroid synthesis, and signal transduction. Mitochondrion contains double membranes, which are mainly composed of phospholipids. Although mitochondria can synthesize some of phospholipids, most of phospholipids are biosynthesized in the endoplasmic reticulum (ER). ER-mitochondria contacts are required for the transfer of some phospholipids, which are critical for mitochondrial phospholipids metabolism, membrane organization and functions. In this review, we will focus on the synthesis, metabolism and function of mitochondrial phospholipids and the role of mitochondria in lipid metabolism. Additionally, we will discuss the connection between mitochondrial phospholipids disorder and human diseases.

线粒体是真核细胞的重要细胞器，参与多种细胞过程，包括产生ATP的氧化磷酸化、细胞凋亡、类固醇合成和信号转导。线粒体含有双层膜，主要由磷脂组成。尽管线粒体可以合成一些磷脂，但大多数磷脂是在内质网（ER）中生物合成的。内质网-线粒体接触是一些磷脂转移所必需的，这些磷脂对线粒体磷脂代谢、膜组织和功能至关重要。在这篇综述中，我们将重点介绍线粒体磷脂的合成、代谢和功能，以及线粒体在脂质代谢中的作用。此外，我们将讨论线粒体磷脂紊乱与人类疾病之间的联系。
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引用次数: 4
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