Pub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)70007-8
E. Al‐Chaer, Yi Feng, W. Willis
{"title":"Visceral pain: A disturbance in the sensorimotor continuum?","authors":"E. Al‐Chaer, Yi Feng, W. Willis","doi":"10.1016/S1082-3174(98)70007-8","DOIUrl":"https://doi.org/10.1016/S1082-3174(98)70007-8","url":null,"abstract":"","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"56 1","pages":"117-125"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77629474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)80042-1
Karen J. Berkley
{"title":"Lesions of the dorsal columns","authors":"Karen J. Berkley","doi":"10.1016/S1082-3174(98)80042-1","DOIUrl":"https://doi.org/10.1016/S1082-3174(98)80042-1","url":null,"abstract":"","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 3","pages":"Pages 129-134"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)80042-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91777024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)70011-X
L.‐Y. M. Huang
{"title":"Tonic release of serotonin","authors":"L.‐Y. M. Huang","doi":"10.1016/S1082-3174(98)70011-X","DOIUrl":"https://doi.org/10.1016/S1082-3174(98)70011-X","url":null,"abstract":"","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"58 1","pages":"151-154"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87495861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)70012-1
Peggy Mason, Keming Gao
We hope that our focus article as well as the commentaries by Huang, Christie, and Wessendorf will encourage the readers to consider the puzzle of serotonin's role in pain modulation. As highlighted in Huang's commentary, more research is particularly necessary with regard to serotonin's actions within the spinal cord. In designing and performing these experiments, we urge our colleagues to consider that: (1) serotonergic cells are likely to use a tonic, concentration-dependent code and (2) serotonin release is likely to modulate the effects of other neurotransmitters as well as have effects on its own.
{"title":"The identification of serotonergic neurons","authors":"Peggy Mason, Keming Gao","doi":"10.1016/S1082-3174(98)70012-1","DOIUrl":"10.1016/S1082-3174(98)70012-1","url":null,"abstract":"<div><p>We hope that our focus article as well as the commentaries by Huang, Christie, and Wessendorf will encourage the readers to consider the puzzle of serotonin's role in pain modulation. As highlighted in Huang's commentary, more research is particularly necessary with regard to serotonin's actions within the spinal cord. In designing and performing these experiments, we urge our colleagues to consider that: (1) serotonergic cells are likely to use a tonic, concentration-dependent code and (2) serotonin release is likely to modulate the effects of other neurotransmitters as well as have effects on its own.</p></div>","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 3","pages":"Pages 163-166"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)70012-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86168564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)70007-8
Elie D. Al-Chaer , Yi Feng , William D. Willis
A painful experience may be brought about by an equilibrium shift in the kinetics of the central nervous system or by the information flow in separate interactive pathways and neural centers. A number of recent studies have addressed the role of spinal pathways, in particular the dorsal column, and other alternative mechanisms in the processing and integration of visceral information into a visceral pain experience. This article reviews newly reported experimental findings and some of the historical clinical evidence that point to a role of the dorsal column in visceral pain. It proposes a shift to a goal-oriented approach to pain issues that defers speculations about the nature of pain and keeps in mind the exigency of pain relief for those who are suffering.
{"title":"Visceral pain","authors":"Elie D. Al-Chaer , Yi Feng , William D. Willis","doi":"10.1016/S1082-3174(98)70007-8","DOIUrl":"https://doi.org/10.1016/S1082-3174(98)70007-8","url":null,"abstract":"<div><p>A painful experience may be brought about by an equilibrium shift in the kinetics of the central nervous system or by the information flow in separate interactive pathways and neural centers. A number of recent studies have addressed the role of spinal pathways, in particular the dorsal column, and other alternative mechanisms in the processing and integration of visceral information into a visceral pain experience. This article reviews newly reported experimental findings and some of the historical clinical evidence that point to a role of the dorsal column in visceral pain. It proposes a shift to a goal-oriented approach to pain issues that defers speculations about the nature of pain and keeps in mind the exigency of pain relief for those who are suffering.</p></div>","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 3","pages":"Pages 117-125"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)70007-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91777023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)70009-1
MacDonald J. Christie
Mason and colleagues have developed an analytical method to reliably identify serotonergic neurons in the rostral ventromedial medulla (RVM), including the raphe magnus, during extracellular recordings in vivo. Results of these studies strongly suggest that the serotonergic neurons do not belong to the major classes of opioid-sensitive neurons phasically activated or inhibited during noxious stimuli. However, their studies have not ruled out any involvement of serotonergic RVM neurons in supraspinal opioid antinociception, and they are at odds with detailed in vitro studies of opioid mechanisms in RVM neurons. It remains possible that tonic activity serotonergic RVM neurons plays an important role in descending opioid modulation of nociception.
{"title":"Do medullary serotonergic neurons tonically modulate nociceptive transmission?","authors":"MacDonald J. Christie","doi":"10.1016/S1082-3174(98)70009-1","DOIUrl":"10.1016/S1082-3174(98)70009-1","url":null,"abstract":"<div><p>Mason and colleagues have developed an analytical method to reliably identify serotonergic neurons in the rostral ventromedial medulla (RVM), including the raphe magnus, during extracellular recordings in vivo. Results of these studies strongly suggest that the serotonergic neurons do not belong to the major classes of opioid-sensitive neurons phasically activated or inhibited during noxious stimuli. However, their studies have not ruled out any involvement of serotonergic RVM neurons in supraspinal opioid antinociception, and they are at odds with detailed in vitro studies of opioid mechanisms in RVM neurons. It remains possible that tonic activity serotonergic RVM neurons plays an important role in descending opioid modulation of nociception.</p></div>","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 3","pages":"Pages 155-158"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)70009-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89890611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)80045-7
Elie D. Al-Chaer , Yi Feng , William D. Willis
{"title":"On the brink of the philosophical ether","authors":"Elie D. Al-Chaer , Yi Feng , William D. Willis","doi":"10.1016/S1082-3174(98)80045-7","DOIUrl":"10.1016/S1082-3174(98)80045-7","url":null,"abstract":"","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 3","pages":"Pages 141-142"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)80045-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83199765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)70010-8
Martin Wessendorf
It has been proposed that serotonergic neurons do not mediate opioid analgesia, based on the observation that the firing rates of serotonergic neurons are not modulated by antinociceptive treatments such as systemic opioids or periaqueductal gray (PAG) stimulation. However, several points need to be clarified regarding the data supporting this hypothesis. These include establishing whether anesthesia has influenced the results of these experiments, whether the serotonergic neurons recorded project to the dorsal horn, and whether presynaptic effects might allow opioids to change serotonin release without changing neuronal firing rate
{"title":"The role of serotonergic neurons in nucleus raphe magnus in opioid antinociception","authors":"Martin Wessendorf","doi":"10.1016/S1082-3174(98)70010-8","DOIUrl":"10.1016/S1082-3174(98)70010-8","url":null,"abstract":"<div><p>It has been proposed that serotonergic neurons do not mediate opioid analgesia, based on the observation that the firing rates of serotonergic neurons are not modulated by antinociceptive treatments such as systemic opioids or periaqueductal gray (PAG) stimulation. However, several points need to be clarified regarding the data supporting this hypothesis. These include establishing whether anesthesia has influenced the results of these experiments, whether the serotonergic neurons recorded project to the dorsal horn, and whether presynaptic effects might allow opioids to change serotonin release without changing neuronal firing rate</p></div>","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 3","pages":"Pages 159-162"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)70010-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85529073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-09-01DOI: 10.1016/S1082-3174(98)80042-1
K. Berkley
{"title":"Lesions of the dorsal columns","authors":"K. Berkley","doi":"10.1016/S1082-3174(98)80042-1","DOIUrl":"https://doi.org/10.1016/S1082-3174(98)80042-1","url":null,"abstract":"","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"41 1","pages":"129-134"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84753066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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