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Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics最新文献

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Thyroid function tests and their alterations by drugs 甲状腺功能测试及其药物改变
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics
Pub Date : 1976-01-01 DOI: 10.1016/S0362-5486(76)80026-X
Inder J. Chopra, David H. Solomon
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引用次数: 5
Clinical use of thyrotropin-releasing hormone 促甲状腺激素释放激素的临床应用
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics
Pub Date : 1976-01-01 DOI: 10.1016/S0362-5486(76)80025-8
Clark T. Sawin, Jerome M. Hershman
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引用次数: 29
Acute and subacute thyroiditis 急性和亚急性甲状腺炎
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics
Pub Date : 1976-01-01 DOI: 10.1016/S0362-5486(76)80013-1
R. Volpe
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引用次数: 25
Treatment of hyperthyroidism in children and adolescents 儿童和青少年甲状腺机能亢进的治疗
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics
Pub Date : 1976-01-01 DOI: 10.1016/S0362-5486(76)80010-6
H. Verdain Barnes

The therapy of thyrotoxicosis in children and adolescents requires careful selection of a primary mode of therapy and secondary therapy if the hypermetabolic manifestations compromise the patient's function at home or in school. The three principle modes of primary therapy, thioamide blockade, subtotal thyroidectomy and radioiodine, are critically reviewed as to advantages, disadvantages, and results. Secondary symptomatic therapy is discussed with an emphasis on the usefulness of beta adrenergic blockade. The application of each potential mode of therapy is discussed. The etiology, natural history, and therapy of neonatal thyrotoxicosis is reviewed. The author concludes that for the majority of patients in this age group with toxic diffuse goiter, definitive thioamide therapy carries the least potential for major complications. An effective approach for utilizing methimazole is outlined.

儿童和青少年甲状腺毒症的治疗需要仔细选择主要治疗模式和次要治疗模式，如果高代谢表现损害了患者在家庭或学校的功能。主要治疗的三种主要模式，硫胺阻断，甲状腺次全切除术和放射性碘，严格审查其优点，缺点和结果。次要对症治疗的讨论，重点是有用的β肾上腺素能阻断。讨论了每种潜在治疗模式的应用。本文综述了新生儿甲状腺毒症的病因、自然史和治疗。作者的结论是，对于这个年龄组中毒性弥漫性甲状腺肿的大多数患者，明确的硫胺治疗具有最小的主要并发症的可能性。概述了一种有效利用甲巯咪唑的方法。
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引用次数: 3
Treatment of hyperthyroidism in children and adolescents 儿童和青少年甲状腺机能亢进的治疗
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics
Pub Date : 1976-01-01 DOI: 10.1016/S0362-5486(76)80010-6
H. Barnes
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引用次数: 4
Iodine-induced goiter; effects of high iodine intake on thyroid function Iodine-induced甲状腺肿;高碘摄入对甲状腺功能的影响
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics
Pub Date : 1976-01-01 DOI: 10.1016/S0362-5486(76)80005-2
Shigenobu Nagataki
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引用次数: 4
Myxedema coma
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics
Pub Date : 1976-01-01 DOI: 10.1016/S0362-5486(76)80012-X
John T. Nicoloff
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引用次数: 0
Comparative clinical pharmacology of thyroid hormones 甲状腺激素的比较临床药理学
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics
Pub Date : 1976-01-01 DOI: 10.1016/S0362-5486(76)80024-6
Herbert A. Selenkow , Leslie I. Rose
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引用次数: 2
Hyperthyroidism. Causes, etiology of Graves’ disease, clinical features, general aspects of treatment 甲状腺机能亢进。格雷夫斯病的病因、病因学、临床特点、治疗的一般方面
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics
Pub Date : 1976-01-01 DOI: 10.1016/S0362-5486(76)80027-1
David Lewis Geffner, Jerome M. Hershman

The etiology of Graves’ disease remains unknown. The leading current theory considers it to be an hereditary autoimmune disorder of both humoral and cell-mediated immunity with production of abnormal thyroid stimulators. Uncommon causes of hyperthyroidism include autonomous thyroid nodules, administration of iodine to patients with nodular goiter, subacute thyroiditis, trophoblastic tumors producing molar thyrotropin, large differentiated thyroid carcinomas, struma ovarii, pituitary tumors producing thyrotropin, and taking excessive amounts of thyroid medication.

The clinical features of hyperthyroidism are described. Subtotal thyroidectomy is effective treatment, but has the disadvantage of significant complications which include hypothyroidism, rare mortality, hypoparathyroidism, paralysis of vocal cords and altered voice, recurrence of hyperthyroidism, rare thyroid crisis and morbidity from the wound.

Graves病的病因尚不清楚。目前领先的理论认为它是一种遗传性自身免疫性疾病，包括体液和细胞介导的免疫，并产生异常的甲状腺刺激物。不常见的甲状腺功能亢进的原因包括自主甲状腺结节、结节性甲状腺肿、亚急性甲状腺炎、产生促甲状腺素的滋养细胞肿瘤、大分化甲状腺癌、卵巢瘤、产生促甲状腺素的垂体肿瘤和服用过量的甲状腺药物。本文描述了甲亢的临床特点。甲状腺次全切除术是一种有效的治疗方法，但缺点是并发症严重，包括甲状腺功能减退、死亡率低、甲状旁腺功能减退、声带麻痹和声音改变、甲状腺功能亢进复发、甲状腺危象和伤口并发症。
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引用次数: 2
The treatment of thyrotoxicosis by radioiodine 放射性碘治疗甲状腺毒症
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics
Pub Date : 1976-01-01 DOI: 10.1016/S0362-5486(76)80008-8
G. M. Wilson
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引用次数: 2
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