首页 > 最新文献

Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics最新文献

英文 中文
Testosterone as growth stimulant in man 睾酮作为男性的生长刺激剂
Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80009-5
J.J. van der Werff ten Bosch
{"title":"Testosterone as growth stimulant in man","authors":"J.J. van der Werff ten Bosch","doi":"10.1016/S0362-5486(77)80009-5","DOIUrl":"10.1016/S0362-5486(77)80009-5","url":null,"abstract":"","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 1","pages":"Pages 17-32"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80009-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87831025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Management of the eye manifestations of thyroid disease 甲状腺疾病眼部表现的处理
Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80015-0
I.R. McDougall, J.P. Kriss
{"title":"Management of the eye manifestations of thyroid disease","authors":"I.R. McDougall, J.P. Kriss","doi":"10.1016/S0362-5486(77)80015-0","DOIUrl":"10.1016/S0362-5486(77)80015-0","url":null,"abstract":"","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 1","pages":"Pages 95-111"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80015-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73993233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
The inherited errors of the thyroid system 甲状腺系统的遗传性错误
Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80003-4
John B. Stanbury, Deanna Talley

Some of the inborn errors of the thyroid system are reconsidered after reflection on old studies and in the light of some new information. The peroxidase defect is seen as at least four distinct entities with deficient iodination of tyrosyl residues of thyroglobulin as the final common expression. Three of these may be allelic for thyroid peroxidase, but the fourth, the Pendred syndrome, is almost surely not.

Present information does not seem to allow for three separate errors which in the past have been designated as ‘coupling defect’, ‘thyroglobulin synthesis defect’, and the syndrome of ‘abnormal plasma iodoprotein’.

Patients with the syndrome of thyroid hormone unresponsiveness differ in different kindreds. The disorders may or may not be allelic. Recent findings on the molecular mechanism of thyroid hormone action promise an early understanding of the nature of this disorder, perhaps as an error in the protein of nuclear chromatin which binds the hormone. Other inborn errors of the thyroid are briefly mentioned.

一些先天性的错误的甲状腺系统是反思后,在旧的研究和一些新的信息的光重新考虑。过氧化物酶缺陷被视为至少四种不同的实体,甲状腺球蛋白酪氨酸残基碘化不足是最终的共同表现。其中三种可能是甲状腺过氧化物酶的等位基因,但第四种,潘德雷德综合征,几乎可以肯定不是。目前的信息似乎不允许三种不同的错误,这三种错误在过去被指定为“偶联缺陷”、“甲状腺球蛋白合成缺陷”和“血浆碘蛋白异常”综合征。甲状腺激素无反应综合征患者类型不同。这些疾病可能是等位基因,也可能不是。最近关于甲状腺激素作用的分子机制的发现有望早期了解这种疾病的本质,可能是结合激素的核染色质蛋白质中的错误。简要地提到了甲状腺的其他先天性错误。
{"title":"The inherited errors of the thyroid system","authors":"John B. Stanbury,&nbsp;Deanna Talley","doi":"10.1016/S0362-5486(77)80003-4","DOIUrl":"10.1016/S0362-5486(77)80003-4","url":null,"abstract":"<div><p>Some of the inborn errors of the thyroid system are reconsidered after reflection on old studies and in the light of some new information. The peroxidase defect is seen as at least four distinct entities with deficient iodination of tyrosyl residues of thyroglobulin as the final common expression. Three of these may be allelic for thyroid peroxidase, but the fourth, the Pendred syndrome, is almost surely not.</p><p>Present information does not seem to allow for three separate errors which in the past have been designated as ‘coupling defect’, ‘thyroglobulin synthesis defect’, and the syndrome of ‘abnormal plasma iodoprotein’.</p><p>Patients with the syndrome of thyroid hormone unresponsiveness differ in different kindreds. The disorders may or may not be allelic. Recent findings on the molecular mechanism of thyroid hormone action promise an early understanding of the nature of this disorder, perhaps as an error in the protein of nuclear chromatin which binds the hormone. Other inborn errors of the thyroid are briefly mentioned.</p></div>","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 2","pages":"Pages 167-176"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80003-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82919333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Antiarrhythmic effects of local anesthetics and calcium antagonists 局部麻醉剂和钙拮抗剂的抗心律失常作用
Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80001-0
B.N. Singh (Director, Inpatient Cardiology, Cedars-Sinai Medical Center and Associate Professor of Medicine)
{"title":"Antiarrhythmic effects of local anesthetics and calcium antagonists","authors":"B.N. Singh (Director, Inpatient Cardiology, Cedars-Sinai Medical Center and Associate Professor of Medicine)","doi":"10.1016/S0362-5486(77)80001-0","DOIUrl":"10.1016/S0362-5486(77)80001-0","url":null,"abstract":"","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 2","pages":"Pages 125-150"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80001-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87648941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Side effects of antiarrhythmic drugs 抗心律失常药物的副作用
Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80002-2
B.N. Singh (Director, Inpatient Cardiology, Cedars-Sinai Medical Center and Associate Professor of Medicine)
{"title":"Side effects of antiarrhythmic drugs","authors":"B.N. Singh (Director, Inpatient Cardiology, Cedars-Sinai Medical Center and Associate Professor of Medicine)","doi":"10.1016/S0362-5486(77)80002-2","DOIUrl":"10.1016/S0362-5486(77)80002-2","url":null,"abstract":"","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 2","pages":"Pages 151-166"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80002-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84705075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Hypothyroidism 甲状腺功能减退
Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80004-6
H.K. Ibbertson
{"title":"Hypothyroidism","authors":"H.K. Ibbertson","doi":"10.1016/S0362-5486(77)80004-6","DOIUrl":"https://doi.org/10.1016/S0362-5486(77)80004-6","url":null,"abstract":"","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 2","pages":"Pages 177-196"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80004-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137403905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital and juvenile nongoitrous hypothyroidism 先天性和青少年非甲状腺功能减退症
Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80005-8
M. Pierre Koenig

Nongoitrous congenital and juvenile hypothyroidism is a rather common endocrine disorder occurring in approximately 1:5000–1:8500 normal children. The most frequent cause is thyroid ectopy (‘cryptothyroidism’) followed by atrophy of unknown cause and chronic atrophic thyroiditis. The clinical symptomatology is defined by disturbances of general metabolism and, most typically, by retarded somatic and mental development, leading in its extreme form when untreated, to so-called cretinism. The i treatment with thyroid hormone replacement has to be administered as early as possible. The prognosis for mental development depends on the brain damage present when treatment was started. Screening of thyroid function in neonates is the most reasonable method to make an early diagnosis.

非甲状腺性先天性和青少年甲状腺功能减退症是一种相当常见的内分泌疾病,发病率约为1:500 - 1:8500。最常见的原因是甲状腺异位(隐甲状腺症),其次是不明原因的萎缩和慢性萎缩性甲状腺炎。临床症状的定义是一般代谢紊乱,最典型的是身体和智力发育迟缓,如果不治疗,其极端形式会导致所谓的克汀病。甲状腺激素替代治疗必须尽早进行。智力发育的预后取决于治疗开始时出现的脑损伤。新生儿甲状腺功能筛查是早期诊断最合理的方法。
{"title":"Congenital and juvenile nongoitrous hypothyroidism","authors":"M. Pierre Koenig","doi":"10.1016/S0362-5486(77)80005-8","DOIUrl":"10.1016/S0362-5486(77)80005-8","url":null,"abstract":"<div><p>Nongoitrous congenital and juvenile hypothyroidism is a rather common endocrine disorder occurring in approximately 1:5000–1:8500 normal children. The most frequent cause is thyroid ectopy (‘cryptothyroidism’) followed by atrophy of unknown cause and chronic atrophic thyroiditis. The clinical symptomatology is defined by disturbances of general metabolism and, most typically, by retarded somatic and mental development, leading in its extreme form when untreated, to so-called cretinism. The i treatment with thyroid hormone replacement has to be administered as early as possible. The prognosis for mental development depends on the brain damage present when treatment was started. Screening of thyroid function in neonates is the most reasonable method to make an early diagnosis.</p></div>","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 2","pages":"Pages 197-204"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80005-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78803816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical studies of thyrotropin and thyrotropin-releasing-hormone 促甲状腺素及促甲状腺素释放激素的临床研究
Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80014-9
Michael D. Okerlund, Francis S. Greenspan

Most clinical studies with thyrotropin have utilized bovine TSH since human TSH has not been available, but more general use of the latter may be possible in the near future. The use of BTSH has been limited to stimulation testing of thyroid function, and the compound has shown lesser, but occasional, usefulness in the treatment of metastatic thyroid carcinoma.

The radioimmunoassay of HTSH has largely replaced the TSH stimulation test in the differential diagnosis of hypothyroidism and has become a valuable tool in the management of thyroid disease. More recently the availability of synthetic TRH has opened a new aspect to the understanding of hypothalamic-pituitary-thyroid interrelationships. The TRH test has also become important in the diagnosis and management of thyroid disease. The role of TRH in the therapy of hypothalamic or thyroid disease is yet to be determined and its usefulness in psychological investigations will no doubt be studied further.

大多数促甲状腺激素的临床研究都使用牛促甲状腺激素,因为还没有人促甲状腺激素,但后者在不久的将来可能会得到更广泛的应用。BTSH的使用仅限于甲状腺功能的刺激试验,该化合物在转移性甲状腺癌的治疗中显示出较少但偶尔的有用性。在甲状腺功能减退的鉴别诊断中,放射免疫法已在很大程度上取代了TSH刺激试验,成为治疗甲状腺疾病的一种有价值的工具。最近合成TRH的可用性为理解下丘脑-垂体-甲状腺相互关系开辟了一个新的方面。TRH试验在甲状腺疾病的诊断和治疗中也变得很重要。TRH在治疗下丘脑或甲状腺疾病中的作用尚未确定,其在心理学研究中的有用性无疑将进一步研究。
{"title":"Clinical studies of thyrotropin and thyrotropin-releasing-hormone","authors":"Michael D. Okerlund,&nbsp;Francis S. Greenspan","doi":"10.1016/S0362-5486(77)80014-9","DOIUrl":"10.1016/S0362-5486(77)80014-9","url":null,"abstract":"<div><p>Most clinical studies with thyrotropin have utilized bovine TSH since human TSH has not been available, but more general use of the latter may be possible in the near future. The use of BTSH has been limited to stimulation testing of thyroid function, and the compound has shown lesser, but occasional, usefulness in the treatment of metastatic thyroid carcinoma.</p><p>The radioimmunoassay of HTSH has largely replaced the TSH stimulation test in the differential diagnosis of hypothyroidism and has become a valuable tool in the management of thyroid disease. More recently the availability of synthetic TRH has opened a new aspect to the understanding of hypothalamic-pituitary-thyroid interrelationships. The TRH test has also become important in the diagnosis and management of thyroid disease. The role of TRH in the therapy of hypothalamic or thyroid disease is yet to be determined and its usefulness in psychological investigations will no doubt be studied further.</p></div>","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 1","pages":"Pages 79-94"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80014-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73983359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Use of androgens and related substances in surgical conditions including burns 在外科手术条件下使用雄激素和相关物质,包括烧伤
Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80013-7
Joseph I. Weinstein , Isaac Kaplan
{"title":"Use of androgens and related substances in surgical conditions including burns","authors":"Joseph I. Weinstein ,&nbsp;Isaac Kaplan","doi":"10.1016/S0362-5486(77)80013-7","DOIUrl":"10.1016/S0362-5486(77)80013-7","url":null,"abstract":"","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 1","pages":"Pages 65-77"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80013-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82742668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pathophysiology and pharmacotherapy of tremor 震颤的病理生理及药物治疗
Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80016-2
Donald B. Calne, Harold L. Klawans
{"title":"Pathophysiology and pharmacotherapy of tremor","authors":"Donald B. Calne,&nbsp;Harold L. Klawans","doi":"10.1016/S0362-5486(77)80016-2","DOIUrl":"10.1016/S0362-5486(77)80016-2","url":null,"abstract":"","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 1","pages":"Pages 113-123"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80016-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82406630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
期刊
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1