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Emerging role of various signaling pathways in the pathogenesis and therapeutics of atherosclerosis 各种信号通路在动脉粥样硬化发病和治疗中的新作用
Pub Date : 2017-12-01 DOI: 10.1016/j.rvm.2017.05.001
Yash Prashar, Ritu, Souravh Bais , Naresh Singh Gill

Atherosclerosis is a leading cause of mortality and morbidity in the western world. It is no longer a disease attributed mainly to the high lipid content of the body but has come to be regarded as a chronic inflammatory disease with an autoimmune component. Studies which explore the interactions between molecular and cellular elements generally focus on pathophysiologic aspect of atherosclerosis. The focus has now shifted to the novel risk factors and the genetic predisposition which has further broadened the pathogenetic mechanisms. Hence, It's high time to understand these processes in depth so that new markers and treatments which target mechanisms specially inflammation which is now the most exact cause of atherosclerosis. Moreover, the diagnosis and management is the guiding element in the understanding, progression of chronic diseases like atherosclerosis. Therefore, targeting and understanding of biochemical pathways would help in more accurate diagnosis and management of disease. Additionally, the use of antihyperlipidemic and anti-inflammatory drugs for the treatment of atherosclerosis was only possibility but it had average results. Henceforth, delving into newer areas or novel drug targets like endoglin receptor, PPARα, squalene synthase, thyroid hormone analogues, scavenger receptors, Leucotriene receptors, calcium signaling, Pentraxin, nitric oxide, heat shock proteins, Liver X Receptors, shear stress pathway, CD14, endotoxin signaling, and nuclear factor kappa B give better treatment possibilities to control the process of atherosclerosis. Therefore, the review briefly focuses on molecular mechanisms involved in the evolution of the atherosclerotic plaque and different novel targets that act at the starting stage of the plaque form to the thrombus formation in the atherosclerosis that may pave the way for selecting optimal therapies and preventing plaque complications.

动脉粥样硬化是西方世界死亡率和发病率的主要原因。它不再是一种主要归因于体内高脂含量的疾病,而是被认为是一种具有自身免疫成分的慢性炎症性疾病。研究分子和细胞之间的相互作用通常集中在动脉粥样硬化的病理生理方面。现在的重点已经转移到新的危险因素和遗传易感性,这进一步拓宽了发病机制。因此,现在是深入了解这些过程的时候了,这样新的标记和治疗就可以针对机制,特别是炎症,这是动脉粥样硬化最确切的原因。此外,诊断和管理是认识和发展动脉粥样硬化等慢性疾病的指导因素。因此,对生化途径的定位和理解将有助于更准确地诊断和管理疾病。此外,使用抗高脂血和抗炎药物治疗动脉粥样硬化是唯一的可能性,但它的结果一般。今后,内啡肽受体、PPARα、角鲨烯合成酶、甲状腺激素类似物、清道夫受体、白三烯受体、钙信号、戊曲霉素、一氧化氮、热休克蛋白、肝X受体、剪切应激途径、CD14、内毒素信号和核因子κ B等新领域或新药物靶点的深入研究,为控制动脉粥样硬化的进程提供了更好的治疗可能性。因此,本文将简要介绍参与动脉粥样硬化斑块演变的分子机制,以及在动脉粥样硬化斑块形成起始阶段起作用的不同新靶点,这可能为选择最佳治疗方法和预防斑块并发症铺平道路。
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引用次数: 19
Placenta percreta with iatrogenic megaureter: A maternal near miss case presentation 医源性胎盘测量仪:一例产妇差点漏诊的病例
Pub Date : 2017-06-01 DOI: 10.1016/j.rvm.2017.04.006
Ahmed Samy El-Agwany

Introduction

Placenta percreta, is a rare pregnancy disorder in which the placenta penetrates the uterine myometrium and can invade the surrounding organs. It is a potentially life-threatening condition with severe maternal morbidity and mortality. Both sonography and MRI are used for prenatal diagnosis of placenta accreta. Prenatal diagnosis allows management of these patients in specialized tertiary centers, where a multidisciplinary approach will improve the outcome. A team of anesthesiologist, obstetrician, urologist, neonatologist, and blood bank officer is needed for successful management of these patients.

Purpose

Management and complications of placenta percreta in rare blood group.

Methods

We present the case of a young age multigravida with placenta percreta and blood group 0 negative.

Results

She was managed by cesarean hysterectomy after bilateral internal iliac artery ligation before proceeding with placenta removal that was not recommended but aiming for excision and conservative surgical treatment with iatrogenic bladder injury and ureteral ligation that was not diagnosed intraoperative. We encountered a fullness in the retro-peritoneum that was not progressing so we considered it as hematoma but was revealed later as acute ureteric dilation from ligation. Due to poor availability of blood, she recieved limited amount. After 10 hours, she was mild hemodynamically unstable with right hydronephrosis and abdominal collection on ultrasound. She was reoperated with ureter caherterization and evacuation of hematoma. The patient was discharged 10 days after in good condition.

Conclusions

A decision between radical and conservative strategies for placenta accreta must be made based on the degree of placental infiltration and other variables: the patient's hemodynamic status and her desire to remain fertile. In our opinion, cesarean hysterectomy remains the best therapeutic option to treat placenta percreta. Radical surgery should be done for poor availability of blood especially in rare blood types in other types of placenta accreta. Fullness in the retroperitoneal space should not be ligated except after excluding ureter dilatation and confirming hematoma by aspiration and disscetion. Megaureter may be gestational or pathological from ureteric ligation that is differentiated by hydronephrosis. Internal iliac artery ligation followed by cesarean hysterectomy with no trial of removal of placenta should be done to limit blood loss in placenta percreta. Fullness of bladder after repair should be washed as may be blood clot retention from bleeding. Megaureter could be presented intraoperative within minutes of ligation of the ureter

percreta胎盘percreta胎盘是一种罕见的妊娠疾病,其胎盘穿透子宫肌层并可侵犯周围器官。这是一种可能危及生命的疾病,具有严重的孕产妇发病率和死亡率。超声和MRI均可用于胎盘增生的产前诊断。产前诊断允许在专门的三级中心管理这些患者,在那里多学科的方法将改善结果。成功管理这些患者需要一个由麻醉师、产科医生、泌尿科医生、新生儿科医生和血库官员组成的团队。目的探讨罕见血型先天性胎盘的处理及并发症。方法报告1例年轻多胎无胎盘,0型血阴性患者。结果患者在双侧髂内动脉结扎后行剖宫产子宫切除术,并行不推荐的胎盘摘除术,针对术中未确诊的医源性膀胱损伤和输尿管结扎行手术切除和保守治疗。我们在腹膜后发现了充盈,没有进展,所以我们认为是血肿,但后来发现是结扎引起的急性输尿管扩张。由于血液供应不足,她的供血量有限。10小时后,患者出现轻度血流动力学不稳定,右侧肾积水,超声显示腹部积液。再次行输尿管置管及血肿清除手术。10天后出院,病情良好。结论对于胎盘增生,应根据胎盘浸润程度及患者血流动力学状况、生育意愿等因素综合考虑,选择根治性或保守性治疗方案。在我们看来,剖宫产子宫切除术仍然是治疗percreta的最佳选择。对于血液供应不足,特别是罕见血型的其他类型的胎盘,应进行根治性手术。腹膜后间隙的充盈不应结扎,除非排除输尿管扩张并通过抽吸和剥离确认血肿。输尿管结扎可能是妊娠性的,也可能是病理性的。髂内动脉结扎后剖宫产子宫切除术,不应进行胎盘切除试验,以限制percreta胎盘的失血。膀胱修复后的充盈应冲洗,因为可能有血块因出血而滞留。输尿管结扎术中几分钟内和几小时后,由于肾积水双肾不对称,血压计可以出现。膀胱修复可以由妇科医生来做,但输尿管结扎最好由泌尿科医生来做。在子宫切除术前应考虑通过目视评估或剥离或在非常靠近子宫颈的地方进行子宫切除术,特别是全子宫切除术。
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引用次数: 0
Multiple interrupted uterine transverse compression sutures with uterine artery ligation: A simple technique for intraoperative bleeding from abnormal placentation and atonic lower uterine segment 子宫动脉结扎术中多次中断子宫横压缝合术:术中胎盘异常及子宫下段无张力出血的简单方法
Pub Date : 2017-06-01 DOI: 10.1016/j.rvm.2017.04.004
Ahmed Samy El-Agwany

Introduction

Fertility preserving surgery is rarely performed in placenta accreta and atonic thinned out lower uterine segment is frequently encountered.

Aim

To evaluate our new method of uterine conservation in abnormal placentation and oozing from the lower uterine segment.

Methods

Multiple interrupted uterine plicating transverse compression sutures with combined multiple level uterine artery ligation were performed over 24 cases.

Results

Six cases were excluded for hemodynamic instability and placenta percreta. It was sucessful in all cases of thinned out lower segment and placenta previa but failed in two cases of placenta accreta.

Conclusion

Conservative management for atonic lower uterine segment and abnormal placentation through modified transverse B-lynch suture can be performed with high success and conserving female fertility.

保留生育能力的手术很少用于胎盘增生,子宫下段无张力变薄是常见的。目的探讨子宫下段异常胎盘及渗液的保存新方法。方法对24例患者行多段间断子宫折叠横压缝合联合多段子宫动脉结扎术。结果6例因血流动力学不稳定和percreta胎盘排除。下节段变薄和前置胎盘均成功,2例胎盘增生失败。结论改良B-lynch横缝保守治疗子宫下段无张力及异常胎盘成功率高,可有效保护女性生育能力。
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引用次数: 2
Identification of vein graft stenosis and assessment of sustainability of outcomes: Two sides of the same coin in vein graft surveillance 静脉移植物狭窄的识别和结果可持续性的评估:同一枚硬币在静脉移植物监测中的两面
Pub Date : 2017-06-01 DOI: 10.1016/j.rvm.2017.04.002
Matthew Thomas, Reza Mofidi

Autologous veins are the conduit of choice when performing an infra-inguinal arterial bypass procedure. However these grafts are at risk of failure. This is multifactorial in nature and relates to patient factors, factors relating to the procedure as well as adaptive processes which occur after the formation of an infrainguinal bypass graft. Duplex ultrasound assessment of haemodynamic findings within the graft is the most accurate method of identifying vein graft stenosis and identifying grafts which are at risk of failure. Duplex ultrasound examination findings together with clinical factors can be used to individualise vein graft surveillance. This review examines the steps involved in a successful vein graft surveillance program, how to optimise the cost utility of vein graft surveillance by identifying the grafts which are at highest risk of failure and how there has been a paradigm shift away from surgical revision and towards endovascular revision of failing infrainguinal grafts.

自体静脉是腹股沟下动脉旁路手术的首选导管。然而,这些移植物有失败的危险。这本质上是多因素的,与患者因素、与手术相关的因素以及腹股沟下旁路移植术形成后发生的适应性过程有关。双工超声对移植物内血流动力学结果的评估是识别静脉移植物狭窄和识别移植物有失败风险的最准确方法。双超声检查结果与临床因素可用于个体化静脉移植监测。这篇综述探讨了成功的静脉移植物监测项目所涉及的步骤,如何通过识别最高失败风险的移植物来优化静脉移植物监测的成本效用,以及如何从手术翻修到血管内翻修失败的腹股沟下移植物的模式转变。
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引用次数: 0
Placental polyps with uterine vascular malformation mimics: Management dilemma 胎盘息肉伴子宫血管畸形:治疗困境
Pub Date : 2017-06-01 DOI: 10.1016/j.rvm.2017.04.001
Ahmed Samy El-Agwany

Purpose

Abnormal uterine bleeding after abortion or delivery requires special management. Sonography with clinical and laboratory findings are important to narrow the differential diagnoses. Presence of increased uterine vascularity and arteriovenous shunting can be detected in retained trophoblastic tissue, gestational trophoblastic disease, and placental polyps and uterine vascular malformation are mainly related to failure of detection of associated pathology in the uterus on ultrasound. Here we are describing to both as a same entity for simplicity.

Methods and results

We present two cases of placental polyp with uterine vascular malformation, one case after abortion and the other case after vaginal delivery. The first case was multiparous female complaining of abnormal uterine bleeding three month after delivery. Ultrasound revealed diffuse uterine vascularity with echogenic vascular mass with blood flow velocity less than 40 cm/s that was evacuated and packed using hysteroscopy. The second case was also multiparus female complaining of abnormal uterine bleeding two months after abortion. Ultrasound revealed abnormal vascularity from perimetrium to the endmometrial mass. Hysteroscopic removal of the mass was done. Both patients were discharged after two days with menses resumed regularly afterwards.

Conclusions

Uterine vascular malformations may be associated with heavy bleeding. They should be suspected on ultrasound with anechoic structures with positive Doppler signal. Dilatation and curettage is therapeutic for evacuation of placental polyps but can induce massive, life-threatening bleeding in cases with uterine arteriovenous shunting or malfomration (AVM), thus it should be done with caution in endometrial pathology with high velocity flow more than 40 cm/s as infection and adhesions are associated. Treatment of uterine AVM varies from medical management (hormonal therapy), minimally invasive uterine artery embolization to more definitive surgical hysterectomy, depending upon age of the patient, size, site of the lesion, and the desire to retain future fertility.

目的流产或分娩后子宫异常出血需要特殊处理。超声与临床和实验室结果是重要的缩小鉴别诊断。保留的滋养层组织中可发现子宫血管增多和动静脉分流,妊娠滋养层疾病、胎盘息肉和子宫血管畸形主要与超声未能发现子宫相关病理有关。这里为了简单起见,我们将两者描述为同一个实体。方法与结果报告2例胎盘息肉合并子宫血管畸形,1例发生于人工流产,1例发生于阴道分娩。第一例为多胎女性,产后3个月主诉子宫异常出血。超声示子宫弥漫性血管,伴回声性血管团块,血流速度小于40 cm/s,宫腔镜下抽离填充。第二个病例也是多胎女性,在流产后两个月出现子宫异常出血。超声显示从子宫四周到子宫内膜肿块的血管异常。经宫腔镜切除肿块。两天后出院,月经恢复正常。结论子宫血管畸形可能与大出血有关。当超声伴有多普勒阳性的无回声结构时,应予以怀疑。子宫扩张刮除术对于胎盘息肉的清除是一种治疗方法,但在子宫动静脉分流或畸形(AVM)的情况下,可能会导致大量危及生命的出血,因此在子宫内膜病理学中,高速血流超过40 cm/s时应谨慎进行,因为感染和粘连相关。子宫AVM的治疗方法多种多样,包括药物治疗(激素治疗)、微创子宫动脉栓塞到更明确的手术子宫切除术,这取决于患者的年龄、大小、病变部位和保留未来生育能力的愿望。
{"title":"Placental polyps with uterine vascular malformation mimics: Management dilemma","authors":"Ahmed Samy El-Agwany","doi":"10.1016/j.rvm.2017.04.001","DOIUrl":"10.1016/j.rvm.2017.04.001","url":null,"abstract":"<div><h3>Purpose</h3><p>Abnormal uterine bleeding after abortion or delivery requires special management. Sonography with clinical and laboratory findings are important to narrow the differential diagnoses. Presence of increased uterine vascularity and arteriovenous shunting can be detected in retained trophoblastic tissue, gestational trophoblastic disease, and placental polyps and uterine vascular malformation are mainly related to failure of detection of associated pathology in the uterus on ultrasound. Here we are describing to both as a same entity for simplicity.</p></div><div><h3>Methods and results</h3><p>We present two cases of placental polyp with uterine vascular malformation, one case after abortion and the other case after vaginal delivery. The first case was multiparous female complaining of abnormal uterine bleeding three month after delivery. Ultrasound revealed diffuse uterine vascularity with echogenic vascular mass with blood flow velocity less than 40<!--> <!-->cm/s that was evacuated and packed using hysteroscopy. The second case was also multiparus female complaining of abnormal uterine bleeding two months after abortion. Ultrasound revealed abnormal vascularity from perimetrium to the endmometrial mass. Hysteroscopic removal of the mass was done. Both patients were discharged after two days with menses resumed regularly afterwards.</p></div><div><h3>Conclusions</h3><p>Uterine vascular malformations may be associated with heavy bleeding. They should be suspected on ultrasound with anechoic structures with positive Doppler signal. Dilatation and curettage is therapeutic for evacuation of placental polyps but can induce massive, life-threatening bleeding in cases with uterine arteriovenous shunting or malfomration (AVM), thus it should be done with caution in endometrial pathology with high velocity flow more than 40<!--> <!-->cm/s as infection and adhesions are associated. Treatment of uterine AVM varies from medical management (hormonal therapy), minimally invasive uterine artery embolization to more definitive surgical hysterectomy, depending upon age of the patient, size, site of the lesion, and the desire to retain future fertility.</p></div>","PeriodicalId":101091,"journal":{"name":"Reviews in Vascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rvm.2017.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80682875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Postpartum purpura fulminans 产后暴发性紫癜
Pub Date : 2017-06-01 DOI: 10.1016/j.rvm.2017.04.005
Ahmed Samy El-Agwany

Purpura Fulminans is a severe disorder of acute onset with high morbidity and mortality. Purpura fulminans (PF) is a hematological emergency in which there is skin necrosis and disseminated intravascular coagulation. This may progress rapidly to multi-organ failure caused by thrombotic occlusion of small and medium-sized blood vessels. PF may complicate severe sepsis. It most often occurs with sudden appearance of symmetrical, tender, ecchymotic skin lesions usually involving the lower extremities. Early recognition and early therapy with appropriate antibiotics and heparin is known to limit both morbidity and mortality. This article reports a case of Purpura Fulminans presented with DIC after hemorrhagic shock of postpartum hemorrhage.

暴发性紫癜是一种急性发作的严重疾病,发病率和死亡率高。暴发性紫癜(PF)是一种血液学急症,其中有皮肤坏死和弥散性血管内凝血。这可能迅速发展为多器官功能衰竭引起血栓闭塞的中小血管。PF可使严重败血症复杂化。它最常发生与突然出现对称,柔软,淤血的皮肤病变,通常累及下肢。已知早期识别和早期使用适当的抗生素和肝素治疗可以限制发病率和死亡率。本文报告一例暴发性紫癜,产后出血失血性休克后表现为DIC。
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引用次数: 1
Cutaneous small vessel vasculitis of the lower legs 小腿皮肤小血管炎
Pub Date : 2017-04-11 DOI: 10.1016/J.RVM.2017.04.003
M. Papi
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引用次数: 0
Modeling vasomotion 建模vasomotion
Pub Date : 2017-03-01 DOI: 10.1016/j.rvm.2016.10.001
A. Fasano , A. Farina , A. Caggiati

The phenomenon of vasomotion, consisting in periodic oscillations of blood vessels walls is particularly important at the scale of small vessels and exhibits different features in arterioles (in which flow is mainly driven by the hydraulic pressure gradient) and in venules provided with valves preventing back flow and helping centripetal hematic propulsion. Here we formulate a model for both situations, based on approximations of the flow equations implied by the smallness of the radius-to-length ratio. For venules we postulate the presence of an inlet and an outlet valve and we show that the model reproduces the periodic pressure pulses that have been detected in the experimental literature devoted to venules of the batwing.

We have developed a model for describing the vasomotion, i.e. the flow in oscillating arterioles and oscillating venules. In arterioles vasomotion has little effect while in venules equipped with valves contraction-expansion cycles exert a propulsive action on the blood. The model reproduces reasonably well the data reported in the experimental literature.

血管舒张现象由血管壁的周期性振荡组成,在小血管尺度上尤为重要,并且在小动脉(其流动主要由水压梯度驱动)和具有防止回流和帮助向心血液推进的瓣膜的小静脉中表现出不同的特征。在这里,我们为这两种情况制定了一个模型,基于由半径与长度比的小所暗示的流动方程的近似值。对于小静脉,我们假设存在一个入口和一个出口阀,并且我们表明该模型再现了在专门研究蝙蝠翼小静脉的实验文献中检测到的周期性压力脉冲。我们已经开发了一个模型来描述血管运动,即振荡小动脉和振荡小静脉的流动。在小动脉中,血管运动几乎没有影响,而在装有瓣膜的小静脉中,收缩-扩张循环对血液有推进作用。该模型较好地再现了实验文献中报告的数据。
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引用次数: 0
WITHDRAWN: Etiology and mechanisms of age-related arterial stiffening 年龄相关性动脉硬化的病因和机制
Pub Date : 2016-12-08 DOI: 10.1016/J.RVM.2016.12.001
N. Boutagy, T. Werner
{"title":"WITHDRAWN: Etiology and mechanisms of age-related arterial stiffening","authors":"N. Boutagy, T. Werner","doi":"10.1016/J.RVM.2016.12.001","DOIUrl":"https://doi.org/10.1016/J.RVM.2016.12.001","url":null,"abstract":"","PeriodicalId":101091,"journal":{"name":"Reviews in Vascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72859696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-thrombotic syndrome – Recent aspects of prevention, diagnosis and clinical management 血栓形成后综合征-预防,诊断和临床管理的最新方面
Pub Date : 2016-09-01 DOI: 10.1016/j.rvm.2016.07.001
Takashi Yamaki

Post-thrombotic syndrome (PTS) is the most frequent chronic complication of acute deep vein thrombosis (DVT). However, gaps in our current understanding of the risk factors, diagnostic criteria, preventive strategies, and even treatment modalities for PTS prevent clinicians from employing measures that could reduce the occurrence of this disorder and the associated morbidity. This review provides an overview of the important elements of PTS, including recent multifaceted aspects related to its definition, pathophysiology, risk factors, prevention and management.

血栓形成后综合征(PTS)是急性深静脉血栓形成(DVT)最常见的慢性并发症。然而,我们目前对PTS的危险因素、诊断标准、预防策略甚至治疗方式的理解存在差距,这使得临床医生无法采取措施减少这种疾病的发生和相关的发病率。本文综述了PTS的重要组成部分,包括其定义、病理生理学、危险因素、预防和管理等方面的最新进展。
{"title":"Post-thrombotic syndrome – Recent aspects of prevention, diagnosis and clinical management","authors":"Takashi Yamaki","doi":"10.1016/j.rvm.2016.07.001","DOIUrl":"10.1016/j.rvm.2016.07.001","url":null,"abstract":"<div><p>Post-thrombotic syndrome (PTS) is the most frequent chronic complication of acute deep vein thrombosis (DVT). However, gaps in our current understanding of the risk factors, diagnostic criteria, preventive strategies, and even treatment modalities for PTS prevent clinicians from employing measures that could reduce the occurrence of this disorder and the associated morbidity. This review provides an overview of the important elements of PTS, including recent multifaceted aspects related to its definition, pathophysiology, risk factors, prevention and management.</p></div>","PeriodicalId":101091,"journal":{"name":"Reviews in Vascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rvm.2016.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84703856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
期刊
Reviews in Vascular Medicine
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