Revista Portuguesa de Pneumologia (English Edition)最新文献

英文中文

Atypical pyoderma gangrenosum simulating pectoral abscess managed using negative pressure wound therapy 非典型脓皮坏疽性胸脓肿应用负压创面治疗

Revista Portuguesa de Pneumologia (English Edition)

Pub Date : 2017-09-01 DOI: 10.1016/j.rppnen.2017.05.007

J. Soro-García, E.M. García-Fontán, R. Carrasco-Rodríguez, M. Blanco-Ramos, M.A. Cañizares-Carretero

引用次数: 1

Diagnostic yield of transbronchial lung cryobiopsy in interstitial lung diseases 经支气管肺低温活检对间质性肺疾病的诊断价值

Revista Portuguesa de Pneumologia (English Edition)

Pub Date : 2017-09-01 DOI: 10.1016/j.rppnen.2017.07.002

R. Marçôa , R. Linhas , D. Apolinário , S. Campainha , A. Oliveira , C. Nogueira , A. Loureiro , J. Almeida , F. Costa , X. Wen , S. Neves

引用次数: 8

Analysis of sarcoidosis in the Oporto region (Portugal) 葡萄牙波尔图地区结节病分析

Revista Portuguesa de Pneumologia (English Edition)

Pub Date : 2017-09-01 DOI: 10.1016/j.rppnen.2017.05.004

A.V. Cardoso , P.C. Mota , N. Melo , S. Guimarães , C. Souto Moura , J.M. Jesus , R. Cunha , A. Morais

Background

Sarcoidosis is a systemic granulomatous disease of unknown etiology. Epidemiological studies of different populations are essential because clinical presentation, organ involvement, disease severity, and prognosis vary significantly according to region and population. The aim of this study was to assess epidemiological and clinical characteristics, staging factors, and clinical course in patients with sarcoidosis from a tertiary hospital in Oporto, Portugal.

Methods

A retrospective analysis of patients with sarcoidosis and at least 2 years of follow-up evaluated at the Centro Hospitalar de São João between 2000 and 2014.

Results

We identified 409 patients with sarcoidosis (females, 58.9%; mean age at diagnosis, 38.9 ± 13.4 years; smokers, 14.4%]. All the patients were diagnosed according to the ERS/ATS/WASOG consensus statement and 64.1% had evidence of noncaseating epithelioid cell granulomas in biopsy specimens. Bronchoalveolar lavage was performed as part of the diagnostic work-up in 289 patients and 90.2% had lymphocytosis (CD4/CD8 ratio ≥ 3.5 in 60.9% of cases). Exertion dyspnea, cough, and constitutional symptoms were the most common presenting symptoms; 10.1% of patients were asymptomatic, 22.8% had Löfgren syndrome, and 50.5% had extrathoracic involvement. Radiographic stages of disease according to the Scadding criteria were as follows: stage 0 (5.2%), stage I (33.7%), stage II (47.0%), stage III (8.4%), and stage IV (5.7%). Impaired respiratory function was observed in 45.6% patients and was mostly mild. Systemic treatment was administered in 58.6% of cases. Overall, 45.3% of patients experienced disease resolution.

Conclusion

The epidemiological and clinical characteristics of this cohort of patients with sarcoidosis from the Oporto region in northern Portugal revealed epidemiological and clinical characteristics that were generally similar to those described in other Western Europe populations and in the US ACCESS study. However, we found a higher proportion of patients who progressed to chronic forms.

背景:结节病是一种病因不明的系统性肉芽肿性疾病。不同人群的流行病学研究是必要的，因为临床表现、器官受累、疾病严重程度和预后因地区和人群而有显著差异。本研究的目的是评估葡萄牙波尔图一家三级医院结节病患者的流行病学和临床特征、分期因素和临床病程。方法回顾性分析2000年至2014年在奥约中心医院接受随访至少2年的结节病患者。结果409例结节病患者(女性，58.9%;平均诊断年龄38.9±13.4岁;烟民,14.4%)。所有患者的诊断均符合ERS/ATS/WASOG共识声明，64.1%的患者活检标本中有非干酪化上皮样细胞肉芽肿的证据。289例患者进行支气管肺泡灌洗作为诊断检查的一部分，90.2%的患者有淋巴细胞增多(60.9%的病例中CD4/CD8比值≥3.5)。用力呼吸困难、咳嗽和体质症状是最常见的症状;10.1%的患者无症状，22.8%有Löfgren综合征，50.5%有胸外受累。scadd标准的x线分期为:0期(5.2%)、I期(33.7%)、II期(47.0%)、III期(8.4%)和IV期(5.7%)。45.6%患者呼吸功能受损，且多为轻度。58.6%的病例接受了全身治疗。总体而言，45.3%的患者经历了疾病缓解。结论来自葡萄牙北部波尔图地区的结节病患者的流行病学和临床特征与其他西欧人群和美国ACCESS研究中描述的流行病学和临床特征大致相似。然而，我们发现进展为慢性形式的患者比例较高。

{"title":"Analysis of sarcoidosis in the Oporto region (Portugal)","authors":"A.V. Cardoso , P.C. Mota , N. Melo , S. Guimarães , C. Souto Moura , J.M. Jesus , R. Cunha , A. Morais","doi":"10.1016/j.rppnen.2017.05.004","DOIUrl":"10.1016/j.rppnen.2017.05.004","url":null,"abstract":"<div><h3>Background</h3><p>Sarcoidosis is a systemic granulomatous disease of unknown etiology. Epidemiological studies of different populations are essential because clinical presentation, organ involvement, disease severity, and prognosis vary significantly according to region and population. The aim of this study was to assess epidemiological and clinical characteristics, staging factors, and clinical course in patients with sarcoidosis from a tertiary hospital in Oporto, Portugal.</p></div><div><h3>Methods</h3><p>A retrospective analysis of patients with sarcoidosis and at least 2 years of follow-up evaluated at the Centro Hospitalar de São João between 2000 and 2014.</p></div><div><h3>Results</h3><p>We identified 409 patients with sarcoidosis (females, 58.9%; mean age at diagnosis, 38.9±13.4 years; smokers, 14.4%]. All the patients were diagnosed according to the ERS/ATS/WASOG consensus statement and 64.1% had evidence of noncaseating epithelioid cell granulomas in biopsy specimens. Bronchoalveolar lavage was performed as part of the diagnostic work-up in 289 patients and 90.2% had lymphocytosis (CD4/CD8 ratio ≥3.5 in 60.9% of cases). Exertion dyspnea, cough, and constitutional symptoms were the most common presenting symptoms; 10.1% of patients were asymptomatic, 22.8% had Löfgren syndrome, and 50.5% had extrathoracic involvement. Radiographic stages of disease according to the Scadding criteria were as follows: stage 0 (5.2%), stage I (33.7%), stage II (47.0%), stage III (8.4%), and stage IV (5.7%). Impaired respiratory function was observed in 45.6% patients and was mostly mild. Systemic treatment was administered in 58.6% of cases. Overall, 45.3% of patients experienced disease resolution.</p></div><div><h3>Conclusion</h3><p>The epidemiological and clinical characteristics of this cohort of patients with sarcoidosis from the Oporto region in northern Portugal revealed epidemiological and clinical characteristics that were generally similar to those described in other Western Europe populations and in the US ACCESS study. However, we found a higher proportion of patients who progressed to chronic forms.</p></div>","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.05.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35099805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Pulmonary tuberculosis: Resistance pattern to first line anti-tuberculosis drugs in the Coimbra District, 2000–2011 肺结核:2000-2011年科英布拉地区一线抗结核药物的耐药性模式

Revista Portuguesa de Pneumologia (English Edition)

Pub Date : 2017-09-01 DOI: 10.1016/j.rppnen.2016.04.001

R. Eufrásio , M. Alcobia , L. Correia

引用次数: 3

Impact of bariatric surgery in obstructive sleep apnea in obese patients 减肥手术对肥胖患者阻塞性睡眠呼吸暂停的影响。

Revista Portuguesa de Pneumologia (English Edition)

Pub Date : 2017-09-01 DOI: 10.1016/j.rppnen.2016.01.008

I.M. Guerreiro , M. Branco , S. Moreira , J. Valença

引用次数: 2

Allergic bronchopulmonary aspergillosis treated successfully with omalizumab 奥玛珠单抗成功治疗过敏性支气管肺曲霉病

Revista Portuguesa de Pneumologia (English Edition)

Pub Date : 2017-09-01 DOI: 10.1016/j.rppnen.2017.05.006

R. Aguiar , N.P. Fernandes , A. Lopes , C. Lopes

引用次数: 2

The frequency of lung cancer in patients with pulmonary hamartomas: An evaluation of clinical, radiological, and pathological features and follow-up data of 96 patients with pulmonary hamartomas 肺错构瘤患者肺癌的发生频率:96例肺错构瘤患者的临床、影像学、病理特征及随访资料的评价

Revista Portuguesa de Pneumologia (English Edition)

Pub Date : 2017-09-01 DOI: 10.1016/j.rppnen.2017.04.008

G.H. Ekinci , O. Hacıömeroğlu , A. Ersev , L. Alpay , H. Özgen , A. Yılmaz

Purpose

To investigate the frequency of lung cancer in patients with pulmonary hamartomas and to evaluate clinical, radiological, and pathological characteristics of pulmonary hamartomas.

Basic procedures

We reviewed pathology records of pulmonary hamartomas diagnosed between 2003 and 2014. Medical records and the hospital electronic database were also reviewed for each patient to obtain clinical, radiological, and pathological characteristics of pulmonary hamartomas and accompanying malignancies.

Main findings

Ninety-six patients with pulmonary hamartomas were identified. There were 26 females (27%) and 70 males (73%), with a mean age of 56.2 years (range 22–87 years). Malignancies were detected in 23 patients (24%), which developed previously in five patients (1 synchronous, 4 metachronous lesions), and concomitantly in 18 patients (with origin from the lung in 17 patients and from the pleura in 1 patient).

Principal conclusions

Our results show that patients with pulmonary hamartomas may have coexisting lung malignancies.

目的探讨肺错构瘤患者发生肺癌的频率，探讨肺错构瘤的临床、影像学和病理特点。我们回顾了2003年至2014年间诊断的肺错构瘤的病理记录。我们还查阅了每位患者的医疗记录和医院电子数据库，以获得肺错构瘤及其伴随的恶性肿瘤的临床、放射学和病理特征。主要发现肺错构瘤96例。女性26例(27%)，男性70例(73%)，平均年龄56.2岁(22 ~ 87岁)。23例患者(24%)检测到恶性肿瘤，其中5例患者(1例同步病变，4例异时病变)发生过恶性肿瘤，18例患者伴有恶性肿瘤(17例起源于肺部，1例起源于胸膜)。结论肺错构瘤患者可能同时存在肺部恶性肿瘤。

{"title":"The frequency of lung cancer in patients with pulmonary hamartomas: An evaluation of clinical, radiological, and pathological features and follow-up data of 96 patients with pulmonary hamartomas","authors":"G.H. Ekinci , O. Hacıömeroğlu , A. Ersev , L. Alpay , H. Özgen , A. Yılmaz","doi":"10.1016/j.rppnen.2017.04.008","DOIUrl":"10.1016/j.rppnen.2017.04.008","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate the frequency of lung cancer in patients with pulmonary hamartomas and to evaluate clinical, radiological, and pathological characteristics of pulmonary hamartomas.</p></div><div><h3>Basic procedures</h3><p>We reviewed pathology records of pulmonary hamartomas diagnosed between 2003 and 2014. Medical records and the hospital electronic database were also reviewed for each patient to obtain clinical, radiological, and pathological characteristics of pulmonary hamartomas and accompanying malignancies.</p></div><div><h3>Main findings</h3><p>Ninety-six patients with pulmonary hamartomas were identified. There were 26 females (27%) and 70 males (73%), with a mean age of 56.2 years (range 22–87 years). Malignancies were detected in 23 patients (24%), which developed previously in five patients (1 synchronous, 4 metachronous lesions), and concomitantly in 18 patients (with origin from the lung in 17 patients and from the pleura in 1 patient).</p></div><div><h3>Principal conclusions</h3><p>Our results show that patients with pulmonary hamartomas may have coexisting lung malignancies.</p></div>","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.04.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35058193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Does omalizumab impair glucose homeostasis in a patient with severe persistent asthma and type 2 diabetes mellitus? omalizumab是否会损害严重持续性哮喘和2型糖尿病患者的葡萄糖稳态?

Revista Portuguesa de Pneumologia (English Edition)

Pub Date : 2017-09-01 DOI: 10.1016/j.rppnen.2017.05.002

S. Hamada , A. Kuroe , M. Tsukino

引用次数: 5

Effects of exposure to biomass burning on pulmonary inflammatory markers and pulmonary function in individuals with COPD 暴露于生物质燃烧对COPD患者肺部炎症标志物和肺功能的影响

Revista Portuguesa de Pneumologia (English Edition)

Pub Date : 2017-09-01 DOI: 10.1016/j.rppnen.2017.04.003

D. Ramos , M. Proença , M.R. Leite , A.D. Ferreira , I.B. Trevisan , G.F.S. Brígida , G.Y. Tacao , E.M.C. Ramos

Introduction

Pulmonary rehabilitation (PR) has many benefits for individuals with COPD. However, it is not clear whether PR could prevent the hazards of air pollution exposure. This study aimed to analyze the effects of biomass burning exposure on pulmonary inflammatory markers and pulmonary function in individuals with COPD, participants and non-participants of PR.

Methods

35 subjects were divided into three groups: individuals with COPD who received PR (G1, n = 15), those who did not (G2, n = 10), and a control group composed of healthy individuals without COPD (CG, n = 10). Measurements of lung function and concentrations of IL-6, IL-10, and TNF-α in exhaled breath condensate samples were collected. The assessment and concentrations of particulate matter (PM₁₀), nitrogen dioxide (NO₂), ozone (O₃), temperature (T), and relative air humidity (RAH) were recorded in biomass burning and non-burning periods.

Results

There was a significant increase in the concentrations of air pollutants in the biomass burning period. In this period, an increase in IL-6 (G1p = 0.041, G2 p = .012), and a reduction in the FEV₁/FVC ratio (G1p = 0.021, G2 p = .007) were observed in individuals with COPD. In G1, the increase in IL-6 concentrations correlated positively with O₃ (r = 0.693; p = .006), and negatively with RAH (r = −0.773; p = .003) in the burning period.

Conclusions

Individuals with COPD exposed to biomass burning demonstrated increased pulmonary inflammation and a reduction in the FEV₁/FVC ratio, regardless of their engagement in PR.

肺康复(PR)对慢性阻塞性肺病患者有许多好处。然而，目前尚不清楚公共关系是否可以防止空气污染的危害。本研究旨在分析生物质燃烧暴露对COPD患者、PR参与者和非PR参与者肺部炎症标志物和肺功能的影响。方法35名受试者分为三组:接受PR的COPD患者(G1, n = 15)，未接受PR的患者(G2, n = 10)，以及由非COPD健康个体组成的对照组(CG, n = 10)。测量呼出液样本的肺功能和IL-6、IL-10、TNF-α浓度。记录了生物质燃烧和非燃烧时期的颗粒物(PM10)、二氧化氮(NO2)、臭氧(O3)、温度(T)和相对空气湿度(RAH)的评估和浓度。结果生物质燃烧期大气污染物浓度明显升高。在此期间，COPD患者IL-6升高(G1p = 0.041, G2 p = 0.012)， FEV1/FVC比值降低(G1p = 0.021, G2 p = 0.007)。G1期，IL-6浓度升高与O3呈正相关(r = 0.693;p = 0.006)，与RAH呈负相关(r = - 0.773;P = .003)。结论:暴露于生物质燃烧的COPD个体表现出肺部炎症增加和FEV1/FVC比率降低，无论他们是否参与PR。

{"title":"Effects of exposure to biomass burning on pulmonary inflammatory markers and pulmonary function in individuals with COPD","authors":"D. Ramos , M. Proença , M.R. Leite , A.D. Ferreira , I.B. Trevisan , G.F.S. Brígida , G.Y. Tacao , E.M.C. Ramos","doi":"10.1016/j.rppnen.2017.04.003","DOIUrl":"10.1016/j.rppnen.2017.04.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Pulmonary rehabilitation (PR) has many benefits for individuals with COPD. However, it is not clear whether PR could prevent the hazards of air pollution exposure. This study aimed to analyze the effects of biomass burning exposure on pulmonary inflammatory markers and pulmonary function in individuals with COPD, participants and non-participants of PR.</p></div><div><h3>Methods</h3><p>35 subjects were divided into three groups: individuals with COPD who received PR (G1, <em>n</em>  =10), and a control group composed of healthy individuals without COPD (CG, <em>n</em>    =.012), and a reduction in the FEV<sub>1</sub>/FVC ratio (G1p=0.021, G2 <em>p</em>  =0.693; <em>p</em>  =−0.773; <em>p</em>  <!-->.003) in the burning period.</p></div><div><h3>Conclusions</h3><p>Individuals with COPD exposed to biomass burning demonstrated increased pulmonary inflammation and a reduction in the FEV<sub>1</sub>/FVC ratio, regardless of their engagement in PR.</p></div>","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.04.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35099804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Are we ready to get in the eye of the storm? 我们准备好进入风暴中心了吗?

Revista Portuguesa de Pneumologia (English Edition)

Pub Date : 2017-09-01 DOI: 10.1016/j.rppnen.2017.08.004

A. Morais (Editor-in-Chief)

引用次数: 2

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Revista Portuguesa de Pneumologia (English Edition)

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀