Pub Date : 2017-03-25DOI: 10.3969/CJCNN.V17I3.1566
Fu-rong Gu, Xiao-ling Yan, J. Qin, Xiao-lin Xu
Objective To study the clinical manifestations, imaging and pathological features, treatment and prognosis of 5 patients diagnosed as demyelinating pseudotumor (DPT) by pathology. Methods The data of clinical features, radiological and histological examination of 5 patients with DPT were retrospectively analyzed, and relevant literatures were reviewed. Results All patients were male. Main symptoms included limb weakness in 3 cases, dizziness and impaired memory in 2 cases, seizures in one case. Head MRI examination revealed space-occupying lesions with hypointense signal on T 1 WI, hyperintense signal on T 2 WI and FLAIR. Enhanced MRI showed obvious enhancement of lesions (open-ring enhancement in 3 cases). The lesion were totally (4 cases) or partially (one case) removed, and postoperative histological examination showed inflammatory demyelination. One case died after twice relapse, and others had favorable prognosis. Conclusions DPT is an inflammatory demyelination with mass effect. It should be differentiated from central nervous system tumors in order to avoid unnecessary resection or radiotherapy. DOI: 10.3969/j.issn.1672-6731.2017.03.010
{"title":"Clinical analysis of five cases of demyelinating pseudotumor","authors":"Fu-rong Gu, Xiao-ling Yan, J. Qin, Xiao-lin Xu","doi":"10.3969/CJCNN.V17I3.1566","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I3.1566","url":null,"abstract":"Objective To study the clinical manifestations, imaging and pathological features, treatment and prognosis of 5 patients diagnosed as demyelinating pseudotumor (DPT) by pathology. Methods The data of clinical features, radiological and histological examination of 5 patients with DPT were retrospectively analyzed, and relevant literatures were reviewed. Results All patients were male. Main symptoms included limb weakness in 3 cases, dizziness and impaired memory in 2 cases, seizures in one case. Head MRI examination revealed space-occupying lesions with hypointense signal on T 1 WI, hyperintense signal on T 2 WI and FLAIR. Enhanced MRI showed obvious enhancement of lesions (open-ring enhancement in 3 cases). The lesion were totally (4 cases) or partially (one case) removed, and postoperative histological examination showed inflammatory demyelination. One case died after twice relapse, and others had favorable prognosis. Conclusions DPT is an inflammatory demyelination with mass effect. It should be differentiated from central nervous system tumors in order to avoid unnecessary resection or radiotherapy. DOI: 10.3969/j.issn.1672-6731.2017.03.010","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"214-222"},"PeriodicalIF":0.0,"publicationDate":"2017-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46454002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-25DOI: 10.3969/CJCNN.V17I3.1565
Yinghua Xia, Xiao-dong Kong, P. Lei, Shi-shuang Zhang, Ming-yi Zhang, Zilong Zhao, X. Ge
Objective To observe the protective effect of nerve growth factor (NGF) on apoptosis of primary cultured rat hippocampal neurons which were induced by glucocorticoids. Methods The neurons isolated from the hippocampus of 18 neonatal Wister rats were cultured in vitro. Methyl thiazolyl tetrazolium (MTT) analysis was used to detect the lowest concentration of dexamethasone-induced hippocampal neuronal apoptosis, so as to explore the protective effect of different concentrations of NGF on 0.10 × 10 6 mol/L dexamethasone-induced hippocampal neuronal apoptosis. Results Compared with negative control group, the activity of rat hippocampal neurons was reduced significantly in dexamethasone Ⅰ (10 × 10 6 mol/L), Ⅱ (1 × 10 6 mol/L) and Ⅲ (0.10 × 10 6 mol/L) groups ( P = 0.000, 0.000, 0.000). After different concentrations of NGF were given, the activity of hippocampal neurons in NGF 0.18 ng/ml group was significantly lower than negative control group ( P = 0.000) and positive control group ( P = 0.010), while the activity of hippocampal neurons in NGF 18 ng/ml group was significantly higher than positive control group ( P = 0.000) and NGF 0.18 ng/ml group ( P = 0.000). Conclusions Glucocorticoids can induce the apoptosis of in vitro cultured rat hippocampal neurons, and 0.10 × 10 6 mol/L dexamethasone is the lowest sensitive dose. NGF plays a role of blocking dexamethasone-induced apoptosis. DOI: 10.3969/j.issn.1672-6731.2017.03.009
{"title":"Protective effect of nerve growth factor on glucocorticoid-induced apoptosis of primary cultured rat hippocampal neurons","authors":"Yinghua Xia, Xiao-dong Kong, P. Lei, Shi-shuang Zhang, Ming-yi Zhang, Zilong Zhao, X. Ge","doi":"10.3969/CJCNN.V17I3.1565","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I3.1565","url":null,"abstract":"Objective To observe the protective effect of nerve growth factor (NGF) on apoptosis of primary cultured rat hippocampal neurons which were induced by glucocorticoids. Methods The neurons isolated from the hippocampus of 18 neonatal Wister rats were cultured in vitro. Methyl thiazolyl tetrazolium (MTT) analysis was used to detect the lowest concentration of dexamethasone-induced hippocampal neuronal apoptosis, so as to explore the protective effect of different concentrations of NGF on 0.10 × 10 6 mol/L dexamethasone-induced hippocampal neuronal apoptosis. Results Compared with negative control group, the activity of rat hippocampal neurons was reduced significantly in dexamethasone Ⅰ (10 × 10 6 mol/L), Ⅱ (1 × 10 6 mol/L) and Ⅲ (0.10 × 10 6 mol/L) groups ( P = 0.000, 0.000, 0.000). After different concentrations of NGF were given, the activity of hippocampal neurons in NGF 0.18 ng/ml group was significantly lower than negative control group ( P = 0.000) and positive control group ( P = 0.010), while the activity of hippocampal neurons in NGF 18 ng/ml group was significantly higher than positive control group ( P = 0.000) and NGF 0.18 ng/ml group ( P = 0.000). Conclusions Glucocorticoids can induce the apoptosis of in vitro cultured rat hippocampal neurons, and 0.10 × 10 6 mol/L dexamethasone is the lowest sensitive dose. NGF plays a role of blocking dexamethasone-induced apoptosis. DOI: 10.3969/j.issn.1672-6731.2017.03.009","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"209-213"},"PeriodicalIF":0.0,"publicationDate":"2017-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41754445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-25DOI: 10.3969/cjcnn.v17i3.1562
Si-wei Liu, Min Guan, Bao-jin Li, Cheng Li, Q. Gao
Objective To discuss the efficacy and safety of fastigial nucleus stimulation (FNS) in the treatment of post-stroke sleep disorders (PSSD). Methods A total of 69 cases with PSSD were randomly divided into 3 groups: control group (N = 23), sham group (N = 23) and treatment group (N = 23). Control group received routine treatment, sham group received routine treatment plus sham FNS treatment, and treatment group received routine treatment plus FNS treatment. Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality of patients in 3 groups before and after 4-week treatment. Adverse reactions during the FNS treatment were also observed. Results There was statistical significance in PSQI scores among 3 groups before and after 4-week treatment ( P = 0.020). PSQI score after 4-week treatment in treatment group was significantly lower than control group and sham group ( P = 0.000, 0.000). Compared to before treatment, PSQI scores were significantly decreased in 3 groups after 4-week treatment ( P = 0.000). Conclusions FNS safely and effectively improves the sleep quality of patients with PSSD, thus it can be used as one of the auxiliary treatments for curing PSSD. DOI: 10.3969/j.issn.1672-6731.2017.03.006
{"title":"Clinical study on treating post-stroke sleep disorders by fastigial nucleus stimulation","authors":"Si-wei Liu, Min Guan, Bao-jin Li, Cheng Li, Q. Gao","doi":"10.3969/cjcnn.v17i3.1562","DOIUrl":"https://doi.org/10.3969/cjcnn.v17i3.1562","url":null,"abstract":"Objective To discuss the efficacy and safety of fastigial nucleus stimulation (FNS) in the treatment of post-stroke sleep disorders (PSSD). Methods A total of 69 cases with PSSD were randomly divided into 3 groups: control group (N = 23), sham group (N = 23) and treatment group (N = 23). Control group received routine treatment, sham group received routine treatment plus sham FNS treatment, and treatment group received routine treatment plus FNS treatment. Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality of patients in 3 groups before and after 4-week treatment. Adverse reactions during the FNS treatment were also observed. Results There was statistical significance in PSQI scores among 3 groups before and after 4-week treatment ( P = 0.020). PSQI score after 4-week treatment in treatment group was significantly lower than control group and sham group ( P = 0.000, 0.000). Compared to before treatment, PSQI scores were significantly decreased in 3 groups after 4-week treatment ( P = 0.000). Conclusions FNS safely and effectively improves the sleep quality of patients with PSSD, thus it can be used as one of the auxiliary treatments for curing PSSD. DOI: 10.3969/j.issn.1672-6731.2017.03.006","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"192-196"},"PeriodicalIF":0.0,"publicationDate":"2017-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46818562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-25DOI: 10.3969/CJCNN.V17I3.1563
Min Guan, Si-wei Liu, Bao-jin Li, Cheng Li, Yun Qu
Objective To explore the effect of motor relearning programme (MRP) on motor function recovery of patients with hemiplegia after acute stroke. Methods A total of 64 hemiplegic patients with acute stroke (duration ≤ 14 d) were randomly divided into 2 groups: control group (N = 32) and observation group (N = 32). Control group received routine drug therapy and conventional rehabilitation training, and observation group was treated by routine therapy and MRP training. Fugl-Meyer Assessment Scale - Balance (FMA - Balance), Modified Rivermead Mobility Index (MRMI) and modified Barthel Index (mBI) were used to assess the motor function of patients in both groups before and after treatment. Results All patients successfully completed the rehabilitation training without severe adverse events. A few patients felt fatigue occasionally after training and recovered after rest. Compared to before treatment, the FMA-Balance score ( P = 0.000), MRMI score ( P = 0.000) and mBI score ( P = 0.000) after treatment in both groups were significantly increased. Compared to control group, the FMA-Balance score ( P = 0.031), MRMI score ( P = 0.013) and mBI score ( P = 0.049) after treatment in observation group were significantly increased. Conclusions MRP training in the early stage of stroke is beneficial to the recovery of motor function of patients. DOI: 10.3969/j.issn.1672-6731.2017.03.007
{"title":"Effect of motor relearning programme on motor function recovery of acute stroke patients with hemiplegia","authors":"Min Guan, Si-wei Liu, Bao-jin Li, Cheng Li, Yun Qu","doi":"10.3969/CJCNN.V17I3.1563","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I3.1563","url":null,"abstract":"Objective To explore the effect of motor relearning programme (MRP) on motor function recovery of patients with hemiplegia after acute stroke. Methods A total of 64 hemiplegic patients with acute stroke (duration ≤ 14 d) were randomly divided into 2 groups: control group (N = 32) and observation group (N = 32). Control group received routine drug therapy and conventional rehabilitation training, and observation group was treated by routine therapy and MRP training. Fugl-Meyer Assessment Scale - Balance (FMA - Balance), Modified Rivermead Mobility Index (MRMI) and modified Barthel Index (mBI) were used to assess the motor function of patients in both groups before and after treatment. Results All patients successfully completed the rehabilitation training without severe adverse events. A few patients felt fatigue occasionally after training and recovered after rest. Compared to before treatment, the FMA-Balance score ( P = 0.000), MRMI score ( P = 0.000) and mBI score ( P = 0.000) after treatment in both groups were significantly increased. Compared to control group, the FMA-Balance score ( P = 0.031), MRMI score ( P = 0.013) and mBI score ( P = 0.049) after treatment in observation group were significantly increased. Conclusions MRP training in the early stage of stroke is beneficial to the recovery of motor function of patients. DOI: 10.3969/j.issn.1672-6731.2017.03.007","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"197-201"},"PeriodicalIF":0.0,"publicationDate":"2017-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44836945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-25DOI: 10.3969/cjcnn.v17i3.1564
Leiming Wang, Yong-juan Fu, Zhuo Li, Cui-cui Liu, D. Lu
Objective To investigate the clinicopathological and molecular genetic features of one case of mixed pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG) with BRAF V600E mutation. Methods and Results A 14-year-old boy mainly presented paroxymal loss of consciousness and tic of limbs for 6 years. Head MRI displayed circular abnormal signal on the hippocampus of left temporal lobe, considering space-occupying lesion. The patient underwent operation, and the lesion was totally removed. Pink gyri in deep temporal lobe could be seen during the operation. The tumor tissue was red grey, tough, nonencapsulated, with calcification, cystic degeneration, rich blood supply and clear boundary. Morphology showed the tumor grew diffusely and was heterogeneous: some areas showed the structure of GG and others showed the structure of PXA. Immunohistochemical staining and special staining showed in the region of GG, the tumor was scatteredly positive for glial fibrillary acidic protein (GFAP) and neurofilament protein (NF), gangliocyte-like cells were positive for microtubule associated protein-2 (MAP-2) and neuronal nuclei (NeuN), Ki-67 labeling index was 2%; in the region of PXA, spindle tumor cells were scatteredly positive for GFAP and NF, xanthomatoid cells were positive for CD163 and CD68, Ki-67 labeling index was 3%-5%, reticular fibers were abundant. Molecular detection showed that BRAF V600E mutation existed in both parts of the tumor. The patient was not treated by postoperative radiotherapy or chemotherapy. He took antiepileptic drugs (AEDs) orally [sodium valproate 1.20 g (twice a day) and levetiracetam 0.50 g (twice a day)] for one year, and the symptoms were greatly improved. He had no evidence of tumor recurrence in the 18-month follow-up period. Conclusions Combined PXA and GG is a rare tumor of the central nervous system (CNS). The tumor showed different morphological features of PXA and GG, but with the same BRAF V600E mutation molecular characteristics. This case may support the study on morphology, histological origin and molecular genetics for PXA and GG. DOI: 10.3969/j.issn.1672-6731.2017.03.008
{"title":"Mixed pleomorphic xanthoastrocytoma and ganglioglioma with existence of BRAF V600E mutation","authors":"Leiming Wang, Yong-juan Fu, Zhuo Li, Cui-cui Liu, D. Lu","doi":"10.3969/cjcnn.v17i3.1564","DOIUrl":"https://doi.org/10.3969/cjcnn.v17i3.1564","url":null,"abstract":"Objective To investigate the clinicopathological and molecular genetic features of one case of mixed pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG) with BRAF V600E mutation. Methods and Results A 14-year-old boy mainly presented paroxymal loss of consciousness and tic of limbs for 6 years. Head MRI displayed circular abnormal signal on the hippocampus of left temporal lobe, considering space-occupying lesion. The patient underwent operation, and the lesion was totally removed. Pink gyri in deep temporal lobe could be seen during the operation. The tumor tissue was red grey, tough, nonencapsulated, with calcification, cystic degeneration, rich blood supply and clear boundary. Morphology showed the tumor grew diffusely and was heterogeneous: some areas showed the structure of GG and others showed the structure of PXA. Immunohistochemical staining and special staining showed in the region of GG, the tumor was scatteredly positive for glial fibrillary acidic protein (GFAP) and neurofilament protein (NF), gangliocyte-like cells were positive for microtubule associated protein-2 (MAP-2) and neuronal nuclei (NeuN), Ki-67 labeling index was 2%; in the region of PXA, spindle tumor cells were scatteredly positive for GFAP and NF, xanthomatoid cells were positive for CD163 and CD68, Ki-67 labeling index was 3%-5%, reticular fibers were abundant. Molecular detection showed that BRAF V600E mutation existed in both parts of the tumor. The patient was not treated by postoperative radiotherapy or chemotherapy. He took antiepileptic drugs (AEDs) orally [sodium valproate 1.20 g (twice a day) and levetiracetam 0.50 g (twice a day)] for one year, and the symptoms were greatly improved. He had no evidence of tumor recurrence in the 18-month follow-up period. Conclusions Combined PXA and GG is a rare tumor of the central nervous system (CNS). The tumor showed different morphological features of PXA and GG, but with the same BRAF V600E mutation molecular characteristics. This case may support the study on morphology, histological origin and molecular genetics for PXA and GG. DOI: 10.3969/j.issn.1672-6731.2017.03.008","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"202-208"},"PeriodicalIF":0.0,"publicationDate":"2017-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41421729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-25DOI: 10.3969/CJCNN.V17I3.1568
Ning Zhang, Hua-tang Yang
Objective To investigate the effect of Glasgow Coma Scale (GCS) on the choice of treatment strategy in acute hypertensive intracerebral hemorrhage. Methods Among 286 patients with hypertensive intracerebral hemorrhage, 186 patients underwent operation. According to GCS scores on admission, 186 cases included 94 cases of GCS 5-8, 71 cases of GCS 9-11 and 21 cases of GCS 12-14. These patients respectively underwent hematoma clearance and decompressive craniotomy (N = 63, 22.03%), hematoma clearance (N = 21, 7.34%), trepanation and drainage or external ventricular drainage (N = 102, 35.66%). The rest (N = 100) underwent conservative treatment, including 25 cases of GCS 5-8, 27 cases of GCS 9-11, 25 cases of GCS 12-14 and 23 cases of GCS 15. Glasgow Outcome Scale (GOS) was used to evaluate curative effect after 3-6 months follow-up. Results The proportion of GOS in GCS 5-8 group was 14 cases (11.76%) of Grade 1, 21 cases (17.65%) of Grade 2, 39 cases (32.77%) of Grade 3, 22 cases (18.49%) of Grade 4 and 17 cases (14.29%) of Grade 5, except 6 lost cases (5.04%). The proportion of GOS in GCS 9-11 group was 6 cases (6.12%) of Grade 1, 2 cases (2.04%) of Grade 2, 6 cases (6.12%) of Grade 3, 48 cases (48.98%) of Grade 4 and 34 cases (34.69%) of Grade 5, except 2 lost cases (2.04%). The proportion of GOS in GCS 12-14 group was 15 cases (32.61%) of Grade 4 and 31 cases (67.39%) of Grade 5. The proportion of GOS in GCS 15 group was one case (4.35%) of Grade 4 and 22 cases (95.65%) of Grade 5. Differences between groups had statistical significance ( χ 2 = 142.966, P = 0.000). Conclusions The prognosis of patients with hypertensive intracerebral hemorrhage is positively related to GCS score on admission. The higher the GCS score is, the higher the GOS grade will be. DOI: 10.3969/j.issn.1672-6731.2017.03.011
{"title":"Effect of Glasgow Coma Scale on the choice of treatment strategy in acute hypertensive intracerebral hemorrhage","authors":"Ning Zhang, Hua-tang Yang","doi":"10.3969/CJCNN.V17I3.1568","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I3.1568","url":null,"abstract":"Objective To investigate the effect of Glasgow Coma Scale (GCS) on the choice of treatment strategy in acute hypertensive intracerebral hemorrhage. Methods Among 286 patients with hypertensive intracerebral hemorrhage, 186 patients underwent operation. According to GCS scores on admission, 186 cases included 94 cases of GCS 5-8, 71 cases of GCS 9-11 and 21 cases of GCS 12-14. These patients respectively underwent hematoma clearance and decompressive craniotomy (N = 63, 22.03%), hematoma clearance (N = 21, 7.34%), trepanation and drainage or external ventricular drainage (N = 102, 35.66%). The rest (N = 100) underwent conservative treatment, including 25 cases of GCS 5-8, 27 cases of GCS 9-11, 25 cases of GCS 12-14 and 23 cases of GCS 15. Glasgow Outcome Scale (GOS) was used to evaluate curative effect after 3-6 months follow-up. Results The proportion of GOS in GCS 5-8 group was 14 cases (11.76%) of Grade 1, 21 cases (17.65%) of Grade 2, 39 cases (32.77%) of Grade 3, 22 cases (18.49%) of Grade 4 and 17 cases (14.29%) of Grade 5, except 6 lost cases (5.04%). The proportion of GOS in GCS 9-11 group was 6 cases (6.12%) of Grade 1, 2 cases (2.04%) of Grade 2, 6 cases (6.12%) of Grade 3, 48 cases (48.98%) of Grade 4 and 34 cases (34.69%) of Grade 5, except 2 lost cases (2.04%). The proportion of GOS in GCS 12-14 group was 15 cases (32.61%) of Grade 4 and 31 cases (67.39%) of Grade 5. The proportion of GOS in GCS 15 group was one case (4.35%) of Grade 4 and 22 cases (95.65%) of Grade 5. Differences between groups had statistical significance ( χ 2 = 142.966, P = 0.000). Conclusions The prognosis of patients with hypertensive intracerebral hemorrhage is positively related to GCS score on admission. The higher the GCS score is, the higher the GOS grade will be. DOI: 10.3969/j.issn.1672-6731.2017.03.011","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"223-227"},"PeriodicalIF":0.0,"publicationDate":"2017-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42327763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-25DOI: 10.3969/CJCNN.V17I3.1569
Jing-wen Liu, Ju-ying Huang, F. Jian
Atlantoaxial joint, which is located in the body of the upper cervical spine, plays an important role in bearing and motion. It is the nerve center of medulla oblongata and spinal cord, and a lot of other important structures, such as neck arteriovenous and great occipital nerve, were distributed in this area, therefore the study on reasons and mechanism of atlantoaxial dislocation (AAD) is of great guiding significance for clinical treatment. This article will explore the specific mechanisms of AAD from the aspects of anatomy of atlantoaxial joint and surrounding structures, biomechanics and histology. DOI: 10.3969/j.issn.1672-6731.2017.03.012
{"title":"Study on the causes and mechanism of atlantoaxial dislocation","authors":"Jing-wen Liu, Ju-ying Huang, F. Jian","doi":"10.3969/CJCNN.V17I3.1569","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I3.1569","url":null,"abstract":"Atlantoaxial joint, which is located in the body of the upper cervical spine, plays an important role in bearing and motion. It is the nerve center of medulla oblongata and spinal cord, and a lot of other important structures, such as neck arteriovenous and great occipital nerve, were distributed in this area, therefore the study on reasons and mechanism of atlantoaxial dislocation (AAD) is of great guiding significance for clinical treatment. This article will explore the specific mechanisms of AAD from the aspects of anatomy of atlantoaxial joint and surrounding structures, biomechanics and histology. DOI: 10.3969/j.issn.1672-6731.2017.03.012","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"228-231"},"PeriodicalIF":0.0,"publicationDate":"2017-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46674046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-25DOI: 10.3969/CJCNN.V17I3.1561
Wei-bo Shao, Yaofei Wang, Wei Jiang, L. Tian, Jiehong Zhang
Objective To investigate the mechanism and effect of columnar balloon dilatation therapy on treating patients with severe dysphagia caused by upper esophageal sphincter (UES) achalasia after stroke. Methods Sixty -four patients with severe dysphagia caused by UES achalasia after stroke were diagnosed through Video Fluoroscopic Swallowing Study (VFSS) and esophageal dynamics testing. The patients were randomly divided into control group (N = 32) and treatment group (N = 32). Patients in control group were treated with routine drug treatment and routine rehabilitation training, while patients in treatment group were treated with columnar balloon dilatation therapy on the basis of routine treatment. The treatment end point was either the patient resuming an oral diet or after 4-weeks treatment. All cases were evaluated by swallowing function of VFSS, high resolution manometry (HRM) and scores of the severity of dysphagia before treatment and at treatment end point. Results Compared with before treatment, UES resting pressure ( P = 0.000) and residual pressure ( P = 0.000) were significantly decreased, peak pressure was significantly increased ( P = 0.000), duration of relaxation was prolonged ( P = 0.000), and scores of the severity of dysphagia were significantly increased ( P = 0.000, 0.000) in both groups after treatment. Compared with control group, UES resting pressure ( P = 0.001) and residual pressure ( P = 0.000) were significantly decreased, peak pressure was significantly increased ( P = 0.002), duration of relaxation was prolonged ( P = 0.000), and scores of the severity of dysphagia were significantly increased ( P = 0.000) in treatment group after treatment. Until the treatment end point or after 4-week treatment, the total effective rate in treatment group was significantly higher than that in control group [93.75% (30/32) vs. 81.25% (26/32); χ 2 = 4.010, P = 0.000]. Conclusions Columnar balloon dilatation therapy is effective for reducing the tension of upper esophageal sphincter and relieving spasm after stroke. It has obvious therapeutic effect on the upper esophageal sphincter achalasia. DOI: 10.3969/j.issn.1672-6731.2017.03.005
{"title":"Clinical study of columnar balloon dilatation therapy for severe dysphagia caused by upper esophageal sphincter achalasia after stroke","authors":"Wei-bo Shao, Yaofei Wang, Wei Jiang, L. Tian, Jiehong Zhang","doi":"10.3969/CJCNN.V17I3.1561","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I3.1561","url":null,"abstract":"Objective To investigate the mechanism and effect of columnar balloon dilatation therapy on treating patients with severe dysphagia caused by upper esophageal sphincter (UES) achalasia after stroke. Methods Sixty -four patients with severe dysphagia caused by UES achalasia after stroke were diagnosed through Video Fluoroscopic Swallowing Study (VFSS) and esophageal dynamics testing. The patients were randomly divided into control group (N = 32) and treatment group (N = 32). Patients in control group were treated with routine drug treatment and routine rehabilitation training, while patients in treatment group were treated with columnar balloon dilatation therapy on the basis of routine treatment. The treatment end point was either the patient resuming an oral diet or after 4-weeks treatment. All cases were evaluated by swallowing function of VFSS, high resolution manometry (HRM) and scores of the severity of dysphagia before treatment and at treatment end point. Results Compared with before treatment, UES resting pressure ( P = 0.000) and residual pressure ( P = 0.000) were significantly decreased, peak pressure was significantly increased ( P = 0.000), duration of relaxation was prolonged ( P = 0.000), and scores of the severity of dysphagia were significantly increased ( P = 0.000, 0.000) in both groups after treatment. Compared with control group, UES resting pressure ( P = 0.001) and residual pressure ( P = 0.000) were significantly decreased, peak pressure was significantly increased ( P = 0.002), duration of relaxation was prolonged ( P = 0.000), and scores of the severity of dysphagia were significantly increased ( P = 0.000) in treatment group after treatment. Until the treatment end point or after 4-week treatment, the total effective rate in treatment group was significantly higher than that in control group [93.75% (30/32) vs. 81.25% (26/32); χ 2 = 4.010, P = 0.000]. Conclusions Columnar balloon dilatation therapy is effective for reducing the tension of upper esophageal sphincter and relieving spasm after stroke. It has obvious therapeutic effect on the upper esophageal sphincter achalasia. DOI: 10.3969/j.issn.1672-6731.2017.03.005","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"185-191"},"PeriodicalIF":0.0,"publicationDate":"2017-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46234284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-25DOI: 10.3969/CJCNN.V17I3.1558
Wanjun Wang, Jia-Ling Wu
Stroke has become the second most common cause of death and the leading common cause of disability in China. Early rehabilitation of ischemic stroke has been approved widely, but early rehabilitation of hemorrhagic stroke has not been agreed, especially regard to the time for commence and the safety of early rehabilitation. Rehabilitation technology after stroke has been explored and researched continuously, in order to improve motor function and activities of daily living (ADL) of patients with stroke. This paper selected three high-quality perspective randomized controlled trails (RCTs) by Chinese scholars regarding early rehabilitation after stroke, which were published in foreign journals during past 3 years, and focused on study methods and results. DOI: 10.3969/j.issn.1672-6731.2017.03.002
{"title":"Study on early rehabilitation and rehabilitation technology after stroke: Chinese scholars' reports published abroad","authors":"Wanjun Wang, Jia-Ling Wu","doi":"10.3969/CJCNN.V17I3.1558","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I3.1558","url":null,"abstract":"Stroke has become the second most common cause of death and the leading common cause of disability in China. Early rehabilitation of ischemic stroke has been approved widely, but early rehabilitation of hemorrhagic stroke has not been agreed, especially regard to the time for commence and the safety of early rehabilitation. Rehabilitation technology after stroke has been explored and researched continuously, in order to improve motor function and activities of daily living (ADL) of patients with stroke. This paper selected three high-quality perspective randomized controlled trails (RCTs) by Chinese scholars regarding early rehabilitation after stroke, which were published in foreign journals during past 3 years, and focused on study methods and results. DOI: 10.3969/j.issn.1672-6731.2017.03.002","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"166-170"},"PeriodicalIF":0.0,"publicationDate":"2017-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45289758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-25DOI: 10.3969/cjcnn.v17i2.1550
Sheng Li, Lin Wang, H. Guan, Jun-ji Wei, B. Peng, X. Wan
Objective To explore the clinical presentations, imaging features, probable pathogenesis and therapy of parkinsonism following ventriculoperitoneal shunt (VPS) in hydrocephalus. Methods and Results There were 3 cases of parkinsonism following VPS in hydrocephalus. Case 1 presented parkinsonism one month after the second ventricular shunt, which was not relieved by another VPS, and was then treated by levodopa and benserazide. Case 2 developed neck rigidity and bradykinesia 17 years after VPS. Symptoms worsened shortly after taking sulpiride and did not improved with sulpiride cessation. Bradykinesia and decreased speech occurred 5 months after VPS in Case 3, and parkinsonism aggravated rapidly on the following day after taking olanzapine. CT and/or MRI of 3 cases showed fluctuating change (enlarging-shrinking) of lateral ventricles. They were diagnosed as parkinsonism following VPS, and responded well to levodopa and benserazide. Conclusions Parkinsonism, a rare complication following VPS in hydrocephalus, may result from interruption of nigrostriatal pathways due to ventricular fluctuations. Administration of dopamine D2 receptor antagonist may exacerbate the symptoms of parkinsonism because of "double hit". Most patients are responsive to dopaminergic drugs. DOI: 10.3969/j.issn.1672-6731.2017.02.008
{"title":"Parkinsonism following ventriculoperitoneal shunt for treating hydrocephalus:clinical analysis on three cases","authors":"Sheng Li, Lin Wang, H. Guan, Jun-ji Wei, B. Peng, X. Wan","doi":"10.3969/cjcnn.v17i2.1550","DOIUrl":"https://doi.org/10.3969/cjcnn.v17i2.1550","url":null,"abstract":"Objective To explore the clinical presentations, imaging features, probable pathogenesis and therapy of parkinsonism following ventriculoperitoneal shunt (VPS) in hydrocephalus. Methods and Results There were 3 cases of parkinsonism following VPS in hydrocephalus. Case 1 presented parkinsonism one month after the second ventricular shunt, which was not relieved by another VPS, and was then treated by levodopa and benserazide. Case 2 developed neck rigidity and bradykinesia 17 years after VPS. Symptoms worsened shortly after taking sulpiride and did not improved with sulpiride cessation. Bradykinesia and decreased speech occurred 5 months after VPS in Case 3, and parkinsonism aggravated rapidly on the following day after taking olanzapine. CT and/or MRI of 3 cases showed fluctuating change (enlarging-shrinking) of lateral ventricles. They were diagnosed as parkinsonism following VPS, and responded well to levodopa and benserazide. Conclusions Parkinsonism, a rare complication following VPS in hydrocephalus, may result from interruption of nigrostriatal pathways due to ventricular fluctuations. Administration of dopamine D2 receptor antagonist may exacerbate the symptoms of parkinsonism because of \"double hit\". Most patients are responsive to dopaminergic drugs. DOI: 10.3969/j.issn.1672-6731.2017.02.008","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"127-132"},"PeriodicalIF":0.0,"publicationDate":"2017-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47116755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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